메뉴 건너뛰기




Volumn 48, Issue 1, 2017, Pages

Innate immune responses induced by the saponin adjuvant Matrix-M in specific pathogen free pigs

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; B7 ANTIGEN; BETA INTERFERON; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CHEMOKINE RECEPTOR CCR1; COMPLEMENT COMPONENT C3; CRYOPYRIN; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE 2; MYELOID DIFFERENTIATION FACTOR 88; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; SAPONIN DERIVATIVE; SERUM AMYLOID A; STAT3 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; CYTOKINE; IMMUNOLOGICAL ADJUVANT; MATRIX-M; NANOPARTICLE; SAPONIN;

EID: 85019846325     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1186/s13567-017-0437-2     Document Type: Article
Times cited : (14)

References (61)
  • 1
    • 84955196539 scopus 로고    scopus 로고
    • Saponins as immunoadjuvant agent: a review
    • de Paula Barbosa A (2014) Saponins as immunoadjuvant agent: a review. Afr J Pharm Pharmacol 8:1049-1057
    • (2014) Afr J Pharm Pharmacol , vol.8 , pp. 1049-1057
    • De Paula Barbosa, A.1
  • 2
    • 77950652380 scopus 로고    scopus 로고
    • Immune mechanisms of protection: can adjuvants rise to the challenge?
    • 20385031 2864095
    • McKee AS, MacLeod MK, Kappler JW, Marrack P (2010) Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol 8:37
    • (2010) BMC Biol , vol.8 , pp. 37
    • McKee, A.S.1    MacLeod, M.K.2    Kappler, J.W.3    Marrack, P.4
  • 3
    • 61349084783 scopus 로고    scopus 로고
    • Advances in saponin-based adjuvants
    • 1:CAS:528:DC%2BD1MXivVWktr8%3D 19208455
    • Sun HX, Xie Y, Ye YP (2009) Advances in saponin-based adjuvants. Vaccine 27:1787-1796
    • (2009) Vaccine , vol.27 , pp. 1787-1796
    • Sun, H.X.1    Xie, Y.2    Ye, Y.P.3
  • 4
    • 34247117348 scopus 로고    scopus 로고
    • Adjuvant effects of saponins on animal immune responses
    • 1:CAS:528:DC%2BD2sXksVOltr0%3D 17323426 1810383
    • Rajput ZI, Hu SH, Xiao CW, Arijo AG (2007) Adjuvant effects of saponins on animal immune responses. J Zhejiang Univ Sci B 8:153-161
    • (2007) J Zhejiang Univ Sci B , vol.8 , pp. 153-161
    • Rajput, Z.I.1    Hu, S.H.2    Xiao, C.W.3    Arijo, A.G.4
  • 5
    • 2942513672 scopus 로고    scopus 로고
    • Current status and potential application of ISCOMs in veterinary medicine
    • 1:CAS:528:DC%2BD2cXkvVCrt7g%3D 15191787
    • Morein B, Hu KF, Abusugra I (2004) Current status and potential application of ISCOMs in veterinary medicine. Adv Drug Deliv Rev 56:1367-1382
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1367-1382
    • Morein, B.1    Hu, K.F.2    Abusugra, I.3
  • 6
    • 0023882657 scopus 로고
    • The requirement of lipids for the formation of immunostimulating complexes (ISCOMS)
    • 2838046
    • Lövgren K, Morein B (1988) The requirement of lipids for the formation of immunostimulating complexes (ISCOMS). Biotechnol Appl Biochem 10:161-172
    • (1988) Biotechnol Appl Biochem , vol.10 , pp. 161-172
    • Lövgren, K.1    Morein, B.2
  • 7
    • 84908461841 scopus 로고    scopus 로고
    • Matrix M(TM) adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man
    • 1:CAS:528:DC%2BC2MXosV2nsw%3D%3D
    • Pedersen GK, Sjursen H, Nøstbakken JK, Jul-Larsen Å, Hoschler K, Cox RJ (2014) Matrix M(TM) adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man. Hum Vaccines Immunother 10:2408-2416
