The effect of exhalation flow on endogenous particle emission and phospholipid composition

Respiratory Physiology and Neurobiology

Volumn 243, Issue , 2017, Pages 39-46

  Larsson, Per ^a   Bake, Björn ^a   Wallin, Anita ^a   Hammar, Oscar ^b   Almstrand, Ann Charlotte ^a   Lärstad, Mona ^a   Ljungström, Evert ^c   Mirgorodskaya, Ekaterina ^a   Olin, Anna Carin ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Airway re opening; Exhaled particles; Forced expiration; Non invasive technique; PEx; Pulmonary surfactant

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; PHOSPHOLIPID; LUNG SURFACTANT;

ADULT; AGED; ARTICLE; BODY HEIGHT; BODY MASS; BREATHING; CONTROLLED STUDY; ELECTROSPRAY; EXHALATION; FEMALE; FORCED EXPIRATION; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FUNCTIONAL RESIDUAL CAPACITY; HUMAN; LUNG FUNCTION; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RESIDUAL VOLUME; SPIROMETRY; TOTAL LUNG CAPACITY; BREATH ANALYSIS; COUGHING; INHALATION; LUNG VOLUME; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY SYSTEM;

ADULT; AGED; BREATH TESTS; COUGH; EXHALATION; FEMALE; FUNCTIONAL RESIDUAL CAPACITY; HEALTHY VOLUNTEERS; HUMANS; INHALATION; LUNG VOLUME MEASUREMENTS; MALE; MASS SPECTROMETRY; MIDDLE AGED; PHOSPHOLIPIDS; PULMONARY SURFACTANTS; RESPIRATION; RESPIRATORY SYSTEM;

EID: 85019609385     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2017.05.003     Document Type: Article

References (44)

