Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiota

Oncotarget

Volumn 8, Issue 27, 2017, Pages 44625-44638

  Ma, Ning ^a   Wu, Yi ^a   Xie, Fei ^a   Du, Kexin ^a   Wang, Yuan ^a   Shi, Linxin ^a   Ji, Linbao ^a   Liu, Tianyi ^a   Ma, Xi ^a,b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Dimethyl fumarate; Intestinal barrier function; Microbial composition and distribution; Mycotoxin; Ultraviolet radiation

Indexed keywords

CLAUDIN 1; FUMARIC ACID DIMETHYL ESTER; MYCOTOXIN; RNA 16S; SHORT CHAIN FATTY ACID; DIMETHYL FUMARATE; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ARTICLE; BACILLUS; BACTERIUM COLONY; BACTEROIDES; BACTEROIDETES; CONTROLLED STUDY; DETOXIFICATION; FIRMICUTES; GEMELLA; GENE SEQUENCE; ILEUM; INTESTINAL BARRIER; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; JEJUNUM; LACTOBACILLUS; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PROTEIN EXPRESSION; RISK REDUCTION; ROSEBURIA; SEQUENCE ANALYSIS; SPECIES COMPOSITION; SPECIES DISTRIBUTION; SPECIES RICHNESS; ULTRAVIOLET RADIATION; UPREGULATION; ANIMAL; ANIMAL FOOD; ANIMAL MODEL; BIODIVERSITY; DRUG EFFECT; FOOD ANALYSIS; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; PATHOLOGY;

ANIMAL FEED; ANIMALS; BIODIVERSITY; DIMETHYL FUMARATE; FOOD ANALYSIS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; MICE; MODELS, ANIMAL; MYCOTOXINS; ULTRAVIOLET RAYS;

EID: 85021813735     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.17886     Document Type: Article

References (43)

