Outcomes of multisite antimicrobial stewardship programme implementation with a shared clinical decision support system

Journal of Antimicrobial Chemotherapy

Volumn 72, Issue 7, 2017, Pages 2110-2118

  Bond, Stuart E ^a,b   Chubaty, Adriana J ^c   Adhikari, Suman ^d,e   Miyakis, Spiros ^a,b   Boutlis, Craig S ^a   Yeo, Wilfred W ^b,f   Batterham, Marijka J ^b   Dickson, Cara ^g   McMullan, Brendan J ^h   Mostaghim, Mona ^h   Li Yan Hui, Samantha ^g   Clezy, Kate R ^c   Konecny, Pamela ^d,e  

^a WOLLONGONG HOSPITAL   (Australia)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c PRINCE OF WALES HOSPITAL   (Australia)

^d ST GEORGE HOSPITAL   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

^f Division of Medicine   (Australia)

^g SOUTH EASTERN SYDNEY LOCAL HEALTH DISTRICT   (Australia)

^h SYDNEY CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPENICILLIN; AMOXICILLIN; AMPHOTERICIN B LIPID COMPLEX; AMPICILLIN; ANIDULAFUNGIN; ANTIINFECTIVE AGENT; AZITHROMYCIN; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CASPOFUNGIN; CEFOTAXIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; CLARITHROMYCIN; DORIPENEM; DOXYCYCLINE; ERTAPENEM; ERYTHROMYCIN; MACROLIDE; MOXIFLOXACIN; NORFLOXACIN; PENICILLIN DERIVATIVE; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; POSACONAZOLE; QUINOLONE DERIVATIVE; ROXITHROMYCIN; TIMENTIN; VORICONAZOLE;

ARTICLE; AUSTRALIA; CLINICAL DECISION SUPPORT SYSTEM; CLOSTRIDIUM DIFFICILE INFECTION; DRUG COST; DRUG USE; HEALTH PROGRAM; HEALTHCARE ASSOCIATED INFECTION; HUMAN; LENGTH OF STAY; OUTCOME ASSESSMENT; RESPIRATORY TRACT INFECTION; SEPTICEMIA; STANDARDIZED MORTALITY RATIO; ANTIMICROBIAL STEWARDSHIP; CROSS INFECTION; ECONOMICS; EPIDEMIOLOGY; HEALTH CARE PLANNING; HOSPITAL; LEGISLATION AND JURISPRUDENCE; MORTALITY; STATISTICS AND NUMERICAL DATA; SUPPLY AND DISTRIBUTION;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL STEWARDSHIP; AUSTRALIA; CROSS INFECTION; DECISION SUPPORT SYSTEMS, CLINICAL; HEALTH PLAN IMPLEMENTATION; HOSPITALS; HUMANS; INTERRUPTED TIME SERIES ANALYSIS; LENGTH OF STAY;

EID: 85021818954     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkx080     Document Type: Article

References (44)

