Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Nature Genetics

Volumn 49, Issue 7, 2017, Pages 1126-1132

  McKay, James D ^a   Hung, Rayjean J ^b   Han, Younghun ^c   Zong, Xuchen ^b   Carreras Torres, Robert ^a   Christiani, David C ^d   Caporaso, Neil E ^e   Johansson, Mattias ^a   Xiao, Xiangjun ^c   Li, Yafang ^c   Byun, Jinyoung ^c   Dunning, Alison ^f   Pooley, Karen A ^f   Qian, David C ^c   Ji, Xuemei ^c   Liu, Geoffrey ^b   Timofeeva, Maria N ^a   Bojesen, Stig E ^g,h   Wu, Xifeng ⁱ   Marchand, Loic Le ^j   Albanes, Demetrios ^e   Bickeböller, Heike ^k   Aldrich, Melinda C ^l   Bush, William S ^m   Tardon, Adonina ⁿ   Rennert, Gad ^o   Teare, M Dawn ^p   Field, John K ^q   Kiemeney, Lambertus A ^r   Lazarus, Philip ^s   Haugen, Aage ^t   Lam, Stephen ^u   Schabath, Matthew B ^v   Andrew, Angeline S ^c   Shen, Hongbing ^w   Hong, Yun Chul ^x   Yuan, Jian Min ^y   Bertazzi, Pier Alberto ^z,aa   Pesatori, Angela C ^aa   Ye, Yuanqing ⁱ   Diao, Nancy ^d   Su, Li ^d   Zhang, Ruyang ^d   Brhane, Yonathan ^b   Leighl, Natasha ^ab   Johansen, Jakob S ^g   Mellemgaard, Anders ^g   Saliba, Walid ^o   Haiman, Christopher A ^ac   Wilkens, Lynne R ^j   Fernandez Somoano, Ana ⁿ   Fernandez Tardon, Guillermo ⁿ   Van Der Heijden, Henricus F M ^r   Kim, Jin Hee ^ad   Dai, Juncheng ^w   Hu, Zhibin ^w   Davies, Michael P A ^q   Marcus, Michael W ^q   Brunnström, Hans ^ae   Manjer, Jonas ^ae   Melander, Olle ^ae   Muller, David C ^af   Overvad, Kim ^ag   Trichopoulou, Antonia ^ah   Tumino, Rosario ^ai   Doherty, Jennifer A ^c,aj,ak   Barnett, Matt P ^aj   Chen, Chu ^aj   Goodman, Gary E ^al   Cox, Angela ^am   Taylor, Fiona ^am   Woll, Penella ^am   Brüske, Irene ^an   Wichmann, H Erich ^an,ao,ap   Manz, Judith ^an   Muley, Thomas R ^aq,ar   Risch, Angela ^{an,aq,ar,as,at}   Rosenberger, Albert ^k   Grankvist, Kjell ^au   Johansson, Mikael ^au   Shepherd, Frances A ^ab   Tsao, Ming Sound ^ab   Arnold, Susanne M ^av   Haura, Eric B ^v   Bolca, Ciprian ^aw   Holcatova, Ivana ^ax   Janout, Vladimir ^ay   Kontic, Milica ^az,ba   Lissowska, Jolanta ^bb   Mukeria, Anush ^bc   Ognjanovic, Simona ^bd   Orlowski, Tadeusz M ^be   Scelo, Ghislaine ^a   Swiatkowska, Beata ^bf   Zaridze, David ^bc   Bakke, Per ^bg   Skaug, Vidar ^t   Zienolddiny, Shanbeh ^t   Duell, Eric J ^bh   Butler, Lesley M ^y   Koh, Woon Puay ^bi   Gao, Yu Tang ^bj   Houlston, Richard S ^bk   McLaughlin, John ^bl   Stevens, Victoria L ^bm   Joubert, Philippe ^bn   Lamontagne, Maxime ^bn   Nickle, David C ^bo   Obeidat, Ma'En ^bp   Timens, Wim ^bq   Zhu, Bin ^e   Song, Lei ^e   Kachuri, Linda ^b   Artigas, María Soler ^br,bs   Tobin, Martin D ^br,bs   Wain, Louise V ^br,bs   Rafnar, Thorunn ^bu   Thorgeirsson, Thorgeir E ^bu   Reginsson, Gunnar W ^bu   Stefansson, Kari ^bu   Hancock, Dana B ^bv   Bierut, Laura J ^bw   Spitz, Margaret R ^bx   Gaddis, Nathan C ^bv   Lutz, Sharon M ^by   Gu, Fangyi ^e   Johnson, Eric O ^bv   Kamal, Ahsan ^c   Pikielny, Claudio ^c   Zhu, Dakai ^c   Lindströem, Sara ^bz   Jiang, Xia ^ca   Tyndale, Rachel F ^cb,cc   Chenevix Trench, Georgia ^cd   Beesley, Jonathan ^cd   Bossé, Yohan ^bn,bt   Chanock, Stephen ^e   Brennan, Paul ^a   Landi, Maria Teresa ^e   Amos, Christopher I ^c   more..

