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Volumn 7, Issue 1, 2017, Pages

A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; REACTIVE OXYGEN METABOLITE;

EID: 85021668982     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-04400-6     Document Type: Article
Times cited : (80)

References (71)
  • 2
    • 85047597137 scopus 로고    scopus 로고
    • NEUROSCIENCE. Alzheimer's amyloid theory gets modest boost
    • Underwood, E. NEUROSCIENCE. Alzheimer's amyloid theory gets modest boost. Science 349, 464 (2015)
    • (2015) Science , vol.349 , pp. 464
    • Underwood, E.1
  • 3
    • 79955006086 scopus 로고    scopus 로고
    • Lung cancer: New biological insights and recent therapeutic advances
    • Ramalingam, S. S., Owonikoko, T. K. & Khuri, F. R. Lung cancer: New biological insights and recent therapeutic advances. CA. Cancer J. Clin. 61, 91-112
    • CA. Cancer J. Clin. , vol.61 , pp. 91-112
    • Ramalingam, S.S.1    Owonikoko, T.K.2    Khuri, F.R.3
  • 4
    • 84927797176 scopus 로고    scopus 로고
    • Glioblastoma survival: Has it improved Evidence from population-based studies
    • Woehrer, A., Bauchet, L. & Barnholtz-Sloan, J. S. Glioblastoma survival: has it improved Evidence from population-based studies. Curr. Opin. Neurol. 27, 666-74 (2014)
    • (2014) Curr. Opin. Neurol. , vol.27 , pp. 666-674
    • Woehrer, A.1    Bauchet, L.2    Barnholtz-Sloan, J.S.3
  • 5
    • 84875477674 scopus 로고    scopus 로고
    • Inverse cancer comorbidity: A serendipitous opportunity to gain insight into CNS disorders
    • Tabarés-Seisdedos, R. & Rubenstein, J. L. Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders. Nat. Rev. Neurosci. 14, 293-304 (2013)
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 293-304
    • Tabarés-Seisdedos, R.1    Rubenstein, J.L.2
  • 6
    • 79957562024 scopus 로고    scopus 로고
    • No paradox, no progress: Inverse cancer comorbidity in people with other complex diseases
    • Tabarés-Seisdedos, R. et al. No paradox, no progress: inverse cancer comorbidity in people with other complex diseases. Lancet. Oncol. 12, 604-8 (2011)
    • (2011) Lancet. Oncol. , vol.12 , pp. 604-608
    • Tabarés-Seisdedos, R.1
  • 7
    • 77953363122 scopus 로고    scopus 로고
    • Glioblastoma and dementia may share a common cause
    • Lehrer, S. Glioblastoma and dementia may share a common cause. Med. Hypotheses 75, 67-68 (2010)
    • (2010) Med. Hypotheses , vol.75 , pp. 67-68
    • Lehrer, S.1
  • 8
    • 84859192682 scopus 로고    scopus 로고
    • Inverse association between cancer and Alzheimer's disease: Results from the Framingham Heart Study
    • Driver, J. A. et al. Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study. BMJ 344, e1442 (2012)
    • (2012) BMJ , vol.344 , pp. e1442
    • Driver, J.A.1
  • 9
    • 84881295894 scopus 로고    scopus 로고
    • Inverse occurrence of cancer and Alzheimer disease: A population-based incidence study
    • Musicco, M. et al. Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study. Neurology 81, 322-8 (2013)
    • (2013) Neurology , vol.81 , pp. 322-328
    • Musicco, M.1
  • 10
    • 84867458469 scopus 로고    scopus 로고
    • Does Alzheimer's disease protect against cancers A nationwide population-based study
    • Ou, S.-M. et al. Does Alzheimer's disease protect against cancers A nationwide population-based study. Neuroepidemiology 40, 42-9 (2013)
    • (2013) Neuroepidemiology , vol.40 , pp. 42-49
    • Ou, S.-M.1
  • 11
    • 84964608136 scopus 로고    scopus 로고
    • Editorial: Direct and Inverse Comorbidities between Complex Disorders
    • Tabarés-Seisdedos, R. & Baudot, A. Editorial: Direct and Inverse Comorbidities Between Complex Disorders. Front. Physiol 7 (2016)
    • (2016) Front. Physiol , vol.7
    • Tabarés-Seisdedos, R.1    Baudot, A.2
  • 12
    • 84901742995 scopus 로고    scopus 로고
