Systemic pharmacologic therapies for low back pain: A systematic review for an American College of physicians clinical practice guideline

Annals of Internal Medicine

Volumn 166, Issue 7, 2017, Pages 480-492

  Chou, Roger ^a   Deyo, Richard ^a   Friedly, Janna ^b   Skelly, Andrea ^c   Weimer, Melissa ^a   Fu, Rochelle ^a   Dana, Tracy ^a   Kraegel, Paul ^d   Griffin, Jessica ^a   Grusing, Sara ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Spectrum Research   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; BUPRENORPHINE; CORTICOSTEROID DERIVATIVE; DULOXETINE; GABAPENTIN; MUSCLE RELAXANT AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE DERIVATIVE; PARACETAMOL; PLACEBO; PREGABALIN; SEROTONIN UPTAKE INHIBITOR; TAPENTADOL; TETRAZEPAM; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; ANALGESIC AGENT; CORTICOSTEROID; NARCOTIC ANALGESIC AGENT;

ANALGESIA; COCHRANE LIBRARY; DATA EXTRACTION; DRUG EFFICACY; FUNCTIONAL ASSESSMENT; HUMAN; INFORMATION RETRIEVAL; LOW BACK PAIN; MEDLINE; PAIN ASSESSMENT; PHARMACEUTICAL CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RADICULOPATHY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SHORT COURSE THERAPY; SYSTEMATIC REVIEW; SYSTEMIC THERAPY; VERTEBRAL CANAL STENOSIS; ACUTE PAIN; CHRONIC PAIN; COMPLICATION;

ACETAMINOPHEN; ACUTE PAIN; ADRENAL CORTEX HORMONES; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; BENZODIAZEPINES; CHRONIC PAIN; HUMANS; LOW BACK PAIN; NEUROMUSCULAR AGENTS; RADICULOPATHY;

EID: 85020731360     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/M16-2458     Document Type: Review

References (137)

1. Deyo RA, Mirza SK, Martin BI. Back pain prevalence and visit rates: Estimates from U.S. national surveys, 2002. Spine (Phila Pa 1976). 2006; 31: 2724-7. [PMID: 17077742]
2. Walker BF. The prevalence of low back pain: A systematic review of the literature from 1966 to 1998. J Spinal Disord. 2000; 13: 205-17. [PMID: 10872758]
3. Carey TS, Freburger JK, Holmes GM, Castel L, Darter J, Agans R, et al. A long way to go: Practice patterns and evidence in chronic low back pain care. Spine (Phila Pa 1976). 2009; 34: 718-24. [PMID: 19282797] doi: 10.1097/BRS.0b013e31819792b0
4. Fritz JM, Brennan GP, Hunter SJ, Magel JS. Initial management decisions after a new consultation for low back pain: Implications of the usage of physical therapy for subsequent health care costs and utilization. Arch Phys Med Rehabil. 2013; 94: 808-16. [PMID: 23337426] doi: 10.1016/j.apmr.2013.01.008
5. Vanova JI, Birnbaum HG, Schiller M, Kantor E, Johnstone BM, Swindle RW. Real-world practice patterns, health-care utilization, and costs in patients with low back pain: The long road to guidelineconcordant care. Spine J. 2011; 11: 622-32. [PMID: 21601533] doi: 10 .1016/j.spinee.2011.03.017
6. Chou R, Qaseem A, Snow V, Casey D, Cross JT Jr, Shekelle P, et al; Clinical Efficacy Assessment Subcommittee of the American College of Physicians. Diagnosis and treatment of low back pain: A joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007; 147: 478-91. [PMID: 17909209]
7. Chou R, Huffman LH; American Pain Society. Medications for acute and chronic low back pain: A review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med. 2007; 147: 505-14. [PMID: 17909211]
8. Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, et al. Nonpharmacologic therapies for low back pain: A systematic review for an American College of Physicians clinical practice guideline. Ann Intern Med. 2017; 166: 493-505. doi: 10.7326/M16-2459
9. Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, et al. Noninvasive Treatments for Low Back Pain. Comparative Effectiveness Review no. 169. (Prepared by the Pacific Northwest Evidencebased Practice Center under contract no. 290-2012-00014-I.) AHRQ publication no. 16-EHC004-EF. Rockville: Agency for Healthcare Research and Quality; 2016.
10. Owens D, Lohr KN, Atkins D, Treadwell J, Reston J, Bass E, et al. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Rockville: Agency for Healthcare Research and Quality; 2011.
11. Noninvasive treatments for low back pain. PROSPERO 2014: CRD42014014735. Accessed at www.crd.york.ac.uk/PROSPERO /display-record.asp?ID=CRD42014014735 on 21 June 2016.
12. Chou R, Huffman L, eds; American Pain Society; American Academy of Pain Medicine. Guideline for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain. Evidence Review. Chicago: American Pain Society; 2009.
13. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. AHRQ publication no. 10(14)-EHC063-EF. Rockville: Agency for Healthcare Research and Quality; 2014.
14. Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, et al. AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol. 2009; 62: 1013-20. [PMID: 19230606] doi: 10.1016/j.jclinepi .2008.10.009
15. Agency for Healthcare Research and Quality. Integrating bodies of evidence: Existing systematic reviews and primary studies. In: Agency for Healthcare Research and Quality; U.S. Department of Health and Human Services, eds. Draft Methods Guidance. Rockville: Agency for Healthcare Research and Quality; 2015.
16. U.S. Preventive Services Task Force. U.S. Preventive Services Task Force Procedure Manual. AHRQ publication no. 08-05118-EF. Rockville: Agency for Healthcare Research and Quality; 2015.
17. Ostelo RW, Deyo RA, Stratford P, Waddell G, Croft P, Von Korff M, et al. Interpreting change scores for pain and functional status in low back pain: Towards international consensus regarding minimal important change. Spine (Phila Pa 1976). 2008; 33: 90-4. [PMID: 18165753] doi: 10.1097/BRS.0b013e31815e3a10
18. Owens DK, Lohr KN, Atkins D, Treadwell JR, Reston JT, Bass EB, et al. AHRQ series paper 5: Grading the strength of a body of evidence when comparing medical interventions-Agency for Healthcare Research and Quality and the effective health-care program. J Clin Epidemiol. 2010; 63: 513-23. [PMID: 19595577] doi: 10.1016/j .jclinepi.2009.03.009
19. Chou R, Huffman L. Guideline for the Evaluation and Management of Low Back Pain: Evidence Review. Glenview, IL: American Pain Society; 2007.
20. Williams CM, Maher CG, Latimer J, McLachlan AJ, Hancock MJ, Day RO, et al. Efficacy of paracetamol for acute low-back pain: A double-blind, randomised controlled trial. Lancet. 2014; 384: 1586-96. [PMID: 25064594] doi: 10.1016/S0140-6736(14)60805-9
21. Roelofs PD, Deyo RA, Koes BW, Scholten RJ, van Tulder MW. Nonsteroidal anti-inflammatory drugs for low back pain: An updated Cochrane review. Spine (Phila Pa 1976). 2008; 33: 1766-74. [PMID: 18580547] doi: 10.1097/BRS.0b013e31817e69d3
22. Roelofs PD, Deyo RA, Koes BW, Scholten RJ, van Tulder MW. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev. 2008: CD000396. [PMID: 18253976] doi: 10 .1002/14651858.CD000396.pub3
23. Hickey RF. Chronic low back pain: A comparison of diflunisal with paracetamol. N Z Med J. 1982; 95: 312-4. [PMID: 6212783]
24. Nadler SF, Steiner DJ, Erasala GN, Hengehold DA, Hinkle RT, Beth Goodale M, et al. Continuous low-level heat wrap therapy provides more efficacy than ibuprofen and acetaminophen for acute low back pain. Spine (Phila Pa 1976). 2002; 27: 1012-7. [PMID: 12004166]
25. Stein D, Peri T, Edelstein E, Elizur A, Floman Y. The efficacy of amitriptyline and acetaminophen in the management of acute low back pain. Psychosomatics. 1996; 37: 63-70. [PMID: 8600497]
26. Milgrom C, Finestone A, Lev B, Wiener M, Floman Y. Overexertional lumbar and thoracic back pain among recruits: A prospective study of risk factors and treatment regimens. J Spinal Disord. 1993; 6: 187-93. [PMID: 8347966]
27. Doran DM, Newell DJ. Manipulation in treatment of low back pain: A multicentre study. Br Med J. 1975; 2: 161-4. [PMID: 123815]
28. Hackett GI, Seddon D, Kaminski D. Electroacupuncture compared with paracetamol for acute low back pain. Practitioner. 1988; 232: 163-4. [PMID: 2973008]
29. Herrmann WA, Geertsen MS. Efficacy and safety of lornoxicam compared with placebo and diclofenac in acute sciatica/lumbo-sciatica: An analysis from a randomised, double-blind, multicentre, parallel-group study. Int J Clin Pract. 2009; 63: 1613-21. [PMID: 19832818] doi: 10.1111/j.1742-1241.2009.02187.x
30. Majchrzycki M, Kocur P, Kotwicki T. Deep tissue massage and nonsteroidal anti-inflammatory drugs for low back pain: A prospective randomized trial. ScientificWorldJournal. 2014; 2014: 287597. [PMID: 24707200] doi: 10.1155/2014/287597