    • (2014) Hum Vaccines Immunother , vol.10 , pp. 2408-2416
    • Pedersen, G.K.1    Sjursen, H.2    Nøstbakken, J.K.3    Jul-Larsen, Å.4    Hoschler, K.5    Cox, R.J.6
  • 8
    • 84887457989 scopus 로고    scopus 로고
    • Coadministration of polyinosinic: polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity
    • 1:CAS:528:DC%2BC3sXhslWlsLzP 24089189 4100557
    • Quinn KM, Yamamoto A, Costa A, Darrah PA, Lindsay RW, Hegde ST et al (2013) Coadministration of polyinosinic: polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity. J Immunol 191:5085-5089
    • (2013) J Immunol , vol.191 , pp. 5085-5089
    • Quinn, K.M.1    Yamamoto, A.2    Costa, A.3    Darrah, P.A.4    Lindsay, R.W.5    Hegde, S.T.6
  • 9
    • 70649084044 scopus 로고    scopus 로고
    • Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice
    • 1:CAS:528:DC%2BD1MXhsFShurrO 19781678
    • Madhun AS, Haaheim LR, Nilsen MV, Cox RJ (2009) Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice. Vaccine 27:7367-7376
    • (2009) Vaccine , vol.27 , pp. 7367-7376
    • Madhun, A.S.1    Haaheim, L.R.2    Nilsen, M.V.3    Cox, R.J.4
  • 10
    • 84961050529 scopus 로고    scopus 로고
    • Matrix-M adjuvant enhances antibody, cellular and protective immune responses of a Zaire Ebola/Makona virus glycoprotein (GP) nanoparticle vaccine in mice
    • 1:CAS:528:DC%2BC28XjtFOnsL8%3D 26921779
    • Bengtsson KL, Song H, Stertman L, Liu Y, Flyer DC, Massare MJ et al (2016) Matrix-M adjuvant enhances antibody, cellular and protective immune responses of a Zaire Ebola/Makona virus glycoprotein (GP) nanoparticle vaccine in mice. Vaccine 34:1927-1935
    • (2016) Vaccine , vol.34 , pp. 1927-1935
    • Bengtsson, K.L.1    Song, H.2    Stertman, L.3    Liu, Y.4    Flyer, D.C.5    Massare, M.J.6
  • 11
    • 0025797566 scopus 로고
    • Evaluation of glycoprotein gII ISCOMs subunit vaccine for pseudorabies in pig
    • 1:CAS:528:DyaK38XhslWktL8%3D 1659053
    • Tsuda T, Sugimura T, Murakami Y (1991) Evaluation of glycoprotein gII ISCOMs subunit vaccine for pseudorabies in pig. Vaccine 9:648-652
    • (1991) Vaccine , vol.9 , pp. 648-652
    • Tsuda, T.1    Sugimura, T.2    Murakami, Y.3
  • 12
    • 10744228649 scopus 로고    scopus 로고
    • Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM
    • 15008967 1808978
    • González AM, Nguyen TV, Azevedo MS, Jeong K, Agarib F, Iosef C et al (2004) Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM. Clin Exp Immunol 135:361-372
    • (2004) Clin Exp Immunol , vol.135 , pp. 361-372
    • González, A.M.1    Nguyen, T.V.2    Azevedo, M.S.3    Jeong, K.4    Agarib, F.5    Iosef, C.6
  • 13
    • 0037086488 scopus 로고    scopus 로고
    • Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes
    • 1:CAS:528:DC%2BD38XitFamtro%3D 11906761
    • Iosef C, Van Nguyen T, Jeong K, Bengtsson KL, Morein B, Kim Y et al (2002) Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes. Vaccine 20:1741-1753
    • (2002) Vaccine , vol.20 , pp. 1741-1753
    • Iosef, C.1    Van Nguyen, T.2    Jeong, K.3    Bengtsson, K.L.4    Morein, B.5    Kim, Y.6
  • 14
    • 20244372106 scopus 로고    scopus 로고
    • Partial protection against tissue cysts formation in pigs vaccinated with crude rhoptry proteins of Toxoplasma gondii
    • 1:CAS:528:DC%2BD2MXjsVemsr4%3D 15845275
    • Garcia JL, Gennari SM, Navarro IT, Machado RZ, Sinhorini IL, Freire RL et al (2005) Partial protection against tissue cysts formation in pigs vaccinated with crude rhoptry proteins of Toxoplasma gondii. Vet Parasitol 129:209-217
