Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli

PLoS ONE

Volumn 12, Issue 6, 2017, Pages

  Karve, Sayali S ^a,c   Pradhan, Suman ^a   Ward, Doyle V ^b   Weiss, Alison A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c PAREXEL INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; INTERLEUKIN 8; REACTIVE OXYGEN METABOLITE;

ACTIN FILAMENT; ARTICLE; BACTERIAL STRAIN; CELL DIFFERENTIATION; CELLULAR IMMUNITY; COMMENSAL ESCHERICHIA COLI; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM CELL; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; INTESTINE CELL; INTESTINE INFECTION; NEUTROPHIL; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; RNA SEQUENCE; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; UPREGULATION; BIOLOGICAL MODEL; CELL CULTURE; COCULTURE; CYTOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; INDUCED PLURIPOTENT STEM CELL; INTESTINE; PATHOGENICITY; SEQUENCE ANALYSIS; VIROLOGY;

CELLS, CULTURED; COCULTURE TECHNIQUES; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTESTINES; MODELS, BIOLOGICAL; NEUTROPHILS; ORGANOIDS; SEQUENCE ANALYSIS, RNA; SHIGA-TOXIGENIC ESCHERICHIA COLI;

EID: 85020914748     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0178966     Document Type: Article

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