31. Shirado O, Doi T, Akai M, Hoshino Y, Fujino K, Hayashi K, et al; Japan Low back-pain Exercise Therapy Study. Multicenter randomized controlled trial to evaluate the effect of home-based exercise on patients with chronic low back pain: The Japan Low back pain Exercise Therapy Study. Spine (Phila Pa 1976). 2010; 35: E811-9. [PMID: 20628332] doi: 10.1097/BRS.0b013e3181d7a4d2
32. Katz N, Borenstein DG, Birbara C, Bramson C, Nemeth MA, Smith MD, et al. Efficacy and safety of tanezumab in the treatment of chronic low back pain. Pain. 2011; 152: 2248-58. [PMID: 21696889] doi: 10.1016/j.pain.2011.05.003
33. Kivitz AJ, Gimbel JS, Bramson C, Nemeth MA, Keller DS, Brown MT, et al. Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain. Pain. 2013; 154: 1009-21. [PMID: 23628600] doi: 10.1016/j.pain.2013.03.006
34. Amlie E, Weber H, Holme I. Treatment of acute low-back pain with piroxicam: Results of a double-blind placebo-controlled trial. Spine (Phila Pa 1976). 1987; 12: 473-6. [PMID: 2957801]
35. Babej-Do? lle R, Freytag S, Eckmeyer J, Zerle G, Schinzel S, Schmeider G, et al. Parenteral dipyrone versus diclofenac and placebo in patients with acute lumbago or sciatic pain: Randomized observer-blind multicenter study. Int J Clin Pharmacol Ther. 1994; 32: 204-9. [PMID: 8032581]
36. Dreiser RL, Le Parc JM, Ve? licitat P, Lleu PL. Oral meloxicam is effective in acute sciatica: Two randomised, double-blind trials versus placebo or diclofenac. Inflamm Res. 2001; 50 Suppl 1: S17-23. [PMID: 11339516]
37. Szpalski M, Hayez JP. Objective functional assessment of the efficacy of tenoxicam in the treatment of acute low back pain. A double-blind placebo-controlled study. Br J Rheumatol. 1994; 33: 74-8. [PMID: 8162464]
38. Basmajian JV. Acute back pain and spasm. A controlled multicenter trial of combined analgesic and antispasm agents. Spine (Phila Pa 1976). 1989; 14: 438-9. [PMID: 2524114]
39. Goldie I. A clinical trial with indomethacin (Indomee?) in low back pain and sciatica. Acta Orthop Scand. 1968; 39: 117-28. [PMID: 4239771]
40. Weber H, Aasand G. The effect of phenylbutazone on patients with acute lumbago-sciatica. A double blind trial. J Oslo City Hosp. 1980; 30: 69-72. [PMID: 6446598]
41. Dreiser RL, Marty M, Ionescu E, Gold M, Liu JH. Relief of acute low back pain with diclofenac-K 12.5 mg tablets: A flexible dose, ibuprofen 200 mg and placebo-controlled clinical trial. Int J Clin Pharmacol Ther. 2003; 41: 375-85. [PMID: 14518597]
42. Birbara CA, Puopolo AD, Munoz DR, Sheldon EA, Mangione A, Bohidar NR, et al; Etoricoxib Protocol 042 Study Group. Treatment of chronic low back pain with etoricoxib, a new cyclo-oxygenase-2 selective inhibitor: Improvement in pain and disability-A randomized, placebo-controlled, 3-month trial. J Pain. 2003; 4: 307-15. [PMID: 14622687]
43. Katz N, Ju WD, Krupa DA, Sperling RS, Bozalis Rodgers D, Gertz BJ, et al; Vioxx Chronic Low Back Pain Study Group. Efficacy and safety of rofecoxib in patients with chronic low back pain: Results from two 4-week, randomized, placebo-controlled, parallel-group, double-blind trials. Spine (Phila Pa 1976). 2003; 28: 851-8. [PMID: 12941996]
44. Weber H, Holme I, Amlie E. The natural course of acute sciatica with nerve root symptoms in a double-blind placebo-controlled trial evaluating the effect of piroxicam. Spine (Phila Pa 1976). 1993; 18: 1433-8. [PMID: 8235813]
45. Chrubasik S, Model A, Black A, Pollak S. A randomized doubleblind pilot study comparing Doloteffin and Vioxx in the treatment of low back pain. Rheumatology (Oxford). 2003; 42: 141-8. [PMID: 12509627]
46. Chaparro LE, Furlan AD, Deshpande A, Mailis-Gagnon A, Atlas S, Turk DC. Opioids compared to placebo or other treatments for chronic low-back pain. Cochrane Database Syst Rev. 2013: CD004959. [PMID: 23983011] doi: 10.1002/14651858.CD004959 .pub4.