    • (2005) Vet Parasitol , vol.129 , pp. 209-217
    • Garcia, J.L.1    Gennari, S.M.2    Navarro, I.T.3    Machado, R.Z.4    Sinhorini, I.L.5    Freire, R.L.6
  • 15
    • 84895909096 scopus 로고    scopus 로고
    • Protective efficacy of a live attenuated Mycoplasma hyopneumoniae vaccine with an ISCOM-matrix adjuvant in pigs
    • 1:CAS:528:DC%2BC3sXitVWjs7fJ 24314715
    • Xiong Q, Wei Y, Feng Z, Gan Y, Liu Z, Liu M et al (2014) Protective efficacy of a live attenuated Mycoplasma hyopneumoniae vaccine with an ISCOM-matrix adjuvant in pigs. Vet J 199:268-274
    • (2014) Vet J , vol.199 , pp. 268-274
    • Xiong, Q.1    Wei, Y.2    Feng, Z.3    Gan, Y.4    Liu, Z.5    Liu, M.6
  • 16
    • 84864351310 scopus 로고    scopus 로고
    • Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs
    • 1:CAS:528:DC%2BC38XosFWltLc%3D 22426325
    • Ahlberg V, Bengtsson KL, Wallgren P, Fossum C (2012) Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs. Dev Comp Immunol 38:17-26
    • (2012) Dev Comp Immunol , vol.38 , pp. 17-26
    • Ahlberg, V.1    Bengtsson, K.L.2    Wallgren, P.3    Fossum, C.4
  • 17
    • 84875237349 scopus 로고    scopus 로고
    • Immune enhancing properties of the novel Matrix-M adjuvant leads to potentiated immune responses to an influenza vaccine in mice
    • Magnusson SE, Reimer JM, Karlsson KH, Lilja L, Bengtsson KL, Stertman L (2012) Immune enhancing properties of the novel Matrix-M adjuvant leads to potentiated immune responses to an influenza vaccine in mice. Vaccine 31:1725-1733
    • (2012) Vaccine , vol.31 , pp. 1725-1733
    • Magnusson, S.E.1    Reimer, J.M.2    Karlsson, K.H.3    Lilja, L.4    Bengtsson, K.L.5    Stertman, L.6
  • 18
    • 84864241231 scopus 로고    scopus 로고
    • Matrix-M adjuvant induces local recruitment, activation and maturation of central immune cells in absence of antigen
    • 1:CAS:528:DC%2BC38XhtFWisrfL 22844480 3402407
    • Reimer JM, Karlsson KH, Bengtsson KL, Magnusson SE, Fuentes A, Stertman L (2012) Matrix-M adjuvant induces local recruitment, activation and maturation of central immune cells in absence of antigen. PLoS One 7:e41451
    • (2012) PLoS One , vol.7 , pp. e41451
    • Reimer, J.M.1    Karlsson, K.H.2    Bengtsson, K.L.3    Magnusson, S.E.4    Fuentes, A.5    Stertman, L.6
  • 19
    • 84989298049 scopus 로고    scopus 로고
    • Transient migration of large numbers of CD14(++) CD16(+) monocytes to the draining lymph node after onset of inflammation
    • 27621730 5002921
    • Lund H, Boysen P, Åkesson CP, Lewandowska-Sabat AM, Storset AK (2016) Transient migration of large numbers of CD14(++) CD16(+) monocytes to the draining lymph node after onset of inflammation. Front Immunol 7:322
    • (2016) Front Immunol , vol.7 , pp. 322
    • Lund, H.1    Boysen, P.2    Åkesson, C.P.3    Lewandowska-Sabat, A.M.4    Storset, A.K.5
  • 21
    • 84975761138 scopus 로고    scopus 로고
    • Immunoprophylaxis in intensive farming systems: the way forward
    • 1:CAS:528:DC%2BC28Xjt1Oltbg%3D 26923880
    • Amadori M, Zanotti C (2016) Immunoprophylaxis in intensive farming systems: the way forward. Vet Immunol Immunopathol 181:2-9
    • (2016) Vet Immunol Immunopathol , vol.181 , pp. 2-9
    • Amadori, M.1    Zanotti, C.2
  • 22
    • 84949655937 scopus 로고    scopus 로고
