Inhibitory effects of doxycycline on the onset and progression of abdominal aortic aneurysm and its related mechanisms

European Journal of Pharmacology

Volumn 811, Issue , 2017, Pages 101-109

  Yu, Maomao ^a,b,c   Chen, Cong ^a,b,c   Cao, Yini ^a,b,c   Qi, Rong ^a,b,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation   (China)

Author keywords

Abdominal aortic aneurysm; Doxycycline; Elastase; Inflammation; MMPs; VSMC

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DOXYCYCLINE; GELATINASE A; GELATINASE B; GLUTATHIONE TRANSFERASE T1; HEME OXYGENASE 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; CYTOKINE; MESSENGER RNA;

ABDOMINAL AORTIC ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT DURATION; TREATMENT OUTCOME; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; AORTA; DISEASE EXACERBATION; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MAPK SIGNALING; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; AORTIC ANEURYSM, ABDOMINAL; BIOMARKERS; CYTOKINES; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MUSCLE, SMOOTH, VASCULAR; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER;

EID: 85020202341     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2017.05.041     Document Type: Article

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