47. Hale ME, Dvergsten C, Gimbel J. Efficacy and safety of oxymorphone extended release in chronic low back pain: Results of a randomized, double-blind, placebo- and active-controlled phase III study. J Pain. 2005; 6: 21-8. [PMID: 15629415]
48. Jamison RN, Raymond SA, Slawsby EA, Nedeljkovic SS, Katz NP. Opioid therapy for chronic noncancer back pain. A randomized prospective study. Spine (Phila Pa 1976). 1998; 23: 2591-600. [PMID: 9854758]
49. Wiesel SW, Cuckler JM, Deluca F, Jones F, Zeide MS, Rothman RH. Acute low-back pain. An objective analysis of conservative therapy. Spine (Phila Pa 1976). 1980; 5: 324-30. [PMID: 6450448]
50. Cloutier C, Taliano J, O'Mahony W, Csanadi M, Cohen G, Sutton I, et al. Controlled-release oxycodone and naloxone in the treatment of chronic low back pain: A placebo-controlled, randomized study. Pain Res Manag. 2013; 18: 75-82. [PMID: 23662289]
51. Lee JH, Lee CS; Ultracet ER Study Group. A randomized, doubleblind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/ acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain. Clin Ther. 2013; 35: 1830-40. [PMID: 24183364] doi: 10.1016/j.clinthera.2013.09.017
52. Rauck RL, Nalamachu S, Wild JE, Walker GS, Robinson CY, Davis CS, et al. Single-entity hydrocodone extended-release capsules in opioid-tolerant subjects with moderate-to-severe chronic low back pain: A randomized double-blind, placebo-controlled study. Pain Med. 2014; 15: 975-85. [PMID: 24517082] doi: 10.1111/pme.12377
53. Schiphorst Preuper HR, Geertzen JH, van Wijhe M, Boonstra AM, Molmans BH, Dijkstra PU, et al. Do analgesics improve functioning in patients with chronic low back pain? An explorative triple-blinded RCT. Eur Spine J. 2014; 23: 800-6. [PMID: 24526247] doi: 10.1007 /s00586-014-3229-7
54. Friedman BW, Dym AA, Davitt M, Holden L, Solorzano C, Esses D, et al. Naproxen with cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: A randomized clinical trial. JAMA. 2015; 314: 1572-80. [PMID: 26501533] doi: 10 .1001/jama.2015.13043
55. Markman JD, Gewandter JS, Frazer ME, Murray NM, Rast SA, McDermott MP, et al. A randomized, double-blind, placebocontrolled crossover trial of oxymorphone hydrochloride and propoxyphene/acetaminophen combination for the treatment of neurogenic claudication associated with lumbar spinal stenosis. Spine (Phila Pa 1976). 2015; 40: 684-91. [PMID: 25705958] doi: 10 .1097/BRS.0000000000000837
56. Wen W, Sitar S, Lynch SY, He E, Ripa SR. A multicenter, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of single-entity, once-daily hydrocodone tablets in patients with uncontrolled moderate to severe chronic low back pain. Expert Opin Pharmacother. 2015; 16: 1593-606. [PMID: 26111544] doi: 10 .1517/14656566.2015.1060221
57. Rauck RL, Potts J, Xiang Q, Tzanis E, Finn A. Efficacy and tolerability of buccal buprenorphine in opioid-naive patients with moderate to severe chronic low back pain. Postgrad Med. 2016; 128: 1-11. [PMID: 26634956] doi: 10.1080/00325481.2016.1128307
58. Furlan A, Chaparro LE, Irvin E, Mailis-Gagnon A. A comparison between enriched and nonenriched enrollment randomized withdrawal trials of opioids for chronic noncancer pain. Pain Res Manag. 2011; 16: 337-51. [PMID: 22059206]
59. Hale M, Khan A, Kutch M, Li S. Once-daily OROS hydromorphone ER compared with placebo in opioid-tolerant patients with chronic low back pain. Curr Med Res Opin. 2010; 26: 1505-18. [PMID: 20429852] doi: 10.1185/03007995.2010.484723
60. Hale ME, Ahdieh H, Ma T, Rauck R; Oxymorphone ER Study Group 1. Efficacy and safety of OPANA ER (oxymorphone extended release) for relief of moderate to severe chronic low back pain in opioid-experienced patients: A 12-week, randomized, double-blind, placebo-controlled study. J Pain. 2007; 8: 175-84. [PMID: 17145204]
61. Katz N, Rauck R, Ahdieh H, Ma T, Gerritsen van der Hoop R, Kerwin R, et al. A 12-week, randomized, placebo-controlled trial assessing the safety and efficacy of oxymorphone extended release for opioid-naive patients with chronic low back pain. Curr Med Res Opin. 2007; 23: 117-28. [PMID: 17257473]
62. Schnitzer TJ, Gray WL, Paster RZ, Kamin M. Efficacy of tramadol in treatment of chronic low back pain. J Rheumatol. 2000; 27: 772-8. [PMID: 10743823]
63. Steiner DJ, Sitar S, Wen W, Sawyerr G, Munera C, Ripa SR, et al. Efficacy and safety of the seven-day buprenorphine transdermal system in opioid-nai?ve patients with moderate to severe chronic low back pain: An enriched, randomized, double-blind, placebocontrolled study. J Pain Symptom Manage. 2011; 42: 903-17. [PMID: 21945130] doi: 10.1016/j.jpainsymman.2011.04.006
64. Vorsanger GJ, Xiang J, Gana TJ, Pascual ML, Fleming RR. Extended-release tramadol (tramadol ER) in the treatment of chronic low back pain. J Opioid Manag. 2008; 4: 87-97. [PMID: 18557165]
65. Allan L, Richarz U, Simpson K, Slappendel R. Transdermal fentanyl versus sustained release oral morphine in strong-opioid nai?ve patients with chronic low back pain. Spine (Phila Pa 1976). 2005; 30: 2484-90. [PMID: 16284584]
66. Rauck RL, Bookbinder SA, Bunker TR, Alftine CD, Ghalie R, Negro-Vilar A, et al. The ACTION study: A randomized, open-label, multicenter trial comparing once-a-day extended-release morphine sulfate capsules (AVINZA) to twice-a-day controlled-release oxycodone hydrochloride tablets (OxyContin) for the treatment of chronic, moderate to severe low back pain. J Opioid Manag. 2006; 2: 155-66. [PMID: 17319449]
67. Hale ME, Fleischmann R, Salzman R, Wild J, Iwan T, Swanton RE, et al. Efficacy and safety of controlled-release versus immediaterelease oxycodone: Randomized, double-blind evaluation in patients with chronic back pain. Clin J Pain. 1999; 15: 179-83. [PMID: 10524470]
68. Salzman RT, Roberts MS, Wild J, Fabian C, Reder RF, Goldenheim PD. Can a controlled-release oral dose form of oxycodone be used as readily as an immediate-release form for the purpose of titrating to stable pain control? J Pain Symptom Manage. 1999; 18: 271-9. [PMID: 10534967]
69. Hale M, Speight K, Harsanyi Z, Iwan T, Slagle N, Lacouture P, et al. Efficacy of 12 hourly controlled-release codeine compared with as required dosing of acetaminophen plus codeine in patients with chronic low back pain. Pain Res Manag. 1997; 2: 33-8.