    • Immune control of PRRS: lessons to be learned and possible ways forward
    • 26664910 4668844
    • Amadori M, Razzuoli E (2014) Immune control of PRRS: lessons to be learned and possible ways forward. Front Vet Sci 1:2
    • (2014) Front Vet Sci , vol.1 , pp. 2
    • Amadori, M.1    Razzuoli, E.2
  • 23
    • 46049118651 scopus 로고    scopus 로고
    • Use of oromucosally administered interferon-alpha in the prevention and treatment of animal diseases
    • 1:CAS:528:DC%2BD1cXht1ems77L 18683548
    • Dec M, Puchalski A (2008) Use of oromucosally administered interferon-alpha in the prevention and treatment of animal diseases. Pol J Vet Sci 11:175-186
    • (2008) Pol J Vet Sci , vol.11 , pp. 175-186
    • Dec, M.1    Puchalski, A.2
  • 25
    • 42949128589 scopus 로고    scopus 로고
    • Dietary modulation of immune function by beta-glucans
    • 1:CAS:528:DC%2BD1cXlslyjs7o%3D 18222501
    • Volman JJ, Ramakers JD, Plat J (2008) Dietary modulation of immune function by beta-glucans. Physiol Behav 94:276-284
    • (2008) Physiol Behav , vol.94 , pp. 276-284
    • Volman, J.J.1    Ramakers, J.D.2    Plat, J.3
  • 26
    • 84859960834 scopus 로고    scopus 로고
    • Emergency and therapeutic vaccination - is stimulating innate immunity an option?
    • 1:STN:280:DC%2BC38zms1yntA%3D%3D 22015261
    • Foster N, Berndt A, Lalmanach AC, Methner U, Pasquali P, Rychlik I et al (2012) Emergency and therapeutic vaccination - is stimulating innate immunity an option? Res Vet Sci 93:7-12
    • (2012) Res Vet Sci , vol.93 , pp. 7-12
    • Foster, N.1    Berndt, A.2    Lalmanach, A.C.3    Methner, U.4    Pasquali, P.5    Rychlik, I.6
  • 27
  • 28
    • 84977602153 scopus 로고    scopus 로고
    • Unravelling the nature of non-specific effects of vaccines - a challenge for innate immunologists
    • 1:CAS:528:DC%2BC28XhtV2gtbrO 27354354
    • Jensen KJ, Benn CS, van Crevel R (2016) Unravelling the nature of non-specific effects of vaccines - a challenge for innate immunologists. Semin Immunol 28:377-383
    • (2016) Semin Immunol , vol.28 , pp. 377-383
    • Jensen, K.J.1    Benn, C.S.2    Van Crevel, R.3
  • 29
    • 0037429188 scopus 로고    scopus 로고
    • Characterisation of porcine monocyte-derived dendritic cells according to their cytokine profile
    • 1:CAS:528:DC%2BD3sXhtVCgtb0%3D 12586481
    • Johansson E, Domeika K, Berg M, Alm GV, Fossum C (2003) Characterisation of porcine monocyte-derived dendritic cells according to their cytokine profile. Vet Immunol Immunopathol 91:183-197
    • (2003) Vet Immunol Immunopathol , vol.91 , pp. 183-197
    • Johansson, E.1    Domeika, K.2    Berg, M.3    Alm, G.V.4    Fossum, C.5
  • 30
    • 84855978888 scopus 로고    scopus 로고
    • Effects of different antimicrobial treatments on serum acute phase responses and leucocyte counts in pigs after a primary and a secondary challenge infection with Actinobacillus pleuropneumoniae
    • 21737462
    • Sjölund M, Fossum C, Martín de la Fuente AJ, Alava M, Juul-Madsen HR, Lampreave F et al (2011) Effects of different antimicrobial treatments on serum acute phase responses and leucocyte counts in pigs after a primary and a secondary challenge infection with Actinobacillus pleuropneumoniae. Vet Rec 169:70
    • (2011) Vet Rec , vol.169 , pp. 70
    • Sjölund, M.1    Fossum, C.2    Martín de La Fuente, A.J.3    Alava, M.4    Juul-Madsen, H.R.5    Lampreave, F.6
  • 31
    • 78650892217 scopus 로고    scopus 로고
