A Systematic Review and Meta-analysis Examining the Impact of Incident Postoperative Delirium on Mortality

Anesthesiology

Volumn 127, Issue 1, 2017, Pages 78-88

  Hamilton, Gavin M ^a   Wheeler, Kathleen ^a   Di Michele, Joseph ^a   Lalu, Manoj M ^a,b   McIsaac, Daniel I ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FOLLOW UP; HOSPITAL MORTALITY; HUMAN; INCIDENCE; META ANALYSIS; POSTOPERATIVE DELIRIUM; PRIORITY JOURNAL; REVIEW; SURGICAL MORTALITY; SURGICAL PATIENT; SYSTEMATIC REVIEW; TREATMENT OUTCOME; AGED; DELIRIUM; FEMALE; MALE; MIDDLE AGED; MORTALITY; ODDS RATIO; POSTOPERATIVE COMPLICATION; STATISTICS AND NUMERICAL DATA; SURGERY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DELIRIUM; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; ODDS RATIO; POSTOPERATIVE COMPLICATIONS; SURGICAL PROCEDURES, OPERATIVE;

EID: 85020845022     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000001660     Document Type: Review

References (71)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Washington, American Psychiatric Association, 2013
2. Inouye SK, Westendorp RG, Saczynski JS: Delirium in elderly people. Lancet 2014; 383:911-22
3. Centers for Disease Control and Prevention (CDC): NCHS National Hospital Discharge Survey 2010. Available at: Http://www.cdc. gov/nchs/fastats/inpatient-surgery.htm. Accessed October 3, 2016
4. Takeuchi M, Takeuchi H, Fujisawa D, Miyajima K, Yoshimura K, Hashiguchi S, Ozawa S, Ando N, Shirahase J, Kitagawa Y, Mimura M: Incidence and risk factors of postoperative delirium in patients with esophageal cancer. Ann Surg Oncol 2012; 19:3963-70
5. van Munster BC, Thomas C, Kreisel SH, Brouwer JP, Nanninga S, Kopitz J, de Rooij SE: Longitudinal assessment of serum anticholinergic activity in delirium of the elderly. J Psychiatr Res 2012; 46:1339-45
6. Pitkala KH, Laurila JV, Strandberg TE, Tilvis RS: Prognostic significance of delirium in frail older people. Dement Geriatr Cogn Disord 2005; 19:158-63
7. Inouye SK: Delirium in older persons. N Engl J Med 2006; 354:1157-65
8. Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, van Gool WA: Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, dementia: A meta-analysis. JAMA 2010; 304:443-51
9. Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, Jones RN: Cognitive trajectories after postoperative delirium. N Engl J Med 2012; 367:30-9
10. Bilimoria KY, Liu Y, Paruch JL, Zhou L, Kmiecik TE, Ko CY, Cohen ME: Development and evaluation of the universal ACS NSQIP surgical risk calculator: A decision aid and informed consent tool for patients and surgeons. J Am Coll Surg 2013; 217:833-42.e1-3
11. Gottschalk A, Hubbs J, Vikani AR, Gottschalk LB, Sieber FE: The impact of incident postoperative delirium on survival of elderly patients after surgery for hip fracture repair. Anesth Analg 2015; 121:1336-43
12. Dubljanin-Raspopovi E, Markovic Denic L, Marinkovic J, Radinovic K, Ilic N, Tomanovic Vujadinovic S, Kadija M: Early mortality after hip fracture: What matters Psychogeriatrics 2015; 15:95-101
13. Dubljanin-Raspopovi E, Markovic Deni L, Marinkovi J, Graji M, Tomanovic Vujadinovi S, Bumbaširevi M: Use of early indicators in rehabilitation process to predict oneyear mortality in elderly hip fracture patients. Hip Int 2012; 22:661-7
14. Elie M, Cole MG, Primeau FJ, Bellavance F: Delirium risk factors in elderly hospitalized patients. J Gen Intern Med 1998; 13:204-12
15. NICE: Delirium: Diagnosis, prevention and management. NICE Clin Guidel 2014; 103. Available at: Www.nice.org.uk/CG103. Accessed October 2, 2016
