Prostaglandin E2/Leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection

Parasites and Vectors

Volumn 7, Issue 1, 2014, Pages

  Araújo Santos, Théo ^a,b   Prates, Deboraci Brito ^a,c   França Costa, Jaqueline ^a,c   Luz, Nívea F ^a,c   Andrade, Bruno B ^d   Miranda, José Carlos ^a   Brodskyn, Claudia I ^a,c,e   Barral, Aldina ^a,c,e   Bozza, Patrícia T ^a   Borges, Valéria Matos ^a,e  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Programa de Pós graduação em História   (Brazil)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e National Institute of Science and Technology   (Brazil)

Author keywords

Leishmania infantum; Leukotriene B4; Lutzomyia longipalpis; Prostaglandina E2; Saliva

Indexed keywords

CYCLOOXYGENASE 2; LEUKOTRIENE B4; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; SULFONAMIDE;

ANIMAL MODEL; ARTICLE; ENZYME INHIBITION; EX VIVO STUDY; IMMUNE EVASION; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LEISHMANIA INFANTUM; LEISHMANIASIS; LEUKOCYTE; LUTZOMYIA LONGIPALPIS; MACROPHAGE; MALE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PARASITE LOAD; PARASITE VIABILITY; SALIVA; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; C57BL MOUSE; DISEASE MODEL; FEMALE; HUMAN; IMMUNOLOGY; METABOLISM; PARASITOLOGY; PSYCHODIDAE; SALIVARY GLAND; VISCERAL LEISHMANIASIS;

LEISHMANIA INFANTUM; LUTZOMYIA LONGIPALPIS; MURINAE; MUS; PHLEBOTOMINAE;

ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LEUKOCYTES; LEUKOTRIENE B4; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NITROBENZENES; PSYCHODIDAE; SALIVARY GLANDS; SULFONAMIDES;

EID: 84929328428     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/s13071-014-0601-8     Document Type: Article

References (36)

