High ceftazidime hydrolysis activity and porin OmpK35 deficiency contribute to the decreased susceptibility to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniae

Journal of Antimicrobial Chemotherapy

Volumn 72, Issue 7, 2017, Pages 1930-1936

  Shen, Zhen ^a,b   Ding, Baixing ^a,b   Ye, Meiping ^a,b   Wang, Peng ^c   Bi, Yingmin ^a,b   Wu, Shi ^a,b   Xu, Xiaogang ^a,b   Guo, Qinglan ^a,b   Wang, Minggui ^a,b  

^a FUDAN UNIVERSITY   (China)

^b National Health and Family Planning Commission   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AVIBACTAM PLUS CEFTAZIDIME; CEFTAZIDIME; NITROCEFIN; PORIN; AVIBACTAM; AVIBACTAM, CEFTAZIDIME DRUG COMBINATION; AZABICYCLO DERIVATIVE; BACTERIAL PROTEIN; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BETA-LACTAMASE KPC-2, KLEBSIELLA PNEUMONIAE; OMPK35 PORIN, KLEBSIELLA PNEUMONIAE; OMPK36 PROTEIN, KLEBSIELLA PNEUMONIAE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; COPY NUMBER VARIATION; GENE OVEREXPRESSION; HYDROLYSIS; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMID; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STOP CODON; BIOSYNTHESIS; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; KLEBSIELLA INFECTION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS;

AZABICYCLO COMPOUNDS; BACTERIAL PROTEINS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; CEFTAZIDIME; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROLYSIS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PORINS;

EID: 85021816193     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkx066     Document Type: Article

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