1. Almstrand, A.C., Ljungstrom, E., Lausmaa, J., Bake, B., Sjovall, P., Olin, A.C., Airway monitoring by collection and mass spectrometric analysis of exhaled particles. Anal. Chem. 81 (2009), 662–668.
2. Almstrand, A.C., Bake, B., Ljungstrom, E., Larsson, P., Bredberg, A., Mirgorodskaya, E., Olin, A.C., Effect of airway opening on production of exhaled particles. J. Appl. Physiol. (1985) 108 (2010), 584–588.
3. Almstrand, A.C., Josefson, M., Bredberg, A., Lausmaa, J., Sjovall, P., Larsson, P., Olin, A.C., TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls. Eur. Resp. J. 39 (2012), 59–66.
4. Bennett, W.D., Zeman, K.L., Effect of enhanced supramaximal flows on cough clearance. J. Appl. Physiol. (1985) 77 (1994), 1577–1583.
5. Bennett, W.D., Foster, W.M., Chapman, W.F., Cough-enhanced mucus clearance in the normal lung. J. Appl. Physiol. (1985) 69 (1990), 1670–1675.
6. Bernhard, W., Haagsman, H.P., Tschernig, T., Poets, C.F., Postle, A.D., van Eijk, M.E., von der Hardt, H., Conductive airway surfactant: surface-tension function, biochemical composition, and possible alveolar origin. Am. J. Respir. Cell Mol. Biol. 17 (1997), 41–50.
7. Bernhard, W., Pynn, C.J., Jaworski, A., Rau, G.A., Hohlfeld, J.M., Freihorst, J., Poets, C.F., Stoll, D., Postle, A.D., Mass spectrometric analysis of surfactant metabolism in human volunteers using deuteriated choline. Am. J. Respir. Crit. Care Med. 170 (2004), 54–58.
8. Bertram, C.D., Elliott, N.S.J., Flow-rate limitation in a uniform thin-walled collapsible tube, with comparison to a uniform thick-walled tube and a tube of tapering thickness. J. Fluid Struct. 17 (2003), 541–559.
9. Bredberg, A., Gobom, J., Almstrand, A.C., Larsson, P., Blennow, K., Olin, A.C., Mirgorodskaya, E., Exhaled endogenous particles contain lung proteins. Clin. Chem. 58 (2012), 431–440.
10. Camner, P., Mossberg, B., Philipson, K., Strandberg, K., Elimination of test particles from the human tracheobronchial tract by voluntary coughing. Scand. J. Respir. Dis. 60 (1979), 56–62.
11. Cardoso, F.E., de Abreu, L.C., Raimundo, R.D., Faustino, N.A., Araujo, S.F., Valenti, V.E., Sato, M.A., Martins, S.R., Torquato, J.A., Evaluation of peak cough flow in Brazilian healthy adults. Int. Arch. Med., 5, 2012, 25.
12. Chao, C.Y.H., Wan, M.P., Morawska, L., Johnson, G.R., Ristovski, Z.D., Hargreaves, M., Mengersen, K., Corbett, S., Li, Y., Xie, X., Katoshevski, D., Characterization of expiration air jets and droplet size distributions immediately at the mouth opening. J. Aerosol. Sci. 40 (2009), 122–133.
13. Chung, E.K.F., Widdicombe, E.J.G., Boushey, Cough: Causes, Mechanisms and Therapy. 2003, John Wiley & Sons.
14. Dawson, S.V., Elliott, E.A., Wave-speed limitation on expiratory flow − unifying concept. J. Appl. Physiol. 43 (1977), 498–515.
15. Desanctis, G.T., Tomkiewicz, R.P., Rubin, B.K., Schurch, S., King, M., Exogenous surfactant enhances mucociliary clearance in the anesthetized dog. Eur. Respir. J. 7 (1994), 1616–1621.
16. Dushianthan, A., Goss, V., Cusack, R., Grocott, M.P., Postle, A.D., Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers. BMC Pulm. Med., 14, 2014, 10.
17. Ericson, P.A., Mirgorodskaya, E., Hammar, O.S., Viklund, E.A., Almstrand, A.R., Larsson, P.J., Riise, G.C., Olin, A.C., Low levels of exhaled surfactant protein an associated with BOS after lung transplantation. Transplant. Direct, 2, 2016, e103.
18. Grotberg, J.B., Shee, T.R., Compressible-flow channel flutter. J. Fluid Mech. 159 (1985), 175–193.
19. Harris, R.S., Lawson, T.V., The relative mechanical effectiveness and efficiency of successive voluntary coughs in healthy young adults. Clin. Sci. 34 (1968), 569–577.
20. Hasani, A., Pavia, D., Agnew, J.E., Clarke, S.W., Regional lung clearance during cough and forced expiration technique (Fet) − effects of flow and viscoelasticity. Thorax 49 (1994), 557–561.
21. Haslbeck, K., Schwarz, K., Hohlfeld, J.M., Seume, J.R., Koch, W., Submicron droplet formation in the human lung. J. Aerosol Sci. 41 (2010), 429–438.
22. Holmgren, H., Ljungstrom, E., Almstrand, A.C., Bake, B., Olin, A.C., Size distribution of exhaled particles in the range from 0.01 to 2.0 mu m. J. Aerosol. Sci. 41 (2010), 439–446.
23. Holmgren, H., Gerth, E., Ljungstrom, E., Larsson, P., Almstrand, A.C., Bake, B., Olin, A.C., Effects of breath holding at low and high lung volumes on amount of exhaled particles. Resp. Physiol. Neurobiol. 185 (2013), 228–234.
