메뉴 건너뛰기




Volumn 130, Issue 6, 2017, Pages S18-S29

Cardiovascular Protection in the Treatment of Type 2 Diabetes: A Review of Clinical Trial Results Across Drug Classes

Author keywords

Cardiovascular disease; Glucose lowering therapy; Type 2 diabetes treatment

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EMPAGLIFLOZIN; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; LIRAGLUTIDE; METFORMIN; PIOGLITAZONE; SEMAGLUTIDE; SULFONYLUREA DERIVATIVE; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 85020036499     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2017.04.008     Document Type: Article
Times cited : (35)

References (77)
  • 1
    • 84882354610 scopus 로고    scopus 로고
    • Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II
    • Beckman, J.A., Paneni, F., Cosentino, F., Creager, M.A., Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II. Eur Heart J 34 (2013), 2444–2452.
    • (2013) Eur Heart J , vol.34 , pp. 2444-2452
    • Beckman, J.A.1    Paneni, F.2    Cosentino, F.3    Creager, M.A.4
  • 2
    • 84885997413 scopus 로고    scopus 로고
    • ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)
    • Authors/Task Force Members, Ryden, L., Grant, P.J., Anker, S.D., et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 34 (2013), 3035–3087.
    • (2013) Eur Heart J , vol.34 , pp. 3035-3087
    • Ryden, L.1    Grant, P.J.2    Anker, S.D.3
  • 3
    • 0034730110 scopus 로고    scopus 로고
    • Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry
    • Malmberg, K., Yusuf, S., Gerstein, H.C., et al. Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry. Circulation 102 (2000), 1014–1019.
    • (2000) Circulation , vol.102 , pp. 1014-1019
    • Malmberg, K.1    Yusuf, S.2    Gerstein, H.C.3
  • 4
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner, S.M., Lehto, S., Ronnemaa, T., Pyorala, K., Laakso, M., Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339 (1998), 229–234.
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 5
    • 85002168805 scopus 로고    scopus 로고
    • Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus
    • Yahagi, K., Kolodgie, F.D., Lutter, C., et al. Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus. Arterioscler Thromb Vasc Biol 37:2 (2017), 191–204.
    • (2017) Arterioscler Thromb Vasc Biol , vol.37 , Issue.2 , pp. 191-204
    • Yahagi, K.1    Kolodgie, F.D.2    Lutter, C.3
  • 6
    • 84991813209 scopus 로고    scopus 로고
    • Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice
    • Avogaro, A., Fadini, G.P., Sesti, G., Bonora, E., Del Prato, S., Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice. Cardiovasc Diabetol, 15, 2016, 111.
    • (2016) Cardiovasc Diabetol , vol.15 , pp. 111
    • Avogaro, A.1    Fadini, G.P.2    Sesti, G.3    Bonora, E.4    Del Prato, S.5
  • 7
    • 84974829707 scopus 로고    scopus 로고
    • Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus - mechanisms, management, and clinical considerations
    • Low Wang, C.C., Hess, C.N., Hiatt, W.R., Goldfine, A.B., Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus - mechanisms, management, and clinical considerations. Circulation 133 (2016), 2459–2502.
    • (2016) Circulation , vol.133 , pp. 2459-2502
    • Low Wang, C.C.1    Hess, C.N.2    Hiatt, W.R.3    Goldfine, A.B.4
  • 9
    • 84882336972 scopus 로고    scopus 로고
    • Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
    • Paneni, F., Beckman, J.A., Creager, M.A., Cosentino, F., Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Eur Heart J 34 (2013), 2436–2443.
    • (2013) Eur Heart J , vol.34 , pp. 2436-2443
    • Paneni, F.1    Beckman, J.A.2    Creager, M.A.3    Cosentino, F.4
  • 10
    • 4644336398 scopus 로고    scopus 로고
    • Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk
    • Khaw, K.T., Wareham, N., Bingham, S., Luben, R., Welch, A., Day, N., Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med 141 (2004), 413–420.