70. Gostick N, Allen J, Cranfield R, Currie J, Grillage M, Hildebrand P, et al. A comparison of the efficacy and adverse effects of controlled-release dihydrocodeine and immediate-release dihydrocodeine in the treatment of pain in osteoarthritis and chronic back pain. In: Twycross RG, ed. Proceedings of The Edinburgh Symposium on Pain Control and Medical Education. London: Royal Soc Medicine Pr; 1989: 137-43.
71. Carson S, Thakurta S, Low A, Smith B, Chou R. Drug Class Review: Long-Acting Opioid Analgesics: Final Update 6 Report. Drug Class Reviews. Portland: Oregon Health & Science Univ; 2011. [PMID: 21977550]
72. Nicholson B, Ross E, Sasaki J, Weil A. Randomized trial comparing polymer-coated extended-release morphine sulfate to controlled-release oxycodone HCl in moderate to severe nonmalignant pain. Curr Med Res Opin. 2006; 22: 1503-14. [PMID: 16870075]
73. Beaulieu AD, Peloso P, Bensen W, Clark AJ, Watson CP, Gardner-Nix J, et al. A randomized, double-blind, 8-week crossover study of once-daily controlled-release tramadol versus immediaterelease tramadol taken as needed for chronic noncancer pain. Clin Ther. 2007; 29: 49-60. [PMID: 17379046]
74. Ueberall MA, Mueller-Schwefe GH. Safety and efficacy of oxycodone/ naloxone vs. oxycodone vs. morphine for the treatment of chronic low back pain: Results of a 12 week prospective, randomized, open-label blinded endpoint streamlined study with prolongedrelease preparations. Curr Med Res Opin. 2015; 31: 1413-29. [PMID: 25942606] doi: 10.1185/03007995.2015.1047747
75. Gordon A, Callaghan D, Spink D, Cloutier C, Dzongowski P, O'Mahony W, et al. Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebocontrolled crossover study, followed by an open-label extension phase. Clin Ther. 2010; 32: 844-60. [PMID: 20685494] doi: 10.1016/j .clinthera.2010.04.018
76. Miller K, Yarlas A, Wen W, Dain B, Lynch SY, Ripa SR, et al. The impact of buprenorphine transdermal delivery system on activities of daily living among patients with chronic low back pain: An application of the international classification of functioning, disability and health. Clin J Pain. 2014; 30: 1015-22. [PMID: 24394747] doi: 10 .1097/AJP.0000000000000068
77. Yarlas A, Miller K, Wen W, Lynch SY, Munera C, Pergolizzi JV Jr, et al. Buprenorphine transdermal system compared with placebo reduces interference in functioning for chronic low back pain. Postgrad Med. 2015; 127: 38-45. [PMID: 25526229]
78. O'Donnell JB, Ekman EF, Spalding WM, Bhadra P, McCabe D, Berger MF. The effectiveness of a weak opioid medication versus a cyclo-oxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug in treating flare-up of chronic low-back pain: Results from two randomized, double-blind, 6-week studies. J Int Med Res. 2009; 37: 1789-802. [PMID: 20146877]
79. Karjalainen KA, Malmivaara A, van Tulder MW, Roine R, Jauhiainen M, Hurri H, et al. WITHDRAWN: Biopsychosocial rehabilitation for upper limb repetitive strain injuries in working age adults. Cochrane Database Syst Rev. 2009: CD002269. [PMID: 19160209] doi: 10.1002/14651858.CD002269.pub2
80. Pareek A, Chandurkar N, Chandanwale AS, Ambade R, Gupta A, Bartakke G. Aceclofenac-tizanidine in the treatment of acute low back pain: A double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone. Eur Spine J. 2009; 18: 1836-42. [PMID: 19421791] doi: 10.1007/s00586-009-1019-4
81. Ralph L, Look M, Wheeler W, Sacks H. Double-blind, placebocontrolled trial of carisoprodol 250-mg tablets in the treatment of acute lower-back spasm. Curr Med Res Opin. 2008; 24: 551-8. [PMID: 18194591] doi: 10.1185/030079908X261014