    • Molecular evidence for the inverse comorbidity between central nervous system disorders and cancers detected by transcriptomic meta-analyses
    • Ibánez, K., Boullosa, C., Tabarés-Seisdedos, R., Baudot, A. & Valencia, A. Molecular evidence for the inverse comorbidity between central nervous system disorders and cancers detected by transcriptomic meta-analyses. PLoS Genet. 10, e1004173 (2014)
    • (2014) PLoS Genet. , vol.10 , pp. e1004173
    • Ibánez, K.1    Boullosa, C.2    Tabarés-Seisdedos, R.3    Baudot, A.4    Valencia, A.5
  • 13
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-50 (2005)
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 14
    • 84878682420 scopus 로고    scopus 로고
    • The Genotype-Tissue Expression (GTEx) project
    • Lonsdale, J. et al. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45, 580-585 (2013)
    • (2013) Nat. Genet. , vol.45 , pp. 580-585
    • Lonsdale, J.1
  • 15
    • 34547571030 scopus 로고    scopus 로고
    • G:Profiler-A web-based toolset for functional profiling of gene lists from large-scale experiments
    • Reimand, J., Kull, M., Peterson, H., Hansen, J. & Vilo, J. g:Profiler-a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res. 35, W193-200 (2007)
    • (2007) Nucleic Acids Res , vol.35 , pp. W193-200
    • Reimand, J.1    Kull, M.2    Peterson, H.3    Hansen, J.4    Vilo, J.5
  • 17
    • 0034933163 scopus 로고    scopus 로고
    • Gene expression profiling in the post-mortem human brain-no cause for dismay
    • Bahn, S. et al. Gene expression profiling in the post-mortem human brain-no cause for dismay. J. Chem. Neuroanat. 22, 79-94 (2001)
    • (2001) J. Chem. Neuroanat. , vol.22 , pp. 79-94
    • Bahn, S.1
  • 18
    • 12144287672 scopus 로고    scopus 로고
    • Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
    • Li, J. Z. et al. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum. Mol. Genet 13, 609-16 (2004)
    • (2004) Hum. Mol. Genet , vol.13 , pp. 609-616
    • Li, J.Z.1
  • 19
    • 10744228401 scopus 로고    scopus 로고
    • Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain
    • Tomita, H. et al. Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biol. Psychiatry 55, 346-352 (2004)
    • (2004) Biol. Psychiatry , vol.55 , pp. 346-352
    • Tomita, H.1
  • 20
    • 84877621451 scopus 로고    scopus 로고
    • Epilepsy in glioblastoma patients: Basic mechanisms and current problems in treatment
    • Bruna, J., Miró, J. & Velasco, R. Epilepsy in glioblastoma patients: basic mechanisms and current problems in treatment. Expert Rev. Clin. Pharmacol 6, 333-344 (2013)
    • (2013) Expert Rev. Clin. Pharmacol , vol.6 , pp. 333-344
    • Bruna, J.1    Miró, J.2    Velasco, R.3
  • 21
    • 0037093972 scopus 로고    scopus 로고
    • Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma
    • Schouten, L. J., Rutten, J., Huveneers, H. A. M. & Twijnstra, A. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94, 2698-705 (2002)
    • (2002) Cancer , vol.94 , pp. 2698-2705
    • Schouten, L.J.1    Rutten, J.2    Huveneers, H.A.M.3    Twijnstra, A.4
  • 22
    • 84857623883 scopus 로고    scopus 로고
    • Epidemiology of brain metastases
    • Nayak, L., Lee, E. Q. & Wen, P. Y. Epidemiology of brain metastases. Curr. Oncol. Rep. 14, 48-54 (2012)
    • (2012) Curr. Oncol. Rep. , vol.14 , pp. 48-54
    • Nayak, L.1    Lee, E.Q.2    Wen, P.Y.3
  • 23
    • 0038505595 scopus 로고    scopus 로고
    • Restoration of CD44S in non-small cell lung cancer cells enhanced their susceptibility to the macrophage cytotoxicity
    • Takahashi, K., Takahashi, F., Hirama, M., Tanabe, K. K. & Fukuchi, Y. Restoration of CD44S in non-small cell lung cancer cells enhanced their susceptibility to the macrophage cytotoxicity. Lung Cancer 41, 145-53 (2003)
    • (2003) Lung Cancer , vol.41 , pp. 145-153
    • Takahashi, K.1    Takahashi, F.2    Hirama, M.3    Tanabe, K.K.4    Fukuchi, Y.5