    • (2004) Ann Intern Med , vol.141 , pp. 413-420
    • Khaw, K.T.1    Wareham, N.2    Bingham, S.3    Luben, R.4    Welch, A.5    Day, N.6
  • 11
    • 0029094533 scopus 로고
    • The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial
    • The Diabetes Control and Complications Trial Research Group. The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Diabetes 44 (1995), 968–983.
    • (1995) Diabetes , vol.44 , pp. 968-983
  • 12
    • 0141446316 scopus 로고    scopus 로고
    • Is HbA(1c) affected by glycemic instability?
    • Derr, R., Garrett, E., Stacy, G.A., Saudek, C.D., Is HbA(1c) affected by glycemic instability?. Diabetes Care 26 (2003), 2728–2733.
    • (2003) Diabetes Care , vol.26 , pp. 2728-2733
    • Derr, R.1    Garrett, E.2    Stacy, G.A.3    Saudek, C.D.4
  • 13
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein, H.C., Miller, M.E., Byington, R.P., et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358 (2008), 2545–2559.
    • (2008) N Engl J Med , vol.358 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3
  • 14
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • ADVANCE Collaborative Group, Patel, A., MacMahon, S., Chalmers, J., et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358 (2008), 2560–2572.
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 15
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • Duckworth, W., Abraira, C., Moritz, T., et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360 (2009), 129–139.
    • (2009) N Engl J Med , vol.360 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 16
    • 84925489733 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi, S.E., Bergenstal, R.M., Buse, J.B., et al. Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 58 (2015), 429–442.
    • (2015) Diabetologia , vol.58 , pp. 429-442
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 17
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352 (1998), 854–865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 18
    • 53749091595 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman, R.R., Paul, S.K., Bethel, M.A., Matthews, D.R., Neil, H.A., 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359 (2008), 1577–1589.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 19
    • 84901768284 scopus 로고    scopus 로고
    • Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes
    • Holman, R.R., Sourij, H., Califf, R.M., Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes. Lancet 383 (2014), 2008–2017.
    • (2014) Lancet , vol.383 , pp. 2008-2017
    • Holman, R.R.1    Sourij, H.2    Califf, R.M.3
  • 20
    • 63849328978 scopus 로고    scopus 로고
    • Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus
    • Kooy, A., de Jager, J., Lehert, P., et al. Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus. Arch Intern Med 169 (2009), 616–625.
    • (2009) Arch Intern Med , vol.169 , pp. 616-625
    • Kooy, A.1    de Jager, J.2    Lehert, P.3
  • 21
    • 0038279359 scopus 로고    scopus 로고
    • Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes
    • Johnson, J.A., Majumdar, S.R., Simpson, S.H., Toth, E.L., Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes. Diabetes Care 25 (2002), 2244–2248.
    • (2002) Diabetes Care , vol.25 , pp. 2244-2248
    • Johnson, J.A.1    Majumdar, S.R.2    Simpson, S.H.3    Toth, E.L.4
  • 22
    • 84860117993 scopus 로고    scopus 로고
    • Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database
    • Tzoulaki, I., Molokhia, M., Curcin, V., et al. Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ, 339, 2009, b4731.
    • (2009) BMJ , vol.339 , pp. b4731
    • Tzoulaki, I.1    Molokhia, M.2    Curcin, V.3
  • 23
    • 84868652782 scopus 로고    scopus 로고
    • Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study
    • Roumie, C.L., Hung, A.M., Greevy, R.A., et al. Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study. Ann Intern Med 157 (2012), 601–610.
    • (2012) Ann Intern Med , vol.157 , pp. 601-610
    • Roumie, C.L.1    Hung, A.M.2    Greevy, R.A.3
  • 24
    • 84881567755 scopus 로고    scopus 로고
    • Mortality among veterans with type 2 diabetes initiating metformin, sulfonylurea or rosiglitazone monotherapy
    • Wheeler, S., Moore, K., Forsberg, C.W., et al. Mortality among veterans with type 2 diabetes initiating metformin, sulfonylurea or rosiglitazone monotherapy. Diabetologia 56 (2013), 1934–1943.
