Reproductive endocrine issues in men with sickle cell anemia

Andrology

Volumn 5, Issue 4, 2017, Pages 679-690

  Huang, A W ^a   Muneyyirci Delale, O ^b,c  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c KINGS COUNTY HOSPITAL CENTER   (United States)

Author keywords

azoospermia; hormones; hypogonadism; infertility; pituitary and hypothalamus; priapism; puberty; semen analysis; sickle cell; testosterone

Indexed keywords

TESTOSTERONE; ANTISICKLING AGENT; HORMONE;

CHILD GROWTH; DELAYED PUBERTY; ENDOCRINOLOGY; ERECTILE DYSFUNCTION; GENITAL SYSTEM; HORMONAL REGULATION; HORMONE DETERMINATION; HUMAN; HYPOGONADISM; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUBERTY; PUBLICATION; REPRODUCTIVE HEALTH; REVIEW; SEMEN ABNORMALITY; SEMEN ANALYSIS; SICKLE CELL ANEMIA; ADOLESCENT; ADULT; BLOOD; CHILD; CHILD DEVELOPMENT; COMPLICATION; DRUG EFFECTS; FEMALE; GROWTH, DEVELOPMENT AND AGING; MALE; MALE INFERTILITY; METABOLISM; PATHOPHYSIOLOGY; PENIS ERECTION; PREGNANCY; PRESCHOOL CHILD; PRIAPISM; REPRODUCTION; RISK FACTOR; TESTIS;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; ANTISICKLING AGENTS; CHILD; CHILD DEVELOPMENT; CHILD, PRESCHOOL; ERECTILE DYSFUNCTION; FEMALE; HORMONES; HUMANS; HYPOGONADISM; INFERTILITY, MALE; MALE; PENILE ERECTION; PREGNANCY; PREGNANCY RATE; PRIAPISM; PUBERTY; REPRODUCTION; RISK FACTORS; SEMEN ANALYSIS; TESTIS;

EID: 85021428391     PISSN: 20472919     EISSN: 20472927     Source Type: Journal    
DOI: 10.1111/andr.12370     Document Type: Review

References (52)

