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Volumn 11, Issue 2, 2018, Pages 171-177

Epidemiology, management, and outcome of carbapenem-resistant Klebsiella pneumoniae bloodstream infections in hospitals within the same endemic metropolitan area

Author keywords

Bloodstream infection; BSI; Carbapenem resistant Klebsiella pneumoniae; CRKP; Epidemiology

Indexed keywords

CARBAPENEM; CARBAPENEM DERIVATIVE; COLISTIN; GENTAMICIN; TIGECYCLINE;

EID: 85021354791     PISSN: 18760341     EISSN: 1876035X     Source Type: Journal    
DOI: 10.1016/j.jiph.2017.06.003     Document Type: Article
Times cited : (38)

References (36)
  • 2
    • 84860516573 scopus 로고    scopus 로고
    • Carbapenem resistance in Enterobacteriaceae: here is the storm!
    • Nordmann, P., Dortet, L., Poirel, L., Carbapenem resistance in Enterobacteriaceae: here is the storm!. Trends Mol Med 18 (2012), 263–272.
    • (2012) Trends Mol Med , vol.18 , pp. 263-272
    • Nordmann, P.1    Dortet, L.2    Poirel, L.3
  • 3
    • 78751685746 scopus 로고    scopus 로고
    • Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, Michigan
    • Marchain, D., Chopra, T., Pogue, J.M., Perez, F., Hujer, A.M., Rudin, S., et al. Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, Michigan. Antimicrob Agents Chemother 55 (2011), 593–599.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 593-599
    • Marchain, D.1    Chopra, T.2    Pogue, J.M.3    Perez, F.4    Hujer, A.M.5    Rudin, S.6
  • 4
    • 84944057059 scopus 로고    scopus 로고
    • Trends in the incidence of carbapenem-resistant Klebsiella pneumoniae bloodstream infections: a 8-year retrospective study in a large teaching hospital in northern Italy
    • Alicino, C., Giacobbe, D.R., Orsi, A., Tassinari, F., Trucchi, C., Sarteschi, G., et al. Trends in the incidence of carbapenem-resistant Klebsiella pneumoniae bloodstream infections: a 8-year retrospective study in a large teaching hospital in northern Italy. BMC Infect Dis, 15, 2015, 415.
    • (2015) BMC Infect Dis , vol.15 , pp. 415
    • Alicino, C.1    Giacobbe, D.R.2    Orsi, A.3    Tassinari, F.4    Trucchi, C.5    Sarteschi, G.6
  • 5
    • 84941960063 scopus 로고    scopus 로고
    • Large nosocomial outbreak of colistin-resistant, carbapenemase-producing klebsiella pneumoniae traced to clonal expansion of an mgrB deletion mutant
    • Giani, T., Arena, F., Vaggelli, G., Conte, V., Chiarelli, A., Henrici De Angelis, L., et al. Large nosocomial outbreak of colistin-resistant, carbapenemase-producing klebsiella pneumoniae traced to clonal expansion of an mgrB deletion mutant. J Clin Microbiol 53 (2015), 3341–3344.
    • (2015) J Clin Microbiol , vol.53 , pp. 3341-3344
    • Giani, T.1    Arena, F.2    Vaggelli, G.3    Conte, V.4    Chiarelli, A.5    Henrici De Angelis, L.6
  • 6
    • 60649091495 scopus 로고    scopus 로고
    • Characterization of blaKPC-containing Klebsiella Pneumoniae isolates detected in different institutions in the eastern USA
    • Endimiani, A., Hujer, A.M., Perez, F., Bethel, C.R., Hujer, K.M., Kroeger, J., et al. Characterization of blaKPC-containing Klebsiella Pneumoniae isolates detected in different institutions in the eastern USA. J Antimicrob Chemother 63 (2009), 427–437.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 427-437
    • Endimiani, A.1    Hujer, A.M.2    Perez, F.3    Bethel, C.R.4    Hujer, K.M.5    Kroeger, J.6
  • 7
    • 84945495879 scopus 로고    scopus 로고
    • Tracking a hospital outbreak of KPC-producing ST11 Klebsiella pneumoniae with whole genome sequencing
    • Jiang, Y., Wei, Z., Wang, Y., Hua, X., Feng, Y., Yu, Y., Tracking a hospital outbreak of KPC-producing ST11 Klebsiella pneumoniae with whole genome sequencing. Clin Microbiol Infect 21 (2015), 1001–1007.