    • (2013) Diabetologia , vol.56 , pp. 1934-1943
    • Wheeler, S.1    Moore, K.2    Forsberg, C.W.3
  • 25
    • 84860167144 scopus 로고    scopus 로고
    • Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials
    • Boussageon, R., Supper, I., Bejan-Angoulvant, T., et al. Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials. PLoS Med, 9, 2012, e1001204.
    • (2012) PLoS Med , vol.9 , pp. e1001204
    • Boussageon, R.1    Supper, I.2    Bejan-Angoulvant, T.3
  • 26
    • 78851470539 scopus 로고    scopus 로고
    • Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials
    • Lamanna, C., Monami, M., Marchionni, N., Mannucci, E., Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 13 (2011), 221–228.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 221-228
    • Lamanna, C.1    Monami, M.2    Marchionni, N.3    Mannucci, E.4
  • 27
    • 84976260652 scopus 로고    scopus 로고
    • Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus
    • Tahrani, A.A., Barnett, A.H., Bailey, C.J., Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat Rev Endocrinol 12 (2016), 566–592.
    • (2016) Nat Rev Endocrinol , vol.12 , pp. 566-592
    • Tahrani, A.A.1    Barnett, A.H.2    Bailey, C.J.3
  • 28
    • 3142728651 scopus 로고    scopus 로고
    • The role of sulphonylureas in the management of type 2 diabetes mellitus
    • Rendell, M., The role of sulphonylureas in the management of type 2 diabetes mellitus. Drugs 64 (2004), 1339–1358.
    • (2004) Drugs , vol.64 , pp. 1339-1358
    • Rendell, M.1
  • 29
    • 0014914649 scopus 로고
    • A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results
    • Meinert, C.L., Knatterud, G.L., Prout, T.E., Klimt, C.R., A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes 19:suppl (1970), 789–830.
    • (1970) Diabetes , vol.19 , pp. 789-830
    • Meinert, C.L.1    Knatterud, G.L.2    Prout, T.E.3    Klimt, C.R.4
  • 30
    • 0036314661 scopus 로고    scopus 로고
    • Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocardial dysfunction in type 2 diabetes
    • Scognamiglio, R., Avogaro, A., Vigili de Kreutzenberg, S., et al. Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocardial dysfunction in type 2 diabetes. Diabetes 51 (2002), 808–812.
    • (2002) Diabetes , vol.51 , pp. 808-812
    • Scognamiglio, R.1    Avogaro, A.2    Vigili de Kreutzenberg, S.3
  • 31
    • 0036781182 scopus 로고    scopus 로고
    • A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes
    • Viberti, G., Kahn, S.E., Greene, D.A., et al. A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes. Diabetes Care 25 (2002), 1737–1743.
    • (2002) Diabetes Care , vol.25 , pp. 1737-1743
    • Viberti, G.1    Kahn, S.E.2    Greene, D.A.3
  • 32
    • 84941243068 scopus 로고    scopus 로고
    • Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
    • Ferrannini, E., DeFronzo, R.A., Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. Eur Heart J 36 (2015), 2288–2296.
    • (2015) Eur Heart J , vol.36 , pp. 2288-2296
    • Ferrannini, E.1    DeFronzo, R.A.2
  • 33
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352 (1998), 837–853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 34
    • 31544482787 scopus 로고    scopus 로고
    • Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: a population-based cohort study
    • Simpson, S.H., Majumdar, S.R., Tsuyuki, R.T., Eurich, D.T., Johnson, J.A., Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: a population-based cohort study. CMAJ 174 (2006), 169–174.
