Screening for obesity and intervention forweight management in children and adolescents evidence report and systematic review for the us preventive services task force

JAMA - Journal of the American Medical Association

Volumn 317, Issue 23, 2017, Pages 2427-2444

  O'Connor, Elizabeth A ^a   Evans, Corinne V ^a   Burda, Brittany U ^a   Walsh, Emily S ^a   Eder, Michelle ^a   Lozano, Paula ^b  

^a CENTER FOR HEALTH RESEARCH   (United States)

^b KAISER PERMANENTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; METFORMIN; PLACEBO; TETRAHYDROLIPSTATIN; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; LACTONE;

ABDOMINAL CRAMP; ABDOMINAL PAIN; ADOLESCENCE; ADOLESCENT; BEHAVIOR CHANGE; BODY MASS; BODY WEIGHT MANAGEMENT; CARDIOMETABOLIC RISK; CHILD; CHILDHOOD; DIASTOLIC BLOOD PRESSURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FECES INCONTINENCE; FLATULENCE; GASTROINTESTINAL DISEASE; HUMAN; LIFESTYLE MODIFICATION; MASS SCREENING; NUTRITIONAL COUNSELING; OBESITY; PATIENT COMPLIANCE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK BENEFIT ANALYSIS; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; UNITED STATES; VOMITING; WEIGHT REDUCTION; ADVERSE EFFECTS; ADVISORY COMMITTEE; BODY WEIGHT; COMPLICATION; CONTROLLED CLINICAL TRIAL (TOPIC); DRUG EFFECTS; OVERWEIGHT; PEDIATRIC OBESITY; PRESCHOOL CHILD;

ADOLESCENT; ADVISORY COMMITTEES; ANTI-OBESITY AGENTS; BODY MASS INDEX; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; HUMANS; HYPOGLYCEMIC AGENTS; LACTONES; MASS SCREENING; METFORMIN; NON-RANDOMIZED CONTROLLED TRIALS AS TOPIC; OVERWEIGHT; PEDIATRIC OBESITY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; UNITED STATES; WEIGHT LOSS;

EID: 85021100510     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2017.0332     Document Type: Review

References (95)