    • (2015) Clin Microbiol Infect , vol.21 , pp. 1001-1007
    • Jiang, Y.1    Wei, Z.2    Wang, Y.3    Hua, X.4    Feng, Y.5    Yu, Y.6
  • 8
    • 84920451329 scopus 로고    scopus 로고
    • Early carbapenem-resistant Klebsiella pneumoniae bacteraemia: should we expand the screening?
    • Giacobbe, D.R., Del Bono, V., Marchese, A., Viscoli, C., Early carbapenem-resistant Klebsiella pneumoniae bacteraemia: should we expand the screening?. Clin Microbiol Infect 20 (2014), O1157–O1158.
    • (2014) Clin Microbiol Infect , vol.20 , pp. O1157-O1158
    • Giacobbe, D.R.1    Del Bono, V.2    Marchese, A.3    Viscoli, C.4
  • 10
    • 84892479911 scopus 로고    scopus 로고
    • Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options
    • Kontopidou, F., Giamarellou, H., Katerelos, P., Maragos, A., Kioumis, I., Trikka-Graphakos, E., et al. Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options. Clin Microbiol Infect 20 (2014), O117–O123.
    • (2014) Clin Microbiol Infect , vol.20 , pp. O117-O123
    • Kontopidou, F.1    Giamarellou, H.2    Katerelos, P.3    Maragos, A.4    Kioumis, I.5    Trikka-Graphakos, E.6
  • 11
    • 84891557171 scopus 로고    scopus 로고
    • An overview of carbapenem-resistant Klebsiella pneumoniae: epidemiology and control measures
    • Spagnolo, A.M., Orlando, P., Panatto, D., Perdelli, F., Cristina, M.L., An overview of carbapenem-resistant Klebsiella pneumoniae: epidemiology and control measures. Rev Med Microbiol 25 (2014), 7–14.
    • (2014) Rev Med Microbiol , vol.25 , pp. 7-14
    • Spagnolo, A.M.1    Orlando, P.2    Panatto, D.3    Perdelli, F.4    Cristina, M.L.5
  • 12
    • 85010049208 scopus 로고    scopus 로고
    • Meropenem for treating KPC-producing Klebsiella pneumoniae bloodstream infections: should we get to the PK/PD root of the paradox?
    • Del Bono, V., Giacobbe, D.R., Marchese, A., Parisini, A., Fucile, C., Coppo, E., et al. Meropenem for treating KPC-producing Klebsiella pneumoniae bloodstream infections: should we get to the PK/PD root of the paradox?. Virulence 18 (2016), 1–8.
    • (2016) Virulence , vol.18 , pp. 1-8
    • Del Bono, V.1    Giacobbe, D.R.2    Marchese, A.3    Parisini, A.4    Fucile, C.5    Coppo, E.6
  • 13
    • 84994032235 scopus 로고    scopus 로고
    • Epidemiology and biomolecular characterization of carbapenem-resistant klebsiella pneumoniae in an Italian hospital
    • Cristina, M.L., Sartini, M., Ottria, G., Schinca, E., Cenderello, N., Crisalli, M.P., et al. Epidemiology and biomolecular characterization of carbapenem-resistant klebsiella pneumoniae in an Italian hospital. J Prev Med Hyg 57 (2016), E149–E156.
    • (2016) J Prev Med Hyg , vol.57 , pp. E149-E156
    • Cristina, M.L.1    Sartini, M.2    Ottria, G.3    Schinca, E.4    Cenderello, N.5    Crisalli, M.P.6
  • 14
    • 79960697003 scopus 로고    scopus 로고
    • Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenem?
