-
1
-
-
84880415141
-
Remodelling of biological parameters during human ageing: Evidence for complex regulation in longevity and in type 2 diabetes
-
Spazzafumo L, Olivieri F, Abbatecola AM et al. Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes. Age (Dordr) 2013;35:419–29.
-
(2013)
Age (Dordr)
, vol.35
, pp. 419-429
-
-
Spazzafumo, L.1
Olivieri, F.2
Abbatecola, A.M.3
-
4
-
-
84858800629
-
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
-
Volkmar M, Dedeurwaerder S, Cunha DA et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 2012;31:1405–26.
-
(2012)
EMBO J
, vol.31
, pp. 1405-1426
-
-
Volkmar, M.1
Dedeurwaerder, S.2
Cunha, D.A.3
-
5
-
-
84863621527
-
Cancer epigenetics: From mechanism to therapy
-
Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012;150:12–27.
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
7
-
-
84876558429
-
Epigenetic regulation of memory: Implications in human cognitive disorders
-
Kramer JM. Epigenetic regulation of memory: implications in human cognitive disorders. BioMolecular Concepts 2012;4:1–12.
-
(2012)
BioMolecular Concepts
, vol.4
, pp. 1-12
-
-
Kramer, J.M.1
-
9
-
-
33646863656
-
The quest for genetic determinants of human longevity: Challenges and insights
-
Christensen K, Johnson TE, Vaupel JW. The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet 2006;7:436–448.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 436-448
-
-
Christensen, K.1
Johnson, T.E.2
Vaupel, J.W.3
-
11
-
-
77950650405
-
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
-
Teschendorff AE, Menon U, Gentry-Maharaj A et al. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 2010;20:440–6.
-
(2010)
Genome Res
, vol.20
, pp. 440-446
-
-
Teschendorff, A.E.1
Menon, U.2
Gentry-Maharaj, A.3
-
12
-
-
77950657253
-
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
-
Rakyan VK, Down TA, Maslau S et al. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res 2010;20:434–9.
-
(2010)
Genome Res
, vol.20
, pp. 434-439
-
-
Rakyan, V.K.1
Down, T.A.2
Maslau, S.3
-
13
-
-
84860572791
-
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
-
Bell JT, Tsai PC, Yang TP et al. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genetics 2012;8:e1002629.
-
(2012)
PLoS Genetics
, vol.8
-
-
Bell, J.T.1
Tsai, P.C.2
Yang, T.P.3
-
14
-
-
84866868744
-
Aging effects on DNA methylation modules in human brain and blood tissue
-
Horvath S, Zhang Y, Langfelder P et al. Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol 2012;13: R97.
-
(2012)
Genome Biol
, vol.13
, pp. R97
-
-
Horvath, S.1
Zhang, Y.2
Langfelder, P.3
-
15
-
-
84886111619
-
DNA methylation age of human tissues and cell types
-
Horvath S. DNA methylation age of human tissues and cell types. Genome Biol 2013;14:R115.
-
(2013)
Genome Biol
, vol.14
, pp. R115
-
-
Horvath, S.1
-
17
-
-
80855144438
-
Epigenetic-aging-signature to determine age in different tissues
-
Koch CM, Wagner W. Epigenetic-aging-signature to determine age in different tissues. Aging 2011;3:1018–27.
-
(2011)
Aging
, vol.3
, pp. 1018-1027
-
-
Koch, C.M.1
Wagner, W.2
-
18
-
-
84872806231
-
Genome-wide methylation profiles reveal quantitative views of human aging rates
-
Hannum G, Guinney J, Zhao L et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 2013;49:359–67.
-
(2013)
Mol Cell
, vol.49
, pp. 359-367
-
-
Hannum, G.1
Guinney, J.2
Zhao, L.3
-
19
-
-
84937809134
-
Biomarkers and ageing: The clock-watcher
-
Gibbs WW. Biomarkers and ageing: the clock-watcher. Nature 2014;508:169–70.
-
(2014)
Nature
, vol.508
, pp. 169-170
-
-
Gibbs, W.W.1
-
20
-
-
84864019015
-
Epigenetic variation during the adult lifespan: Cross-sectional and longitudinal data on monozygotic twin pairs
-
Talens RP, Christensen K, Putter H et al. Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell 2012;11:694–703.
-
(2012)
Aging Cell
, vol.11
, pp. 694-703
-
-
Talens, R.P.1
Christensen, K.2
Putter, H.3
-
21
-
-
84878004354
-
Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance
-
Martino D, Loke YJ, Gordon L et al. Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biol 2013;14:R42.
-
(2013)
Genome Biol
, vol.14
, pp. R42
-
-
Martino, D.1
Loke, Y.J.2
Gordon, L.3
-
22
-
-
77957353569
-
A longitudinal study of epigenetic variation in twins
-
Wong CC, Caspi A, Williams B et al. A longitudinal study of epigenetic variation in twins. Epigenetics 2010;5:516–26.