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b MOUNT SINAI HOSPITAL   (Canada)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

ⁱ UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^j UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^k UNIVERSITY OF GÖTTINGEN   (Germany)

^l VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^m CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ UNIVERSITY OF OVIEDO   (Spain)

^o CLALIT HEALTH SERVICES   (Israel)

^p UNIVERSITY OF SHEFFIELD   (United Kingdom)

^q UNIVERSITY OF LIVERPOOL   (United Kingdom)

^r RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^s WASHINGTON STATE UNIVERSITY   (United States)

^t NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH   (Norway)

^u BRITISH COLUMBIA CANCER AGENCY   (Canada)

^v H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^w NANJING MEDICAL UNIVERSITY   (China)

^x Seoul National University College of Medicine   (South Korea)

^y UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^z FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^aa UNIVERSITY OF MILAN   (Italy)

^ab PRINCESS MARGARET HOSPITAL   (Canada)

^ac UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^ad Sejong University   (South Korea)

^ae LUND UNIVERSITY   (Sweden)

^af IMPERIAL COLLEGE LONDON   (United Kingdom)

^ag AARHUS UNIVERSITY   (Denmark)

^ah HELLENIC HEALTH FOUNDATION   (Greece)

^ai CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^aj USA   (United States)

^ak UNIVERSITY OF UTAH   (United States)

^al Swedish Medical Group   (United States)

^am UNIVERSITY OF SHEFFIELD   (United Kingdom)

^an INSTITUTE OF EPIDEMIOLOGY   (Germany)

^ao UNIVERSITY OF MUNICH   (Germany)

^ap TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^aq UNIVERSITY OF HEIDELBERG   (Germany)

^ar Heidelberg Translational Lung Research Center (TLRC)   (Germany)

^as German Center for Lung Research (DZL)   (Germany)

^at UNIVERSITY OF SALZBURG   (Austria)

^au UMEÅ UNIVERSITY   (Sweden)

^av UNIVERSITY OF KENTUCKY   (United States)

^aw Marius Nasta Institute   (Romania)

^ax CHARLES UNIVERSITY   (Czech Republic)

^ay UNIVERSITY OF OSTRAVA   (Czech Republic)

^az CLINICAL CENTER OF SERBIA   (Serbia)

^ba UNIVERSITY OF BELGRADE   (Serbia)

^bb INSTITUTE OF ONCOLOGY   (Poland)

^bc N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^bd International Organization for Cancer Prevention and Research (IOCPR)   (Serbia)

^be NATIONAL TUBERCULOSIS AND LUNG DISEASES RESEARCH INSTITUTE   (Poland)

^bf NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

^bg UNIVERSITY OF BERGEN   (Norway)

^bh CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^bi DUKE NUS MEDICAL SCHOOL   (Singapore)

^bj SHANGHAI CANCER INSTITUTE   (China)

^bk INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^bl PUBLIC HEALTH ONTARIO   (Canada)

^bm AMERICAN CANCER SOCIETY   (United States)

^bn LAVAL UNIVERSITY   (Canada)

^bo MERCK RESEARCH LABORATORIES   (United States)

^bp UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^bq UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^br UNIVERSITY OF LEICESTER   (United Kingdom)

^bs GLENFIELD HOSPITAL   (United Kingdom)

^bt UNIVERSITÉ LAVAL   (Canada)

^bu DECODE GENETICS   (Iceland)

^bv RTI INTERNATIONAL   (United States)

^bw WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bx BAYLOR COLLEGE OF MEDICINE   (United States)

^by UNIVERSITY OF COLORADO   (United States)

^bz UNIVERSITY OF WASHINGTON   (United States)

^ca HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^cb UNIVERSITY OF TORONTO   (Canada)

^cc CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^cd QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2A6; NEU DIFFERENTIATION FACTOR; REACTIVE OXYGEN METABOLITE;

ADULT; ARTICLE; CANCER GENETICS; CANCER PATIENT; CANCER SUSCEPTIBILITY; CHRNA2 GENE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CROHN DISEASE; EXPIRATORY RESERVE VOLUME; FEMALE; FORCED VITAL CAPACITY; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HERITABILITY; HISTOLOGY; HUMAN; INFLAMMATORY BOWEL DISEASE; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; OFBC1 GENE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RNASET2 GENE; RTEL1 GENE; SECISBP2L GENE; SMALL CELL LUNG CANCER; SMOKING; SPIROMETRY; SQUAMOUS CELL LUNG CARCINOMA; TELOMERE LENGTH; TUMOR GENE; XENOBIOTIC METABOLISM; ADENOCARCINOMA; AGED; CAUCASIAN; CHROMOSOMAL MAPPING; ETHNOLOGY; FAMILY HEALTH; GENETIC PREDISPOSITION; GENETICS; LUNG NEOPLASMS; META ANALYSIS; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM; TELOMERE HOMEOSTASIS;

ADENOCARCINOMA; ADULT; AGED; CHROMOSOME MAPPING; EUROPEAN CONTINENTAL ANCESTRY GROUP; FAMILY HEALTH; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; SMOKING; TELOMERE HOMEOSTASIS;

EID: 85020451435     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3892     Document Type: Article

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