Functional selectivity of GPCR-directed drug action through location bias

Nature Chemical Biology

Volumn 13, Issue 7, 2017, Pages 799-806

  Irannejad, Roshanak ^a   Pessino, Veronica ^a,b   Mika, Delphine ^a,c   Huang, Bo ^a,b   Wedegaertner, Philip B ^d   Conti, Marco ^a   Von Zastrow, Mark ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Universite Paris Sud   (France)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; CYCLIC AMP; DOBUTAMINE; EPINEPHRINE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ORGANIC CATION TRANSPORTER 3; RNA; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; LIGAND;

ADULT; ARTICLE; CARDIAC MUSCLE CELL; CELL SURFACE; CONTROLLED STUDY; DIFFUSION; DRUG SELECTIVITY; EMBRYO; FEMALE; GOLGI COMPLEX; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTRACELLULAR SIGNALING; NEWBORN; PRIORITY JOURNAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION;

ADRENERGIC BETA-ANTAGONISTS; DOBUTAMINE; EPINEPHRINE; GOLGI APPARATUS; HELA CELLS; HUMANS; LIGANDS; RECEPTORS, ADRENERGIC, BETA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85021081360     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2389     Document Type: Article

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