    • Cytokine induction by immunostimulatory DNA in porcine PBMC is impaired by a hairpin forming sequence motif from the genome of Porcine circovirus type 2 (PCV2)
    • 20980058
    • Wikström FH, Fossum C, Fuxler L, Kruse R, Lövgren T (2011) Cytokine induction by immunostimulatory DNA in porcine PBMC is impaired by a hairpin forming sequence motif from the genome of Porcine circovirus type 2 (PCV2). Vet Immunol Immunopathol 139:156-166
    • (2011) Vet Immunol Immunopathol , vol.139 , pp. 156-166
    • Wikström, F.H.1    Fossum, C.2    Fuxler, L.3    Kruse, R.4    Lövgren, T.5
  • 32
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • 12184808 126239 RESEARCH0034
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A et al (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6
  • 33
    • 68549122709 scopus 로고    scopus 로고
    • Development of primer-probe energy transfer real-time PCR for the detection and quantification of Porcine circovirus type 2
    • 19635716
    • Bálint A, Tenk M, Deim Z, Rasmussen TB, Uttenthal A, Csagola A et al (2009) Development of primer-probe energy transfer real-time PCR for the detection and quantification of Porcine circovirus type 2. Acta Vet Hung 57:441-452
    • (2009) Acta Vet Hung , vol.57 , pp. 441-452
    • Bálint, A.1    Tenk, M.2    Deim, Z.3    Rasmussen, T.B.4    Uttenthal, A.5    Csagola, A.6
  • 34
    • 0034485480 scopus 로고    scopus 로고
    • Relationship between the amounts of antibodies to Actinobacillus pleuropneumoniae serotype 2 detected in blood serum and in fluids collected from muscles of pigs
    • 1:STN:280:DC%2BD3M7lsV2rsA%3D%3D
    • Wallgren P, Persson M (2000) Relationship between the amounts of antibodies to Actinobacillus pleuropneumoniae serotype 2 detected in blood serum and in fluids collected from muscles of pigs. J Vet Med B Infect Vet Public Health 47:727-737
    • (2000) J Vet Med B Infect Vet Public Health , vol.47 , pp. 727-737
    • Wallgren, P.1    Persson, M.2
  • 35
    • 84905397553 scopus 로고    scopus 로고
    • IL-12 and IL-18 induce interferon-γ production and de novo CD2 expression in porcine γδ T cells
    • 1:CAS:528:DC%2BC2cXhtlahsbfN 25036760
    • Sedlak C, Patzl M, Saalmüller A, Gerner W (2014) IL-12 and IL-18 induce interferon-γ production and de novo CD2 expression in porcine γδ T cells. Dev Comp Immunol 47:115-122
    • (2014) Dev Comp Immunol , vol.47 , pp. 115-122
    • Sedlak, C.1    Patzl, M.2    Saalmüller, A.3    Gerner, W.4
  • 36
    • 84859216477 scopus 로고    scopus 로고
    • CD4+ and γδTCR+ T lymphocytes are sources of interleukin-17 in swine
    • 1:CAS:528:DC%2BC38XitVWqu7o%3D 22321808
    • Stepanova H, Mensikova M, Chlebova K, Faldyna M (2012) CD4+ and γδTCR+ T lymphocytes are sources of interleukin-17 in swine. Cytokine 58:152-157
    • (2012) Cytokine , vol.58 , pp. 152-157
    • Stepanova, H.1    Mensikova, M.2    Chlebova, K.3    Faldyna, M.4
  • 37
    • 60649102809 scopus 로고    scopus 로고
    • Performance of the whole-blood stimulation assay for assessing innate immune activation under field conditions
    • 1:CAS:528:DC%2BD1MXis1Cht7Y%3D 19185506
    • May L, van Bodegom D, Kuningas M, Meij JJ, de Craen AJM, Frölich M et al (2009) Performance of the whole-blood stimulation assay for assessing innate immune activation under field conditions. Cytokine 45:184-189
    • (2009) Cytokine , vol.45 , pp. 184-189