1. ACSQHC 2011. Antimicrobial Stewardship in Australian Hospitals. https://www.safetyandquality.gov.au/wp-content/uploads/2011/01/Antimicrobialstewardship- in-Australian-Hospitals-2011.pdf.
2. Barlam TF, Cosgrove SE, Abbo LM et al. Implementing an antibiotic stewardship program: guidelines by the infectious diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 2016; 62: e51-77.
3. Cairns KA, Jenney AW, Abbott IJ et al. Prescribing trends before and after implementation of an antimicrobial stewardship program. Med J Aust 2013; 198: 262-6.
4. Sick AC, Lehmann CU, Tamma PD et al. Sustained savings from a longitudinal cost analysis of an internet-based preapproval antimicrobial stewardship program. Infect Control Hosp Epidemiol 2013; 34: 573-80.
5. Standiford HC, Chan S, Tripoli M et al. Antimicrobial stewardship at a large tertiary care academic medical center: cost analysis before, during, and after a 7-year program. Infect Control Hosp Epidemiol 2012; 33: 338-45.
6. Nowak MA, Nelson RE, Breidenbach JL et al. Clinical and economic outcomes of a prospective antimicrobial stewardship program. Am J Health Syst Pharm 2012; 69: 1500-8.
7. Baysari MT, Lehnbom EC, Li L et al. The effectiveness of information technology to improve antimicrobial prescribing in hospitals: a systematic review andmeta-analysis. Int J Med Inform 2016; 92: 15-34.
8. Schuts EC, Hulscher ME, Mouton JW et al. Current evidence on hospital antimicrobial stewardship objectives: a systematic review andmeta-analysis. Lancet Infect Dis 2016; 16: 847-56.
9. Ostrowsky B, Ruiz R, Brown S et al. Lessons learned from implementing Clostridium difficile-focused antibiotic stewardship interventions. Infect Control Hosp Epidemiol 2014; 35 Suppl 3: S86-95.
10. Lai CC, Shi ZY, Chen YH et al. Effects of various antimicrobial stewardship programs on antimicrobial usage and resistance among common gramnegative bacilli causing health care-associated infections: amulticenter comparison. JMicrobiol Immunol Infect 2016; 49: 74-82.
11. Cosgrove SE, Seo SK, Bolon MK et al. Evaluation of postprescription review and feedback as a method of promoting rational antimicrobial use: a multicenter intervention. Infect Control Hosp Epidemiol 2012; 33: 374-80.
12. Davey P, Brown E, Charani E et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev 2013; issue 4: CD003543.
13. Carling P, Fung T, Killion A et al. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol 2003; 24: 699-706.
14. Ansari F, Gray K, Nathwani D et al. Outcomes of an intervention to improve hospital antibiotic prescribing: interrupted time series with segmented regression analysis.JAntimicrobChemother 2003; 52: 842-8.
15. Aldeyab MA, Kearney MP, Scott MG et al. An evaluation of the impact of antibiotic stewardship on reducing the use of high-risk antibiotics and its effect on the incidence of Clostridium difficile infection in hospital settings. J Antimicrob Chemother 2012; 67: 2988-96.
16. Morris AM, Brener S, Dresser L et al. Use of a structured panel process to define quality metrics for antimicrobial stewardship programs. Infect Control Hosp Epidemiol 2012; 33: 500-6.
17. KhademTM, Dodds Ashley E,WrobelMJ et al. Antimicrobial stewardship: a matter of process or outcome? Pharmacotherapy 2012; 32: 688-706.
18. NSW Health. Services and Facilities Annual Report 2009-2010. http://www.health.nsw.gov.au/publications/Publications/Annual-Report-2009-10/09-Services-and-Facilities.pdf.
19. Guidance Group. GuidanceMS. http://www.guidancems.org.au/.
20. Antibiotic Expert Group. Therapeutic Guidelines: Antibiotic. Version 14. Melbourne: Therapeutic Guidelines Limited, 2010.
21. SA Health. National Antimicrobial Utilisation Surveillance Program. http://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+int ernet/about+us/health+statistics/healthcare+infection+statistics/antimicro bial+utilisation+surveillance+statistics.
22. WHO. ATC/DDD Index. http://www.whocc.no/atc_ddd_index/.
23. Australian Council on Healthcare Standards. Infection Control Version 4: Clinical Indicator UserManual. ACHS: Ultimo, NSW, Australia, 2014.
24. AIHW. Hospitals Data. http://www.aihw.gov.au/hospitals-data.
25. ACSQHC. Antimicrobial Prescribing Practice in Australian Hospitals: Results of the 2014 National Antimicrobial Prescribing Survey. https://www.safetyand quality.gov.au/wp-content/uploads/2015/07/Antimicrobial-prescribing-prac tice-in-Aust-hospitals-NAPS-2014-Results.pdf.
26. Gauer RL. Early recognition and management of sepsis in adults: the first six hours.AmFamPhysician 2013; 88: 44-53.
27. National Health Funding Pool. Calculation of NWAU. http://www.publicho spitalfunding.gov.au/national-health-reform/reporting-calculation-nwau.
28. Linden A. Conducting interrupted time series analysis for single and multiple group comparison. Stata J 2015; 15: 480-500.
29. Charlson ME, Pompei P, Ales KL et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. JChronicDis.1987; 40: 373-83.
30. Antibiotic Expert Groups. Therapeutic Guidelines: Antibiotic. Version 15. Melbourne: Therapeutic Guidelines Limited, 2014.
31. Antoine TL, Curtis AB, Blumberg HMet al. Knowledge, attitudes, and behaviors regarding piperacillin-tazobactam prescribing practices: results fromamulticenter study. Infect Control Hosp Epidemiol 2006; 27: 1274-7.
32. Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and clinical decision support systems on medication safety. Arch Intern Med 2003; 163: 1409-16.
33. Buising KL, Thursky KA, Black JF et al. Improving antibiotic prescribing for adults with community acquired pneumonia: does a computerised decision support system achieve more than academic detailing alone?-A time series analysis. BMCMed Inform DecisMak 2008; 8: 35.
34. Thursky K. Use of computerized decision support systems to improve antibiotic prescribing. Expert Rev Anti Infect Ther 2006; 4: 491-507.
35. Fowler S, Webber A, Cooper BS et al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series. J Antimicrob Chemother.2007; 59: 990-5.
36. BroomA, Broom J, Kirby E. Cultures of resistance? A Bourdieusian analysis of doctors' antibiotic prescribing. Soc Sci Med 2014; 110: 81-8.
37. Charani E, Edwards R, SevdalisNet al. Behavior change strategies to influence antimicrobial prescribing in acute care: a systematic review. Clin Infect Dis 2011; 53: 651-62.
38. Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med 2015; 372: 1539-48.
39. Slimings C, Armstrong P, Beckingham WD et al. Increasing incidence of Clostridium difficile infection, Australia, 2011-2012. Med J Aust 2014; 200: 272-6.
40. Porta A, Hsia Y, Doerholt K et al. Comparing neonatal and paediatric antibiotic prescribing between hospitals: a new algorithm to help international benchmarking. J Antimicrob Chemother 2012; 67: 1278-86.
41. Sammons JS, Localio R, Xiao R et al. Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children. Clin Infect Dis 2013; 57: 1-8.
42. McGowan JE. Antimicrobial stewardship-the state of the art in 2011: focus on outcome and methods. Infect Control Hosp Epidemiol 2012; 33: 331-7.
43. Goff DA. Antimicrobial stewardship: bridging the gap between quality care and cost. Curr Opin Infect Dis 2011; 24 Suppl 1: S11-20.
44. CEC. Patient Safety Programs. http://www.cec.health.nsw.gov.au/patientsafety- programs.