    • Daikos, G.L., Markogiannakis, A., Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenem?. Clin Microbiol Infect 17 (2011), 1135–1141.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 1135-1141
    • Daikos, G.L.1    Markogiannakis, A.2
  • 16
    • 84941662888 scopus 로고    scopus 로고
    • Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case–control–control study
    • 1106.e1-8
    • Giacobbe, D.R., Del Bono, V., Trecarichi, E.M., De Rosa, F.G., Giannella, M., Bassetti, M., et al. Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case–control–control study. Clin Microbiol Infect, 21, 2015 1106.e1-8.
    • (2015) Clin Microbiol Infect , vol.21
    • Giacobbe, D.R.1    Del Bono, V.2    Trecarichi, E.M.3    De Rosa, F.G.4    Giannella, M.5    Bassetti, M.6
  • 17
    • 84896940320 scopus 로고    scopus 로고
    • Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems
    • Daikos, G.L., Tsaousi, S., Tzouvelekis, L.S., Anyfantis, I., Psichogiou, M., Argyropoulou, A., et al. Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents Chemother 58 (2014), 2322–2328.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 2322-2328
    • Daikos, G.L.1    Tsaousi, S.2    Tzouvelekis, L.S.3    Anyfantis, I.4    Psichogiou, M.5    Argyropoulou, A.6
  • 18
    • 84936929460 scopus 로고    scopus 로고
    • Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentric study
    • Tumbarello, M., Trecarichi, E.M., De Rosa, F.G., Giannella, M., Giacobbe, D.R., Bassetti, M., et al. Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentric study. J Antimicrob Chemother 70 (2015), 2133–2143.
    • (2015) J Antimicrob Chemother , vol.70 , pp. 2133-2143
    • Tumbarello, M.1    Trecarichi, E.M.2    De Rosa, F.G.3    Giannella, M.4    Giacobbe, D.R.5    Bassetti, M.6
  • 19
    • 85042730678 scopus 로고    scopus 로고
    • HELICS Surveillance of Nosocomial Infections in Intensive Care Units protocol, version 6.1, September 2004. Available from: (accessed 19.06.16).
    • HELICS Surveillance of Nosocomial Infections in Intensive Care Units protocol, version 6.1, September 2004. Available from: http://ecdc.europa.eu/en/activities/surveillance/HAI/Documents/0409_IPSE_ICU_protocol.pdf (accessed 19.06.16).
  • 20
    • 0023092594 scopus 로고
    • A new method of classifying prognostic comorbidity in longitudinal studies: development and validation
    • Charlson, M.E., Pompei, P., Ales, K.L., MacKenzie, C.R., A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40 (1987), 373–383.
    • (1987) J Chronic Dis , vol.40 , pp. 373-383
    • Charlson, M.E.1    Pompei, P.2    Ales, K.L.3    MacKenzie, C.R.4
  • 21
    • 84959273475 scopus 로고    scopus 로고
    • The third international consensus definitions for sepsis and septic shock (sepsis-3)
    • Singer, M., Deutschman, C.S., Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:8 (2016), 801–810.
    • (2016) JAMA , vol.315 , Issue.8 , pp. 801-810
    • Singer, M.1    Deutschman, C.S.2    Seymour, C.W.3    Shankar-Hari, M.4    Annane, D.5    Bauer, M.6
  • 23
    • 84933531045 scopus 로고    scopus 로고
    • Impact of a hospital-wide multifaceted programme for reducing carbapenem-resistant Enterobacteriaceae infections in a large teaching hospital in northern Italy
    • Viale, P., Tumietto, F., Giannella, M., Bartoletti, M., Tedeschi, S., Ambretti, S., et al. Impact of a hospital-wide multifaceted programme for reducing carbapenem-resistant Enterobacteriaceae infections in a large teaching hospital in northern Italy. Clin Microbiol Infect 21 (2015), 242–247.