1. Chilaka CA, De Boevre M, Atanda OO, De Saeger S. The status of fusarium mycotoxins in sub-Saharan Africa: a review of emerging trends and post-harvest mitigation strategies towards food control. Toxins (Basel). 2017; 9:19.
2. Lessard M, Savard C, Deschene K, Lauzon K, Pinilla VA, Gagnon CA, Lapointe J, Guay F, Chorfi Y. Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine. Food Chem Toxicol. 2015; 80:7-16.
3. Park SH, Choi HJ, Yang H, Do KH, Kim J, Moon Y. Repression of peroxisome proliferator-activated receptor gamma by mucosal ribotoxic insult-activated CCAAT/enhancer-binding protein homologous protein. J Immunol. 2010; 185:5522-5530.
4. Fan P, Song P, Li L, Huang C, Chen J, Yang W, Qiao S, Zhang G, Ma X. Roles of biogenic amines in intestinal signaling. Curr Protein Pept Sci. 2017; 18:532-540.
5. Wang W, Yang Q, Sun Z, Chen X, Yang C, Ma X. Editorial: advance of interactions between exogenous natural bioactive peptides and intestinal barrier and immune responses. Curr Protein Pept Sci. 2015; 16:574-575.
6. Fan P, Liu P, Song P, Chen X, Ma X. Moderate dietary protein restriction improves the composition of gut microbiota and ileal barrier function in adult pig model. Sci Rep. 2017; 7:43412.
7. Pinton P, Braicu C, Nougayrede JP, Laffitte J, Taranu I, Oswald IP. Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinasedependent mechanism. J Nutr. 2010; 140:1956-1962.
8. Park SH, Kim J, Kim D, Moon Y. Mycotoxin detoxifiers attenuate deoxynivalenol-induced pro-inflammatory barrier insult in porcine enterocytes as an in vitro evaluation model of feed mycotoxin reduction. Toxicol In Vitro. 2017; 38:108-116.
9. Chen J, Li Y, Tian Y, Huang C, Li D, Zhong Q, Ma X. Interaction between microbes and host intestinal health: modulation by dietary nutrients and gut-brain-endocrineimmune axis. Curr Protein Pept Sci. 2015; 16:592-603.
10. Garcia-Cela E, Marin S, Sanchis V, Crespo-Sempere A, Ramos AJ. Effect of ultraviolet radiation A and B on growth and mycotoxin production by Aspergillus carbonarius and Aspergillus parasiticus in grape and pistachio media. Fungal Biol. 2015; 119:67-78.
11. McMullin D, Mizaikoff B, Krska R. Advancements in IR spectroscopic approaches for the determination of fungal derived contaminations in food crops. Anal Bioanal Chem. 2015; 407:653-660.
12. Brezina U, Kersten S, Valenta H, Sperfeld P, Riedel J, Danicke S. UV-induced cis-trans isomerization of zearalenone in contaminated maize. Mycotoxin Res. 2013; 29:221-227.
13. Fan P, Tan Y, Jin K, Lin C, Xia S, Han B, Zhang F, Wu L, Ma X. Supplemental lipoic acid relieves post-weaning diarrhoea by decreasing intestinal permeability in rats. J Anim Physiol Anim Nutr (Berl). 2017; 101:136-146.
14. Lin M, Zhang B, Yu C, Li J, Zhang L, Sun H, Gao F, Zhou G. L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. PLoS One. 2014; 9:e111950.
15. He L, Han M, Qiao S, He P, Li D, Li N, Ma X. Soybean antigen proteins and their intestinal sensitization activities. Curr Protein Pept Sci. 2015; 16:613-621.
16. Huang C, Zang J, Song P, Fan P, Chen J, Liu D, He P, Ma X. Effects of particle size and drying methods of corn on growth performance, digestibility and haematological and immunological characteristics of weaned piglets. Arch Anim Nutr. 2015; 69:30-45.
17. Xiao L, Rao JN, Cao S, Liu L, Chung HK, Zhang Y, Zhang J, Liu Y, Gorospe M, Wang JY. Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins. Mol Biol Cell. 2016; 27:617-626.
18. Ma X, Fan P, Li L, Qiao S, Zhang G, Li D. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J Anim Sci. 2012; 90:266-268.
19. Ma X, Chen J, Tian Y. Pregnane X receptor as the "sensor and effector" in regulating epigenome. J Cell Physiol. 2015; 230:752-757.
20. Silhavy J, Zidek V, Mlejnek P, Landa V, Simakova M, Strnad H, Oliyarnyk O, Skop V, Kazdova L, Kurtz T, Pravenec M. Fumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats. PLoS One. 2014; 9:e101906.
21. Wang Q, Chuikov S, Taitano S, Wu Q, Rastogi A, Tuck SJ, Corey JM, Lundy SK, Mao-Draayer Y. Dimethyl fumarate protects neural stem/progenitor cells and neurons from oxidative damage through Nrf2-ERK1/2 MAPK pathway. Int J Mol Sci. 2015; 16:13885-13907.
22. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014; 94:329-354.