  • 24
    • 84862873512 scopus 로고    scopus 로고
    • CD44 in human glioma correlates with histopathological grade and cell migration
    • Yoshida, T., Matsuda, Y., Naito, Z. & Ishiwata, T. CD44 in human glioma correlates with histopathological grade and cell migration. Pathol. Int. 62, 463-70 (2012)
    • (2012) Pathol. Int. , vol.62 , pp. 463-470
    • Yoshida, T.1    Matsuda, Y.2    Naito, Z.3    Ishiwata, T.4
  • 25
    • 0027751737 scopus 로고
    • Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease
    • Akiyama, H., Tooyama, I., Kawamata, T., Ikeda, K. & McGeer, P. L. Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease. Brain Res. 632, 249-59 (1993)
    • (1993) Brain Res. , vol.632 , pp. 249-259
    • Akiyama, H.1    Tooyama, I.2    Kawamata, T.3    Ikeda, K.4    McGeer, P.L.5
  • 26
    • 77449118423 scopus 로고    scopus 로고
    • Increased CD44 gene expression in lymphocytes derived from Alzheimer disease patients
    • Uberti, D. et al. Increased CD44 gene expression in lymphocytes derived from Alzheimer disease patients. Neurodegener. Dis. 7, 143-7 (2010)
    • (2010) Neurodegener. Dis. , vol.7 , pp. 143-147
    • Uberti, D.1
  • 27
    • 84923076131 scopus 로고    scopus 로고
    • UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1
    • Goto, Y. et al. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1. Nat. Commun. 6, 6153 (2015)
    • (2015) Nat. Commun. , vol.6 , pp. 6153
    • Goto, Y.1
  • 28
    • 84906939415 scopus 로고    scopus 로고
    • The proteomic response in glioblastoma in young patients
    • Deighton, R. F. et al. The proteomic response in glioblastoma in young patients. J. Neurooncol. 119, 79-89 (2014)
    • (2014) J. Neurooncol. , vol.119 , pp. 79-89
    • Deighton, R.F.1
  • 29
    • 35148859639 scopus 로고    scopus 로고
    • Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NFkappaB activation
    • Takami, Y. et al. Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NFkappaB activation. Arterioscler. Thromb. Vasc. Biol. 27, 2184-90 (2007)
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 2184-2190
    • Takami, Y.1
  • 30
    • 84946590579 scopus 로고    scopus 로고
    • Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo
    • Zhang, M., Cai, F., Zhang, S., Zhang, S. & Song, W. Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo. Sci. Rep. 4, 7298 (2014)
    • (2014) Sci. Rep. , vol.4 , pp. 7298
    • Zhang, M.1    Cai, F.2    Zhang, S.3    Zhang, S.4    Song, W.5
  • 31
    • 71749121998 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
    • Moreira, P. I., Carvalho, C., Zhu, X., Smith, M. A. & Perry, G. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochim. Biophys. Acta 1802, 2-10 (2010)
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 2-10
    • Moreira, P.I.1    Carvalho, C.2    Zhu, X.3    Smith, M.A.4    Perry, G.5
  • 32
    • 38449094180 scopus 로고    scopus 로고
    • Role of the ubiquitin proteasome system in Alzheimer's disease
    • Upadhya, S. C. & Hegde, A. N. Role of the ubiquitin proteasome system in Alzheimer's disease. BMC Biochem. 8(Suppl 1), S12 (2007)
    • (2007) BMC Biochem. , vol.8 , pp. S12
    • Upadhya, S.C.1    Hegde, A.N.2
  • 33
    • 41949086089 scopus 로고    scopus 로고
    • Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
    • Liang, W. S. et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc. Natl. Acad. Sci. USA 105, 4441-6 (2008)
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4441-4446
    • Liang, W.S.1
  • 35
    • 79959926983 scopus 로고    scopus 로고
    • Mitochondria: The common upstream driver of amyloid-and tau pathology in Alzheimer's disease
    • Silva, D. F. F., Esteves, A. R., Oliveira, C. R. & Cardoso, S. M. Mitochondria: the common upstream driver of amyloid-and tau pathology in Alzheimer's disease. Curr. Alzheimer Res. 8, 563-72 (2011)
    • (2011) Curr. Alzheimer Res. , vol.8 , pp. 563-572
