Is testosterone deficiency a possible risk factor for priapism associated with sickle-cell disease?

International Urology and Nephrology

Volumn 47, Issue 1, 2015, Pages 47-52

  Morrison, Belinda F ^a   Anele, Uzoma A ^b   Reid, Marvin E ^a   Madden, Wendy A ^a   Feng, Zhaoyong ^b   Burnett, Arthur L ^b  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Erection; Hypogonadism; Ischemic priapism; SCD

Indexed keywords

FOLLITROPIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; TESTOSTERONE; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; BLOOD; BLOOD CELL COUNT; COMPLICATION; CROSS-SECTIONAL STUDY; DEFICIENCY; HUMAN; MALE; MIDDLE AGED; PRIAPISM; RISK FACTOR; SICKLE CELL ANEMIA; YOUNG ADULT;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; BLOOD CELL COUNT; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; FOLLICLE STIMULATING HORMONE; HUMANS; L-LACTATE DEHYDROGENASE; LUTEINIZING HORMONE; MALE; MIDDLE AGED; PRIAPISM; RISK FACTORS; TESTOSTERONE; TRIGLYCERIDES; YOUNG ADULT;

EID: 84930947847     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-014-0864-1     Document Type: Article

References (29)

1. Montague DK, Jarow J, Broderick GA, Dmochowski RR, Heaton JP, Lue TF, Nehra A, Sharlip ID (2003) American Urological Association guideline on the management of priapism. J Urol 170(4 Pt 1):1318–1324
2. Emond AM, Holman R, Hayes RJ, Serjeant GR (1980) Priapism and impotence in homozygous sickle cell disease. Arch Intern Med 140(11):1434–1437
3. Pryor J, Akkus E, Alter G, Jordan G, Lebret T, Levine L, Mulhall J, Perovic S, Ralph D, Stackl W (2004) Priapism. J Sex Med 1(1):116–120
4. Osegbe DN, Akinyanju OO (1987) Testicular dysfunction in men with sickle cell disease. Postgrad Med J 63(736):95–98
5. Parshad O, Stevens MC, Preece MA, Thomas PW, Serjeant GR (1994) The mechanism of low testosterone levels in homozygous sickle-cell disease. West Indian Med J 43(1):12–14
6. Dada OA, Nduka EU (1980) Endocrine function and haemoglobinopathies: relation between the sickle cell gene and circulating plasma levels of testosterone, luteinising hormone (LH) and follicle stimulating hormone (FSH) in adult males. Clin Chim Acta 105(2):269–273
7. Singhal A, Gabay L, Serjeant GR (1995) Testosterone deficiency and extreme retardation of puberty in homozygous sickle-cell disease. West Indian Med J 44(1):20–23
8. Modebe O, Ezeh UO (1995) Effect of age on testicular function in adult males with sickle cell anemia. Fertil Steril 63(4):907–912
9. Traish A, Kim N (2005) The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function. J Sex Med 2(6):759–770
10. Morelli A, Filippi S, Mancina R, Luconi M, Vignozzi L, Marini M, Orlando C, Vannelli GB, Aversa A, Natali A, Forti G, Giorgi M, Jannini EA, Ledda F, Maggi M (2004) Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinology 145(5):2253–2263
11. Slayton W, Kedar A, Schatz D (1995) Testosterone induced priapism in two adolescents with sickle cell disease. J Pediatr Endocrinol Metab 8(3):199–203
12. Lundh B, Gardner FH (1970) The haematological response to androgens in sickle cell anaemia. Scand J Haematol 7(5):389–397
13. Serjeant GR, de Ceulaer K, Maude GH (1985) Stilboestrol and stuttering priapism in homozygous sickle-cell disease. Lancet 2(8467):1274–1276
14. Costabile RA (1998) Successful treatment of stutter priapism with an antiandrogen. Tech Urol 4(3):167–168
15. Abern MR, Levine LA (2009) Ketoconazole and prednisone to prevent recurrent ischemic priapism. J Urol 182(4):1401–1406
16. Kato GJ, McGowan V, Machado RF, Little JA, Taylor J, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM Jr, Gladwin MT (2006) Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 107(6):2279–2285
17. Saad F, Gooren LJ (2011) The role of testosterone in the etiology and treatment of obesity, the metabolic syndrome, and diabetes mellitus type 2. J Obes 2011:1–10
18. Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, O’Neill TW, Bartfai G, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Boonen S, Vanderschueren D, Labrie F, Huhtaniemi IT (2010) Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 363(2):123–135
19. Seo SI, Kim SW, Paick JS (1999) The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat. Asian J Androl 1(4):169–174
20. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH (1992) Nitric oxide: a physiologic mediator of penile erection. Science 257(5068):401–403
21. Bivalacqua TJ, Musicki B, Kutlu O, Burnett AL (2012) New insights into the pathophysiology of sickle cell disease-associated priapism. J Sex Med 9(1):79–87
22. Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I (1999) Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 140(4):1861–1868
23. Meusburger SM, Keast JR (2001) Testosterone and nerve growth factor have distinct but interacting effects on structure and neurotransmitter expression of adult pelvic ganglion cells in vitro. Neuroscience 108(2):331–340
24. Champion HC, Bivalacqua TJ, Takimoto E, Kass DA, Burnett AL (2005) Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism. Proc Natl Acad Sci USA 102(5):1661–1666
25. Bivalacqua TJ, Liu T, Musicki B, Champion HC, Burnett AL (2007) Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis. Eur Urol 51(6):1732–1740
26. Yuan J, Desouza R, Westney OL, Wang R (2008) Insights of priapism mechanism and rationale treatment for recurrent priapism. Asian J Androl 10(1):88–101
27. Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW, Molina JG, Weisbrodt NW, Kellems RE, Blackburn MR, Xia Y (2008) Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest 118(4):1491–1501
28. Kanika ND, Tar M, Tong Y, Kuppam DS, Melman A, Davies KP (2009) The mechanism of opiorphin-induced experimental priapism in rats involves activation of the polyamine synthetic pathway. Am J Physiol Cell Physiol 297(4):C916–C927
29. Morrison BF, Reid M, Madden W, Burnett AL (2013) Testosterone replacement therapy does not promote priapism in hypogonadal men with sickle cell disease: 12-month safety report. Andrology 1(4):576–582