16. Fong TG, Jones RN, Marcantonio ER, Tommet D, Gross AL, Habtemariam D, Schmitt E, Yap L, Inouye SK: Adverse outcomes after hospitalization and delirium in persons with Alzheimer disease. Ann Intern Med 2012; 156:848-56, W296
17. Seitz DP, Gill SS, Gruneir A, Austin PC, Anderson GM, Bell CM, Rochon PA: Effects of dementia on postoperative outcomes of older adults with hip fractures: A population-based study. J Am Med Dir Assoc 2014; 15:334-41
18. Salluh JI, Wang H, Schneider EB, Nagaraja N, Yenokyan G, Damluji A, Serafim RB, Stevens RD: Outcome of delirium in critically ill patients: Systematic review and meta-analysis. BMJ 2015; 350:h2538
19. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB: Metaanalysis of observational studies in epidemiology: A proposal for reporting: Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283:2008-12
20. Higgins J, Green S: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Cochrane Collab 2011. Available at: Www.handbook. cochrane.org. Accessed April 24, 2016
21. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group: Preferred reporting items for systematic reviews and metaanalyses: The PRISMA statement. Ann Intern Med 2009; 151:264-9, W64
22. McGowan J, Sampson M, Salzwedel DM, Cogo, E, Foerster V, Lefebvre C: PRESS Peer review of electronic search strategies: 2015 guideline statement. J Clin Epidemiol 2016; 75:40-6
23. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. Washington, American Psychiatric Association, 1980
24. Sterne JAC, Higgins JPT, Reeves BC; on behalf of the development group for ACROBAT-NRSI: A Cochrane Risk Of Bias Assessment Tool: For Non-Randomized Studies of Interventions (ACROBAT-NRSI), version 1.0.0. 2014. Available at: Http://www.riskofbias.info. Accessed April 24, 2016
25. Young J, Inouye SK: Delirium in older people. BMJ 2007; 334:842-6
26. Mohanty S, Rosenthal RA, Russell MM, Neuman MD, Ko CY, Esnaola NF: Optimal perioperative management of the geriatric patient: A best practices guideline from the American College of Surgeons NSQIP and the American Geriatrics Society. J Am Coll Surg 2016; 222:930-47
27. Dales LG, Ury HK: An improper use of statistical significance testing in studying covariables. Int J Epidemiol 1978; 7:373-5
28. Hernán MA, Hernández-Diáz S, Werler MM, Mitchell AA: Causal knowledge as a prerequisite for confounding evaluation: An application to birth defects epidemiology. Am J Epidemiol 2002; 155:176-84
29. Robins JM, Greenland S: The role of model selection in causal inference from nonexperimental data. Am J Epidemiol 1986; 123:392-402
30. Sun GW, Shook TL, Kay GL: Inappropriate use of bivariable analysis to screen risk factors for use in multivariable analysis. J Clin Epidemiol 1996; 49:907-16
31. Jung SW, Park SC, Rim JS: The risk factor of delirium after transurethral resection of the prostate. Korean J Urol 2006; 47:953-7
32. Vieta E, de Pablo J, Cirera E, Pujol A, Grande L, Rimola A, Visa J: Postoperative psychiatric complications following liver transplantation [in Spanish]. Med Clin (Barc) 1993; 100:210-3
33. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA; PRISMA-P Group: Preferred reporting items for systematic review and metaanalysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015; 4:1
34. Radinovic K, Markovic-Denic L, Dubljanin-Raspopovic E, Marinkovic J, Milan Z, Bumbasirevic V: Estimating the effect of incident delirium on short-term outcomes in aged hip fracture patients through propensity score analysis. Geriatr Gerontol Int 2015; 15:848-55
