The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes

Human and Experimental Toxicology

Volumn 36, Issue 6, 2017, Pages 594-602

  Pósa, Anikó ^a   Szabó, Renáta ^a   Szalai, Zita ^a   Kupai, Krisztina ^a   Deim, Zoltán ^a   Murlasits, Zsolt ^b   Bencsik, Ottó ^c   Szekeres, András ^c   Vágvölgyi, Csaba ^c   Balogh, László ^d   Juhász, Béla ^e   Szilvássy, Zoltán ^e   Varga, Csaba ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Qatar University ^*  (Qatar)

^c UNIVERSITY OF SZEGED   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

^e UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

heme oxygenase; inflammation; myeloperoxidase; Ophiobolin A (OPA); pro inflammatory cytokines

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYTOTOXIC AGENT; HEME OXYGENASE; INTERLEUKIN 6; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; MYELOPEROXIDASE; OPHIOBOLIN A; TERPENOID DERIVATIVE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; PEROXIDASE; SESTERTERPENE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CARDITIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; EXPERIMENTAL HEPATITIS; HEART TISSUE; LIVER TISSUE; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; HEART VENTRICLE; INFLAMMATION; METABOLISM; WISTAR RAT;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; HEART VENTRICLES; HEME OXYGENASE (DECYCLIZING); INFLAMMATION; INTERLEUKIN-6; MALE; PEROXIDASE; RATS, WISTAR; SESTERTERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85019693759     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327116658107     Document Type: Article

References (39)

1. Nathan C,. Points of control in inflammation. Nature 2002; 420: 846-852.
2. Dinarello CA,. Proinflammatory cytokines. Chest 2000; 118: 503-508.
3. Faith M, Sukumaran A, Pulimood AB, et al. How reliable an indicator of inflammation is myeloperoxidase activity? Clin Chim Acta 2008; 396: 23-25.
4. Kothari N, Keshari RS, Bogra J, et al. Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis. J Crit Care 2011; 26: 435 e1-435. e7.
5. Blancou P, Tardif V, Simon T, et al. Immunoregulatory properties of heme oxygenase-1. Methods Mol Biol 2011; 677: 247-268.
6. Simon T, Anegon I, Blancou P,. Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer. Immunotherapy 2011; 3: 15-18.
7. Apetz N, Munch G, Govindaraghavan S, et al. Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease - a translational perspective. CNS Neurol Disord Drug Targets 2014; 13: 1175-1191.
8. Rogerio AP, Sa-Nunes A, Faccioli LH,. The activity of medicinal plants and secondary metabolites on eosinophilic inflammation. Pharmacol Res 2010; 62: 298-307.
9. Au TK, Chick WS, Leung PC,. The biology of ophiobolins. Life Sci 2000; 67: 733-742.
10. Liu Y, Wang L, Jung JH, et al. Sesterterpenoids. Nat Prod Rep 2007; 24: 1401-1429.
11. Evidente A, Andolfi A, Cimmino A, et al. Herbicidal potential of ophiobolins produced by Drechslera gigantea. J Agr Food Chem 2006; 54: 1779-1783.
12. Leung PC, Taylor WA, Wang JH, et al. Ophiobolin A. A natural product inhibitor of calmodulin. J Biol Chem 1984; 259: 2742-2747.
13. Bury M, Girault A, Megalizzi V, et al. Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity. Cell Death Dis 2013; 4: e561.
14. Fujiwara H, Matsunaga K, Kumagai H, et al. Ophiobolin A, a novel apoptosis-inducing agent from fungus strain f-7438. Pharm Pharmacol Commun 2000; 6: 427-431.
15. Bencsik O, Papp T, Berta M, et al. Ophiobolin A from Bipolaris oryzae perturbs motility and membrane integrities of porcine sperm and induces cell death on mammalian somatic cell lines. Toxins 2014; 6: 2857-2871.
16. Brower V., Back to nature: Extinction of medicinal plants threatens drug discovery. J Natl Cancer Inst 2008; 100: 838-839.
17. Ghosh S, Karin M,. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109: S81-S96.
18. Nagashima H, Nakamura K, Goto T,. Rubratoxin B caused hypoglycemia and elevated serum interleukin-6 levels in mice. Mycotoxins 2001; 51: 7-12.
19. Dugyala RR, Sharma RP, Tsunoda M, et al. Tumor necrosis factor-alpha as a contributor in fumonisin B1 toxicity. J Pharmacol Exp Ther 1998; 285: 317-324.
20. van der Veen BS, de Winther MP, Heeringa P,. Myeloperoxidase: Molecular mechanisms of action and their relevance to human health and disease. Antioxid Redox Signal 2009; 11: 2899-2937.
21. Bradley PP, Priebat DA, Christensen RD, et al. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78: 206-209.
22. Posa A, Szabo R, Csonka A, et al. Endogenous estrogen-mediated heme oxygenase regulation in experimental menopause. Oxid Med Cell Longev 2015; 2015: 429713.
23. Szalai Z, Szasz A, Nagy I, et al. Anti-inflammatory effect of recreational exercise in TNBS-induced colitis in rats: Role of NOS/HO/MPO system. Oxid Med Cell Longev 2014; 2014: 925981.
24. Abraham NG, Kappas A,. Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 2008; 60: 79-127.
25. Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000; 6: 422-428.
26. Morse D, Pischke SE, Zhou Z, et al. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem 2003; 278: 36993-36998.
27. Sawle P, Foresti R, Mann BE, et al. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br J Pharmacol 2005; 145: 800-810.
28. Jung SS, Moon JS, Xu JF, et al. Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages. Am J Physiol Lung Cell Mol Physiol 2015; 308: L1058-L1067.
29. Devey L, Ferenbach D, Mohr E, et al. Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol Ther 2009; 17: 65-72.
30. Kapturczak MH, Wasserfall C, Brusko T, et al. Heme oxygenase-1 modulates early inflammatory responses: Evidence from the heme oxygenase-1-deficient mouse. Am J Pathol 2004; 165: 1045-1053.
31. Willerson JT, Ridker PM,. Inflammation as a cardiovascular risk factor. Circulation 2004; 109: II2-II10.
32. Mantovani A., Cancer: Inflammation by remote control. Nature 2005; 435: 752-753.
33. Branen L, Hovgaard L, Nitulescu M, et al. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2004; 24: 2137-2142.
34. Schreyer SA, Vick CM, LeBoeuf RC,. Loss of lymphotoxin-alpha but not tumor necrosis factor-alpha reduces atherosclerosis in mice. J Biol Chem 2002; 277: 12364-12368.
35. Bury M, Novo-Uzal E, Andolfi A, et al. Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity. Int J Oncol 2013; 43: 575-585.
36. Li S, Tan HY, Wang N, et al. The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci 2015; 16: 26087-26124.
37. Origassa CS, Camara NO,. Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury. World J Hepatol 2013; 5: 541-549.
38. Ozer J, Ratner M, Shaw M, et al. The current state of serum biomarkers of hepatotoxicity. Toxicology 2008; 245: 194-205.
39. Alvarez AM, Mukherjee D,. Liver abnormalities in cardiac diseases and heart failure. Int J Angiol 2011; 20: 135-142.