1. Abbasi AA, Prasad AS, Ortega J, Congco E & Oberleas D. (1976) Gonadal function abnormalities in sickle cell anemia: studies in adult male patients. Ann Intern Med 85, 601–605.
2. Adeyoju AB, Olujohungbe ABK, Morris J, Yardumian A, Bareford D, Akenova A, Akinyanju O, Cinkotai K & O'Reilly PH. (2002) Priapism in sickle-cell disease; incidence, risk factors and complications – an international multicentre study. BJU Int 90, 898–902.
3. Agbaraji VO, Leto S & Kingslow LW. (1988) Fertility studies in sickle cell disease: semen analysis in adult male patients. Int J Fertil 33, 347–352.
4. Al-Saqladi AWM, Cipolotti R, Fijnvandraat K & Brabin BJ. (2008) Growth and nutritional status of children with homozygous sickle cell disease. Ann Trop Paediatr 28, 165–189.
5. Athanasou NA, Hatton C, McGee JOD & Weatherall DJ. (1985) Vascular occlusion and infarction in sickle cell crisis and the sickle chest syndrome. J Clin Pathol 38, 659–664.
6. Benz EJ Jr (2012) Chapter 104. Disorders of hemoglobin. In: Harrison's Principles of Internal Medicine, 18e (eds DL Longo, AS Fauci, DL Kasper, SL Hauser, J Jameson & J Loscalzo), pp. 852–861. McGraw-Hill, New York, NY.
7. Berthaut I, Guignedoux G, Kirsch-Noir F, de Larouziere V, Ravel C, Bachir D, Galacteros F, Ancel P, Kunstmann J, Levy L, Jouannet P, Girot R & Mandelbaum J. (2008) Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males. Haematologica 93, 988–993.
8. Broderick GA. (2012) Priapism and sickle-cell anemia: diagnosis and nonsurgical therapy. J Sex Med 9, 88–103.
9. Bruno D, Wigfall DR, Zimmerman SA, Rosoff PM & Wiener JS. (2001) Genitourinary complications of sickle cell disease. J Urol 166, 803–811.
10. Burnett AL, Allen RR, Tempany CM, Dover GJ & Brendler CB. (1995) Evaluation of erectile function in men with sickle cell disease. Urology 45, 657–663.
11. Dada OA & Nduka EU. (1976) Endocrine function and haemoglobinopathies: relation between the sickle cell gene and circulating plasma levels of testosterone, luteinising hormone (LH) and follicle stimulating hormone (FSH) in adult males. Clin Chim Acta 105, 269–273.
12. Elliot JA, Horton E & Fibuch EE. (2011) The endocrine effects of long-term oral opioid therapy: a case report and review of the literature. J Opioid Manag 7, 145–154.
13. Emond AM, Holman R, Hayes RJ & Serjeant GR. (1980) Priapism and impotence in homozygous sickle cell disease. Arch Intern Med 140, 1434–1437.
14. Fowler JE Jr, Koshy M, Strub M & Chinn SK. (1991) Priapism associated with the sickle cell hemoglobinopathies: prevalence, natural history and sequelae. J Urol 145, 65–68.
15. Frenette PS & Atweh GF. (2007) Sickle cell disease: old discoveries, new concepts, and future promise. J Clin Invest 117, 850–858.
16. Friedman G, Freeman R, Bookchin R, Boyar R, Murthy G & Hellman L. (1974) Testicular function in sickle cell disease. Fertil Steril 25, 1018–1021.
17. Fung EB, Harmatz PR, Lee PDK, Milet M, Bellevue R, Jeng MR, Kalinyak KA, Hudes M, Bhatia S, Vichinsky EP & the Multi-Centre Study of Iron Overload Research Group (2006) Increased prevalence of iron-overload associated endocrinopathy in thalassaemia versus sickle-cell disease. Brit J Haematol 135, 574–582.
18. Gallo AM, Wilkie D, Suarez M, Labotka R, Molokie R, Thompson A, Hershberger P & Johnson B. (2010) Reproductive decisions in people with sicle cell disease or sickle cell trait. Western J Nurs Res 32, 1073–1090.
19. Garozzo G, Disca S, Fidone C & Bonomo P. (2000) Azoospermia in a patient with sickle cell disease treated with hydroxyurea. Haematologica 85, 1216–1218.
20. Grigg A. (2007) Effect of hydroxyurea on sperm count, motility and morphology in adult men with sickle cell or myeloproliferative disease. Intern Med J 37, 190–192.
21. Han J, Saraf SL, Zhang X, Gowhari M, Molokie RE, Hassan J, Alhandalous C, Jain S, Younge J, Abbasi T, Machado RF & Gordeuk VR. (2016) Patterns of opioid use in sickle cell disease. Am J Hematol 91, 1102–1106.
22. Henderson RA, Saavedra JM & Dover GJ. (1994) Prevalence of impaired growth in children with homozygous sickle cell anemia. Am J Med Sci 307, 405–407.
23. Hsieh MM, Fitzhugh CD, Weitzel RP, Link ME, Coles WA, Zhao X, Rodgers GP, Powell JD & Tisdale JF. (2014) Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. J Am Med Assoc 312, 48–56.
24. Jones KM, Niaz MS, Brooks CM, Roberson SI, Aguinaga MP, Hills ER, Rice VM, Bourne P, Bruce D & Archibong AE. (2009) Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints. Int J Environ Res Public Health 6, 1124–1144.
25. Li M, Fogarty J, Whitney KD & Stone P (2003) Repeated testicular infarction in a patient with sickle cell disease: a possible mechanism for testicular failure. Urology 62, 551xi–551xiv.
26. Lukusa AK, Vermylen C, Vanabelle B, Curaba M, Brichard B, Chantrain C, Dupont S, Ferrant A & Wyns C. (2009) Bone marrow transplantation or hydroxyurea for sickle cell anemia: long-term effects on semen variables and hormone profiles. Pediatr Hematol Oncol 26, 186–194.
