Short-term efficacy of intravenous pulse glucocorticoids in acute discogenic sciatica. A randomized controlled trial

Spine

Volumn 31, Issue 4, 2006, Pages 377-381

  Finckh, Axel ^a,b,d   Zufferey, Pascal ^b   Schurch, Marc André ^b   Balagué, Federico ^c   Waldburger, Maurice ^c   So, Alexander K L ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c Hopital Cantonal de Fribourg   (Switzerland)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Discogenic compression; Glucocorticoids; Sciatica; Therapy

Indexed keywords

GLUCOCORTICOID; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE;

ADULT; ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG INFUSION; DRUG PULSE THERAPY; FEMALE; FLUSHING; FOLLOW UP; HUMAN; HYPERGLYCEMIA; ISCHIALGIA; LEG PAIN; LINEAR REGRESSION ANALYSIS; LOW BACK PAIN; MALE; MEASUREMENT; MULTICENTER STUDY; PATIENT; PRIORITY JOURNAL; RADIOLOGY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME;

DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ENDPOINT DETERMINATION; FEMALE; GLUCOCORTICOIDS; HEALTH STATUS; HUMANS; INJECTIONS, INTRAVENOUS; INTERVERTEBRAL DISK DISPLACEMENT; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PAIN MEASUREMENT; QUESTIONNAIRES; RADICULOPATHY; SCIATICA; TREATMENT OUTCOME;

EID: 33644846672     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000199917.04145.80     Document Type: Article

References (27)

1. Frymoyer JW. Back pain and sciatica. N Engl J Med 1988;318:291-300.
2. Battie MC, Videman T, Gibbons LE, et al. 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 1995;20:2601-12.
3. Richardson JK, Chung T, Schultz JS, et al. A familial predisposition toward lumbar disc injury. Spine 1997;22:1487-92.
4. Olmarker K, Holm S, Rosenqvist AL, et al. Experimental nerve root compression. A model of acute, graded compression of the porcine cauda equina and an analysis of neural and vascular anatomy. Spine 1991;16:61-9.
5. Ozaktay AC, Kallakuri S, Cavanaugh JM. Phospholipase A2 sensitivity of the dorsal root and dorsal root ganglion. Spine 1998;23:1297-306.
6. Takahashi H, Suguro T, Okazima Y, et al. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine 1996;21:218-24.
7. Willburger RE, Wittenberg RH. Prostaglandin release from lumbar disc and facet joint tissue. Spine 1994;19:2068-70.
8. Muramoto T, Atsuta Y, Iwahara T, et al. The action of prostaglandin E2 and triamcinolone acetonide on the firing activity of lumbar nerve roots. Int Orthop 1997;21:172-5.
9. Ozaktay AC, Cavanaugh JM, Asik I, et al. Dorsal root sensitivity to interleukin-1 beta, interleukin-6 and tumor necrosis factor in rats. Eur Spine J 2002;11:467-75.
10. Bigos S, Bowyer O, Brean G. Acute Low Back Problems in Adults. Clinical Practice Guideline. AHCPR Publications Clearinghouse ed. Washington, DC: US Government Printing Office; 1994.
11. Koes BW, Scholten RJ, Mens JM, et al. Efficacy of epidural steroid injections for low-back pain and sciatica: A systematic review of randomized clinical trials. Pain 1995;63:279-88.
12. Hayashi N, Weinstein JN, Meller ST, et al. The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy. Spine 1998;23:877-85.
13. Carette S, Leclaire R, Marcoux S, et al. Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. N Engl J Med 1997;336:1634-40.
14. Karppinen J, Malmivaara A, Kurunlahti M, et al. Periradicular infiltration for sciatica: A randomized controlled trial. Spine 2001;26:1059-67.
15. Imbasciati E, Gusmano R, Edefonti A, et al. Controlled trial of methylprednisolone pulses and low dose oral prednisone for the minimal change nephrotic syndrome. Br Med J (Clin Res Ed) 1985;291:1305-8.
16. Picco P, Gattorno M, Buoncompagni A, et al. 6-methylprednisolone 'mini-pulses': A new modality of glucocorticoid treatment in systemic onset juvenile chronic arthritis. Scand J Rheumatol 1996;25:24-7.
17. Droogan AG, Crockard AD, McMillan SA, et al. Effects of intravenous methylprednisolone therapy on leukocyte and soluble adhesion molecule expression in MS. Neurology 1998;50:224-9.
18. Roujeau JC. Pulse glucocorticoid therapy. The 'big shot' revisited. Arch Dermatol 1996;132:1499-502.
19. Melzack R. The McGill Pain Questionnaire: Major properties and scoring methods. Pain 1975;1:277-99.
20. Fairbank JC, Couper J, Davies JB, et al. The Oswestry low back pain disability questionnaire. Physiotherapy 1980;66:271-3.
21. Zuffrey P, Guerne P, Vischer T. Effectiveness of IV bolus of methylprednisolone on radicular pain in patients with acute sciatalgias. Prospective study of 10 patients, [French]. Poster presented at the Annual Meeting of the French Society of Rheumatology. Paris; 1998.
22. Skrondal A, Rabe-Hesketh S. Generalized Latent Variable Modeling: Multilevel, Longitudinal and Structural Equation Models. Boca Raton, FL: Chapman & Hall/CRC; 2004.
23. Haimovic IC, Beresford HR. Dexamethasone is not superior to placebo for treating lumbosacral radicular pain. Neurology 1986;36:1593-4.
24. Kwasucki J, Olbrych-Karpinska B, Stepien A, et al. Assessment of dexamethasone effectiveness in the treatment of ischalgia [in Polish]. Neurol Neurochir Pol 1993;27:515-22.
25. Porsman O, Friis H. Prolapsed lumbar disc treated with intramuscularly administered dexamethasone phosphate. A prospectively planned, double-blind, controlled clinical trial in 52 patients. Scand J Rheumatol 1979;8:142-4.
26. Hedeboe J, Buhl M, Ramsing P. Effects of using dexamethasone and placebo in the treatment of prolapsed lumbar disc. Acta Neurol Scand 1982;65:6-10.
27. Weinstein SM, Herring SA, Derby R. Contemporary concepts in spine care. Epidural steroid injections. Spine 1995;20:1842-6.