Genetic evidence that b-arrestins are dispensable for the initiation of b2-adrenergic receptor signaling to ERK

Science Signaling

Volumn 10, Issue 484, 2017, Pages

  O'Hayre, Morgan ^a   Eichel, Kelsie ^b   Avino, Silvia ^a,c   Zhao, Xuefeng ^a,d,e   Steffen, Dana J ^d   Feng, Xiaodong ^a,d   Kawakami, Kouki ^f   Aoki, Junken ^f,g   Messer, Karen ^d   Sunahara, Roger ^d   Inoue, Asuka ^f,h   Von Zastrow, Mark ^b,i   Gutkind, J Silvio ^a,d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALABRIA   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SICHUAN UNIVERSITY   (China)

^f TOHOKU UNIVERSITY   (Japan)

^g JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT   (Japan)

^h JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN SHC; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR 1; BETA ADRENERGIC RECEPTOR 2; BETA ARRESTIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE SRC; RAS PROTEIN; UNCLASSIFIED DRUG; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 1; BETA ARRESTIN 2; LIGAND; PROTEIN BINDING; SMALL INTERFERING RNA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOSOME; GENETIC ANALYSIS; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; ANIMAL; ENDOCYTOSIS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHOSPHORYLATION; RNA INTERFERENCE;

ANIMALS; BETA-ARRESTIN 1; BETA-ARRESTIN 2; ENDOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HUMANS; LIGANDS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-2; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES;

EID: 85021129764     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aal3395     Document Type: Article

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