Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy

Nature Neuroscience

Volumn 20, Issue 7, 2017, Pages 905-916

  Fletcher, Emily V ^a,b   Simon, Christian M ^a,b   Pagiazitis, John G ^a,b   Chalif, Joshua I ^a,b   Vukojicic, Aleksandra ^a,b   Drobac, Estelle ^a,b   Wang, Xiaojian ^a,b   Mentis, George Z ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM CHANNEL KV2.1; UNCLASSIFIED DRUG; KAINIC ACID; METALLOPROTEINASE; SHAB POTASSIUM CHANNEL; SMN1 PROTEIN, MOUSE; SMN2 PROTEIN, HUMAN; SURVIVAL MOTOR NEURON PROTEIN 1; SURVIVAL MOTOR NEURON PROTEIN 2; TETANUS TOXIN; ZINC-ENDOPEPTIDASE, TETANUS NEUROTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FIRING RATE; IN VIVO STUDY; MALE; MOLECULAR PATHOLOGY; MOTONEURON; MOTOR PERFORMANCE; MOUSE; MOUSE MODEL; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEUROMUSCULAR JUNCTION; NEUROPATHOLOGY; NEUROTRANSMITTER RELEASE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROPRIOCEPTION; PROTEIN EXPRESSION; SENSORY STIMULATION; SPINAL MUSCULAR ATROPHY; SYNAPTIC TRANSMISSION; UPREGULATION; WAVEFORM; ACTION POTENTIAL; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RIGHTING REFLEX; SYNAPSE; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; KAINIC ACID; METALLOENDOPEPTIDASES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; NEUROMUSCULAR JUNCTION; PROPRIOCEPTION; REFLEX, RIGHTING; SHAB POTASSIUM CHANNELS; SURVIVAL OF MOTOR NEURON 1 PROTEIN; SURVIVAL OF MOTOR NEURON 2 PROTEIN; SYNAPSES; TETANUS TOXIN;

EID: 85021443970     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.4561     Document Type: Article

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