    • (2015) Clin Microbiol Infect , vol.21 , pp. 242-247
    • Viale, P.1    Tumietto, F.2    Giannella, M.3    Bartoletti, M.4    Tedeschi, S.5    Ambretti, S.6
  • 24
    • 85000961931 scopus 로고    scopus 로고
    • Previous bloodstream infections due to other pathogens as predictors of carbapenem-resistant Klebsiella pneumoniae bacteraemia in colonized patients: results from a retrospective multicentre study
    • (in press)
    • Giacobbe, D.R., Del Bono, V., Bruzzi, P., Corcione, S., Giannella, M., Marchese, A., et al. Previous bloodstream infections due to other pathogens as predictors of carbapenem-resistant Klebsiella pneumoniae bacteraemia in colonized patients: results from a retrospective multicentre study. Eur J Clin Microbiol Infect Dis, 2016, 10.1007/s10096-016-2843-1 (in press).
    • (2016) Eur J Clin Microbiol Infect Dis
    • Giacobbe, D.R.1    Del Bono, V.2    Bruzzi, P.3    Corcione, S.4    Giannella, M.5    Marchese, A.6
  • 25
    • 84960802837 scopus 로고    scopus 로고
    • A ten-year surveillance study of carbapenemase-producing Klebsiella pneumoniae in a tertiary care Greek university hospital: predominance of KPC- over VIM- or NDM-producing isolates
    • Spyropoulou, A., Papadimitriou-Olivgeris, M., Bartzavali, C., Vamvakopoulou, S., Marangos, M., Spiliopoulou, I., et al. A ten-year surveillance study of carbapenemase-producing Klebsiella pneumoniae in a tertiary care Greek university hospital: predominance of KPC- over VIM- or NDM-producing isolates. J Med Microbiol 65 (2016), 240–246.
    • (2016) J Med Microbiol , vol.65 , pp. 240-246
    • Spyropoulou, A.1    Papadimitriou-Olivgeris, M.2    Bartzavali, C.3    Vamvakopoulou, S.4    Marangos, M.5    Spiliopoulou, I.6
  • 28
    • 84971277787 scopus 로고    scopus 로고
    • Multicentre open-label randomised controlled trial to compare colistin alone with colistin plus meropenem for the treatment of severe infections caused by carbapenem-resistant Gram-negative infections (AIDA): a study protocol
    • Dickstein, Y., Leibovici, L., Yahav, D., Eliakim-Raz, N., Daikos, G.L., Skiada, A., et al. Multicentre open-label randomised controlled trial to compare colistin alone with colistin plus meropenem for the treatment of severe infections caused by carbapenem-resistant Gram-negative infections (AIDA): a study protocol. BMJ Open, 6(April (4)), 2016, e009956.
    • (2016) BMJ Open , vol.6 , Issue.April (4) , pp. e009956
    • Dickstein, Y.1    Leibovici, L.2    Yahav, D.3    Eliakim-Raz, N.4    Daikos, G.L.5    Skiada, A.6
  • 29
    • 85008198146 scopus 로고    scopus 로고
    • Might real-time pharmacokinetic/pharmacodynamic optimisation of high-dose continuous-infusion meropenem improve clinical cure in infections caused by KPC-producing Klebsiella pneumoniae?
    • Pea, F., Della Siega, P., Cojutti, P., Sartor, A., Crapis, M., Scarparo, C., et al. Might real-time pharmacokinetic/pharmacodynamic optimisation of high-dose continuous-infusion meropenem improve clinical cure in infections caused by KPC-producing Klebsiella pneumoniae?. Int J Antimicrob Agents 49 (2017), 255–258.