    • (2006) CMAJ , vol.174 , pp. 169-174
    • Simpson, S.H.1    Majumdar, S.R.2    Tsuyuki, R.T.3    Eurich, D.T.4    Johnson, J.A.5
  • 35
    • 84870753442 scopus 로고    scopus 로고
    • What next after metformin? A retrospective evaluation of the outcome of second-line, glucose-lowering therapies in people with type 2 diabetes
    • Morgan, C.L., Poole, C.D., Evans, M., Barnett, A.H., Jenkins-Jones, S., Currie, C.J., What next after metformin? A retrospective evaluation of the outcome of second-line, glucose-lowering therapies in people with type 2 diabetes. J Clin Endocrinol Metab 97 (2012), 4605–4612.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4605-4612
    • Morgan, C.L.1    Poole, C.D.2    Evans, M.3    Barnett, A.H.4    Jenkins-Jones, S.5    Currie, C.J.6
  • 36
    • 84926475145 scopus 로고    scopus 로고
    • Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA)
    • Marx, N., Rosenstock, J., Kahn, S.E., et al. Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA). Diab Vasc Dis Res 12 (2015), 164–174.
    • (2015) Diab Vasc Dis Res , vol.12 , pp. 164-174
    • Marx, N.1    Rosenstock, J.2    Kahn, S.E.3
  • 37
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Jarvinen, H., Thiazolidinediones. N Engl J Med 351 (2004), 1106–1118.
    • (2004) N Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 38
    • 58849094131 scopus 로고    scopus 로고
    • Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis
    • Loke, Y.K., Singh, S., Furberg, C.D., Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ 180 (2009), 32–39.
    • (2009) CMAJ , vol.180 , pp. 32-39
    • Loke, Y.K.1    Singh, S.2    Furberg, C.D.3
  • 39
    • 37149034178 scopus 로고    scopus 로고
    • Thiazolidinediones and cardiovascular outcomes in older patients with diabetes
    • Lipscombe, L.L., Gomes, T., Levesque, L.E., Hux, J.E., Juurlink, D.N., Alter, D.A., Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA 298 (2007), 2634–2643.
    • (2007) JAMA , vol.298 , pp. 2634-2643
    • Lipscombe, L.L.1    Gomes, T.2    Levesque, L.E.3    Hux, J.E.4    Juurlink, D.N.5    Alter, D.A.6
  • 40
    • 77954988618 scopus 로고    scopus 로고
    • Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
    • Graham, D.J., Ouellet-Hellstrom, R., MaCurdy, T.E., et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. JAMA 304 (2010), 411–418.
    • (2010) JAMA , vol.304 , pp. 411-418
    • Graham, D.J.1    Ouellet-Hellstrom, R.2    MaCurdy, T.E.3
  • 41
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen, S.E., Wolski, K., Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356 (2007), 2457–2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 42
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis
    • Singh, S., Loke, Y.K., Furberg, C.D., Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA 298 (2007), 1189–1195.
    • (2007) JAMA , vol.298 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 43
    • 50249179311 scopus 로고    scopus 로고
    • A retrospective evaluation of congestive heart failure and myocardial ischemia events in 14,237 patients with type 2 diabetes mellitus enrolled in 42 short-term, double-blind, randomized clinical studies with rosiglitazone
    • Cobitz, A., Zambanini, A., Sowell, M., et al. A retrospective evaluation of congestive heart failure and myocardial ischemia events in 14,237 patients with type 2 diabetes mellitus enrolled in 42 short-term, double-blind, randomized clinical studies with rosiglitazone. Pharmacoepidemiol Drug Saf 17 (2008), 769–781.
    • (2008) Pharmacoepidemiol Drug Saf , vol.17 , pp. 769-781
    • Cobitz, A.1    Zambanini, A.2    Sowell, M.3
  • 44
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    • Home, P.D., Pocock, S.J., Beck-Nielsen, H., et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 373 (2009), 2125–2135.
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3
  • 45
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    • Dormandy, J.A., Charbonnel, B., Eckland, D.J., et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366 (2005), 1279–1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 46
    • 84962114446 scopus 로고    scopus 로고
    • Pioglitazone after ischemic stroke or transient ischemic attack
    • Kernan, W.N., Viscoli, C.M., Furie, K.L., et al. Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med 374 (2016), 1321–1331.