    • Silva, D.F.F.1    Esteves, A.R.2    Oliveira, C.R.3    Cardoso, S.M.4
  • 36
    • 84901911564 scopus 로고    scopus 로고
    • The emerging role of glutathione in Alzheimer's disease
    • Saharan, S. & Mandal, P. K. The emerging role of glutathione in Alzheimer's disease. J. Alzheimers. Dis. 40, 519-29 (2014)
    • (2014) J. Alzheimers. Dis. , vol.40 , pp. 519-529
    • Saharan, S.1    Mandal, P.K.2
  • 37
    • 0031015250 scopus 로고    scopus 로고
    • Glutathione metabolism in patients with non-small cell lung cancers
    • Blair, S. L. et al. Glutathione metabolism in patients with non-small cell lung cancers. Cancer Res. 57, 152-5 (1997)
    • (1997) Cancer Res. , vol.57 , pp. 152-155
    • Blair, S.L.1
  • 38
    • 77958494422 scopus 로고    scopus 로고
    • Linking Alzheimer's disease to insulin resistance: The FoxO response to oxidative stress
    • Manolopoulos, K. N., Klotz, L.-O., Korsten, P., Bornstein, S. R. & Barthel, A. Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress. Mol. Psychiatry 15, 1046-52 (2010)
    • (2010) Mol. Psychiatry , vol.15 , pp. 1046-1052
    • Manolopoulos, K.N.1    Klotz, L.-O.2    Korsten, P.3    Bornstein, S.R.4    Barthel, A.5
  • 39
    • 68249162573 scopus 로고    scopus 로고
    • Expression and localization of FOXO1 in non-small cell lung cancer
    • Maekawa, T. et al. Expression and localization of FOXO1 in non-small cell lung cancer. Oncol. Rep. 22, 57-64 (2009)
    • (2009) Oncol. Rep. , vol.22 , pp. 57-64
    • Maekawa, T.1
  • 40
    • 11244320393 scopus 로고    scopus 로고
    • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    • Essers, M. A. G. et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802-12 (2004)
    • (2004) EMBO J. , vol.23 , pp. 4802-4812
    • Essers, M.A.G.1
  • 41
    • 41849108086 scopus 로고    scopus 로고
    • Many forks in the path: Cycling with FoxO
    • Ho, K. K., Myatt, S. S. & Lam, E. W.-F. Many forks in the path: cycling with FoxO. Oncogene 27, 2300-11 (2008)
    • (2008) Oncogene , vol.27 , pp. 2300-2311
    • Ho, K.K.1    Myatt, S.S.2    Lam, E.W.-F.3
  • 42
    • 62149107892 scopus 로고    scopus 로고
    • DNA damage and repair in Alzheimer's disease
    • Coppede, F. & Migliore, L. DNA damage and repair in Alzheimer's disease. Curr. Alzheimer Res. 6, 36-47 (2009)
    • (2009) Curr. Alzheimer Res. , vol.6 , pp. 36-47
    • Coppede, F.1    Migliore, L.2
  • 43
    • 84883543030 scopus 로고    scopus 로고
    • Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer
    • Cron, K. R. et al. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One 8, e73710 (2013)
    • (2013) PLoS One , vol.8 , pp. e73710
    • Cron, K.R.1
  • 45
    • 84906808180 scopus 로고    scopus 로고
    • Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration
    • Zismanov, V., Drucker, L. & Gottfried, M. Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration. Anticancer. Drugs 25, 998-1006 (2014)
    • (2014) Anticancer. Drugs , vol.25 , pp. 998-1006
    • Zismanov, V.1    Drucker, L.2    Gottfried, M.3
  • 46
    • 84866082182 scopus 로고    scopus 로고
    • Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and-untied toxicity mechanisms common to neurodegenerative diseases
    • Cabeza-Arvelaiz, Y. & Schiestl, R. H. Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and-untied toxicity mechanisms common to neurodegenerative diseases. PLoS One 7, e44700 (2012)
    • (2012) PLoS One , vol.7 , pp. e44700
    • Cabeza-Arvelaiz, Y.1    Schiestl, R.H.2
  • 47
    • 84892723201 scopus 로고    scopus 로고
    • Inverse and direct cancer comorbidity in people with central nervous system disorders: A meta-analysis of cancer incidence in 577,013 participants of 50 observational studies
    • Catalá-López, F. et al. Inverse and direct cancer comorbidity in people with central nervous system disorders: a meta-analysis of cancer incidence in 577,013 participants of 50 observational studies. Psychother. Psychosom. 83, 89-105 (2014)