35. Radinovic KS, Markovic-Denic L, Dubljanin-Raspopovic E, Marinkovic J, Jovanovic LB, Bumbasirevic V: Effect of the overlap syndrome of depressive symptoms and delirium on outcomes in elderly adults with hip fracture: A prospective cohort study. J Am Geriatr Soc 2014; 62:1640-8
36. Abelha FJ, Luís C, Veiga D, Parente D, Fernandes V, Santos P, Botelho M, Santos A, Santos C: Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery. Crit Care 2013; 17:R257
37. Veiga D, Luís C, Parente D, Abelha F: Outcome after hepatectomy-delirium as an independent predictor for mortality. BMC Anesthesiol 2013; 13:4
38. Veiga D, Luis C, Parente D, Fernandes V, Botelho M, Santos P, Abelha F: Postoperative delirium in intensive care patients: Risk factors and outcome. Brazilian J Anesthesiol 2012; 62:469-83
39. Bickel H, Gradinger R, Kochs E, Förstl H: High risk of cognitive and functional decline after postoperative delirium: A three-year prospective study. Dement Geriatr Cogn Disord 2008; 26:26-31
40. Nightingale S, Holmes J, Mason J, House A: Psychiatric illness and mortality after hip fracture. Lancet 2001; 357:1264-5
41. Holmes J, House A: Psychiatric illness predicts poor outcome after surgery for hip fracture: A prospective cohort study. Psychol Med 2000; 30:921-9
42. Furlaneto ME, Garcez-Leme LE: Impact of delirium on mortality and cognitive and functional performance among elderly people with femoral fractures. Clinics (Sao Paulo) 2007; 62:545-52
43. Hempenius L, Slaets JP, van Asselt D, de Bock TH, Wiggers T, van Leeuwen BL: Long term outcomes of a geriatric liaison intervention in frail elderly cancer patients. PLoS One 2016; 11:e0143364
44. Raats JW, Steunenberg SL, Crolla RM, Wijsman JH, te Slaa A, van der Laan L: Postoperative delirium in elderly after elective and acute colorectal surgery: A prospective cohort study. Int J Surg 2015; 18:216-9
45. Raats JW, van Eijsden WA, Crolla RM, Steyerberg EW, van der Laan L: Risk factors and outcomes for postoperative delirium after major surgery in elderly patients. PLoS One 2015; 10:e0136071
46. Carnevali L, Bellelli G, Mazzola P, Aletti G, Corsi M, Annoni G: Effect of the overlap syndrome of depressive symptoms and delirium on outcomes in elderly adults with hip fracture: A comment. J Am Geriatr Soc 2015; 63:1051-3
47. Visser L, Prent A, van der Laan MJ, van Leeuwen BL, Izaks GJ, Zeebregts CJ, Pol RA: Predicting postoperative delirium after vascular surgical procedures. J Vasc Surg 2015; 62:183-9
48. Parente D, Luís C, Veiga D, Silva H, Abelha F: Congestive heart failure as a determinant of postoperative delirium. Rev Port Cardiol 2013; 32:665-71
49. Large MC, Reichard C, Williams JT, Chang C, Prasad S, Leung Y, DuBeau C, Bales GT, Steinberg GD: Incidence, risk factors, complications of postoperative delirium in elderly patients undergoing radical cystectomy. Urology 2013; 81:123-8
50. Kat MG, de Jonghe JF, Vreeswijk R, van der Ploeg T, van Gool WA, Eikelenboom P, Kalisvaart KJ: Mortality associated with delirium after hip-surgery: A 2-year follow-up study. Age Ageing 2011; 40:312-8
51. Brouquet A, Cudennec T, Benoist S, Moulias S, Beauchet A, Penna C, Teillet L, Nordlinger B: Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery. Ann Surg 2010; 251:759-65
52. Koebrugge B, van Wensen RJ, Bosscha K, Dautzenberg PL, Koning OH: Delirium after emergency/elective open and endovascular aortoiliac surgery at a surgical ward with a high-standard delirium care protocol. Vascular 2010; 18:279-87
