Effects of computerized physician order entry and clinical decision support systems on medication safety: A systematic review

Archives of Internal Medicine

Volumn 163, Issue 12, 2003, Pages 1409-1416

  Kaushal, Rainu ^a   Shojania, Kaveh G ^b   Bates, David W ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; GLUCOSE; HEPARIN; INSULIN; MORPHINE; PENICILLIN G; THEOPHYLLINE; WARFARIN;

BLEEDING; CLINICAL DECISION SUPPORT SYSTEM; CLINICAL TRIAL; COCHRANE LIBRARY; COMPUTER SYSTEM; COMPUTERIZED PHYSICIAN ORDER ENTRY; CONTROLLED CLINICAL TRIAL; COST BENEFIT ANALYSIS; DRUG DOSE REGIMEN; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; DRUG SAFETY; DRUG UTILIZATION; ERROR; EVALUATION; HUMAN; IATROGENIC DISEASE; MEDICAL DECISION MAKING; MEDICAL TECHNOLOGY; MEDLINE; NEPHROTOXICITY; OBSERVATION; OUTCOMES RESEARCH; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; REVIEW; SYSTEM ANALYSIS; TECHNIQUE;

COST-BENEFIT ANALYSIS; DECISION SUPPORT SYSTEMS, CLINICAL; DRUG THERAPY, COMPUTER-ASSISTED; HOSPITAL INFORMATION SYSTEMS; HUMANS; MEDICAL RECORDS SYSTEMS, COMPUTERIZED; MEDICATION ERRORS; MEDICATION SYSTEMS, HOSPITAL;

EID: 0037663736     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.163.12.1409     Document Type: Review

References (63)