    • May, L.1    Van Bodegom, D.2    Kuningas, M.3    Meij, J.J.4    De Craen, A.J.M.5    Frölich, M.6
  • 38
    • 78650175744 scopus 로고    scopus 로고
    • In vitro identification and verification of inflammatory biomarkers in swine
    • 1:CAS:528:DC%2BC3cXhsF2isLbL 20828834
    • Peters SM, Yancy H, Bremer E, Monroe J, Paul D, Stubbs JT 3rd et al (2011) In vitro identification and verification of inflammatory biomarkers in swine. Vet Immunol Immunopathol 139:67-72
    • (2011) Vet Immunol Immunopathol , vol.139 , pp. 67-72
    • Peters, S.M.1    Yancy, H.2    Bremer, E.3    Monroe, J.4    Paul, D.5    Stubbs, J.T.6
  • 39
    • 0035834972 scopus 로고    scopus 로고
    • The plasmid pcDNA3 differentially induces production of interferon-alpha and interleukin-6 in cultures of porcine leukocytes
    • 1:CAS:528:DC%2BD3MXhtFarsbc%3D 11182147
    • Magnusson M, Johansson E, Berg M, Eloranta ML, Fuxler L, Fossum C (2001) The plasmid pcDNA3 differentially induces production of interferon-alpha and interleukin-6 in cultures of porcine leukocytes. Vet Immunol Immunopathol 78:45-56
    • (2001) Vet Immunol Immunopathol , vol.78 , pp. 45-56
    • Magnusson, M.1    Johansson, E.2    Berg, M.3    Eloranta, M.L.4    Fuxler, L.5    Fossum, C.6
  • 40
    • 0030797056 scopus 로고    scopus 로고
    • Tissue chambers - a useful model for in vivo studies of cytokine production in the pig
    • 1:CAS:528:DyaK2sXktVagsrc%3D 9220587
    • Wattrang E, Wallgren P, Fuxler L, Lindersson M, Fossum C (1997) Tissue chambers - a useful model for in vivo studies of cytokine production in the pig. Vet Immunol Immunopathol 56:133-150
    • (1997) Vet Immunol Immunopathol , vol.56 , pp. 133-150
    • Wattrang, E.1    Wallgren, P.2    Fuxler, L.3    Lindersson, M.4    Fossum, C.5
  • 41
    • 84861661926 scopus 로고    scopus 로고
    • ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway
    • 1:CAS:528:DC%2BC38XnvFCitLo%3D 21894173
    • Wilson NS, Yang B, Morelli AB, Koernig S, Yang A, Loeser S et al (2012) ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway. Immunol Cell Biol 90:540-552
    • (2012) Immunol Cell Biol , vol.90 , pp. 540-552
    • Wilson, N.S.1    Yang, B.2    Morelli, A.B.3    Koernig, S.4    Yang, A.5    Loeser, S.6
  • 42
    • 44449092493 scopus 로고    scopus 로고
    • Changes in haptoglobin, C-reactive protein and pig-MAP during a housing period following long distance transport in swine
    • 1:CAS:528:DC%2BD1cXmvVOnsrY%3D 17509918
    • Salamano G, Mellia E, Candiani D, Ingravalle F, Bruno R, Ru G et al (2008) Changes in haptoglobin, C-reactive protein and pig-MAP during a housing period following long distance transport in swine. Vet J 177:110-115
    • (2008) Vet J , vol.177 , pp. 110-115
    • Salamano, G.1    Mellia, E.2    Candiani, D.3    Ingravalle, F.4    Bruno, R.5    Ru, G.6
  • 44
    • 84946925126 scopus 로고    scopus 로고
    • Time course of the response to ACTH in pig: biological and transcriptomic study
    • 26578410 4650497
    • Sautron V, Terenina E, Gress L, Lippi Y, Billon Y, Larzul C et al (2015) Time course of the response to ACTH in pig: biological and transcriptomic study. BMC Genomics 16:961
    • (2015) BMC Genomics , vol.16 , pp. 961
    • Sautron, V.1    Terenina, E.2    Gress, L.3    Lippi, Y.4    Billon, Y.5    Larzul, C.6
  • 47
    • 39049107089 scopus 로고    scopus 로고
    • Expression of toll-like receptor 2 (TLR2) in porcine leukocyte subsets and tissues
