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Volumn 7, Issue 2, 2011, Pages 145-154

The endocrine effects of long-term oral opioid therapy: A case report and review of the literature

Author keywords

Endocrine; Hypogonadism; Opioids; Osteoporosis; Testosterone

Indexed keywords

HYDROMORPHONE; MORPHINE; OXYCODONE; OXYMORPHONE;

EID: 79955941856     PISSN: 15517489     EISSN: None     Source Type: Journal    
DOI: 10.5055/jom.2011.0057     Document Type: Article
Times cited : (39)

References (59)
  • 1
  • 2
    • 61849123196 scopus 로고    scopus 로고
    • Oral opioids for chronic non-cancer pain: Higher prevalence of hypogonadism in men than in women
    • Fraser L-A, Morrison D, Morley-Forster P, et al.: Oral opioids for chronic non-cancer pain: Higher prevalence of hypogonadism in men than in women. Exp Clin Endocrinol Diabetes. 2009; 117: 38-43.
    • (2009) Exp Clin Endocrinol Diabetes , vol.117 , pp. 38-43
    • Fraser, L.-A.1    Morrison, D.2    Morley-Forster, P.3
  • 3
    • 0033830276 scopus 로고    scopus 로고
    • Hypogonadism in patients treated with intrathecal morphine
    • Finch PM, Roberts LJ, Price LS, et al.: Hypogonadism in patients treated with intrathecal morphine. Clin J Pain. 2000; 16(3): 251-254.
    • (2000) Clin J Pain , vol.16 , Issue.3 , pp. 251-254
    • Finch, P.M.1    Roberts, L.J.2    Price, L.S.3
  • 4
    • 0028293990 scopus 로고
    • Altered sexual function and decreased testosterone in patients receiving intraspinal opioids
    • DOI 10.1016/0885-3924(94)90166-X
    • Paice JA, Penn RD, Ryan WG: Altered sexual function and decreased testosterone in patients receiving intraspinal opioids. J Pain Symptom Manage. 1994; 9(2): 126-131. (Pubitemid 24105187)
    • (1994) Journal of Pain and Symptom Management , vol.9 , Issue.2 , pp. 126-131
    • Pake, J.A.1    Penn, R.D.2    Ryan, W.G.3
  • 6
    • 0035686367 scopus 로고    scopus 로고
    • Outcome of intrathecal opioids in chronic non-cancer pain
    • DOI 10.1053/eujp.2001.0255
    • Roberts LJ, Finch PM, Goucke CR, et al.: Outcome of intrathecal opioids in chronic non-cancer pain. Eur J Pain. 2001; 5: 353-361. (Pubitemid 34072462)
    • (2001) European Journal of Pain , vol.5 , Issue.4 , pp. 353-361
    • Roberts, L.J.1    Finch, P.M.2    Goucke, C.R.3    Price, L.M.4
  • 8
    • 0018641929 scopus 로고
    • Heroin addiction: Relationship between the plasma levels of testosterone, dihydrotestosterone, androstenedione, LH, FSH, and the plasma concentration of heroin
    • DOI 10.1016/0300-483X(79)90016-7
    • Bolelli G, Lafisca S, Flamigni C, et al.: Heroin addiction: Relationship between the plasma levels of testosterone, dihydrotestosterone, androstenedione, LH, FSH, and the plasma concentration of heroin. Toxicology. 1979; 15: 19-29. (Pubitemid 10134450)
    • (1979) Toxicology , vol.15 , Issue.1 , pp. 19-29
    • Bolelli, G.1    Lafisca, S.2    Flamigni, C.3
  • 9
    • 0036399514 scopus 로고    scopus 로고
    • Narcotic-induced hypogonadism during therapy for heroin addiction
    • Daniell HW: Narcotic-induced hypogonadism during therapy for heroin addiction. J Addict Dis. 2002; 21(4): 47-53.