82. Casale R. Acute low back pain: Symptomatic treatment with a muscle relaxing drug. Clin J Pain. 1988; 4: 81-8.
83. Basmajian JV. Cyclobenzaprine hydrochloride effect on skeletal muscle spasm in the lumbar region and neck: Two double-blind con- trolled clinical and laboratory studies. Arch Phys Med Rehabil. 1978; 59: 58-63. [PMID: 623512]
84. Pratzel HG, Alken RG, Ramm S. Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: Results of a prospective placebocontrolled double-blind trial. Pain. 1996; 67: 417-25. [PMID: 8951937]
85. Rollings H. Management of acute musculoskeletal conditions- thoracolumbar strain or sprain: A double-blind evaluation comparing the efficacy and safety of carisoprodol with cyclobenzaprine hydrochloride. Curr Ther Res. 1983; 34: 917-28.
86. Bragstad A, Bilkra G. Evaluation of a new skeletal muscle relaxant in the treatment of low back pain (a comparison of DS 103-282 with chlorzoxazone). Curr Ther Res. 1979; 26: 39-43.
87. Pipino F, Menarini C, Lombardi G, Guerzoni P, Ferrini A, Pizzoli A, et al. A direct myotonolytic (pridinol mesylate) for the management of chronic low back pain: A multicentre, comparative clinical evaluation. European Journal of Clinical Research. 1991; 1: 55-70.
88. Bro? tz D, Maschke E, Burkard S, Engel C, Ma?nz C, Ernemann U, et al. Is there a role for benzodiazepines in the management of lumbar disc prolapse with acute sciatica? Pain. 2010; 149: 470-5. [PMID: 20362397] doi: 10.1016/j.pain.2010.02.015
89. Hingorani K. Diazepam in backache. A double-blind controlled trial. Ann Phys Med. 1966; 8: 303-6. [PMID: 4224750]
90. Moll W. [Therapy of acute lumbovertebral syndromes through optimal muscle relaxation using diazepam. Results of a double-blind study on 68 cases]. Med Welt. 1973; 24: 1747-51. [PMID: 4272092]
91. Arbus L, Fajadet B, Aubert D, Morre M, Goldberger E. Activity of tetrazepam (Myolastan) in low back pain. A double-blind trial v. placebo. Clin Trials J. 1990; 27: 258-67.
92. Salzmann E, Pforringer W, Paal G, Gierend M. Treatment of chronic low-back syndrome with tetrazepam in a placebo controlled double-blind trial. Journal of Drug Development. 1992; 4: 219-28.
93. Hennies OL. A new skeletal muscle relaxant (DS 103-282) compared to diazepam in the treatment of muscle spasm of local origin. J Int Med Res. 1981; 9: 62-8. [PMID: 6451461]
94. Boyles WF, Glassmann JM, Soyka JP. Management of acute musculoskeletal conditions: Thoracolumbar strain or sprain. A double-blind evaluation comparing the efficacy and safety of carisoprodol with diazepam. Today's Therapeutic Trends. 1983; 1: 1-16.
95. Urquhart DM, Hoving JL, Assendelft WW, Roland M, van Tulder MW. Antidepressants for non-specific low back pain. Cochrane Database Syst Rev. 2008: CD001703. [PMID: 18253994] doi: 10.1002 /14651858.CD001703.pub3
96. Skljarevski V, Ossanna M, Liu-Seifert H, Zhang Q, Chappell A, Iyengar S, et al. A double-blind, randomized trial of duloxetine versus placebo in the management of chronic low back pain. Eur J Neurol. 2009; 16: 1041-8. [PMID: 19469829] doi: 10.1111/j.1468-1331 .2009.02648.x
97. Skljarevski V, Zhang S, Desaiah D, Alaka KJ, Palacios S, Miazgowski T, et al. Duloxetine versus placebo in patients with chronic low back pain: A 12-week, fixed-dose, randomized, double-blind trial. J Pain. 2010; 11: 1282-90. [PMID: 20472510] doi: 10.1016/j.jpain .2010.03.002
98. Skljarevski V, Desaiah D, Liu-Seifert H, Zhang Q, Chappell AS, Detke MJ, et al. Efficacy and safety of duloxetine in patients with chronic low back pain. Spine (Phila Pa 1976). 2010; 35: E578-85. [PMID: 20461028] doi: 10.1097/BRS.0b013e3181d3cef6
99. Mazza M, Mazza O, Pazzaglia C, Padua L, Mazza S. Escitalopram 20 mg versus duloxetine 60 mg for the treatment of chronic low back pain. Expert Opin Pharmacother. 2010; 11: 1049-52. [PMID: 20402551] doi: 10.1517/14656561003730413
100. Farajirad S, Behdani F, Hebrani P, Farajirad M. Comparison between the effects of amitriptyline and bupropione on the quality of life and the reduction in the severity of pain in patients with chronic low-back pain. Neurosurg Q. 2013; 23: 227-9.