    • 18096121
    • Alvarez B, Revilla C, Domenech N, Pérez C, Martínez P, Alonso F et al (2008) Expression of toll-like receptor 2 (TLR2) in porcine leukocyte subsets and tissues. Vet Res 39:13
    • (2008) Vet Res , vol.39 , pp. 13
    • Alvarez, B.1    Revilla, C.2    Domenech, N.3    Pérez, C.4    Martínez, P.5    Alonso, F.6
  • 48
    • 77954384233 scopus 로고    scopus 로고
    • Assessing the human immune system through blood transcriptomics
    • 20619006 2895587
    • Chaussabel D, Pascual V, Banchereau J (2010) Assessing the human immune system through blood transcriptomics. BMC Biol 8:84
    • (2010) BMC Biol , vol.8 , pp. 84
    • Chaussabel, D.1    Pascual, V.2    Banchereau, J.3
  • 49
    • 84928473024 scopus 로고    scopus 로고
    • The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm
    • 25932368 4406982
    • Ghimire TR (2015) The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm. Springerplus 4:181
    • (2015) Springerplus , vol.4 , pp. 181
    • Ghimire, T.R.1
  • 50
    • 79956341877 scopus 로고    scopus 로고
    • Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture
    • 1:CAS:528:DC%2BC3MXmvFWlsr0%3D 21493088
    • Findlay L, Sharp G, Fox B, Ball C, Robinson CJ, Bird C et al (2011) Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture. Cytokine 55:141-151
    • (2011) Cytokine , vol.55 , pp. 141-151
    • Findlay, L.1    Sharp, G.2    Fox, B.3    Ball, C.4    Robinson, C.J.5    Bird, C.6
  • 51
    • 84857356335 scopus 로고    scopus 로고
    • Immunology of Porcine circovirus type 2 (PCV2)
    • 1:CAS:528:DC%2BC38XjtVOisb0%3D 22178803
    • Darwich L, Mateu E (2012) Immunology of Porcine circovirus type 2 (PCV2). Virus Res 164:61-67
    • (2012) Virus Res , vol.164 , pp. 61-67
    • Darwich, L.1    Mateu, E.2
  • 52
    • 1342285619 scopus 로고    scopus 로고
    • Haemophilus parasuis: new trends on diagnosis, epidemiology and control
    • 15019107
    • Oliveira S, Pijoan C (2004) Haemophilus parasuis: new trends on diagnosis, epidemiology and control. Vet Microbiol 99:1-12
    • (2004) Vet Microbiol , vol.99 , pp. 1-12
    • Oliveira, S.1    Pijoan, C.2
  • 53
    • 76049086133 scopus 로고    scopus 로고
    • Acute phase response in animals: a review
    • 1:CAS:528:DC%2BC3cXht1ahsbzM 20034426 2798837
    • Cray C, Zaias J, Altman NH (2009) Acute phase response in animals: a review. Comp Med 59:517-526
    • (2009) Comp Med , vol.59 , pp. 517-526
    • Cray, C.1    Zaias, J.2    Altman, N.H.3
  • 54
    • 34948893564 scopus 로고    scopus 로고
    • Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR
    • 17697375 2000887
    • Nygard AB, Jørgensen CB, Cirera S, Fredholm M (2007) Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. BMC Mol Biol 8:67
    • (2007) BMC Mol Biol , vol.8 , pp. 67
    • Nygard, A.B.1    Jørgensen, C.B.2    Cirera, S.3    Fredholm, M.4
  • 55
    • 78149468986 scopus 로고    scopus 로고
    • Selection of reference genes for gene expression studies in porcine skeletal muscle using SYBR green qPCR
    • 1:CAS:528:DC%2BC3cXhsVahtb%2FE 20887758
    • Feng X, Xiong Y, Qian H, Lei M, Xu D, Ren Z (2010) Selection of reference genes for gene expression studies in porcine skeletal muscle using SYBR green qPCR. J Biotechnol 150:288-293
    • (2010) J Biotechnol , vol.150 , pp. 288-293
    • Feng, X.1    Xiong, Y.2    Qian, H.3    Lei, M.4    Xu, D.5    Ren, Z.6
  • 56
    • 33748298830 scopus 로고    scopus 로고