    • (2002) J Addict Dis , vol.21 , Issue.4 , pp. 47-53
    • Daniell, H.W.1
  • 11
    • 0842347571 scopus 로고    scopus 로고
    • Symptomatic Hypogonadism in Male Survivors of Cancer with Chronic Exposure to Opioids
    • DOI 10.1002/cncr.20028
    • Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, et al.: Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer. 2004; 100(4): 851-858. (Pubitemid 38176866)
    • (2004) Cancer , vol.100 , Issue.4 , pp. 851-858
    • Rajagopal, A.1    Vassilopoulou-Sellin, R.2    Palmer, J.L.3    Kaur, G.4    Bruera, E.5
  • 12
    • 0036796181 scopus 로고    scopus 로고
    • Hypogonadism in men consuming sustained-action oral opioids
    • Daniell HW: Hypogonadism in men consuming sustained-action oral opioids. J Pain. 2002; 3(5): 377-384.
    • (2002) J Pain , vol.3 , Issue.5 , pp. 377-384
    • Daniell, H.W.1
  • 13
    • 37349031455 scopus 로고    scopus 로고
    • Opioid endocrinopathy in women consuming prescribed sustained-action opioids for control of nonmalignant pain
    • Daniell HW: Opioid endocrinopathy in women consuming prescribed sustained-action opioids for control of nonmalignant pain. J Pain. 2008; 9(1): 28-36.
    • (2008) J Pain , vol.9 , Issue.1 , pp. 28-36
    • Daniell, H.W.1
  • 14
    • 33644657895 scopus 로고    scopus 로고
    • Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency
    • DOI 10.1016/j.jpain.2005.10.009, PII S1526590005009600
    • Daniell HW, Lentz R, Mazer NA: Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency. J Pain. 2006; 7(3): 200-210. (Pubitemid 43324996)
    • (2006) Journal of Pain , vol.7 , Issue.3 , pp. 200-210
    • Daniell, H.W.1    Lentz, R.2    Mazer, N.A.3
  • 15
    • 34147100831 scopus 로고    scopus 로고
    • The impact of opioids on the endocrine system
    • Katz N: The impact of opioids on the endocrine system. Pain Manage Rounds. 2005; 1(9).
    • (2005) Pain Manage Rounds , vol.1 , Issue.9
    • Katz, N.1
  • 16
    • 67049116471 scopus 로고    scopus 로고
    • The impact of opioids on the endocrine system
    • Katz N, Mazer NA: The impact of opioids on the endocrine system. Clin J Pain. 2009; 25(2): 170-175.
    • (2009) Clin J Pain , vol.25 , Issue.2 , pp. 170-175
    • Katz, N.1    Mazer, N.A.2
  • 17
    • 79955939298 scopus 로고    scopus 로고
    • Male hypogonadism: Male endocrinology
    • Available at Accessed August 30, 2010
    • Merck Manual Professional: Male hypogonadism: Male endocrinology. Available at www.merck.com/mmpe/sec17/ch227/ch227b.html. Accessed August 30, 2010.
    • Merck Manual Professional
  • 18
    • 73249120982 scopus 로고    scopus 로고
    • Causes of secondary hypogonadism in males
    • Martin KA (ed.): Waltham, MA: UpToDate
    • Snyder PJ: Causes of secondary hypogonadism in males. In Martin KA (ed.): Up To Date. Waltham, MA: UpToDate, 2010.
    • (2010) Up to Date
    • Snyder, P.J.1
  • 19
    • 34248545711 scopus 로고    scopus 로고
    • Gonadal dysfunction and fertility problems in cancer survivors
    • DOI 10.1080/02841860601166958, PII 778490991
    • Brydoy M, Fossa SD, Dahl O, et al.: Gonadal dysfunction and fertility problems in cancer survivors. Acta Oncol. 2007; 46(4): 480-489. (Pubitemid 46752258)
    • (2007) Acta Oncologica , vol.46 , Issue.4 , pp. 480-489
    • Brydoy, M.1    Fossa, S.D.2    Dahl, O.3    Bjoro, T.4
  • 20
    • 79955941862 scopus 로고    scopus 로고
    • Effects of cytotoxic agents on gonadal function in adult men
    • Martin KD (ed.): Waltham, MA: UpToDate
    • Hayes FJ, Bubley GJ: Effects of cytotoxic agents on gonadal function in adult men. In Martin KD (ed.): Up To Date. Waltham, MA: UpToDate, 2010.
