BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancerinitiating cells

Oncotarget

Volumn 8, Issue 21, 2017, Pages 35019-35032

  Cuyàs, Elisabet ^a,b   Corominas Faja, Bruna ^a,b   Martín, María Muñoz San ^b   Martin Castillo, Begoña ^a,b   Lupu, Ruth ^c,d   Brunet, Joan ^a,e   Bosch Barrera, Joaquim ^a,e   Menendez, Javier A ^a,b  

^a CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^b GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^c MAYO CLINIC   (United States)

^d MAYO CLINIC CANCER CENTER   (United States)

^e UNIVERSITY OF GIRONA   (Spain)

Author keywords

BRCA1; Cancer stem cells; Denosumab; RANK; RANKL

Indexed keywords

DENOSUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; OSTEOCLAST DIFFERENTIATION FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; ZOLEDRONIC ACID; BRCA1 PROTEIN; BRCA1 PROTEIN, HUMAN; TNFRSF11A PROTEIN, HUMAN; TNFSF11 PROTEIN, HUMAN;

ALLELE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CANCER CLASSIFICATION; CANCER STEM CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; GENE INACTIVATION; GENE MUTATION; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; OSTEOCLASTOGENESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; UPREGULATION; BREAST TUMOR; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MCF-7 CELL LINE; METABOLISM; TUMOR CELL LINE;

BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DENOSUMAB; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HAPLOINSUFFICIENCY; HUMANS; MCF-7 CELLS; NEOPLASTIC STEM CELLS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; UP-REGULATION;

EID: 85019963624     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16558     Document Type: Article

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