Previous bloodstream infections due to other pathogens as predictors of carbapenem-resistant Klebsiella pneumoniae bacteraemia in colonized patients: results from a retrospective multicentre study

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 36, Issue 4, 2017, Pages 663-669

  Giacobbe, D R ^a   Del Bono, V ^a   Bruzzi, P ^a   Corcione, S ^b   Giannella, M ^c   Marchese, A ^a   Magnasco, L ^a   Maraolo, A E ^d   Pagani, N ^b   Saffioti, C ^a   Ambretti, S ^c   Cardellino, C S ^b   Coppo, E ^a   De Rosa, F G ^b   Viale, P ^c   Viscoli, C ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; COLISTIN; POLYPEPTIDE ANTIBIOTIC AGENT; QUINOLONE DERIVATIVE; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL COLONIZATION; BLOODSTREAM INFECTION; CANDIDA; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CENTRAL VENOUS CATHETER; ENTEROBACTERIACEAE; ENTEROCOCCUS; FEMALE; HUMAN; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK FACTOR; STAPHYLOCOCCUS AUREUS; URINARY CATHETER; AGED; ANTIBIOTIC RESISTANCE; BACTEREMIA; CLINICAL TRIAL; DRUG EFFECTS; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIOLOGY; MIDDLE AGED; MULTICENTER STUDY;

AGED; ANTI-BACTERIAL AGENTS; BACTEREMIA; BETA-LACTAM RESISTANCE; CARBAPENEMS; FEMALE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 85000961931     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-016-2843-1     Document Type: Article

References (27)

1. Hauck C, Cober E, Richter SS, Perez F, Salata RA, Kalayjian RC et al (2016) Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections. Clin Microbiol Infect 22(6):513–519
2. Tumbarello M, Trecarichi EM, De Rosa FG, Giannella M, Giacobbe DR, Bassetti M et al (2015) Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentric study. J Antimicrob Chemother 70:2133–2143
3. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M et al (2013) Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 13:785–796
4. Nordmann P, Dortet L, Poirel L (2012) Carbapenem resistance in Enterobacteriaceae: here is the storm! Trends Mol Med 18:263–272
5. Alicino C, Giacobbe DR, Orsi A et al (2015) Trends in the annual incidence of carbapenem-resistant Klebsiella pneumoniae bloodstream infections: a 8-year retrospective study in a large teaching hospital in northern Italy. BMC Infect Dis 15:415
6. Del Bono V, Giacobbe DR, Marchese A, Parisini A, Fucile C, Coppo E et al (2016) Meropenem for treating KPC-producing Klebsiella pneumoniae bloodstream infections: should we get to the PK/PD root of the paradox? Virulence. doi:10.1080/21505594.2016.1213476
7. Bogan C, Kaye KS, Chopra T, Hayakawa K, Pogue JM, Lephart PR et al (2014) Outcomes of carbapenem-resistant Enterobacteriaceae isolation: matched analysis. Am J Infect Control 42(6):612–620
8. Giacobbe DR, Del Bono V, Trecarichi EM, De Rosa FG, Giannella M, Bassetti M et al (2015) Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case–control-control study. Clin Microbiol Infect 21:1106.e1–1106.e8
9. Falcone M, Russo A, Iacovelli A et al (2016) Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Clin Microbiol Infect 22(5):444–450
10. Borer A, Saidel-Odes L, Eskira S et al (2012) Risk factors for developing clinical infection with carbapenem-resistant klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant k pneumoniae. Am J Infect Control 40:421–425
11. Schechner V, Kotlovsky T, Kazma M et al (2013) Asymptomatic rectal carriage of blakpc producing carbapenem-resistant enterobacteriaceae: who is prone to become clinically infected? Clin Microbiol Infect 19:451–456
12. Giannella M, Trecarichi EM, De Rosa FG, Del Bono V, Bassetti M, Lewis RE et al (2014) Risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infection among rectal carriers: a prospective observational multicentre study. Clin Microbiol Infect 20:1357–1362
13. Salsano A, Giacobbe DR, Sportelli E, Olivieri GM, Brega C, Di Biase C et al (2016) Risk factors for infections due to carbapenem-resistant Klebsiella pneumoniae after open heart surgery. Interact Cardiovasc Thorac Surg 23(5):762–768
14. Giannella M, Bartoletti M, Morelli MC, Tedeschi S, Cristini F, Tumietto F et al (2015) Risk factors for infection with carbapenem-resistant Klebsiella pneumoniae after liver transplantation: the importance of pre- and post-transplant colonization. Am J Transplant 15:1708–1715
15. Di Carlo P, Gulotta G, Casuccio A et al (2013) KPC — 3 Klebsiella pneumoniae ST258 clone infection in postoperative abdominal surgery patients in an intensive care setting: analysis of a case series of 30 patients. BMC Anesthesiol 13:13
16. Tumbarello M, Trecarichi EM, Tumietto F, Del Bono V, De Rosa FG, Bassetti M et al (2014) Predictive models for identification of hospitalized patients harboring KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 58:3514–3520
17. Daikos GL, Tsaousi S, Tzouvelekis LS, Anyfantis I, Psichogiou M, Argyropoulou A et al (2014) Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents Chemother 58:2322–2328
18. Amit S, Mishali H, Kotlovsky T, Schwaber MJ, Carmeli Y (2015) Bloodstream infections among carriers of carbapenem-resistant Klebsiella pneumoniae: etiology, incidence and predictors. Clin Microbiol Infect 21:30–34
19. Tumbarello M, Viale P, Viscoli C et al (2012) Predictors of mortality in bloodstream infections caused by kpc-producing klebsiella pneumoniae: importance of combination therapy. Clin Infect Dis 55:943–950
20. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383
21. Martin DO, Austin H (1996) Exact estimates for a rate ratio. Epidemiology 7:29–33
22. Cole GT, Halawa AA, Anaissie EJ (1996) The role of the gastrointestinal tract in hematogenous candidiasis: from the laboratory to the bedside. Clin Infect Dis 22(Suppl 2):S73–S88
23. Russo A, Falcone M, Fantoni M et al (2015) Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection. Clin Microbiol Infect 21:493.e1–493.e4
24. Papadimitriou-Olivgeris M, Spiliopoulou A, Fligou F et al (2014) Association of KPC-producing Klebsiella pneumoniae colonization or infection with Candida isolation and selection of non-albicans species. Diagn Microbiol Infect Dis 80:227–232
25. De Rosa FG, Corcione S, Pagani N, Di Perri G (2015) From ESKAPE to ESCAPE, from KPC to CCC. Clin Infect Dis 60:1289–1290
26. Munoz-Price LS, Frencken JF, Tarima S, Bonten M (2016) Handling time-dependent variables: antibiotics and antibiotic resistance. Clin Infect Dis 62(12):1558–1563
27. Souvenir D, Anderson DE Jr, Palpant S et al (1998) Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients. J Clin Microbiol 36:1923–1926