    • (2016) N Engl J Med , vol.374 , pp. 1321-1331
    • Kernan, W.N.1    Viscoli, C.M.2    Furie, K.L.3
  • 47
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • Marso, S.P., Daniels, G.H., Brown-Frandsen, K., et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375 (2016), 311–322.
    • (2016) N Engl J Med , vol.375 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Brown-Frandsen, K.3
  • 48
    • 84994813253 scopus 로고    scopus 로고
    • Semaglutide and cardiovascular outcomes in patients with type 2 iabetes
    • Marso, S.P., Bain, S.C., Consoli, A., et al. Semaglutide and cardiovascular outcomes in patients with type 2 iabetes. N Engl J Med 375 (2016), 1834–1844.
    • (2016) N Engl J Med , vol.375 , pp. 1834-1844
    • Marso, S.P.1    Bain, S.C.2    Consoli, A.3
  • 49
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman, B., Wanner, C., Lachin, J.M., et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373 (2015), 2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 50
    • 84898614282 scopus 로고    scopus 로고
    • Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial
    • Lincoff, A.M., Tardif, J.C., Schwartz, G.G., et al. Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial. JAMA 311 (2014), 1515–1525.
    • (2014) JAMA , vol.311 , pp. 1515-1525
    • Lincoff, A.M.1    Tardif, J.C.2    Schwartz, G.G.3
  • 51
    • 84930625640 scopus 로고    scopus 로고
    • DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition
    • Zhong, J., Maiseyeu, A., Davis, S.N., Rajagopalan, S., DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition. Circ Res 116 (2015), 1491–1504.
    • (2015) Circ Res , vol.116 , pp. 1491-1504
    • Zhong, J.1    Maiseyeu, A.2    Davis, S.N.3    Rajagopalan, S.4
  • 52
    • 84873099484 scopus 로고    scopus 로고
    • Cardiovascular effects of gliptins
    • Scheen, A.J., Cardiovascular effects of gliptins. Nat Rev Cardiol 10 (2013), 73–84.
    • (2013) Nat Rev Cardiol , vol.10 , pp. 73-84
    • Scheen, A.J.1
  • 53
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica, B.M., Bhatt, D.L., Braunwald, E., et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 369 (2013), 1317–1326.
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 54
    • 84930085787 scopus 로고    scopus 로고
    • Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
    • Zannad, F., Cannon, C.P., Cushman, W.C., et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet 385 (2015), 2067–2076.
    • (2015) Lancet , vol.385 , pp. 2067-2076
    • Zannad, F.1    Cannon, C.P.2    Cushman, W.C.3
  • 55
    • 84937053742 scopus 로고    scopus 로고
    • Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
    • Green, J.B., Bethel, M.A., Armstrong, P.W., et al. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med 373 (2015), 232–242.
    • (2015) N Engl J Med , vol.373 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3
  • 56
    • 84963764907 scopus 로고    scopus 로고
    • DPP-4 inhibitors, heart failure and type 2 diabetes: all eyes on safety
    • Paneni, F., DPP-4 inhibitors, heart failure and type 2 diabetes: all eyes on safety. Cardiovasc Diagn Ther 5 (2015), 471–478.
    • (2015) Cardiovasc Diagn Ther , vol.5 , pp. 471-478
    • Paneni, F.1
  • 57
    • 84929942240 scopus 로고    scopus 로고
    • DPP-4 inhibitors and risk of heart failure EXAMINEd
    • Standl, E., Schnell, O., DPP-4 inhibitors and risk of heart failure EXAMINEd. Lancet 385 (2015), 2022–2024.
    • (2015) Lancet , vol.385 , pp. 2022-2024
    • Standl, E.1    Schnell, O.2
  • 58
    • 84928699536 scopus 로고    scopus 로고
    • Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials
    • Udell, J.A., Cavender, M.A., Bhatt, D.L., Chatterjee, S., Farkouh, M.E., Scirica, B.M., Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol 3 (2015), 356–366.