24. Hornung, R.W., Reed, L.D., Estimation of average concentration in the presence of nondetectable values, applied occupational and environmental hygiene. Appl. Occup. Environ. Hyg., 1990, 46–51.
25. Hughes, J.M.B., Rosenzwe, D.Y., Kivitz, P.B., Site of airway closure in excised dog lungs − histologic demonstratiion. J. Appl. Physiol., 29, 1970, 340.
26. Johnson, G.R., Morawska, L., The mechanism of breath aerosol formation. J. Aerosol Med. Drug Pulm. Deliv. 22 (2009), 229–237.
27. Johnson, G.R., Morawska, L., Ristovski, Z.D., Hargreaves, M., Mengersen, K., Chao, C.Y.H., Wan, M.P., Li, Y., Xie, X., Katoshevski, D., Corbett, S., Modality of human expired aerosol size distributions. J. Aerosol Sci. 42 (2011), 839–851.
28. Langlands, J., The dynamics of cough in health and in chronic bronchitis. Thorax 22 (1967), 88–96.
29. Larsson, P., Mirgorodskaya, E., Samuelsson, L., Bake, B., Almstrand, A.C., Bredberg, A., Olin, A.C., Surfactant protein A and albumin in particles in exhaled air. Respir. Med. 106 (2012), 197–204.
30. Larsson, P., Larstad, M., Bake, B., Hammar, O., Bredberg, A., Almstrand, A.C., Mirgorodskaya, E., Olin, A.C., Exhaled particles as markers of small airway inflammation in subjects with asthma. Clin. Physiol. Funct. Imaging, 2015.
31. Larstad, M., Almstrand, A.C., Larsson, P., Bake, B., Larsson, S., Ljungstrom, E., Mirgorodskaya, E., Olin, A.C., Surfactant protein a in exhaled endogenous particles is decreased in chronic obstructive pulmonary disease (COPD) patients: a pilot study. PLoS One, 10, 2015, e0144463.
32. Miller, M.R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Crapo, R., Enright, P., van der Grinten, C.P., Gustafsson, P., Jensen, R., Johnson, D.C., MacIntyre, N., McKay, R., Navajas, D., Pedersen, O.F., Pellegrino, R., Viegi, G., Wanger, J., Force, A.E.T., Standardisation of spirometry. Eur. Respir. J. 26 (2005), 319–338.
33. Moriarty, J.A., Grotberg, J.B., Flow-induced instabilities of a mucus-serous bilayer. J. Fluid Mech. 397 (1999), 1–22.
34. Papineni, R.S., Rosenthal, F.S., The size distribution of droplets in the exhaled breath of healthy human subjects. J. Aerosol Med. 10 (1997), 105–116.
35. Pettenazzo, A., Jobe, A., Humme, J., Seidner, S., Ikegami, M., Clearance of surfactant phosphatidylcholine via the upper airways in rabbits. J. Appl. Physiol. 65 (1988), 2151–2155.
36. Postle, A.D., Heeley, E.L., Wilton, D.C., A comparison of the molecular species compositions of mammalian lung surfactant phospholipids. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 129 (2001), 65–73.
37. Quanjer, P.H., Tammeling, G.J., Cotes, J.E., Pedersen, O.F., Peslin, R., Yernault, J.C., Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests European community for steel and coal. Official statement of the European respiratory society. Eur. Respir. J.(Suppl. 16), 1993, 5–40.
38. Rau, G.A., Dombrowsky, H., Gebert, A., Thole, H.H., von der Hardt, H., Freihorst, J., Bernhard, W., Phosphatidylcholine metabolism of rat trachea in relation to lung parenchyma and surfactant. J. Appl. Physiol. 95 (2003), 1145–1152.
39. Rubin, B.K., Physiology of airway mucus clearance. Respir. Care 47 (2002), 761–768.
40. Schwarz, K., Biller, H., Windt, H., Koch, W., Hohlfeld, J.M., Characterization of exhaled particles from the healthy human lung–a systematic analysis in relation to pulmonary function variables. J. Aerosol. Med. Pulm. Drug Deliv. 23 (2010), 371–379.
41. Tinglev, A.D., Ullah, S., Ljungkvist, G., Viklund, E., Olin, A.C., Beck, O., Characterization of exhaled breath particles collected by an electret filter technique. J. Breath Res., 10, 2016, 026001.
42. Wright, S.M., Hockey, P.M., Enhorning, G., Strong, P., Reid, K.B.M., Holgate, S.T., Djukanovic, R., Postle, A.D., Altered airway surfactant phospholipid composition and reduced lung function in asthma. J. Appl. Physiol. 89 (2000), 1283–1292.
43. Yang, S., Lee, G.W., Chen, C.M., Wu, C.C., Yu, K.P., The size and concentration of droplets generated by coughing in human subjects. J. Aerosol Med. 20 (2007), 484–494.
44. Zuo, Y.Y., Veldhuizen, R.A., Neumann, A.W., Petersen, N.O., Possmayer, F., Current perspectives in pulmonary surfactant-inhibition, enhancement and evaluation. Biochim. Biophys. Acta 1778 (2008), 1947–1977.