1. Barker KN, Mikeal RL, Pearson RE, Illig NA, Morse ML. Medication errors in nursing homes and small hospitals. Am J Hosp Pharm. 1982;39:987-991.
2. Bates DW, Cullen D, Laird N, et al. Incidence of adverse drug events and potential adverse drug events: implications for prevention. JAMA. 1995;274:29-34.
3. Dean BS, Allan EL, Barber ND, Barker KN. Comparison of medication errors in an American and a British hospital. Am J Health Syst Pharm. 1995; 52:2543-2549.
4. Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients: excess length of stay, extra costs, and attributable mortality. JAMA. 1997;277:301-306.
5. Cullen DJ, Sweitzer BJ, Bates DW, Burdick E, Edmondson A, Leape LL. Preventable adverse drug events in hospitalized patients: a comparative study of intensive care units and general care units. Crit Care Med. 1997;25:1289-1297.
6. Lesar TS, Lomaestro BM, Pohl H. Medication-prescribing errors in a teaching hospital: a 9-year experience. Arch Intern Med. 1997;157:1569-1576.
7. Kaushal R, Bates DW, Landrigan C, et al. Medication errors and adverse drug events in pediatric inpatients. JAMA. 2001;285:2114-2120.
8. Cullen DJ, Bates DW, Small SD, Cooper JB, Nemeskal AR, Leape LL. The incident reporting system does not detect adverse drug events: a problem for quality improvement. Jt Comm J Qual Improv. 1995;21:541-548.
9. Bates DW, Boyle DL, Vander Vliet MB, Schneider J, Leape LL. Relationship between medication errors and adverse drug events. J Gen Intern Med. 1995;10:199-205.
10. Jha AK, Kuperman GJ, Teich JM, et al. Identifying adverse drug events: development of a computer-based monitor and comparison with chart review and stimulated voluntary report. J Am Med Inform Assoc. 1998;5:305-314.
11. US General Accounting Office. Adverse Drug Events. Washington, DC: US General Accounting Office; 2000. Publication No. GAO/HEHS-00-21.
12. Leape LL, Bates DW, Cullen DJ, et al. Systems analysis of adverse drug events. JAMA. 1995; 274:35-43.
13. Institute of Medicine. To Err Is Human: Building a Safer Health System. Washington, DC: National Academy Press; 1999.
14. Ash JS, Gorman PN, Hersh WR. Physician order entry in US hospitals. Proc AMIA Symp. 1998; 235-239.
15. Pedersen CA, Schneider PJ, Santell JP. ASHP national survey of pharmacy practice in hospital settings: prescribing and transcribing-2001. Am J Health Syst Pharm. 2001;58:2251-2266.
16. Bates DW, Cohen M, Leape LL, Overhage JM, Shabot MM, Sheridan T. Reducing the frequency of errors in medicine using information technology. J Am Med Inform Assoc. 2001;8:299-308.
17. Walton RT, Harvey E, Dovey S, Freemantle N. Computerised advice on drug dosage to improve prescribing practice. Cochrane Database Syst Rev. 2001;1;CD002894.
18. Hunt DL, Haynes RB, Hanna SE, Smith K. Effects of computer-based clinical decision support systems on physician performance and patient outcomes: a systematic review. JAMA. 1998;280: 1339-1346.
19. Raschke RA, Gollihare B, Wunderlich TA, et al. A computer alert system to prevent injury from adverse drug events: development and evaluation in a community teaching hospital. JAMA. 1998;280:1317-1320.
20. Rind DM, Safran C, Phillips RS, et al. Effect of computer-based alerts on the treatment and outcomes of hospitalized patients. Arch Intern Med. 1994;154:1511-1517.
21. Theil DR, Stanley TE III, White WD, et al. Midazolam and fentanyl continuous infusion anesthesia for cardiac surgery: a comparison of computer-assisted versus manual infusion systems. J Cardiothorac Vasc Anesth. 1993;7:300-306.
22. Ruiz R, Borches D, Gonzalez A, Corral J. A new sodium-nitroprusside-infusion controller for the regulation of arterial blood pressure. Biomed Instrum Technol. 1993;27:244-251.
23. Alvis JM, Reyes JG, Govier AV, et al. Computer-assisted continuous infusions of fentanyl during cardiac anesthesia: comparison with a manual method. Anesthesiology. 1985;63:41-49.
24. Owens DK, Nease RF Jr. A normative analytic framework for development of practice guidelines for specific clinical populations. Med Decis Making. 1997;17:409-426.
25. Harris RP, Helfand M, Woolf SH, et al. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med. 2001; 20(suppl):21-35.
26. Guyatt G, Schunemann H, Cook D, et al. Grades of recommendation for antithrombotic agents. Chest. 2001;119:3S-7S.
27. Bucher HC, Guyatt GH, Cook DJ, Holbrook A, McAlister FA, for the Evidence-Based Medicine Working Group. Users' guides to the medical literature, XIX: applying clinical trial results, A: how to use an article measuring the effect of an intervention on surrogate end points. JAMA. 1999; 282:771-778.
28. Mulrow C, Langhorne P, Grimshaw J. Integrating heterogeneous pieces of evidence in systematic reviews. Ann Intern Med. 1997;127:989-995.
29. Juni P, Witschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trials for meta-analysis. JAMA. 1999;282:1054-1060.
30. McKee M, Britton A, Black N, McPherson K, Sanderson C, Bain C. Methods in health services research: interpreting the evidence: choosing between randomized and non-randomized studies. BMJ. 1999;319:312-315.
31. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000;283: 2008-2012.