    • (2015) Lancet Diabetes Endocrinol , vol.3 , pp. 356-366
    • Udell, J.A.1    Cavender, M.A.2    Bhatt, D.L.3    Chatterjee, S.4    Farkouh, M.E.5    Scirica, B.M.6
  • 59
    • 85021438535 scopus 로고    scopus 로고
    • Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: secondary analysis of a randomized clinical trial
    • McGuire, D.K., Van de Werf, F., Armstrong, P.W., et al. Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: secondary analysis of a randomized clinical trial. JAMA Cardiol 1 (2016), 126–135.
    • (2016) JAMA Cardiol , vol.1 , pp. 126-135
    • McGuire, D.K.1    Van de Werf, F.2    Armstrong, P.W.3
  • 60
    • 85007017847 scopus 로고    scopus 로고
    • Glucagon like peptide-1 and its receptor agonists: their roles in management of type 2 diabetes mellitus
    • [Epub ahead of print]. doi:
    • Gupta, A., Jelinek, H.F., Al-Aubaidy, H., Glucagon like peptide-1 and its receptor agonists: their roles in management of type 2 diabetes mellitus. Diabetes Metab Syndr, 2016 [Epub ahead of print]. doi: 10.1016/j.dsx.2016.09.003.
    • (2016) Diabetes Metab Syndr
    • Gupta, A.1    Jelinek, H.F.2    Al-Aubaidy, H.3
  • 61
    • 84996917635 scopus 로고    scopus 로고
    • Efficacy and safety of insulin-GLP-1 receptor agonists combination in type 2 diabetes mellitus: a systematic review
    • Cimmaruta, D., Maiorino, M.I., Scavone, C., et al. Efficacy and safety of insulin-GLP-1 receptor agonists combination in type 2 diabetes mellitus: a systematic review. Expert Opin Drug Saf 15 (2016), 77–83.
    • (2016) Expert Opin Drug Saf , vol.15 , pp. 77-83
    • Cimmaruta, D.1    Maiorino, M.I.2    Scavone, C.3
  • 62
    • 80054090833 scopus 로고    scopus 로고
    • Effects of exenatide on measures of beta-cell function after 3 years in metformin-treated patients with type 2 diabetes
    • Bunck, M.C., Corner, A., Eliasson, B., et al. Effects of exenatide on measures of beta-cell function after 3 years in metformin-treated patients with type 2 diabetes. Diabetes Care 34 (2011), 2041–2047.
    • (2011) Diabetes Care , vol.34 , pp. 2041-2047
    • Bunck, M.C.1    Corner, A.2    Eliasson, B.3
  • 63
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban, K., Noyan-Ashraf, M.H., Hoefer, J., Bolz, S.S., Drucker, D.J., Husain, M., Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 117 (2008), 2340–2350.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 64
    • 84992358035 scopus 로고    scopus 로고
    • The cardiovascular biology of glucagon-like peptide-1
    • Drucker, D.J., The cardiovascular biology of glucagon-like peptide-1. Cell Metab 24 (2016), 15–30.
    • (2016) Cell Metab , vol.24 , pp. 15-30
    • Drucker, D.J.1
  • 65
    • 78650733949 scopus 로고    scopus 로고
    • Cardiovascular comorbidities of type 2 diabetes mellitus: defining the potential of glucagonlike peptide-1-based therapies
    • Chilton, R., Wyatt, J., Nandish, S., Oliveros, R., Lujan, M., Cardiovascular comorbidities of type 2 diabetes mellitus: defining the potential of glucagonlike peptide-1-based therapies. Am J Med 124 (2011), S35–S53.
    • (2011) Am J Med , vol.124 , pp. S35-S53
    • Chilton, R.1    Wyatt, J.2    Nandish, S.3    Oliveros, R.4    Lujan, M.5
  • 66
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos, G.G., Nikolaidis, L.A., Mankad, S., Elahi, D., Shannon, R.P., Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 12 (2006), 694–699.