    • (2010) Up to Date
    • Hayes, F.J.1    Bubley, G.J.2
  • 21
    • 0034037097 scopus 로고    scopus 로고
    • Osteoporosis due to cancer treatment: Pathogenesis and management
    • Pfeilschifter J, Diel IJ: Osteoporosis due to cancer treatment: Pathogenesis and management. J Clin Oncol. 2000; 18(7): 1570-1593.
    • (2000) J Clin Oncol , vol.18 , Issue.7 , pp. 1570-1593
    • Pfeilschifter, J.1    Diel, I.J.2
  • 22
    • 73349095062 scopus 로고    scopus 로고
    • Do male lymphoma survivors have impaired sexual function?
    • Kiserud CE, Schover LR, Dahl AA, et al.: Do male lymphoma survivors have impaired sexual function? J Clin Oncol. 2009; 27(35): 6019-6026.
    • (2009) J Clin Oncol , vol.27 , Issue.35 , pp. 6019-6026
    • Kiserud, C.E.1    Schover, L.R.2    Dahl, A.A.3
  • 23
    • 0023868608 scopus 로고
    • The relationship of gonadal activity and chemotherapy-induced gonadal damage
    • DOI 10.1001/jama.259.14.2123
    • Rivkees SA, Crawford JD: The relationship of gonadal activity and chemotherapy-induced gonadal damage. JAMA. 1988; 259(14): 2123-2125. (Pubitemid 18088500)
    • (1988) Journal of the American Medical Association , vol.259 , Issue.14 , pp. 2123-2125
    • Rivkees, S.A.1    Crawford, J.D.2
  • 24
    • 0035095869 scopus 로고    scopus 로고
    • Androgen deficiency in women with hypopituitarism
    • Miller KK, Sesmilo G, Schiller A, et al.: Androgen deficiency in women with hypopituitarism. J Clin Endocrinol Metab. 2001; 86(2): 561-567.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.2 , pp. 561-567
    • Miller, K.K.1    Sesmilo, G.2    Schiller, A.3
  • 26
    • 33845189661 scopus 로고    scopus 로고
    • DHEAS deficiency during consumption of sustained-action prescribed opioids: Evidence for opioid-induced inhibition of adrenal androgen production
    • Daniell HW: DHEAS deficiency during consumption of sustained-action prescribed opioids: Evidence for opioid-induced inhibition of adrenal androgen production. J Pain. 2006; 7(12): 901-907.
    • (2006) J Pain , vol.7 , Issue.12 , pp. 901-907
    • Daniell, H.W.1
  • 27
    • 0035074494 scopus 로고    scopus 로고
    • Testosterone deficiency in women
    • Davis S: Testosterone deficiency in women. J Reprod Med. 2001; 46(3): 291-296.
    • (2001) J Reprod Med , vol.46 , Issue.3 , pp. 291-296
    • Davis, S.1
  • 28
    • 1842731327 scopus 로고    scopus 로고
    • Sex hormone deficiency in depressed patients receiving opioids
    • Letter
    • Daniell HW: Sex hormone deficiency in depressed patients receiving opioids. Arch Intern Med. 2004; 164: 804 (Letter).
    • (2004) Arch Intern Med , vol.164 , pp. 804
    • Daniell, H.W.1
  • 30
    • 68949192561 scopus 로고    scopus 로고
    • Testosterone and depression: Systematic review and meta-analysis
    • Zarrouf FA, Artz S, Griffith J, et al.: Testosterone and depression: Systematic review and meta-analysis. J Psychiatr Pract. 2009; 15(4): 289-305.
    • (2009) J Psychiatr Pract , vol.15 , Issue.4 , pp. 289-305
    • Zarrouf, F.A.1    Artz, S.2    Griffith, J.3
  • 31
    • 67649274349 scopus 로고    scopus 로고
    • Effects of testosterone replacement in middle-aged men with dysthymia: A randomized, placebo-controlled trial
    • Seidman SN, Orr G, Raviv G, et al.: Effects of testosterone replacement in middle-aged men with dysthymia: A randomized, placebo-controlled trial. J Clin Psychopharmacol. 2009; 29(3): 216-221.