    • (2014) Psychother. Psychosom. , vol.83 , pp. 89-105
    • Catalá-López, F.1
  • 48
    • 85027948510 scopus 로고    scopus 로고
    • Differential risks of cancer types in people with Parkinson's disease: A national recordlinkage study
    • Ong, E. L. H., Goldacre, R. & Goldacre, M. Differential risks of cancer types in people with Parkinson's disease: a national recordlinkage study. Eur. J. Cancer 50, 2456-62 (2014)
    • (2014) Eur. J. Cancer , vol.50 , pp. 2456-2462
    • Ong, E.L.H.1    Goldacre, R.2    Goldacre, M.3
  • 49
    • 77951046871 scopus 로고    scopus 로고
    • High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease
    • Serrano, J., Fernández, A. P., Martínez-Murillo, R. & Martínez, A. High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease. Oncogene 29, 2165-71 (2010)
    • (2010) Oncogene , vol.29 , pp. 2165-2171
    • Serrano, J.1    Fernández, A.P.2    Martínez-Murillo, R.3    Martínez, A.4
  • 50
    • 84885074034 scopus 로고    scopus 로고
    • The somatic genomic landscape of glioblastoma
    • Brennan, C. W. et al. The Somatic Genomic Landscape of Glioblastoma. Cell 155, 462-477 (2013)
    • (2013) Cell , vol.155 , pp. 462-477
    • Brennan, C.W.1
  • 51
    • 0015251175 scopus 로고    scopus 로고
    • Bioenergetics and the problem of tumor growth
    • Racker, E. Bioenergetics and the problem of tumor growth. Am. Sci. 60, 56-63
    • Am. Sci. , vol.60 , pp. 56-63
    • Racker, E.1
  • 52
    • 77956211109 scopus 로고    scopus 로고
    • Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase
    • Atamna, H. & Kumar, R. Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase. J. Alzheimers. Dis. 20(Suppl 2), S439-52 (2010)
    • (2010) J. Alzheimers. Dis. , vol.20 , pp. S439-S452
    • Atamna, H.1    Kumar, R.2
  • 53
    • 84876004187 scopus 로고    scopus 로고
    • Reversing the Warburg effect as a treatment for glioblastoma
    • Poteet, E. et al. Reversing the Warburg effect as a treatment for glioblastoma. J. Biol. Chem. 288, 9153-64 (2013)
    • (2013) J. Biol. Chem. , vol.288 , pp. 9153-9164
    • Poteet, E.1
  • 54
    • 84941595622 scopus 로고    scopus 로고
    • The role of mitochondrially derived atp in synaptic vesicle recycling
    • Pathak, D. et al. The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling. J. Biol. Chem. 290, 22325-36 (2015)
    • (2015) J. Biol. Chem. , vol.290 , pp. 22325-22336
    • Pathak, D.1
  • 55
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    • Stewart, C. R. et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11, 155-61 (2010)
    • (2010) Nat. Immunol. , vol.11 , pp. 155-161
    • Stewart, C.R.1
  • 56
    • 47849120645 scopus 로고    scopus 로고
    • Chronic inflammation and amyloidogenesis in Alzheimer's disease-role of Spirochetes
    • Miklossy, J. Chronic inflammation and amyloidogenesis in Alzheimer's disease-role of Spirochetes. J. Alzheimers. Dis. 13, 381-91 (2008)
    • (2008) J. Alzheimers. Dis. , vol.13 , pp. 381-391
    • Miklossy, J.1
  • 57
    • 84857225543 scopus 로고    scopus 로고
    • Viral and inflammatory triggers of neurodegenerative diseases
    • Deleidi, M. & Isacson, O. Viral and inflammatory triggers of neurodegenerative diseases. Sci. Transl. Med. 4, 121ps3 (2012)
    • (2012) Sci. Transl. Med. , vol.4 , pp. 121ps3
    • Deleidi, M.1    Isacson, O.2
  • 58
    • 33646160623 scopus 로고    scopus 로고
    • Inflammation, a key event in cancer development
    • Lu, H., Ouyang, W. & Huang, C. Inflammation, a key event in cancer development. Mol. Cancer Res. 4, 221-33 (2006)
    • (2006) Mol. Cancer Res. , vol.4 , pp. 221-233
    • Lu, H.1    Ouyang, W.2    Huang, C.3
  • 59
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas, G., Germano, G., Mantovani, A. & Allavena, P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 86, 1065-73 (2009)