27. Martins PR, Kerbauy J, Moraes-Souza H, Pereira Gde A, Figueiredo MS & Verreschi IT. (2015) Impaired pubertal development and testicular hormone function in males with sickle cell anemia. Blood Cells Mol Dis 54, 29–32.
28. Melmed S & Jameson J. (2012) Chapter 339. Disorders of the anterior pituitary and hypothalamus. In: Harrison's Principles of Internal Medicine, 18e (eds DL Longo, AS Fauci, DL Kasper, SL Hauser, J Jameson & J Loscalzo). McGraw-Hill, New York, NY.
29. Modebe O & Ezeh UO. (1995) Effect of age on testicular function in adult males with sickle cell anemia. Fertil Steril 63, 907–912.
30. Morrison BF, Reid M, Madden W & Burnett AL. (2013) Testosterone replacement therapy does not promote priapism in hypogonadal men with sickle cell disease: 12-month safety report. Andrology 1, 576–582.
31. Morrison BF, Anele UA, Reid ME, Madden WA, Feng Z & Burnett AL. (2015) Is testosterone deficiency a possible risk factor for priapism associated with sickle cell disease? Int Urol Nephrol 47, 47–52.
32. Noetzli LJ, Panigrahy A, Mittelman SD, Hyderi A, Dongelyan A, Coates TD & Wood JC. (2012) Pituitary iron and volume predict hypogonadism in transfusional iron overload. Am J Hematol 87, 167–171.
33. Olambiwonnu NO, Penny R & Frasier SD. (1975) Sexual maturation in subjects with sickle cell anemia: studies of serum gonadotropin concentration, height, weight, and skeletal age. J Pediatr 87, 459–464.
34. Olujohungbe AB, Adeyoju A, Yardumian A, Akinyanju O, Morris J, Westerdale N, Akenova Y, Kehinde MO, Anie K, Howard J, Brooks A, Davis VA & Khoriatry AI. (2011) A prospective diary study of stuttering priapism in adolescents and young men with sickle cell anemia: report of an international randomized control trial—the priapism in sickle cell study. J Androl 32, 375–382.
35. Osegbe DN & Akinyanju OO. (1987) Testicular dysfunction in men with sickle cell disease. Postgrad Med J 63, 95–98.
36. Osegbe DN, Akinyanju OO & Amaku EO. (1981) Fertility in males with sickle cell disease. Lancet 2, 275–276.
37. Ozen S, Unal S, Erçetin N & Taşdelen B. (2013) Frequency and risk factors of endocrine complications in Turkish children and adolescents with sickle cell anemia. Turk J Haematol 30, 25–31.
38. Platt OS, Rosenstock W & Espeland MA. (1984) Influence of sickle hemoglobinopathies on growth and development. New Engl J Med 311, 7–12.
39. Prasad AS. (2002) Zinc deficiency in patients with sickle cell disease. Am J Clin Nutr 74, 181–182.
40. Rhodes M, Akohoue SA, Shankar SM, Fleming I, An A, Yu C, Acra S & Buchowski MS. (2009) Growth patterns in children with sickle cell anemia during puberty. Pediatr Blood Cancer 53, 635–641.
41. Singhal A, Thomas P, Cook R, Wierenga K & Serjeant GR. (1994) Delayed adolescent growth in homozygous sickle cell disease. Arch Dis Child 71, 404–408.
42. Singhal A, Gabay L & Serjeant GR. (1995) Testosterone deficiency and extreme retardation of puberty in homozygous sickle-cell disease. W Indian Med J 44, 20–23.
43. Smith WR, McClish DK, Dahman BA, Levenson JL, Aisiku IP, de A Citero V, Bovbjerg VE, Roberts JD, Penberthy LT & Roseff SD (2015) Daily home opioid use in adults with sickle cell disease: the PiSCES project. J Opioid Manag 11, 243–253.
44. Soliman AT, Yasin M, El-Awwa A, Abdelrahman MO & De Sanctis V. (2013) Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease? Indian J Endocrinol Metab 17, 962–968.
45. Spycher MA & Hauri D. (1986) The ultrastructure of the erectile tissue during priapism. J Urol 135, 142–147.
46. Taddesse A, Woldie IL, Khana P, Swerdlow PS, Chu JW, Abrams J & Abou-Samra AB. (2012) Hypogonadism in patients with sickle cell disease: central or peripheral? Acta Haematol 128, 65–68.
47. Tichelli A & Rovo A. (2013) Fertility issues following hematopoietic stem cell transplant. Expert Rev Hematol 6, 375–388.
48. Voskaridou E, Christoulas D, Bilalis A, Plata E, Varvagiannis K, Stamatopoulos G, Sinopoulou K, Balassopoulou A, Loukopoulos D & Terpos E. (2010) The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). Blood 115, 2354–2363.
49. Walters MC, Hardy K, Edwards S, Adamkiewicz T, Barkovich J, Bernaudin F, Sullivan KM & for the Multicenter Study of Bone Marrow Transplantation for Sickle Cell Disease (2010) Pumonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. Biol Blood Marrow Transplant 16, 263–272.
50. Wang WC, Helms RW, Lynn HS, Redding-Lallinger R, Gee BE, Ohene-Frempong K, Smith-Whitley K, Waclawiw MA, Vichinsky EP, Styles LA, Ware RE & Kinney TR. (2002) Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS Study. J Pediatr 140, 225–229.
51. Wang WC, Morales KH, Scher CD, Styles L, Olivieri N, Adams R, Brambilla D & for the STOP Investigators. (2005) Effect of long-term transfusion on growth in children with sickle cell anemia: results of the STOP Trial. J Pediatr 147, 244–247.
52. Zemel BS, Kawchak DA, Ohene-Frempong K, Schall JI & Stallings VA. (2007) Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease. Pediatr Res 61, 607–613.