1. Samuelson J, Lerner E, Tesh R, Titus R: A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. J Exp Med 1991, 173:49-54.
2. Belkaid Y, Kamhawi S, Modi G, Valenzuela J, Noben-Trauth N, Rowton E, Ribeiro J, Sacks DL: Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J Exp Med 1998, 188:1941-1953.
3. Kamhawi S, Belkaid Y, Modi G, Rowton E, Sacks D: Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies. Science (80-) 2000, 290:1351-1354.
4. Andrade BB, Teixeira CR, Barral A, Barral-Netto M: Haematophagous arthropod saliva and host defense system: a tale of tear and blood. An Acad Bras Cienc 2005, 77:665-693.
5. Andrade BB, de Oliveira CI, Brodskyn CI, Barral A, Barral-Netto M: Role of sand fly saliva in human and experimental leishmaniasis: current insights. Scand J Immunol 2007, 66:122-127.
6. Ribeiro JM: Role of saliva in blood-feeding by arthropods. Annu Rev Entomol 1987, 32:463-478.
7. Teixeira CR, Teixeira MJ, Gomes RB, Santos CS, Andrade BB, Raffaele-Netto I, Silva JS, Guglielmotti A, Miranda JC, Barral A, Brodskyn C, Barral-Netto M: Saliva from Lutzomyia longipalpis induces CC chemokine ligand 2/monocyte chemoattractant protein-1 expression and macrophage recruitment. J Immunol 2005, 175:8346-8353.
8. Silva F, Gomes R, Prates D, Miranda JC, Andrade B, Barral-Netto M, Barral A: Inflammatory cell infiltration and high antibody production in BALB/c mice caused by natural exposure to Lutzomyia longipalpis bites. Am J Trop Med Hyg 2005, 72:94-98.
9. Monteiro MC, Lima HC, Souza AAA, Titus RG, Romao PRT, Cunha FDQ: Effect of Lutzomyia longipalpis salivary gland extracts on leukocyte migration induced by Leishmania major. Am J Trop Med Hyg 2007, 76:88-94.
10. 2/IL-10 sequential pathway. J Leukoc Biol 2008, 84:104-114.
11. Prates DB, Araujo-Santos T, Brodskyn C, Barral-Netto M, Barral A, Borges VM: New Insights on the Inflammatory Role of Lutzomyia longipalpis Saliva in Leishmaniasis. J Parasitol Res 2012, 2012:643029.
12. 4 derived from human neutrophils. J Infect Dis 2014, 210(4):656-666.
13. Araujo-Santos T, Rodriguez NE, Moura Pontes S, Dixt UG, Abanades DR, Bozza PT, Wilson ME, Borges VM: Role of prostaglandin F2α production in lipid bodies from Leishmania infantum chagasi: insights on virulence. J Infect Dis 2014, 210(12):1951-1961.
14. Serezani CH, Perrela JH, Russo M, Peters-Golden M, Jancar S: Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. J Immunol 2006, 177:3201-3208.
15. Prates DB, Araujo-Santos T, Luz NF, Andrade BB, Franca-Costa J, Afonso L, Clarencio J, Miranda JC, Bozza PT, Dosreis GA, Brodskyn C, Barral-Netto M, Borges VM, Barral A: Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils. J Leukoc Biol 2011, 90:575-582.
16. 2 negatively regulates the production of inflammatory cytokines/Chemokines and IL-17 in visceral leishmaniasis. J Immunol 2014, 193:2330-2339.
17. Lonardoni MV, Barbieri CL, Russo M, Jancar S: Modulation of Leishmania (L.) amazonensis growth in cultured mouse macrophages by prostaglandins and platelet activating factor. Mediat Inflamm 1994, 3:137-141.
18. Pinheiro RO, Nunes MP, Pinheiro CS, D'Avila H, Bozza PT, Takiya CM, Corte-Real S, Freire-de-Lima CG, Dos Reis GA, Corte-Real S: Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB/c but not C57BL/6 macrophages. Microbes Infect 2008, 11:181-190.
19. 4 modulates P2×7 receptor-mediated Leishmania amazonensis elimination in murine macrophages. J Immunol 2014, 192:4765-4773.
20. 2 production in murine macrophages. PLoS Negl Trop Dis 2010, 4:e873.
21. Soares MB, Titus RG, Shoemaker CB, David JR, Bozza M: The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor. J Immunol 1998, 160:1811-1816.
22. Prates DB, Santos LD, Miranda JC, Souza APA, Palma MS, Barral-Netto M, Barral A: Changes in amounts of total salivary gland proteins of Lutzomyia longipalpis (Diptera: Psychodidae) according to age and diet. J Med Entomol 2008, 45:409-413.
23. Gomes NA, Gattass CR, Barreto-De-Souza V, Wilson ME, DosReis GA: TGF-beta mediates CTLA-4 suppression of cellular immunity in murine kalaazar. J Immunol 2000, 164:2001-2008.
24. Lawrence T, Willoughby DA, Gilroy DW: Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2002, 2:787-795.
25. Lefevre L, Lugo-Villarino G, Meunier E, Valentin A, Olagnier D, Authier H, Duval C, Dardenne C, Bernad J, Lemesre JL, Auwerx J, Neyrolles O, Pipy B, Coste A: The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. Immunity 2013, 38:1038-1049.
26. D'Avila H, Maya-Monteiro CM, Bozza PT: Lipid bodies in innate immune response to bacterial and parasite infections. Int Immunopharmacol 2008, 8:1308-1315.
27. Melo RCN, D'Avila H, Fabrino DL, Almeida PE, Bozza PT: Macrophage lipid body induction by Chagas disease in vivo: putative intracellular domains for eicosanoid formation during infection. Tissue Cell 2003, 35:59-67.
28. 2 generation and increased parasite growth. J Infect Dis 2011, 204:951-961.
29. Freire-de-Lima CG, Nascimento DO, Soares MB, Bozza PT, Castro-Faria-Neto HC, de Mello FG, Dos Reis GA, Lopes MF: Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Nature 2000, 403:199-203.
30. D'Avila H, Melo RCN, Parreira GG, Werneck-barroso E, Castro-faria-neto HC, Bozza PT, Avila HD, Bozza T: Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 2006, 3:3087-3097.
31. Afonso L, Borges VM, Cruz H, Ribeiro-Gomes FL, DosReis GA, Dutra AN, Clarencio J, de Oliveira CI, Barral A, Barral-Netto M, Brodskyn CI: Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis. J Leukoc Biol 2008, 84:389-396.
32. Peters-Golden M, Canetti C, Mancuso P, Coffey MJ: Leukotrienes: underappreciated mediators of innate immune responses. J Immunol 2005, 174:589-594.
33. Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M: Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood 2005, 106:1067-1075.
34. Anstead GM, Chandrasekar B, Zhao W, Yang JUE, Perez LE, Melby PC: Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection. Infect Immun 2001, 69:4709-4718.
35. Ibrahim MK, Barnes JL, Anstead GM, Jimenez F, Travi BL, Peniche AG, Osorio EY, Ahuja SS, Melby PC: The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow. PLoS Negl Trop Dis 2013, 7:e2329.
36. 2 Pathways Suppress the Inflammatory Response and Contribute to Diffuse Cutaneous Leishmaniasis. J Infect Dis 2014, doi:10.1093/infdis/jiu455.