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 60
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015)
    • (2015) Nucleic Acids Res. , vol.43 , pp. e47
    • Ritchie, M.E.1
  • 61
    • 84870409265 scopus 로고    scopus 로고
    • FRMA ST: Frozen robust multiarray analysis for Affymetrix Exon and Gene ST arrays
    • McCall, M. N., Jaffee, H. A. & Irizarry, R. A. fRMA ST: frozen robust multiarray analysis for Affymetrix Exon and Gene ST arrays. Bioinformatics 28, 3153-4 (2012)
    • (2012) Bioinformatics , vol.28 , pp. 3153-3154
    • McCall, M.N.1    Jaffee, H.A.2    Irizarry, R.A.3
  • 62
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: Tool for the unification of biology
    • Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25-9 (2000)
    • (2000) The Gene Ontology Consortium. Nat. Genet. , vol.25 , pp. 25-29
    • Ashburner, M.1
  • 63
    • 84862499271 scopus 로고    scopus 로고
    • Pathway analysis of genomic data: Concepts, methods, and prospects for future development
    • Ramanan, V. K., Shen, L., Moore, J. H. & Saykin, A. J. Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet. 28, 323-32 (2012)
    • (2012) Trends Genet. , vol.28 , pp. 323-332
    • Ramanan, V.K.1    Shen, L.2    Moore, J.H.3    Saykin, A.J.4
  • 64
    • 58149177166 scopus 로고    scopus 로고
    • Reactome knowledgebase of human biological pathways and processes
    • Matthews, L. et al. Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res. 37, D619-22 (2009)
    • (2009) Nucleic Acids Res. , vol.37 , pp. D619-D622
    • Matthews, L.1
  • 65
  • 66
    • 53149135477 scopus 로고    scopus 로고
    • Key issues in conducting a meta-analysis of gene expression microarray datasets
    • Ramasamy, A., Mondry, A., Holmes, C. C. & Altman, D. G. Key issues in conducting a meta-analysis of gene expression microarray datasets. PLoS Med. 5, e184 (2008)
    • (2008) PLoS Med. , vol.5 , pp. e184
    • Ramasamy, A.1    Mondry, A.2    Holmes, C.C.3    Altman, D.G.4
  • 67
    • 1342288026 scopus 로고    scopus 로고
    • Affy-analysis of Affymetrix GeneChip data at the probe level
    • Gautier, L., Cope, L., Bolstad, B. M. & Irizarry, R. A. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307-15 (2004)
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 68
    • 84867308536 scopus 로고    scopus 로고
    • An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection
    • Wang, X. et al. An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection. Bioinformatics 28, 2534-6 (2012)
    • (2012) Bioinformatics , vol.28 , pp. 2534-2536
    • Wang, X.1
  • 69
    • 4444287699 scopus 로고    scopus 로고
    • Regional patterns of gene expression in human and chimpanzee brains
    • Khaitovich, P. Regional Patterns of Gene Expression in Human and Chimpanzee Brains. Genome Res. 14, 1462-1473 (2004)
    • (2004) Genome Res. , vol.14 , pp. 1462-1473
    • Khaitovich, P.1
  • 70
    • 84878883768 scopus 로고    scopus 로고
    • Neuron-Enriched Gene Expression Patterns are Regionally Anti-Correlated with Oligodendrocyte-Enriched Patterns in the Adult Mouse and Human Brain
    • Tan, P. P. C., French, L. & Pavlidis, P. Neuron-Enriched Gene Expression Patterns are Regionally Anti-Correlated with Oligodendrocyte-Enriched Patterns in the Adult Mouse and Human Brain. Front. Neurosci. 7, 5 (2013)
    • (2013) Front. Neurosci. , vol.7 , pp. 5
    • Tan, P.P.C.1    French, L.2    Pavlidis, P.3
  • 71
    • 77957044703 scopus 로고    scopus 로고
    • Discovery of drug mode of action and drug repositioning from transcriptional responses
    • Iorio, F. et al. Discovery of drug mode of action and drug repositioning from transcriptional responses. Proc. Natl. Acad. Sci. 107, 14621-14626 (2010).
    • (2010) Proc. Natl. Acad. Sci. , vol.107 , pp. 14621-14626
    • Iorio, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.