23. Chen J, Wang J, Song P, Ma X. Determination of glycinin in soybean and soybean products using a sandwich enzymelinked immunosorbent assay. Food Chem. 2014; 162:27-33.
24. Liu H, Zhang J, Zhang S, Yang F, Thacker PA, Zhang G, Qiao S, Ma X. Oral administration of Lactobacillus fermentum I5007 favors intestinal development and alters the intestinal microbiota in formula-fed piglets. J Agric Food Chem. 2014; 62:860-866.
25. Tsang SW, Ip SP, Wu JC, Ng SC, Yung KK, Bian ZX. A Chinese medicinal formulation ameliorates dextran sulfate sodium-induced experimental colitis by suppressing the activity of nuclear factor-kappaB signaling. J Ethnopharmacol. 2015; 162:20-30.
26. Chatterjee P, Chiasson VL, Kopriva SE, Young KJ, Chatterjee V, Jones KA, Mitchell BM. Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice. Hypertension. 2011; 58:489-496.
27. Hu S, Liu H, Qiao S, He P, Ma X, Lu W. Development of immunoaffinity chromatographic method for isolating glycinin (11S) from soybean proteins. J Agric Food Chem. 2013; 61:4406-4410.
28. Spehlmann ME, Eckmann L. Nuclear factor-kappa B in intestinal protection and destruction. Curr Opin Gastroenterol. 2009; 25:92-99.
29. Han M, Song P, Huang C, Rezaei A, Farrar S, Brown MA, Ma X. Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model. Oncotarget. 2016; 7:80313-80326. doi: 10.18632/oncotarget.13450.
30. Song P, Zhang R, Wang X, He P, Tan L, Ma X. Dietary grape-seed procyanidins decreased post-weaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats. J Agric Food Chem. 2011; 59:6227-6232.
31. Mao S, Huo W, Zhu W. Microbiome-metabolome analysis reveals unhealthy alterations in the composition and metabolism of ruminal microbiota with increasing dietary grain in a goat model. Environ Microbiol. 2016; 18:525-541.
32. Wang J, Han M, Zhang G, Qiao S, Li D, Ma X. The signal pathway of antibiotic alternatives on intestinal microbiota and immune function. Curr Protein Pept Sci. 2016; 17:785-796.
33. Kittelmann S, Seedorf H, Walters WA, Clemente JC, Knight R, Gordon JI, Janssen PH. Simultaneous amplicon sequencing to explore co-occurrence patterns of bacterial, archaeal and eukaryotic microorganisms in rumen microbial communities. PLoS One. 2013; 8:e47879.
34. Constantinos M, Marios S. Gemella morbillorum tricuspid valve endocarditis resulting in septic pulmonary emboli in a patient with intracranial hemorrhage. Int J Cardiol. 2015; 184:769-771.
35. Polansky O, Sekelova Z, Faldynova M, Sebkova A, Sisak F, Rychlik I. Important metabolic pathways and biological processes expressed by chicken cecal microbiota. Appl Environ Microbiol. 2015; 82:1569-1576.
36. Huang C, Song P, Fan P, Hou C, Thacker P, Ma X. Dietary sodium butyrate decreases postweaning diarrhea by modulating intestinal permeability and changing the bacterial communities in weaned piglets. J Nutr. 2015; 145:2774-2780.
37. Prieto ML, O'Sullivan L, Tan SP, McLoughlin P, Hughes H, O'Donovan O, Rea MC, Kent RM, Cassidy JP, Gardiner GE, Lawlor PG. Evaluation of the efficacy and safety of a marine-derived Bacillus strain for use as an in-feed probiotic for newly weaned pigs. PLoS One. 2014; 9:e88599.
38. Ma X, Sun P, He P, Han P, Wang J, Qiao S, Li D. Development of monoclonal antibodies and a competitive ELISA detection method for glycinin, an allergen in soybean. Food Chem. 2010; 121:546-551.
39. Zhang-Sun W, Augusto LA, Zhao L, Caroff M. Desulfovibrio desulfuricans isolates from the gut of a single individual: structural and biological lipid A characterization. FEBS Lett. 2015; 589:165-171.
40. Sonnenburg JL, Backhed F. Diet-microbiota interactions as moderators of human metabolism. Nature. 2016; 535:56-64.
41. Berry D, Mader E, Lee TK, Woebken D, Wang Y, Zhu D, Palatinszky M, Schintlmeister A, Schmid MC, Hanson BT, Shterzer N, Mizrahi I, Rauch I, et al. Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells. Proc Natl Acad Sci U S A. 2015; 112:E194-203.
42. Zang J, Chen J, Wang A, Liu H, Hu S, Che X, Ma Y, Wang J, Wang C, Du G, Ma X. Effects of magnesium on the performance of sows and their piglets. J Anim Sci Biotech. 2014, 5:39.
43. Fan P, Li L, Rezaei A, Eslamfam S, Che D, Ma X. Metabolites of dietary protein and peptides by intestinal microbes and their impacts on gut. Curr Protein Pept Sci. 2015; 16:646-654.