    • (2017) Int J Antimicrob Agents , vol.49 , pp. 255-258
    • Pea, F.1    Della Siega, P.2    Cojutti, P.3    Sartor, A.4    Crapis, M.5    Scarparo, C.6
  • 30
    • 84875256128 scopus 로고    scopus 로고
    • Outcome of inadequate empirical antibiotic therapy in emergency department patients with community-onset bloodstream infections
    • Chen, H.C., Lin, W.L., Lin, C.C., Hsieh, W.H., Hsieh, C.H., Wu, M.H., et al. Outcome of inadequate empirical antibiotic therapy in emergency department patients with community-onset bloodstream infections. J Antimicrob Chemother 68 (2013), 947–953.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 947-953
    • Chen, H.C.1    Lin, W.L.2    Lin, C.C.3    Hsieh, W.H.4    Hsieh, C.H.5    Wu, M.H.6
  • 31
    • 84455173002 scopus 로고    scopus 로고
    • Impact of inadequate empirical therapy on the mortality of patients with blood-stream infections: a propensity score-based analysis
    • Retamar, P., Portillo, M.M., Lopez-Prieto, M.D., Rodriguez- Lopez, F., de Cueto, M., Garcia, M.V., et al. Impact of inadequate empirical therapy on the mortality of patients with blood-stream infections: a propensity score-based analysis. Antimicrob Agents Chemother 56 (2012), 472–478.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 472-478
    • Retamar, P.1    Portillo, M.M.2    Lopez-Prieto, M.D.3    Rodriguez-Lopez, F.4    de Cueto, M.5    Garcia, M.V.6
  • 32
    • 84964478798 scopus 로고    scopus 로고
    • Bloodstream infections in internal medicine
    • Del Bono, V., Giacobbe, D.R., Bloodstream infections in internal medicine. Virulence 7 (2016), 353–365.
    • (2016) Virulence , vol.7 , pp. 353-365
    • Del Bono, V.1    Giacobbe, D.R.2
  • 33
    • 84912534678 scopus 로고    scopus 로고
    • The impact of infectious disease specialists on antibiotic prescribing in hospitals
    • Pulcini, C., Botelho-Nevers, E., Dyar, O.J., Harbarth, S., The impact of infectious disease specialists on antibiotic prescribing in hospitals. Clin Microbiol Infect 20 (2014), 963–972.
    • (2014) Clin Microbiol Infect , vol.20 , pp. 963-972
    • Pulcini, C.1    Botelho-Nevers, E.2    Dyar, O.J.3    Harbarth, S.4
  • 34
    • 43049150444 scopus 로고    scopus 로고
    • Role of the infectious diseases specialist consultant on the appropriateness of antimicrobial therapy prescription in an intensive care unit
    • Raineri, E., Pan, A., Mondello, P., Acquarolo, A., Candiani, A., Crema, L., Role of the infectious diseases specialist consultant on the appropriateness of antimicrobial therapy prescription in an intensive care unit. Am J Infect Control 36 (2008), 283–290.
    • (2008) Am J Infect Control , vol.36 , pp. 283-290
    • Raineri, E.1    Pan, A.2    Mondello, P.3    Acquarolo, A.4    Candiani, A.5    Crema, L.6
  • 35
    • 84883653653 scopus 로고    scopus 로고
    • Impact of regular collaboration between infectious diseases and critical care practitioners on antimicrobial utilization and patient outcome
    • Rimawi, R.H., Mazer, M.A., Siraj, D.S., Gooch, M., Cook, P.P., Impact of regular collaboration between infectious diseases and critical care practitioners on antimicrobial utilization and patient outcome. Crit Care Med 41 (2013), 2099–2107.
    • (2013) Crit Care Med , vol.41 , pp. 2099-2107
    • Rimawi, R.H.1    Mazer, M.A.2    Siraj, D.S.3    Gooch, M.4    Cook, P.P.5
  • 36
    • 2342623332 scopus 로고    scopus 로고
    • Why don't they listen? Adherence to recommendations of infectious disease consultations
    • Lo, E., Rezai, K., Evans, A.T., Madariaga, M.G., Phillips, M., Brobbey, W., et al. Why don't they listen? Adherence to recommendations of infectious disease consultations. Clin Infect Dis 38 (2004), 1212–1218.
    • (2004) Clin Infect Dis , vol.38 , pp. 1212-1218
    • Lo, E.1    Rezai, K.2    Evans, A.T.3    Madariaga, M.G.4    Phillips, M.5    Brobbey, W.6


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