Lipid bodies accumulation in Leishmania infantum-infected C57BL/6 macrophages

Parasite Immunology

Volumn 39, Issue 8, 2017, Pages

  Rodriguez N E ^a   Lockard, R D ^a   Turcotte, E A ^a   Araujo Santos T ^b   Bozza, P T ^c   Borges, V M ^c   Wilson, M E ^d,e,f  

^a UNIVERSITY OF NORTHERN IOWA   (United States)

^b Programa de Pós graduação em História   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d UNIVERSITY OF IOWA   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Leishmania; lipid bodies; macrophage; protozoan parasite

Indexed keywords

HOST FACTOR; LIPID; LIPID BODY; PROSTAGLANDIN E2; PROSTAGLANDIN F SYNTHASE; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE; PROTOZOAL DNA; UNCLASSIFIED DRUG; FAT DROPLET;

AMASTIGOTE; ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HOST PARASITE INTERACTION; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; LEISHMANIA INFANTUM; LIFE CYCLE STAGE; LIPID STORAGE; MOUSE; NONHUMAN; PARASITE IMMUNITY; PARASITOPHOROUS VACUOLE; PRIORITY JOURNAL; VISCERAL LEISHMANIASIS; ANIMAL; BAGG ALBINO MOUSE; BRAZIL; C57BL MOUSE; IMMUNOLOGY; MACROPHAGE; METABOLISM; MICROBIOLOGY; PATHOLOGY;

ANIMALS; BRAZIL; FEMALE; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LIPID DROPLETS; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL;

EID: 85020524945     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/pim.12443     Document Type: Article

References (19)

1. de Freitas EO, Leoratti FM, Freire-de-Lima CG, Morrot A, Feijo DF. The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis. Front Immunol 2016;7:153.
2. Melo RC, Dvorak AM. Lipid body-phagosome interaction in macrophages during infectious diseases: host defense or pathogen survival strategy? PLoS Pathog 2012;8:e1002729. Epub 1002012 Jul 1002725.
3. Melo RC, Weller PF. Lipid droplets in leukocytes: organelles linked to inflammatory responses. Exp Cell Res. 2016;340:193-197. Epub 2015 Oct 1029.
4. Saka HA, Valdivia R. Emerging roles for lipid droplets in immunity and host-pathogen interactions. Annu Rev Cell Dev Biol. 2012;28:411-37. Epub 092012 May 092911.
5. Toledo DA, D'Avila H, Melo RC. Host Lipid Bodies as Platforms for Intracellular Survival of Protozoan Parasites. Front Immunol 2016;7:174. eCollection 02016.
6. Kumar Y, Cocchiaro J, Valdivia RH. The obligate intracellular pathogen Chlamydia trachomatis targets host lipid droplets. Curr Biol. 2006;16:1646-1651.
7. Mattos KA, Lara FA, Oliveira VG, et al. Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes. Cell Microbiol. 2011;13:259-273. Epub 02010 Nov 01532.
8. Mattos KA, Oliveira VC, Berredo-Pinho M, et al. Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment. Cell Microbiol. 2014;16:797-815. Epub 12014 Mar 12221.
9. Araujo-Santos T, Rodriguez NE, Moura-Pontes S, et al. Role of prostaglandin F2alpha production in lipid bodies from Leishmania infantum chagasi: insights on virulence. J Infect Dis. 2014;210:1951-1961. Epub 2014 May 1921.
10. Rabhi S, Rabhi I, Trentin B, et al. Lipid Droplet Formation, Their Localization and Dynamics during Leishmania major Macrophage Infection. PLoS ONE. 2016;11:e0148640.
11. Cocchiaro JL, Kumar Y, Fischer ER, Hackstadt T, Valdivia RH. Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole. Proc Natl Acad Sci U S A. 2008;105:9379-9384. Epub 0712242008 Jun 0712241130.
12. Araujo-Santos T, Prates DB, Franca-Costa J, et al. Prostaglandin E2/leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection. Parasit Vectors 2014;7:601.
13. Pearson RD, Sousa AQ. Clinical spectrum of Leishmaniasis. Clin Infect Dis. 1996;22:1-13.
14. Rabhi I, Rabhi S, Ben-Othman R, et al. Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view. PLoS Negl Trop Dis. 2012;6:e1763. Epub 0002012 Aug 0001721.
15. Araujo-Santos T, Prates DB, Andrade BB, et al. Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E(2) production in murine macrophages. PLoS Negl Trop Dis. 2010;4:e873.
16. Abu Kwaik Y, Bumann D. Host Delivery of Favorite Meals for Intracellular Pathogens. PLoS Pathog 2015;11:e1004866.
17. Pinheiro RO, Nunes MP, Pinheiro CS, et al. Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB/c but not C57BL/6 macrophages. Microbes Infect. 2009;11:181-190.
18. Lecoeur H, Giraud E, Prevost MC, Milon G, Lang T. Reprogramming neutral lipid metabolism in mouse dendritic leucocytes hosting live Leishmania amazonensis amastigotes. PLoS Negl Trop Dis. 2013;7:e2276.
19. Toledo DA, Roque NR, Teixeira L, et al. Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism. PLoS ONE. 2016;11:e0160433.