    • Effects of commensal bacteria on intestinal morphology and expression of proinflammatory cytokines in the gnotobiotic pig
    • 1:CAS:528:DC%2BD28XptlSgsb8%3D
    • Shirkey TW, Siggers RH, Goldade BG, Marshall JK, Drew MD, Laarveld B et al (2006) Effects of commensal bacteria on intestinal morphology and expression of proinflammatory cytokines in the gnotobiotic pig. Exp Biol Med 231:1333-1345
    • (2006) Exp Biol Med , vol.231 , pp. 1333-1345
    • Shirkey, T.W.1    Siggers, R.H.2    Goldade, B.G.3    Marshall, J.K.4    Drew, M.D.5    Laarveld, B.6
  • 57
    • 28444494443 scopus 로고    scopus 로고
    • Quantitative simultaneous multiplex real-time PCR for the detection of porcine cytokines
    • 1:CAS:528:DC%2BD2MXhtlSjt7%2FL 16223507
    • Duvigneau JC, Hartl RT, Groiss S, Gemeiner M (2005) Quantitative simultaneous multiplex real-time PCR for the detection of porcine cytokines. J Immunol Methods 306:16-27
    • (2005) J Immunol Methods , vol.306 , pp. 16-27
    • Duvigneau, J.C.1    Hartl, R.T.2    Groiss, S.3    Gemeiner, M.4
  • 58
    • 84890212777 scopus 로고    scopus 로고
    • Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage
    • 1:CAS:528:DC%2BC3sXivFGks7Y%3D 23146128 3503854
    • McCulloch RS, Ashwell MS, O’Nan AT, Mente PL (2012) Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage. J Anim Sci Biotechnol 3:36
    • (2012) J Anim Sci Biotechnol , vol.3 , pp. 36
    • McCulloch, R.S.1    Ashwell, M.S.2    O’Nan, A.T.3    Mente, P.L.4
  • 59
    • 1642555875 scopus 로고    scopus 로고
    • High frequency oscillatory ventilation suppresses inflammatory response in lung tissue and microdissected alveolar macrophages in surfactant depleted piglets
    • 14663153
    • von der Hardt K, Kandler MA, Fink L, Schoof E, Dötsch J, Brandenstein O et al (2004) High frequency oscillatory ventilation suppresses inflammatory response in lung tissue and microdissected alveolar macrophages in surfactant depleted piglets. Pediatr Res 55:339-346
    • (2004) Pediatr Res , vol.55 , pp. 339-346
    • Von der Hardt, K.1    Kandler, M.A.2    Fink, L.3    Schoof, E.4    Dötsch, J.5    Brandenstein, O.6
  • 60
    • 55749093073 scopus 로고    scopus 로고
    • Patterns of cellular gene expression in swine macrophages infected with highly virulent classical swine fever virus strain Brescia
    • 1:CAS:528:DC%2BD1cXhsVSjsLvN 18796318
    • Borca MV, Gudmundsdottir I, Fernandez-Sainz IJ, Holinka LG, Risatti GR (2008) Patterns of cellular gene expression in swine macrophages infected with highly virulent classical swine fever virus strain Brescia. Virus Res 138:89-96
    • (2008) Virus Res , vol.138 , pp. 89-96
    • Borca, M.V.1    Gudmundsdottir, I.2    Fernandez-Sainz, I.J.3    Holinka, L.G.4    Risatti, G.R.5
  • 61
    • 84899783397 scopus 로고    scopus 로고
    • Selective antegrade cerebral perfusion attenuating the TLR4/NF-kappaB pathway during deep hypothermia circulatory arrest in a pig model
    • 1:CAS:528:DC%2BC2cXpvFCrsbc%3D 24819356
    • Tang ZX, Chen GX, Liang MY, Rong J, Yao JP, Yang X et al (2014) Selective antegrade cerebral perfusion attenuating the TLR4/NF-kappaB pathway during deep hypothermia circulatory arrest in a pig model. Cardiology 128:243-250
    • (2014) Cardiology , vol.128 , pp. 243-250
    • Tang, Z.X.1    Chen, G.X.2    Liang, M.Y.3    Rong, J.4    Yao, J.P.5    Yang, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.