메뉴 건너뛰기




Volumn 13, Issue 6, 2017, Pages 701-711

Eupafolin exhibits potent anti-angiogenic and antitumor activity in hepatocellular carcinoma

Author keywords

Eupafolin; Tumor angiogenesis

Indexed keywords

EUPAFOLIN; FLAVONE DERIVATIVE; VASCULOTROPIN A;

EID: 85020175521     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.17534     Document Type: Article
Times cited : (23)

References (44)
  • 1
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell. 2011; 146: 873-87.
    • (2011) Cell. , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 2
    • 32944463899 scopus 로고    scopus 로고
    • Angiogenesis
    • Folkman J. Angiogenesis. Annu Rev Med. 2006; 57: 1-18.
    • (2006) Annu Rev Med. , vol.57 , pp. 1-18
    • Folkman, J.1
  • 3
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer. 2002; 2: 795-803.
    • (2002) Nat Rev Cancer. , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 4
    • 84872577704 scopus 로고    scopus 로고
    • Angiogenesis in hepatocellular carcinoma: A potential target for chemoprevention and therapy
    • Bishayee A, Darvesh AS. Angiogenesis in hepatocellular carcinoma: a potential target for chemoprevention and therapy. Curr Cancer Drug Targets. 2012; 12: 1095-118.
    • (2012) Curr Cancer Drug Targets. , vol.12 , pp. 1095-1118
    • Bishayee, A.1    Darvesh, A.S.2
  • 6
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003; 9: 669-76.
    • (2003) Nat Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 7
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature. 2005; 438: 932-6.
    • (2005) Nature. , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 8
    • 33746858881 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-Receptor2: Its biological functions, major signaling pathway, and specific ligand VEGF-E
    • Shibuya M. Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. Endothelium. 2006; 13: 63-9.
    • (2006) Endothelium. , vol.13 , pp. 63-69
    • Shibuya, M.1
  • 10
    • 18744371056 scopus 로고    scopus 로고
    • Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma
    • Hu TH, Huang CC, Wu CL, Lin PR, Liu SY, Lin JW, et al. Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma. Mod Pathol. 2005; 18: 663-72.
    • (2005) Mod Pathol. , vol.18 , pp. 663-672
    • Hu, T.H.1    Huang, C.C.2    Wu, C.L.3    Lin, P.R.4    Liu, S.Y.5    Lin, J.W.6
  • 11
    • 79953090713 scopus 로고    scopus 로고
    • Prognostic significance and potential therapeutic target of VEGFR2 in hepatocellular carcinoma
    • Huang J, Zhang X, Tang Q, Zhang F, Li Y, Feng Z, et al. Prognostic significance and potential therapeutic target of VEGFR2 in hepatocellular carcinoma. J Clin Pathol. 2011; 64: 343-8.
    • (2011) J Clin Pathol. , vol.64 , pp. 343-348
    • Huang, J.1    Zhang, X.2    Tang, Q.3    Zhang, F.4    Li, Y.5    Feng, Z.6
  • 12
    • 4444366693 scopus 로고    scopus 로고
    • Effect of c-myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinoma patients undergoing tumor resection
    • Cui J, Dong BW, Liang P, Yu XL, Yu DJ. Effect of c-myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinoma patients undergoing tumor resection. World J Gastroenterol. 2004; 10: 1533-6.
    • (2004) World J Gastroenterol. , vol.10 , pp. 1533-1536
    • Cui, J.1    Dong, B.W.2    Liang, P.3    Yu, X.L.4    Yu, D.J.5
  • 13
    • 84909629461 scopus 로고    scopus 로고
    • Clinical trials of combined molecular targeted therapy and locoregional therapy in hepatocellular carcinoma: Past, present, and future
    • Kim HY, Park JW. Clinical trials of combined molecular targeted therapy and locoregional therapy in hepatocellular carcinoma: past, present, and future. Liver Cancer. 2014; 3: 9-17.
    • (2014) Liver Cancer. , vol.3 , pp. 9-17
    • Kim, H.Y.1    Park, J.W.2
  • 14
    • 84896957174 scopus 로고    scopus 로고
    • Systemic therapy of hepatocellular carcinoma: Current status and future perspectives
    • Germano D, Daniele B. Systemic therapy of hepatocellular carcinoma: current status and future perspectives. World J Gastroenterol. 2014; 20: 3087-99.
    • (2014) World J Gastroenterol. , vol.20 , pp. 3087-3099
    • Germano, D.1    Daniele, B.2
  • 15
    • 85050578352 scopus 로고    scopus 로고
    • Systemic therapies for hepatocellular carcinoma
    • Ge S, Huang D. Systemic therapies for hepatocellular carcinoma. Drug Discov Ther. 2015; 9: 352-62.