32. Juni P, Altman DG, Egger M. Systematic reviews in health care: assessing the quality of controlled clinical trials. BMJ. 2001;323:42-46.
33. Shojania KG, Duncan BW, McDonald KM, Wachter RM. Making Health Care Safer: A Critical Analysis of Patient Safety Practices. Rockville, Md: Agency for Healthcare Research and Quality; 2001. AHRQ publication No. 01-E058.
34. Overhage JM, Tierney WM, Zhou XH, McDonald CJ. A randomized trial of "corollary orders" to prevent errors of omission. J Am Med Inform Assoc. 1997;4:364-375.
35. Bates DW, Leape LL, Cullen DJ, et al. Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. JAMA. 1998;280:1311-1316.
36. Bates DW, Teich J, Lee J, et al. The impact of computerized physician order entry on medication error prevention. J Am Med Inform Assoc, 1999;6: 313-321.
37. Teich JM, Merchia PR, Schmiz JL, Kuperman GJ, Spurr C, Bates DW. Effects of computerized physician order entry in prescribing practices. Arch Intern Med. 2000;160:2741-2747.
38. Chertow GM, Lee J, Kuperman GJ, et al. Guided medication dosing for inpatients with renal insufficiency. JAMA. 2001;286:2839-2844.
39. Burton ME, Ash CL, Hill DP Jr, Handy T, Shepherd MD, Vasko MR. A controlled trial of the cost benefit of computerized bayesian aminoglycoside administration. Clin Pharmacol Ther. 1991; 49:685-694.
40. Evans RS, Classen DC, Pestonik SL, Lundsgaarde HP, Burke JP. Improving empiric antibiotic selection using computer decision support. Arch Intern Med. 1994;154:878-884.
41. Evans RS, Pestotnik SL, Classen DC, et al. A computer-assisted management program for antibiotics and other antiinfective agents. N Engl J Med. 1998;338:232-238.
42. Casner PR, Reilly R, Ho H. A randomized controlled trial of computerized pharmacokinetic theophylline dosing versus empiric physician dosing. Clin Pharmacol Ther. 1993;53:684-690.
43. Hurley SF, Dziukas LJ, McNeil JJ, Brignell MJ. A randomized controlled clinical trial of pharmacokinetic theophylline dosing. Am Rev Respir Dis. 1986;134:1219-1224.
44. Mungall DR, Anbe D, Forrester PL, et al. A prospective randomized comparison of the accuracy of computer-assisted versus GUSTO nomogram: directed heparin therapy. Clin Pharmacol Ther. 1994;55:591-596.
45. White RH, Hong R, Venook AP, et al. Initiation of warfarin therapy: comparison of physician dosing with computer-assisted dosing. J Gen Intern Med. 1987;2:141-148.
46. McAlister FA, Laupacis A, Wells GA, Sackett DL. Users' guides to the medical literature, XIX: applying clinical trial results, B: guidelines for determining whether a drug is exerting (more than) a class effect. JAMA. 1999;282:1371-1377.
47. Rogers EM. Diffusion of Innovations. New York, NY: Free Press; 1983.
48. Lorenzi NM, Riley RT, Blyth AJ, Southon G, Dixon BJ. Antecedents of the people and organizational aspects of medical informatics: review of the literature. J Am Med Inform Assoc. 1997;4:79-93.
49. Oostendorp A, Hoekstra S, Aarts J. Exploring factors required for successful implementation of healthcare informatics. Stud Health Technol Inform. 1998;51:146-151.
50. Berg M. Patient care information systems and health care work: a sociotechnical approach. Int J Med Inf 1999;55:87-101.
51. Massaro TA. Introducing physician order entry at a major academic medical center, I: impact on organizational culture and behavior. Acad Med. 1993; 68:20-25.
52. Kleinke JD. Release 0.0: clinical information technology in the real world. Health Aff (Millwood). 1998;17:23-38.
53. Glaser J, Teich JM, Kuperman G. Impact of information events on medical care. In: Proceedings of the 1996 HIMMS Annual Conference: Chicago, III: Healthcare Information and Management Systems Society; 1996:1-9.
54. Shojania KG, Yokoe D, Platt R, Fiskio J, Ma'luf N, Bates, DW. Reducing vancomycin utilization using a computerized guideline: results of a randomized control trial. J Am Med Inform Assoc. 1998;5:554-562.
55. Teich J, Glaser J, Beckley RF, et al. Toward cost-effective, quality care: the Brigham Integrated Computing System. Steen EB, ed. Proceedings From the Second Annual Nicholas E. Davies CPR Recognition Symposium. Washington, DC: Computer-based Patient Record Institute; 1996:5-34.
56. Tierney WM, Miller ME, Overhage JM, McDonald CJ. Physician inpatient order writing on microcomputer workstations: effects on resource utilization. JAMA. 1993;269:379-383.
57. Bates DW, Spell N, Cullen D, et al. The costs of adverse drug events in hospitalized patients. JAMA. 1997;277:307-311.
58. Evans RS, Pestonik SL, Classen DC, Burke JP. Evaluation of a computer-assisted antibiotic-dose monitor. Ann Pharmacother. 1999;33:1026-1031.
59. Nadzam DM, Macklis RM. Promoting patient safety: is technology the solution? Jt Comm J Qual Improv. 2001;27:430-436.
60. Milstein A, Galvin RS, Delbanco SF, Salber P, Buck CR. Improving the safety of health care: the Leapfrog initiative. Eff Clin Pract. 2000;3:313-316.
61. Medicare Payment Advisory Commission. Report to the Congress: Selected Medicare Issues. Washington, DC: Medicare Payment Advisory Commission; 1999.
62. Medication Errors Reduction Act of 2001, S 824, 107th Cong, 1st Sess (2001).
63. California Senate Bill 1875, Chapter 816 §1339.63 (September 28, 2000).