101. Schukro RP, Oehmke MJ, Geroldinger A, Heinze G, Kress HG, Pramhas S. Efficacy of duloxetine in chronic low back pain with a neuropathic component: A randomized, double-blind, placebocontrolled crossover trial. Anesthesiology. 2016; 124: 150-8. [PMID: 26517858] doi: 10.1097/ALN.0000000000000902
102. Dickens C, Jayson M, Sutton C, Creed F. The relationship between pain and depression in a trial using paroxetine in sufferers of chronic low back pain. Psychosomatics. 2000; 41: 490-9. [PMID: 11110112]
103. Pheasant H, Bursk A, Goldfarb J, Azen SP, Weiss JN, Borelli L. Amitriptyline and chronic low-back pain. A randomized double-blind crossover study. Spine (Phila Pa 1976). 1983; 8: 552-7. [PMID: 6228015]
104. Khoromi S, Patsalides A, Parada S, Salehi V, Meegan JM, Max MB. Topiramate in chronic lumbar radicular pain. J Pain. 2005; 6: 829-36. [PMID: 16326371]
105. McCleane GJ. Does gabapentin have an analgesic effect on background, movement and referred pain? A randomised, double-blind, placebo controlled study. The Pain Clinic. 2001; 13: 103-7.
106. Muehlbacher M, Nickel MK, Kettler C, Tritt K, Lahmann C, Leiberich PK, et al. Topiramate in treatment of patients with chronic low back pain: A randomized, double-blind, placebo-controlled study. Clin J Pain. 2006; 22: 526-31. [PMID: 16788338]
107. Yildirim K, Sis?eciog? lu M, Karatay S, Erdal A, Levent A, Ug? ur M, et al. The effectiveness of gabapentin in patients with chronic radiculopathy. The Pain Clinic. 2003; 15: 213-8.
108. Baron R, Freynhagen R, To? lle TR, Cloutier C, Leon T, Murphy TK, et al; A0081007 Investigators. The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy. Pain. 2010; 150: 420-7. [PMID: 20493632] doi: 10.1016/j.pain.2010.04.013
109. Baron R, Martin-Mola E, Mu? ller M, Dubois C, Falke D, Steigerwald I. Effectiveness and safety of tapentadol prolonged release (PR) versus a combination of tapentadol PR and pregabalin for the management of severe, chronic low back pain with a neuropathic component: A randomized, double-blind, phase 3b study. Pain Pract. 2015; 15: 455-70. [PMID: 24738609] doi: 10.1111 /papr.12200
110. Kalita J, Kohat AK, Misra UK, Bhoi SK. An open labeled randomized controlled trial of pregabalin versus amitriptyline in chronic low backache. J Neurol Sci. 2014; 342: 127-32. [PMID: 24857356] doi: 10.1016/j.jns.2014.05.002
111. Markman JD, Frazer ME, Rast SA, McDermott MP, Gewandter JS, Chowdhry AK, et al. Double-blind, randomized, controlled, crossover trial of pregabalin for neurogenic claudication. Neurology. 2015; 84: 265-72. [PMID: 25503625] doi: 10.1212/WNL.0000000000001168
112. Pota V, Barbarisi M, Sansone P, Moraci M, Pace MC, Passavanti MB, et al. Combination therapy with transdermal buprenorphine and pregabalin for chronic low back pain. Pain Manag. 2012; 2: 23-31. [PMID: 24654615] doi: 10.2217/pmt.11.71
113. Romanò CL, Romanò D, Bonora C, Mineo G. Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain. J Orthop Traumatol. 2009; 10: 185-91. [PMID: 19921480] doi: 10 .1007/s10195-009-0077-z
114. Yaksi A, Ozgo? nenel L, Ozgo? nenel B. The efficiency of gabapentin therapy in patients with lumbar spinal stenosis. Spine (Phila Pa 1976). 2007; 32: 939-42. [PMID: 17450066]
115. Sakai Y, Ito K, Hida T, Ito S, Harada A. Pharmacological management of chronic low back pain in older patients: A randomized controlled trial of the effect of pregabalin and opioid administration. Eur Spine J. 2015; 24: 1309-17. [PMID: 25682273] doi: 10.1007 /s00586-015-3812-6
116. Finckh A, Zufferey P, Schurch MA, Balague? F, Waldburger M, So AK. Short-term efficacy of intravenous pulse glucocorticoids in acute discogenic sciatica. A randomized controlled trial. Spine (Phila Pa 1976). 2006; 31: 377-81. [PMID: 16481946]
117. Friedman BW, Holden L, Esses D, Bijur PE, Choi HK, Solorzano C, et al. Parenteral corticosteroids for emergency department patients with non-radicular low back pain. J Emerg Med. 2006; 31: 365-70. [PMID: 17046475]
118. Haimovic IC, Beresford HR. Dexamethasone is not superior to placebo for treating lumbosacral radicular pain. Neurology. 1986; 36: 1593-4. [PMID: 2946981]