    • (2015) Drug Discov Ther. , vol.9 , pp. 352-362
    • Ge, S.1    Huang, D.2
  • 16
    • 79955580873 scopus 로고    scopus 로고
    • HCC and angiogenesis: Possible targets and future directions
    • Zhu AX, Duda DG, Sahani DV, Jain RK. HCC and angiogenesis: possible targets and future directions. Nat Rev Clin Oncol. 2011; 8: 292-301.
    • (2011) Nat Rev Clin Oncol. , vol.8 , pp. 292-301
    • Zhu, A.X.1    Duda, D.G.2    Sahani, D.V.3    Jain, R.K.4
  • 17
    • 84864434569 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Tanaka S, Arii S. Molecular targeted therapies in hepatocellular carcinoma. Semin Oncol. 2012; 39: 486-92.
    • (2012) Semin Oncol. , vol.39 , pp. 486-492
    • Tanaka, S.1    Arii, S.2
  • 18
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. 2011; 10: 417-27.
    • (2011) Nat Rev Drug Discov. , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 19
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
    • Newman DJ. Natural products as leads to potential drugs: an old process or the new hope for drug discovery?. J Med Chem. 2008; 51: 2589-99.
    • (2008) J Med Chem. , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 21
    • 81155135189 scopus 로고    scopus 로고
    • Antioxidant, anti-inflammatory and antiproliferative activities of Kalanchoe gracilis (L.) DC stem
    • Lai ZR, Ho YL, Huang SC, Huang TH, Lai SC, Tsai JC, et al. Antioxidant, anti-inflammatory and antiproliferative activities of Kalanchoe gracilis (L.) DC stem. Am J Chin Med. 2011; 39: 1275-90.
    • (2011) Am J Chin Med. , vol.39 , pp. 1275-1290
    • Lai, Z.R.1    Ho, Y.L.2    Huang, S.C.3    Huang, T.H.4    Lai, S.C.5    Tsai, J.C.6
  • 22
    • 84863112637 scopus 로고    scopus 로고
    • AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and anti-tumour activity via targeting VEGFR, FGFR and PDGFR
    • Zhou Y, Chen Y, Tong L, Xie H, Wen W, Zhang J, et al. AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and anti-tumour activity via targeting VEGFR, FGFR and PDGFR. J Cell Mol Med. 2012; 16: 2321-30.
    • (2012) J Cell Mol Med. , vol.16 , pp. 2321-2330
    • Zhou, Y.1    Chen, Y.2    Tong, L.3    Xie, H.4    Wen, W.5    Zhang, J.6
  • 23
    • 0033544876 scopus 로고    scopus 로고
    • Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2)
    • Ashton AW, Yokota R, John G, Zhao S, Suadicani SO, Spray DC, et al. Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem. 1999; 274: 35562-70.
    • (1999) J Biol Chem. , vol.274 , pp. 35562-35570
    • Ashton, A.W.1    Yokota, R.2    John, G.3    Zhao, S.4    Suadicani, S.O.5    Spray, D.C.6
  • 24
    • 51049120763 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    • Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, Wang Y, et al. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Cancer Ther. 2008; 7: 1789-96.
    • (2008) Mol Cancer Ther. , vol.7 , pp. 1789-1796
    • Yi, T.1    Cho, S.G.2    Yi, Z.3    Pang, X.4    Rodriguez, M.5    Wang, Y.6
  • 26
    • 84898894775 scopus 로고    scopus 로고
    • Chemotherapy for advanced hepatocellular carcinoma in the sorafenib age
    • Miyahara K, Nouso K, Yamamoto K. Chemotherapy for advanced hepatocellular carcinoma in the sorafenib age. World J Gastroenterol. 2014; 20: 4151-9.
    • (2014) World J Gastroenterol. , vol.20 , pp. 4151-4159
    • Miyahara, K.1    Nouso, K.2    Yamamoto, K.3
  • 27
    • 84964227484 scopus 로고    scopus 로고
    • Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib
    • Mazzoccoli G, Miele L, Oben J, Grieco A, Vinciguerra M. Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib. Curr Drug Targets. 2016; 17: 783-99.
    • (2016) Curr Drug Targets. , vol.17 , pp. 783-799
    • Mazzoccoli, G.1    Miele, L.2    Oben, J.3    Grieco, A.4    Vinciguerra, M.5
  • 28
    • 84938968012 scopus 로고    scopus 로고
    • Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling
    • Liu K, Park C, Chen H, Hwang J, Thimmegowda NR, Bae EY, et al. Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling. Mol Carcinog. 2015; 54: 751-60.
    • (2015) Mol Carcinog. , vol.54 , pp. 751-760
    • Liu, K.1    Park, C.2    Chen, H.3    Hwang, J.4    Thimmegowda, N.R.5    Bae, E.Y.6
  • 29
    • 77957028146 scopus 로고    scopus 로고
    • Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells
    • Chung KS, Choi JH, Back NI, Choi MS, Kang EK, Chung HG, et al. Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. Mol Nutr Food Res. 2010; 54: 1318-28.
    • (2010) Mol Nutr Food Res. , vol.54 , pp. 1318-1328
    • Chung, K.S.1    Choi, J.H.2    Back, N.I.3    Choi, M.S.4    Kang, E.K.5    Chung, H.G.6
  • 30
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003; 3: 401-10.
    • (2003) Nat Rev Cancer. , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 31
    • 70350736093 scopus 로고    scopus 로고
    • The angiogenic switch: Implications in the regulation of tumor dormancy
    • Moserle L, Amadori A, Indraccolo S. The angiogenic switch: implications in the regulation of tumor dormancy. Curr Mol Med. 2009; 9: 935-41.
    • (2009) Curr Mol Med. , vol.9 , pp. 935-941
    • Moserle, L.1    Amadori, A.2    Indraccolo, S.3
  • 32
    • 84919479359 scopus 로고    scopus 로고
    • Autocrine vascular endothelial growth factor signaling promotes cell proliferation and modulates sorafenib treatment efficacy in hepatocellular carcinoma
    • Peng S, Wang Y, Peng H, Chen D, Shen S, Peng B, et al. Autocrine vascular endothelial growth factor signaling promotes cell proliferation and modulates sorafenib treatment efficacy in hepatocellular carcinoma. Hepatology. 2014; 60: 1264-77.
    • (2014) Hepatology. , vol.60 , pp. 1264-1277
    • Peng, S.1    Wang, Y.2    Peng, H.3    Chen, D.4    Shen, S.5    Peng, B.6
  • 33
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009; 9: 550-62.
    • (2009) Nat Rev Cancer. , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 34
    • 84890290884 scopus 로고    scopus 로고
    • TRAF4 is a critical molecule for Akt activation in lung cancer
    • Li W, Peng C, Lee MH, Lim D, Zhu F, Fu Y, et al. TRAF4 is a critical molecule for Akt activation in lung cancer. Cancer Res. 2013; 73: 6938-50.
    • (2013) Cancer Res. , vol.73 , pp. 6938-6950
    • Li, W.1    Peng, C.2    Lee, M.H.3    Lim, D.4    Zhu, F.5    Fu, Y.6
  • 35
    • 6344275304 scopus 로고    scopus 로고
    • Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism
    • Pore N, Liu S, Shu HK, Li B, Haas-Kogan D, Stokoe D, et al. Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell. 2004; 15: 4841-53.
    • (2004) Mol Biol Cell. , vol.15 , pp. 4841-4853
    • Pore, N.1    Liu, S.2    Shu, H.K.3    Li, B.4    Haas-Kogan, D.5    Stokoe, D.6
  • 36
    • 46749092963 scopus 로고    scopus 로고
    • Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma
    • Huang Y, Hua K, Zhou X, Jin H, Chen X, Lu X, et al. Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma. Cell Res. 2008; 18: 780-91.
    • (2008) Cell Res. , vol.18 , pp. 780-791
    • Huang, Y.1    Hua, K.2    Zhou, X.3    Jin, H.4    Chen, X.5    Lu, X.6
  • 37
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem. 2001; 276: 38349-52.
    • (2001) J Biol Chem. , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 39
    • 8544273759 scopus 로고    scopus 로고
    • Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling
    • Skinner HD, Zheng JZ, Fang J, Agani F, Jiang BH. Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling. J Biol Chem. 2004; 279: 45643-51.
    • (2004) J Biol Chem. , vol.279 , pp. 45643-45651
    • Skinner, H.D.1    Zheng, J.Z.2    Fang, J.3    Agani, F.4    Jiang, B.H.5
  • 40
  • 41
    • 0035933094 scopus 로고    scopus 로고
    • Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
    • Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A. 2001; 98: 6074-9.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , pp. 6074-6079
    • Ong, S.H.1    Hadari, Y.R.2    Gotoh, N.3    Guy, G.R.4    Schlessinger, J.5    Lax, I.6
  • 42
    • 0035421326 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
    • Dong G, Chen Z, Li ZY, Yeh NT, Bancroft CC, Van Waes C. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res. 2001; 61: 5911-8.
    • (2001) Cancer Res. , vol.61 , pp. 5911-5918
    • Dong, G.1    Chen, Z.2    Li, Z.Y.3    Yeh, N.T.4    Bancroft, C.C.5    Van Waes, C.6
  • 43
    • 25444482837 scopus 로고    scopus 로고
    • Mutated PI 3-kinases: Cancer targets on a silver platter
    • Kang S, Bader AG, Zhao L, Vogt PK. Mutated PI 3-kinases: cancer targets on a silver platter. Cell Cycle. 2005; 4: 578-81.
    • (2005) Cell Cycle. , vol.4 , pp. 578-581
    • Kang, S.1    Bader, A.G.2    Zhao, L.3    Vogt, P.K.4
  • 44


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.