    • (2009) J Clin Psychopharmacol , vol.29 , Issue.3 , pp. 216-221
    • Seidman, S.N.1    Orr, G.2    Raviv, G.3
  • 33
    • 0037223737 scopus 로고    scopus 로고
    • Testosterone gel supplementation for men with refractory depression: A randomized, placebo-controlled trial
    • DOI 10.1176/appi.ajp.160.1.105
    • Pope HG, Cohane GH, Kanayama G, et al.: Testosterone gel supplementation for men with refractory depression: A randomized, placebo-controlled trial. Am J Psychiatry. 2003; 160: 105-111. (Pubitemid 36042433)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.1 , pp. 105-111
    • Pope Jr., H.G.1    Cohane, G.H.2    Kanayama, G.3    Siegel, A.J.4    Hudson, J.I.5
  • 34
    • 79955932288 scopus 로고    scopus 로고
    • Epidemiology and etiology of osteoporosis in men
    • Mulder JE (ed.): Waltham, MA: UpToDate
    • Finkelstein JS: Epidemiology and etiology of osteoporosis in men. In Mulder JE (ed.): Up To Date. Waltham, MA: UpToDate, 2010.
    • (2010) Up to Date
    • Finkelstein, J.S.1
  • 37
    • 33750499768 scopus 로고    scopus 로고
    • Low bone density in patients receiving methadone maintenance treatment
    • DOI 10.1016/j.drugalcdep.2006.05.027, PII S0376871606002213
    • Kim TW, Alford DP, Malabanan A, et al: Low bone density in patients receiving methadone maintenance treatment. Drug Alcohol Depend. 2006; 85: 258-262. (Pubitemid 44666285)
    • (2006) Drug and Alcohol Dependence , vol.85 , Issue.3 , pp. 258-262
    • Kim, T.W.1    Alford, D.P.2    Malabanan, A.3    Holick, M.F.4    Samet, J.H.5
  • 38
    • 0034890081 scopus 로고    scopus 로고
    • Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men
    • DOI 10.1210/jc.86.8.3555
    • Khosla S, Melton LJ III, Atkinson EJ, et al.: Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab. 2001; 86(8): 3555-3561. (Pubitemid 32755943)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.8 , pp. 3555-3561
    • Khosla, S.1    Melton III, L.J.2    Atkinson, E.J.3    O'Fallon, W.M.4
  • 39
    • 0035378238 scopus 로고    scopus 로고
    • Androgen deficiency in women
    • Commentary
    • Miller KK: Androgen deficiency in women. J Clin Endocrinol Metab. 2001; 86(6): 2395-2401 (Commentary).
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.6 , pp. 2395-2401
    • Miller, K.K.1
  • 40
    • 0033304561 scopus 로고    scopus 로고
    • Androgen replacement in women: A commentary
    • Davis S: Androgen replacement in women: A commentary. J Clin Endocrinol Metab. 1999; 84: 1886-1891.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1886-1891
    • Davis, S.1
  • 41
    • 33646489631 scopus 로고    scopus 로고
    • Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study
    • Amin S, Zhang Y, Felson DT, et al: Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med. 2006; 119: 426-433.
    • (2006) Am J Med , vol.119 , pp. 426-433
    • Amin, S.1    Zhang, Y.2    Felson, D.T.3
  • 43
    • 56549083703 scopus 로고    scopus 로고
    • Does opioid use for pain management warrant routine bone mass density screening in men?
    • Fortin JD, Bailey GM, Vilensky JA: Does opioid use for pain management warrant routine bone mass density screening in men? Pain Physician. 2008; 11: 539-541.
    • (2008) Pain Physician , vol.11 , pp. 539-541
    • Fortin, J.D.1    Bailey, G.M.2    Vilensky, J.A.3
  • 44
    • 85044704881 scopus 로고    scopus 로고
    • Opioid osteoporosis
    • Letter
    • Daniell HW: Opioid osteoporosis. Arch Intern Med. 2004; 164: 338 (Letter).
    • (2004) Arch Intern Med , vol.164 , pp. 338
    • Daniell, H.W.1
  • 45
    • 76149108432 scopus 로고    scopus 로고
    • The effects of opioids and opioid analogs on animal and human endocrine systems
    • Vuong C, Van Uum SHM, O'Dell LE, et al.: The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010; 31(1): 98-132.