119. Porsman O, Friis H. Prolapsed lumbar disc treated with intramuscularly administered dexamethasonephosphate. A prospectively planned, double-blind, controlled clinical trial in 52 patients. Scand J Rheumatol. 1979; 8: 142-4. [PMID: 386492]
120. Eskin B, Shih RD, Fiesseler FW, Walsh BW, Allegra JR, Silverman ME, et al. Prednisone for emergency department low back pain: A randomized controlled trial. J Emerg Med. 2014; 47: 65-70. [PMID: 24739318] doi: 10.1016/j.jemermed.2014.02.010
121. Friedman BW, Esses D, Solorzano C, Choi HK, Cole M, Davitt M, et al. A randomized placebo-controlled trial of single-dose IM corticosteroid for radicular low back pain. Spine (Phila Pa 1976). 2008; 33: E624-9. [PMID: 18665021] doi: 10.1097/BRS.0b013e3181822711
122. Hedeboe J, Buhl M, Ramsing P. Effects of using dexamethasone and placebo in the treatment of prolapsed lumbar disc. Acta Neurol Scand. 1982; 65: 6-10. [PMID: 7039210]
123. Holve RL, Barkan H. Oral steroids in initial treatment of acute sciatica. J Am Board Fam Med. 2008; 21: 469-74. [PMID: 18772303] doi: 10.3122/jabfm.2008.05.070220
124. Rodrigues LC, Natour J. A double-blind, randomized controlled, prospective trial assessing the effectiveness of oral corticoids in the treatment of symptomatic lumbar canal stenosis. J Negat Results Biomed. 2014; 13: 13. [PMID: 25099318] doi: 10.1186 /1477-5751-13-13
125. Goldberg H, Firtch W, Tyburski M, Pressman A, Ackerson L, Hamilton L, et al. Oral steroids for acute radiculopathy due to a herniated lumbar disk: A randomized clinical trial. JAMA. 2015; 313: 1915-23. [PMID: 25988461] doi: 10.1001/jama.2015.4468
126. Chou R, Deyo R, Devine B, Hansen R, Sullivan S, Jarvik JG, et al. The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain. Evidence Report/Technology Assessment no. 218.
127. (Prepared by the Pacific Northwest Evidence-based Practice Center under contract no. 290-212-00014-I.) AHRQ publication no. 14- E005-EF. Rockville: Agency for Healthcare Research and Quality; 2014.
128. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain-United States, 2016. JAMA. 2016; 315: 1624-45. [PMID: 26977696] doi: 10.1001/jama.2016.1464
129. Licciardone JC, Kearns CM, Minotti DE. Outcomes of osteopathic manual treatment for chronic low back pain according to baseline pain severity: Results from the OSTEOPATHIC Trial. Man Ther. 2013; 18: 533-40. [PMID: 23759340] doi: 10.1016/j.math.2013 .05.006
130. National Institute for Health and Care Excellence. Low back pain in adults. Clinical guideline no. CG88. May 2009. Accessed at www.nice.org.uk/guidance/cg88/chapter/1-guidance on 10 March 2015.
131. Chou R, Turner JA, Devine EB, Hansen RN, Sullivan SD, Blazina I, et al. The effectiveness and risks of long-term opioid therapy for chronic pain: A systematic review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med. 2015; 162: 276-86. [PMID: 25581257] doi: 10.7326/M14-2559
132. Whitlock EP, Lin JS, Chou R, Shekelle P, Robinson KA. Using existing systematic reviews in complex systematic reviews. Ann Intern Med. 2008; 148: 776-82. [PMID: 18490690]
133. Enthoven WT, Roelofs PD, Deyo RA, van Tulder MW, Koes BW. Non-steroidal anti-inflammatory drugs for chronic low back pain. Cochrane Database Syst Rev. 2016; 2: CD012087. [PMID: 26863524] doi: 10.1002/14651858.CD012087
134. Abdel Shaheed C, Maher CG, Williams KA, Day R, McLachlan AJ. Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain: A systematic review and meta-analysis. JAMA Intern Med. 2016; 176: 958-68. [PMID: 27213267] doi: 10 .1001/jamainternmed.2016.1251
135. Saragiotto BT, Machado GC, Ferreira ML, Pinheiro MB, Abdel Shaheed C, Maher CG. Paracetamol for low back pain. Cochrane Database Syst Rev. 2016: CD012230. [PMID: 27271789] doi: 10 .1002/14651858.CD012230
136. Chou R, Hashimoto R, Friedly J, Fu R, Bougatsos C, Dana T, et al. Epidural corticosteroid injections for radiculopathy and spinal stenosis: A systematic review and meta-analysis. Ann Intern Med. 2015; 163: 373-81. [PMID: 26302454] doi: 10.7326/M15-0934
137. Moore RA, Derry S, Wiffen PJ. Challenges in design and interpretation of chronic pain trials. Br J Anaesth. 2013; 111: 38-45. [PMID: 23794643] doi: 10.1093/bja/aet126