    • (2006) J Card Fail , vol.12 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 67
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis, L.A., Mankad, S., Sokos, G.G., et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 109 (2004), 962–965.
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3
  • 68
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • Lonborg, J., Vejlstrup, N., Kelbaek, H., et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur Heart J 33 (2012), 1491–1499.
    • (2012) Eur Heart J , vol.33 , pp. 1491-1499
    • Lonborg, J.1    Vejlstrup, N.2    Kelbaek, H.3
  • 69
    • 84948740668 scopus 로고    scopus 로고
    • Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • Pfeffer, M.A., Claggett, B., Diaz, R., et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373 (2015), 2247–2257.
    • (2015) N Engl J Med , vol.373 , pp. 2247-2257
    • Pfeffer, M.A.1    Claggett, B.2    Diaz, R.3
  • 70
    • 85006241166 scopus 로고    scopus 로고
    • Following the LEADER - why this and other recent trials signal a major paradigm shift in the management of type 2 diabetes
    • Kosiborod, M., Following the LEADER - why this and other recent trials signal a major paradigm shift in the management of type 2 diabetes. J Diabetes Complications 31:2 (2017), 517–519.
    • (2017) J Diabetes Complications , vol.31 , Issue.2 , pp. 517-519
    • Kosiborod, M.1
  • 71
    • 84983452534 scopus 로고    scopus 로고
    • Sodium glucose CoTransporter 2 (SGLT2) inhibitors: current status and future perspective
    • Madaan, T., Akhtar, M., Najmi, A.K., Sodium glucose CoTransporter 2 (SGLT2) inhibitors: current status and future perspective. Eur J Pharm Sci 93 (2016), 244–252.
    • (2016) Eur J Pharm Sci , vol.93 , pp. 244-252
    • Madaan, T.1    Akhtar, M.2    Najmi, A.K.3
  • 72
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • Abdul-Ghani, M.A., Norton, L., Defronzo, R.A., Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev 32 (2011), 515–531.
    • (2011) Endocr Rev , vol.32 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 73
    • 85047287122 scopus 로고    scopus 로고
    • Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease
    • Sanchez, R.A., Sanabria, H., de Los Santos, C., Ramirez, A.J., Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease. World J Diabetes 6 (2015), 1186–1197.
    • (2015) World J Diabetes , vol.6 , pp. 1186-1197
    • Sanchez, R.A.1    Sanabria, H.2    de Los Santos, C.3    Ramirez, A.J.4
  • 74
    • 84975698839 scopus 로고    scopus 로고
    • Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME trial
    • Fitchett, D., Zinman, B., Wanner, C., et al. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME trial. Eur Heart J 37 (2016), 1526–1534.
    • (2016) Eur Heart J , vol.37 , pp. 1526-1534
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3
  • 75
    • 84991665527 scopus 로고    scopus 로고
    • Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: focus on SGLT2 inhibitors and EMPA-REG OUTCOME
    • Scheen, A.J., Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: focus on SGLT2 inhibitors and EMPA-REG OUTCOME. Diabetes Res Clin Pract 121 (2016), 204–214.
    • (2016) Diabetes Res Clin Pract , vol.121 , pp. 204-214
    • Scheen, A.J.1
  • 76
    • 84975853831 scopus 로고    scopus 로고
    • CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis
    • Ferrannini, E., Mark, M., Mayoux, E., CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis. Diabetes Care 39 (2016), 1108–1114.
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 77
    • 84995814726 scopus 로고    scopus 로고
    • Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors in patients with type II diabetes mellitus: a meta-analysis of placebo-controlled randomized trials
    • Saad, M., Mahmoud, A.N., Elgendy, I.Y., et al. Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors in patients with type II diabetes mellitus: a meta-analysis of placebo-controlled randomized trials. Int J Cardiol 228 (2017), 352–358.
    • (2017) Int J Cardiol , vol.228 , pp. 352-358
    • Saad, M.1    Mahmoud, A.N.2    Elgendy, I.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.