AMBRA1-induced mitophagy: A new mechanism to cope with cancer?

Molecular and Cellular Oncology

Volumn 2, Issue 2, 2015, Pages

  Strappazzon, Flavie ^a,b   Cecconi, Francesco ^a,b,c  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

AMBRA1; cancer; mitophagy

Indexed keywords

EID: 85019738249     PISSN: None     EISSN: 23723556     Source Type: Journal    
DOI: 10.4161/23723556.2014.975647     Document Type: Article

References (11)

1. Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper Vandenberghe W. Parkin intercats with ambra1 to induce mitophagy. J Neurosi 2011; 28:10249-61; PMID:21753002; http://dx.doi.org/10.1523/JNEUROSCI.1917-11.2011
2. Strappazzon F, Nazio F, Corrado M, Cianfanelli V, Romagnoli A, Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M, et al. AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Diff 2014; Sept 12; PMID:25215947; http://dx.doi.org/10.1038/cdd.2014.139
3. -2 inhibits AMBRA1-induced autophagy. EMBO J 2011; 30:1195-208; PMID:21358617; http://dx.doi.org/10.1038/emboj.2011.49
4. Choubey V, Cagalinec M, Liiv J, Safiulina D, Hockey M, Kuum M, Liiv M, Anwar T, Eskelinen EL, Kaasik A. BECN1 is involved in the initiation of mitophagy. It facilitates PARK2 translocation to mitochondria. Autophagy 2014; 10:1092-1106; PMID:24879156; http://dx.doi.org/10.4161/auto.28615
5. Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem 2013;2:1099-113; PMID:23209295; http://dx.doi.org/10.1074/jbc.M112.399345
6. Wu W, Tian W, Hu Z, Chen G, Huang L, Li W, Zhang X, Xue P, Zhou C, Liu L, et al. ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep 2014;5:566-75; PMID:24671035; http://dx.doi.org/10.1002/embr.201438501
7. Cesari R, Martin E, Calin GA, Pentimalli F, Bichi R, McAdams H, Trapasso F, Drusco A, Shimizu M, Masciullo V., Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. PNAS 2003; 100:5956-5961; PMID:12719539
8. Koop EA, Van Laar T, Van Wichen D, Weger RA, Van der Wall E, Diest PJ. Expression of BNIP3 in invasive breast cancer:correlations with the hypoxic response and clinicopathological features. BMC Cancer 2009; 9:175; PMID:19505343; http://dx.doi.org/10.1186/1471-2407-9-175
9. Sowter HM, Ferguson M, Pym C, Watson P, Fox SB, Han C, Harris AL. Expression of the cell death genes BNip3 and nix in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade. J Path 2003; 201:573-80; PMID:14648660
10. Cianfanelli V, Fuoco C, Lorente M, Salazar M, Quondamatteo F, Gherardini PF, De Zio D, Nazio F, Antonioli M, D'Orazio M, Skobo T, Bordi M, Rohde M, Dalla Valle L, Helmer-Citterich M, Gretzmeier C, Dengjel J, Fimia GM, Piacentini M, Di Bartolomeo S, Velasco G, Cecconi F. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat Cell Biol. 2015 Jan;17(1):20-30.
11. Nazio F, Strappazzon F, Antonioli M, Bielli P, Cianfanelli V, Bordi M, Gretzmeier C, Dengjel J, Piacentini M, Fimia GM, mTOR inhibits autophagy by controlling ULK1 ubiquitination, self-association and function via AMBRA1 and TRAF6. Nat Cell Biol 2013; 4:406-16; PMID:23524951; http://dx.doi.org/10.1038/ncb2708