1. Friedemann C, Heneghan C, Mahtani K, Thompson M, Perera R, Ward AM. Cardiovascular disease risk in healthy children and its association with body mass index: systematic review and meta-analysis. BMJ. 2012;345:e4759.
2. Silveira LS, Monteiro PA, Antunes Bde M, et al. Intra-abdominal fat is related to metabolic syndrome and non-alcoholic fat liver disease in obese youth. BMC Pediatr. 2013;13:115.
3. Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med. 2015;373 (14):1307-1317.
4. Bocca G, Ongering EC, Stolk RP, Sauer PJ. Insulin resistance and cardiovascular risk factors in 3- to 5-year-old overweight or obese children. Horm Res Paediatr. 2013;80(3):201-206.
5. May AL, Kuklina EV, Yoon PW. Prevalence of cardiovascular disease risk factors among US adolescents, 1999-2008. Pediatrics. 2012;129(6): 1035-1041.
6. Pećin I, Samovojska R, Heinrich B, Zeljković-Vrkić T, Laganović M, Jelaković B. Hypertension, overweight and obesity in adolescents: The CRO-KOP study. Coll Antropol. 2013;37(3):761-764.
7. Mazor-Aronovitch K, Lotan D, Modan-Moses D, Fradkin A, Pinhas-Hamiel O. Blood pressure in obese and overweight children and adolescents. Isr Med Assoc J. 2014;16(3):157-161.
8. Egan KB, Ettinger AS, Bracken MB. Childhood body mass index and subsequent physician-diagnosed asthma: A systematic review and meta-analysis of prospective cohort studies. BMC Pediatr. 2013;13(1):121.
9. Barton M; US Preventive Services Task Force. Screening for obesity in children and adolescents: US Preventive Services Task Force recommendation statement. Pediatrics. 2010;125 (2):361-367.
10. US Preventive Services Task Force. US Preventive Services Task Force Procedure Manual. Rockville, MD: US Preventive Services Task Force; 2015.
11. Whitlock EP, Williams SB, Gold R, Smith PR, Shipman SA. Screening and interventions for childhood overweight: A summary of evidence for the US Preventive Services Task Force. Pediatrics. 2005;116(1):e125-e144.
12. Whitlock EP, O'Connor EA, Williams SB, Beil TL, Lutz KW. Effectiveness of Primary Care Interventions forWeight Management in Children and Adolescents: An Updated, Targeted Systematic Review for the USPSTF. Rockville, MD: Agency for Healthcare Research and Quality; 2010. AHRQ publication 10-05144-EF-1.
13. Turner EH. How to access and process FDA drug approval packages for use in research. BMJ. 2013; 347:f5992.
14. Yanovski J. Safety and efficacy of Xenical in children and adolescents with obesity-related diseases [NCT00001723]. ClinicalTrials.gov website. https://clinicaltrials.gov/ct2/show/NCT00001723. 2012. Accessed February 2, 2016.
15. Organisation for Economic Co-operation and Development (OECD). List of OECD Member countries-ratification of the convention of the OECD. OECD website. http://www.oecd.org/about/membersandpartners/list-oecd-member-countries.htm. 2015. Accessed January 19, 2017.
16. Kuczmarski RJ, Ogden CL, Guo SS, et al. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11. 2002;246 (246):1-190.
17. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320(7244):1240-1243.
18. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-188.
19. Knapp G, Hartung J. Improved tests for a random effects meta-regression with a single covariate. Stat Med. 2003;22(17):2693-2710.
20. Harville DA. Maximum likelihood approaches to variance component estimation and to related problems. J AmStat Assoc. 1977;72(358):320-338.
21. Hardy RJ, Thompson SG. A likelihood approach to meta-analysis with random effects. Stat Med. 1996;15(6):619-629.
22. Higgins JP, Thompson SG. Quantifying heterogeneity in ameta-analysis. Stat Med. 2002; 21(11):1539-1558.
23. Arauz Boudreau AD, Kurowski DS, Gonzalez WI, Dimond MA, Oreskovic NM. Latino families, primary care, and childhood obesity: A randomized controlled trial. Am J Prev Med. 2013;44(3)(suppl 3):S247-S257.
24. Boutelle KN, Zucker N, Peterson CB, Rydell S, Carlson J, Harnack LJ. An intervention based on Schachter's externality theory for overweight children: The regulation of cues pilot. J Pediatr Psychol. 2014;39(4):405-417.
25. Bryant M, Farrin A, Christie D, Jebb SA, Cooper AR, Rudolf M. Results of a feasibility randomised controlled trial (RCT) forWATCH IT: A programme for obese children and adolescents. Clin Trials. 2011; 8(6):755-764.
26. Croker H, Viner RM, Nicholls D, et al. Family-based behavioural treatment of childhood obesity in a UK National Health Service setting: randomized controlled trial. Int J Obes (Lond). 2012; 36(1):16-26.