53. Ansaloni L, Catena F, Chattat R, Fortuna D, Franceschi C, Mascitti P, Melotti RM: Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. Br J Surg 2010; 97:273-80
54. Robinson TN, Raeburn CD, Tran ZV, Angles EM, Brenner LA, Moss M: Postoperative delirium in the elderly: Risk factors and outcomes. Ann Surg 2009; 249:173-8
55. Koebrugge B, Koek HL, van Wensen RJ, Dautzenberg PL, Bosscha K: Delirium after abdominal surgery at a surgical ward with a high standard of delirium care: Incidence, risk factors and outcomes. Dig Surg 2009; 26:63-8
56. Kat MG, Vreeswijk R, de Jonghe JFM, van der Ploeg T, van Gool WA, Eikelenboom P, Kalisvaart KJ: Long-term cognitive outcome of delirium in elderly hip surgery patients. Dement Geriatr Cogn Disord 2008; 26:1-8
57. Minden SL, Carbone LA, Barsky A, Borus JF, Fife A, Fricchione GL, Orav EJ: Predictors and outcomes of delirium. Gen Hosp Psychiatry 2005; 27:209-14
58. Zakriya K, Sieber FE, Christmas C, Wenz JF Sr, Franckowiak S: Brief postoperative delirium in hip fracture patients affects functional outcome at three months. Anesth Analg 2004; 98:1798-802, table of contents
59. Lundström M, Edlund A, Bucht G, Karlsson S, Gustafson Y: Dementia after delirium in patients with femoral neck fractures. J Am Geriatr Soc 2003; 51:1002-6
60. Edlund A, Lundström M, Brännström B, Bucht G, Gustafson Y: Delirium before and after operation for femoral neck fracture. J Am Geriatr Soc 2001; 49:1335-40
61. Milisen K, Foreman MD, Abraham IL, De Geest S, Godderis J, Vandermeulen E, Fischler B, Delooz HH, Spiessens B, Broos PL: A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. J Am Geriatr Soc 2001; 49:523-32
62. Neufeld KJ, Leoutsakos JM, Sieber FE, Wanamaker BL, Gibson Chambers JJ, Rao V, Schretlen DJ, Needham DM: Outcomes of early delirium diagnosis after general anesthesia in the elderly. Anesth Analg 2013; 117:471-8
63. Neufeld KJ, Leoutsakos JM, Oh E, Sieber FE, Chandra A, Ghosh A, Schretlen DJ, Needham DM: Long-term outcomes of older adults with and without delirium immediately after recovery from general anesthesia for surgery. Am J Geriatr Psychiatry 2015; 23:1067-74
64. Edelstein DM, Aharonoff GB, Karp A, Capla EL, Zuckerman JD, Koval KJ: Effect of postoperative delirium on outcome after hip fracture. Clin Orthop Relat Res 2004:195-200
65. Gallagher TK, McErlean S, O'Farrell A, Hoti E, Maguire D, Traynor OJ, Conlon KC, Geoghegan JG: Incidence and risk factors of delirium in patients post pancreaticoduodenectomy. HPB (Oxford) 2014; 16:864-9
66. Liu P, Li YW, Wang XS, Zou X, Zhang DZ, Wang DX, Li SZ: High serum interleukin-6 level is associated with increased risk of delirium in elderly patients after noncardiac surgery: A prospective cohort study. Chin Med J (Engl) 2013; 126:3621-7
67. Kawaguchi Y, Kanamori M, Ishihara H, Abe Y, Nobukiyo M, Sigeta T, Hori T, Kimura T: Postoperative delirium in spine surgery. Spine J 2006; 6:164-9
68. Brännström B, Gustafson Y, Norberg A, Winblad B: Problems of basic nursing care in acutely confused and non-confused hip-fracture patients. Scand J Caring Sci 1989; 3:27-34
69. Harris RJ, Bradburn MJ, Deeks JJ, Altman DG, Harbord RM, Sterne JAC: Metan: Fixed-A nd random-effects meta-analysis. Stata J 2008; 8:3-28
70. Smith T, Li X, Nylander W, Gunnar W: Thirty-day postoperative mortality risk estimates and 1-year survival in veterans health administration surgery patients. JAMA Surg 2016; 151:417-22
71. Brauer C, Morrison RS, Silberzweig SB, Siu AL: The cause of delirium in patients with hip fracture. Arch Intern Med 2000; 160:1856-60