Risk factors for infections due to carbapenem-resistant Klebsiella pneumoniae after open heart surgery

Interactive Cardiovascular and Thoracic Surgery

Volumn 23, Issue 5, 2016, Pages 762-768

  Salsano, Antonio ^a   Giacobbe, Daniele Roberto ^a   Sportelli, Elena ^a   Olivieri, Guido Maria ^a   Brega, Carlotta ^a   Di Biase, Carlo ^a   Coppo, Erika ^a   Marchese, Anna ^a   Del Bono, Valerio ^a   Viscoli, Claudio ^a   Santini, Francesco ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Carbapenemases; Cardiac surgery; Klebsiella; KPC; Postoperative infections

Indexed keywords

ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL COLONIZATION; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CARDIOPULMONARY BYPASS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; FEMALE; HUMAN; INFECTION RISK; ITALY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OPEN HEART SURGERY; POSTOPERATIVE INFECTION; PREOPERATIVE CARE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SEX DIFFERENCE; SURGICAL MORTALITY; SURVIVAL; TEACHING HOSPITAL; ADVERSE EFFECTS; DRUG EFFECTS; HEART SURGERY; HOSPITAL MORTALITY; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; MICROBIOLOGY; MIDDLE AGED; RISK FACTOR; SURGICAL WOUND INFECTION; SURVIVAL RATE; TRENDS;

CARBAPENEM DERIVATIVE;

AGED; BETA-LACTAM RESISTANCE; CARBAPENEMS; CARDIAC SURGICAL PROCEDURES; FEMALE; HOSPITAL MORTALITY; HUMANS; ITALY; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SURGICAL WOUND INFECTION; SURVIVAL RATE;

EID: 84994667322     PISSN: 15699293     EISSN: 15699285     Source Type: Journal    
DOI: 10.1093/icvts/ivw228     Document Type: Article

References (25)

1. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 2013;13:785-96
2. Tumbarello M, Trecarichi EM, De Rosa FG, Giannella M, Giacobbe DR, Bassetti M et al. Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentric study. J Antimicrob Chemother 2015;70:2133-43
3. Giacobbe DR, Del Bono V, Trecarichi EM, De Rosa FG, Giannella M, Bassetti M et al. Risk factors for bloodstream infections due to colistinresistant KPC-producing Klebsiella pneumoniae: results from a multicenter case-control-control study. Clin Microbiol Infect 2015;21:1106-8
4. Giannella M, Trecarichi EM, De Rosa FG, Del Bono V, Bassetti M, Lewis RE et al. Risk factors for carbapenem-resistant Klebsiella pneumoniae blood stream infection among rectal carriers: a prospective observational multicentre study. Clin Microbiol Infect 2014;20:1357-62
5. Tumbarello M, Trecarichi EM, Tumietto F, Del Bono V, De Rosa FG, Bassetti M et al. Predictive models for identification of hospitalized patients harboring KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2014;58:3514-20
6. Freire MP, Abdala E, Moura ML, de Paula FJ, Spadão F, Caiaffa-Filho HH et al. Risk factors and outcome of infections with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae in kidney transplant recipients. Infection 2015;43:315-23
7. Giannella M, Bartoletti M, Morelli MC, Tedeschi S, Cristini F, Tumietto F et al. Risk factors for infection with carbapenem-resistant Klebsiella pneumoniae after liver transplantation: the importance of pre-and posttransplant colonization. Am J Transplant 2015;15:1708-15
8. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309-32
9. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-83
10. Marchese A, Coppo E, Barbieri R, Debbia E. Emergence of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains and spread of an isolate of sequence type 258 in the neuro-rehabilitation unit of an Italian hospital. J Chemother 2010;22:212-4
11. Thomas L, Reyes EM. Tutorial: survival estimation for Cox regression models with time-varying coefficients. J Stat Softw 2014;61(1):1-23
12. Heinze G, Dunkler D. Avoiding infinite estimates of time-dependent effects in small-sample survival studies. Stat Med 2008;27:6455-69
13. Borer A, Saidel-Odes L, Eskira S, Nativ R, Riesenberg K, Livshiz-Riven I et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K. pneumoniae. Am J Infect Control 2012;40:421-5
14. Hayden MK, Lin MY, Lolans K,Weiner S, Blom D, Moore NM et al. Prevention of colonization and infection by Klebsiella pneumoniae carbapenemaseproducing Enterobacteriaceae in long-term acute-care hospitals. Clin Infect Dis 2015;60:1153-61
15. Rossi M, Sganga G, Mazzone M, Valenza V, Guarneri S, Portale G et al. Cardiopulmonary bypass in man: role of the intestine in a self-limiting inflammatory response with demonstrable bacterial translocation. Ann Thorac Surg 2004;77:612-8
16. Feltis BA, Wells CL. Does microbial translocation play a role in critical illness? Curr Opin Crit Care 2000;6:117-22
17. Rady MY, Ryan T, Starr NJ. Perioperative determinants of morbidity and mortality in elderly patients undergoing cardiac surgery. Crit Care Med 1998;26:225-35
18. He S, Chen B, Li W, Yan J, Chen L, Wang X et al. Ventilator-associated pneumonia after cardiac surgery: a meta-analysis and systematic review. J Thorac Cardiovasc Surg 2014;148:3148-55. e1-5
19. Levine SA, NiedermanMS. The impact of tracheal intubation on host defenses and risks for nosocomial pneumonia. Clin Chest Med 1991;12:523-43
20. Robich MP, Sabik JF, Houghtaling PL, Kelava M, Gordon S, Blackstone EH et al. Prolonged effect of postoperative infectious complications on survival after cardiac surgery. Ann Thorac Surg 2015;99:1591-9
21. Rogers MA, Langa KM, Kim C, Nallamothu BK, McMahon LF Jr, Malani PN et al. Contribution of infection to increased mortality in women after cardiac surgery. Arch Intern Med 2006;166:437-43
22. Koch CG, Khandwala F, Nussmeier N, Blackstone EH. Gender and outcomes after coronary artery bypass grafting: a propensity-matched comparison. J Thorac Cardiovasc Surg 2003;126:2032-43
23. Retamar P, Portillo MM, Lopez-Prieto MD, Rodriguez-Lopez F, Cueto MGarcia MV et al. Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis. Antimicrob Agents Chemother 2012;56:472-8
24. Vittinghoff E, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 2007;165:710-8
25. Alicino C, Giacobbe DR, Orsi A, Tassinari F, Trucchi C, Sarteschi G et al. Trends in the incidence of carbapenem-resistant Klebsiella pneumoniae bloodstream infections: a 8-year retrospective study in a large teaching hospital in northern Italy. BMC Infect Dis 2015;15:415