27. Davis JN, Ventura EE, Tung A, et al. Effects of a randomized maintenance intervention on adiposity and metabolic risk factors in overweight minority adolescents. Pediatr Obes. 2012;7(1):16-27.
28. Broccoli S, Davoli AM, Bonvicini L, et al. Motivational interviewing to treat overweight children: 24-month follow-up of a randomized controlled trial. Pediatrics. 2016;137(1):1-10.
29. De Bar LL, Stevens VJ, Perrin N, et al. A primary care-based, multicomponent lifestyle intervention for overweight adolescent females. Pediatrics. 2012;129(3):e611-e620.
30. Gerards SM, Dagnelie PC, Gubbels JS, et al. The effectiveness of Lifestyle Triple P in the Netherlands: A randomized controlled trial. PLoS One. 2015;10(4):e0122240.
31. Golley RK, Magarey AM, Baur LA, Steinbeck KS, Daniels LA. Twelve-month effectiveness of a parent-led, family-focused weight-management program for prepubertal children: A randomized, controlled trial. Pediatrics. 2007;119(3):517-525.
32. Hofsteenge GH, Chinapaw MJ, Delemarre-van de Waal HA, Weijs PJ. Long-term effect of the Go4it group treatment for obese adolescents: A randomised controlled trial. Clin Nutr. 2014;33(3):385-391.
33. Kalarchian MA, Levine MD, Arslanian SA, et al. Family-based treatment of severe pediatric obesity: randomized, controlled trial. Pediatrics. 2009;124 (4):1060-1068.
34. Kalavainen MP, Korppi MO, Nuutinen OM. Clinical efficacy of group-based treatment for childhood obesity compared with routinely given individual counseling. Int J Obes (Lond). 2007;31 (10):1500-1508.
35. Kong AS, Sussman AL, Yahne C, Skipper BJ, Burge MR, Davis SM. School-based health center intervention improves body mass index in overweight and obese adolescents. J Obes. 2013; 2013:575016.
36. Lison JF, Real-Montes JM, Torro I, et al. Exercise intervention in childhood obesity: A randomized controlled trial comparing hospitalversus home-based groups. Acad Pediatr. 2012;12 (4):319-325.
37. Looney SM, Raynor HA. Examining the effect of three low-intensity pediatric obesity interventions: A pilot randomized controlled trial. Clin Pediatr (Phila). 2014;53(14):1367-1374.
38. Love-Osborne K, Fortune R, Sheeder J, Federico S, Haemer MA. School-based health center-based treatment for obese adolescents: feasibility and body mass index effects. Child Obes. 2014;10(5):424-431.
39. McCallum Z, Wake M, Gerner B, et al. Outcome data from the LEAP (Live, Eat and Play) trial: A randomized controlled trial of a primary care intervention for childhood overweight/mild obesity. Int J Obes (Lond). 2007;31(4):630-636.
40. Mellin LM, Slinkard LA, Irwin CE Jr. Adolescent obesity intervention: validation of the SHAPEDOWN program. J AmDiet Assoc. 1987;87 (3):333-338.
41. Nowicka P, Hoglund P, Pietrobelli A, Lissau I, Flodmark CE. Family Weight School treatment: 1-year results in obese adolescents. Int J Pediatr Obes. 2008;3(3):141-147.
42. Nemet D, Barkan S, Epstein Y, Friedland O, Kowen G, Eliakim A. Short- and long-term beneficial effects of a combined dietary-behavioral-physical activity intervention for the treatment of childhood obesity. Pediatrics. 2005;115(4):e443-e449.
43. O'Connor TM, Hilmers A, Watson K, Baranowski T, Giardino AP. Feasibility of an obesity intervention for paediatric primary care targeting parenting and children: Helping HAND. Child Care Health Dev. 2013;39(1):141-149.
44. Raynor HA, Osterholt KM, Hart CN, Jelalian E, Vivier P, Wing RR. Efficacy of U.S. paediatric obesity primary care guidelines: Two randomized trials. Pediatr Obes. 2012;7(1):28-38.
45. Reinehr T, de Sousa G, Toschke AM, Andler W. Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention. Am J Clin Nutr. 2006;84(3):490-496.
46. Reinehr T, Kleber M, Toschke AM. Lifestyle intervention in obese children is associated with a decrease of the metabolic syndrome prevalence. Atherosclerosis. 2009;207(1):174-180.
47. Reinehr T, Schaefer A, Winkel K, Finne E, Toschke AM, Kolip P. An effective lifestyle intervention in overweight children: findings from a randomized controlled trial on "Obeldicks light." Clin Nutr. 2010;29(3):331-336.
48. Resnicow K, McMaster F, Bocian A, et al. Motivational interviewing and dietary counseling for obesity in primary care: An RCT. Pediatrics. 2015; 135(4):649-657.
49. Sacher PM, Kolotourou M, Chadwick PM, et al. Randomized controlled trial of the MEND program: A family-based community intervention for childhood obesity. Obesity (Silver Spring). 2010;18 (suppl 1):S62-S68.