    • (2010) Endocr Rev , vol.31 , Issue.1 , pp. 98-132
    • Vuong, C.1    Van Uum, S.H.M.2    O'Dell, L.E.3
  • 47
    • 32844463502 scopus 로고    scopus 로고
    • Androgen therapy in women
    • Arlt W: Androgen therapy in women. Eur J Endocrinol. 2006; 154: 1-11.
    • (2006) Eur J Endocrinol , vol.154 , pp. 1-11
    • Arlt, W.1
  • 48
    • 34548187665 scopus 로고    scopus 로고
    • Opioid-induced androgen deficiency discussion in opioid contracts
    • Letter
    • Daniell HW: Opioid-induced androgen deficiency discussion in opioid contracts. Am J Med. 2007; 120: e21 (Letter).
    • (2007) Am J Med , vol.120
    • Daniell, H.W.1
  • 49
    • 27144528828 scopus 로고    scopus 로고
    • Available at Accessed August 30, 2010
    • American Academy of Pain Medicine: Consent for chronic opioid therapy. Available at www.painmed.org/Workarea/DownloadAsset.aspx?id=3211. Accessed August 30, 2010.
    • Consent for Chronic Opioid Therapy
  • 51
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society Clinical Practice Guideline
    • Bhasin S, Cunningham GR, Hayes FJ, et al.: Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2010; 95(6): 2536-2559.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3
  • 52
  • 53
    • 77954394453 scopus 로고    scopus 로고
    • Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis
    • Fernandez-Balsells MM, Murad MH, Lane M, et al.: Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis. J Clin Endocrinol Metab. 2010; 95: 2560-2575.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2560-2575
    • Fernandez-Balsells, M.M.1    Murad, M.H.2    Lane, M.3
  • 54
    • 77954421915 scopus 로고    scopus 로고
    • Adverse events associated with testosterone administration
    • Basaria S, Coviello AD, Travison TG, et al.: Adverse events associated with testosterone administration. N Engl J Med. 2010; 363(2): 109-122.
    • (2010) N Engl J Med , vol.363 , Issue.2 , pp. 109-122
    • Basaria, S.1    Coviello, A.D.2    Travison, T.G.3
  • 55
    • 34147134484 scopus 로고    scopus 로고
    • Anterior pituitary hormone replacement therapy - A clinical review
    • DOI 10.1007/s11102-007-0001-6
    • Auernhammer CJ, Vlotides G: Anterior pituitary hormone replacement therapyÑA clinical review. Pituitary. 2007; 10: 1-15. (Pubitemid 46562803)
    • (2007) Pituitary , vol.10 , Issue.1 , pp. 1-15
    • Auernhammer, C.J.1    Vlotides, G.2
  • 56
    • 84899058313 scopus 로고    scopus 로고
    • Testosterone treatment of male hypogonadism
    • Marin KA (ed.): Waltham, MA: UpToDate
    • Snyder PJ: Testosterone treatment of male hypogonadism. In Marin KA (ed.): Up To Date. Waltham, MA: UpToDate, 2010.
    • (2010) Up to Date
    • Snyder, P.J.1
  • 57
    • 79955941997 scopus 로고
    • Testosterone
    • Lexi-Comp Online: Lexi-Comp, Inc., Available at
    • Lexi-Comp Online: Testosterone. Lexi-Drugs Online. Lexi-Comp, Inc., 1978-2010. Available at www.lexi.com.
    • (1978) Lexi-Drugs Online
  • 58
    • 0036227440 scopus 로고    scopus 로고
    • Testosterone deficiency in women: Etiologies, diagnosis, and emerging treatments
    • Mazer NA: Testosterone deficiency in women: Etiologies, diagnosis, and emerging treatments. Int J Fertil. 2002; 47(2): 77-86.
    • (2002) Int J Fertil , vol.47 , Issue.2 , pp. 77-86
    • Mazer, N.A.1
  • 59
    • 79955938135 scopus 로고    scopus 로고
    • Testosterone replacement in female chronic pain patients
    • Tennant F: Testosterone replacement in female chronic pain patients. Pract Pain Manage. 2009; November/December: 25-27.
    • (2009) Pract Pain Manage , vol.NOVEMBER-DECEMBER , pp. 25-27
    • Tennant, F.1


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