50. Saelens BE, Sallis JF, Wilfley DE, Patrick K, Cella JA, Buchta R. Behavioral weight control for overweight adolescents initiated in primary care. Obes Res. 2002;10(1):22-32.
51. Savoye M, Caprio S, Dziura J, et al. Reversal of early abnormalities in glucose metabolism in obese youth: results of an intensive lifestyle randomized controlled trial. Diabetes Care. 2014;37(2):317-324.
52. Savoye M, Shaw M, Dziura J, et al. Effects of a weight management program on body composition and metabolic parameters in overweight children: A randomized controlled trial. JAMA. 2007;297(24): 2697-2704.
53. Stark LJ, Clifford LM, Towner EK, et al. A pilot randomized controlled trial of a behavioral family-based intervention with and without home visits to decrease obesity in preschoolers. J Pediatr Psychol. 2014;39(9):1001-1012.
54. Stark LJ, Spear S, Boles R, et al. A pilot randomized controlled trial of a clinic and home-based behavioral intervention to decrease obesity in preschoolers. Obesity (Silver Spring). 2011;19(1):134-141.
55. Stettler N, Wrotniak BH, Hill DL, et al. Prevention of excess weight gain in paediatric primary care: beverages only or multiple lifestyle factors: The Smart Step Study, a cluster-randomized clinical trial. Pediatr Obes. 2015;10(4):267-274.
56. Tanofsky-Kraff M, Wilfley DE, Young JF, et al. A pilot study of interpersonal psychotherapy for preventing excess weight gain in adolescent girls at risk for obesity. Int J Eat Disord. 2010;43(8):701-706.
57. Taveras EM, Gortmaker SL, Hohman KH, et al. Randomized controlled trial to improve primary care to prevent and manage childhood obesity: The High Five for Kids study. Arch Pediatr Adolesc Med. 2011;165(8):714-722.
58. Taveras EM, Marshall R, Kleinman KP, et al. Comparative effectiveness of childhood obesity interventions in pediatric primary care: A cluster-randomized clinical trial. JAMA Pediatr. 2015;169(6):535-542.
59. Taylor RW, Cox A, Knight L, et al. A tailored family-based obesity intervention: A randomized trial. Pediatrics. 2015;136(2):281-289.
60. van Grieken A, Veldhuis L, Renders CM, et al. Population-based childhood overweight prevention: outcomes of the "Be Active, Eat Right" study. PLoS One. 2013;8(5):e65376.
61. Vos RC, Wit JM, Pijl H, Houdijk EC. Long-term effect of lifestyle intervention on adiposity, metabolic parameters, inflammation and physical fitness in obese children: A randomized controlled trial. Nutr Diabetes. 2011;1:e9.
62. Wake M, Baur LA, Gerner B, et al. Outcomes and costs of primary care surveillance and intervention for overweight or obese children: The LEAP 2 randomised controlled trial. BMJ. 2009; 339:b3308.
63. Wake M, Lycett K, Clifford SA, et al. Shared care obesity management in 3-10 year old children: 12 month outcomes of HopSCOTCH randomised trial. BMJ. 2013;346:f3092.
64. Weigel C, Kokocinski K, Lederer P, Dotsch J, Rascher W, Knerr I. Childhood obesity: concept, feasibility, and interim results of a local group-based, long-term treatment program. J Nutr Educ Behav. 2008;40(6):369-373.
65. Norman G, Huang J, Davila EP, et al. Outcomes of a 1-year randomized controlled trial to evaluate a behavioral "stepped-down" weight loss intervention for adolescent patients with obesity. Pediatr Obes. 2016;11(1):18-25.
66. Sherwood NE, JaKa MM, Crain AL, Martinson BC, Hayes MG, Anderson JD. Pediatric primary care-based obesity prevention for parents of preschool children: A pilot study. Child Obes. 2015;11 (6):674-682.
67. Wiegand S, l'Allemand D, Hubel H, et al. Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: A prospective, placebo-controlled, randomized study. Eur J Endocrinol. 2010;163(4):585-592.
68. Wilson DM, Abrams SH, Aye T, et al; Glaser Pediatric Research Network Obesity Study Group. Metformin extended release treatment of adolescent obesity: A 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up. Arch Pediatr Adolesc Med. 2010;164(2): 116-123.
69. Yanovski JA, Krakoff J, Salaita CG, et al. Effects of metformin on body weight and body composition in obese insulin-resistant children: A randomized clinical trial. Diabetes. 2011;60(2): 477-485.
70. Love-Osborne K, Sheeder J, Zeitler P. Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. J Pediatr. 2008;152(6):817-822.
71. Kendall D, Vail A, Amin R, et al. Metformin in obese children and adolescents: The MOCA trial. J Clin Endocrinol Metab. 2013;98(1):322-329.
72. Srinivasan S, Ambler GR, Baur LA, et al. Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin. J Clin Endocrinol Metab. 2006; 91(6):2074-2080.
73. Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics. 2001;107(4):E55.
74. Clarson CL, Brown HK, De Jesus S, et al. Effects of a comprehensive, intensive lifestyle intervention combined with metformin extended release in obese adolescents. Int Sch Res Notices. 2014;2014: 659410.
75. Chanoine JP, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents: A randomized controlled trial. JAMA. 2005;293(23):2873-2883.
76. Maahs D, de Serna DG, Kolotkin RL, et al. Randomized, double-blind, placebo-controlled trial of orlistat forweight loss in adolescents. Endocr Pract. 2006;12(1):18-28.
77. Kay JP, Alemzadeh R, Langley G, D'Angelo L, Smith P, Holshouser S. Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metabolism. 2001;50(12):1457-1461.
78. Evia-Viscarra ML, Rodea-Montero ER, Apolinar-Jimenez E, et al. The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance: controlled randomized clinical trial. J Pediatr Endocrinol Metab. 2012;25(1- 2):41-49.
79. Burgert TS, Duran EJ, Goldberg-Gell R, et al. Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatr Diabetes. 2008;9 (6):567-576.
80. Markert J, Herget S, Petroff D, et al. Telephone-based adiposity prevention for families with overweight children (T.A.F.F.-Study): one year outcome of a randomized, controlled trial. Int J Environ Res Public Health. 2014;11(10):10327-10344.
81. Ford AL, Hunt LP, Cooper A, Shield JP. What reduction in BMI SDS is required in obese adolescents to improve body composition and cardiometabolic health? Arch Dis Child. 2010;95(4): 256-261.
82. Reinehr T, Andler W. Changes in the atherogenic risk factor profile according to degree of weight loss. Arch Dis Child. 2004;89(5):419-422.
83. Kolsgaard ML, Joner G, Brunborg C, Anderssen SA, Tonstad S, Andersen LF. Reduction in BMI z-score and improvement in cardiometabolic risk factors in obese children and adolescents: The Oslo Adiposity Intervention Study-a hospital/public health nurse combined treatment. BMC Pediatr. 2011;11:47.
84. Abrams P, Levitt Katz LE, Moore RH, et al. Threshold for improvement in insulin sensitivity with adolescent weight loss. J Pediatr. 2013;163(3): 785-790.
85. Kirk S, Zeller M, Claytor R, Santangelo M, Khoury PR, Daniels SR. The relationship of health outcomes to improvement in BMI in children and adolescents. Obes Res. 2005;13(5):876-882.
86. Peirson L, Fitzpatrick-Lewis D, Morrison K, Warren R, Usman Ali M, Raina P. Treatment of overweight and obesity in children and youth: A systematic review and meta-analysis. CMAJ Open. 2015;3(1):E35-E46.
87. Ho M, Garnett SP, Baur L, et al. Effectiveness of lifestyle interventions in child obesity: systematic review with meta-analysis. Pediatrics. 2012;130(6): e1647-e1671.
88. Oude Luttikhuis H, Baur L, Jansen H, et al. Interventions for treating obesity in children. Cochrane Database Syst Rev. 2009;(1):CD001872.
89. Janicke DM, Steele RG, Gayes LA, et al. Systematic review and meta-analysis of comprehensive behavioral family lifestyle interventions addressing pediatric obesity. J Pediatr Psychol. 2014;39(8):809-825.
90. McDonagh MS, Selph S, Ozpinar A, Foley C. Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger. JAMA Pediatr. 2014;168(2):178- 184.
91. Rezvanian H, Hashemipour M, Kelishadi R, Tavakoli N, Poursafa P. A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity. World J Pediatr. 2010;6(4):317-322.
92. Clarson CL, Mahmud FH, Baker JE, et al. Metformin in combination with structured lifestyle intervention improved body mass index in obese adolescents, but did not improve insulin resistance. Endocrine. 2009;36(1):141-146.
93. Mauras N, DelGiorno C, Hossain J, et al. Metformin use in children with obesity and normal glucose tolerance-effects on cardiovascular markers and intrahepatic fat. J Pediatr Endocrinol Metab. 2012;25(1-2):33-40.
94. Atabek ME, Pirgon O. Use of metformin in obese adolescents with hyperinsulinemia: A 6-month, randomized, double-blind, placebo-controlled clinical trial. J Pediatr Endocrinol Metab. 2008;21(4):339-348.
95. Lavine JE, Schwimmer JB, Van Natta ML, et al; Nonalcoholic Steatohepatitis Clinical Research Network. Effect of vitamin E ormetformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial. JAMA. 2011;305(16):1659-1668.