-
(2010)
Epigenetics
, vol.5
, pp. 516-526
-
-
Wong, C.C.1
Caspi, A.2
Williams, B.3
-
23
-
-
84894088246
-
Cross-sectional and longitudinal changes in DNA methylation with age: An epigenome-wide analysis revealing over 60 novel age-associated CpG sites
-
Florath I, Butterbach K, Müller H, Bewerunge-Hudler M, Brenner H. Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites. Hum Mol Genet 2014;23:1186–1201.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 1186-1201
-
-
Florath, I.1
Butterbach, K.2
Müller, H.3
Bewerunge-Hudler, M.4
Brenner, H.5
-
24
-
-
84928533443
-
Genetic and environmental exposures constrain epigenetic drift over the human life course
-
Shah S, McRae AF, Marioni RE et al. Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Res 2014;24:1725–33.
-
(2014)
Genome Res
, vol.24
, pp. 1725-1733
-
-
Shah, S.1
McRae, A.F.2
Marioni, R.E.3
-
25
-
-
77950299137
-
Mixed linear model approach adapted for genome-wide association studies
-
Zhang Z, Ersoz E, Lai CQ et al. Mixed linear model approach adapted for genome-wide association studies. Nat Genet 2010;42:355–60.
-
(2010)
Nat Genet
, vol.42
, pp. 355-360
-
-
Zhang, Z.1
Ersoz, E.2
Lai, C.Q.3
-
26
-
-
85018193324
-
Hierarchical linear modeling of longitudinal pedigree data for genetic association analysis
-
Tan Q, Hjelmborg B Thomassen, JVM et al. Hierarchical linear modeling of longitudinal pedigree data for genetic association analysis. BMC Proc 2014;8:S82.
-
(2014)
BMC Proc
, vol.8
, pp. S82
-
-
Tan, Q.1
Hjelmborg, B.2
Thomassen, J.V.M.3
-
27
-
-
84924324495
-
Epigenetic signature of birth weight discordance in adult twins
-
Tan Q, Frost M, Heijmans BT et al. Epigenetic signature of birth weight discordance in adult twins. BMC Genomics 2014;15:1062
-
(2014)
BMC Genomics
, vol.15
, pp. 1062
-
-
Tan, Q.1
Frost, M.2
Heijmans, B.T.3
-
28
-
-
0032920561
-
A Danish population-based twin study on general health in the elderly
-
Christensen K, Holm NV, McGue M, Corder L, Vaupel JW. A Danish population-based twin study on general health in the elderly. Journal of Aging and Health 1999;11:49–64.
-
(1999)
Journal of Aging and Health
, vol.11
, pp. 49-64
-
-
Christensen, K.1
Holm, N.V.2
McGue, M.3
Corder, L.4
Vaupel, J.W.5
-
29
-
-
0024284028
-
A simple salting out procedure for extracting DNA from human nucleated cells
-
Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16(3):1215.
-
(1988)
Nucleic Acids Res
, vol.16
, Issue.3
, pp. 1215
-
-
Miller, S.A.1
Dykes, D.D.2
Polesky, H.F.3
-
30
-
-
84862173149
-
SWAN: Subset-quantile within array normalization for Illumina Infinium Human Methylation450 BeadChips
-
Maksimovic J, Gordon L, Oshlack A: SWAN: subset-quantile within array normalization for Illumina Infinium Human Methylation450 BeadChips. Genome Biol 2012;13(6): R44.
-
(2012)
Genome Biol
, vol.13
, Issue.6
, pp. R44
-
-
Maksimovic, J.1
Gordon, L.2
Oshlack, A.3
-
31
-
-
84860637797
-
DNA methylation arrays as surrogate measures of cell mixture distribution
-
Houseman EA, Accomando WP, Koestler DC et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 2012;13:86.
-
(2012)
BMC Bioinformatics
, vol.13
, pp. 86
-
-
Houseman, E.A.1
Accomando, W.P.2
Koestler, D.C.3
-
35
-
-
0036596190
-
Analytic approaches to twin data using structural equation models
-
Rijsdijk FV, Sham PC. Analytic approaches to twin data using structural equation models. Brief Bioinform 2002;3:119–33.
-
(2002)
Brief Bioinform
, vol.3
, pp. 119-133
-
-
Rijsdijk, F.V.1
Sham, P.C.2
-
36
-
-
0016355478
-
A new look at the statistical model identification
-
Akaike H. A new look at the statistical model identification. IEEE Trans Automat Control 1974;19:716–23.
-
(1974)
IEEE Trans Automat Control
, vol.19
, pp. 716-723
-
-
Akaike, H.1
-
37
-
-
84924990048
-
A meta-analysis on age-associated change in blood DNA methylation: Results from an original analysis pipeline for Infinium 450k data
-
Bacalini MG, Boattini A, Gentilini D et al. A meta-analysis on age-associated change in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data. Aging (Albany NY) 2015;7:1.
-
(2015)
Aging (Albany NY)
, vol.7
, pp. 1
-
-
Bacalini, M.G.1
Boattini, A.2
Gentilini, D.3
-
38
-
-
84869187936
-
Methylation of ELOVL2 gene as a new epigenetic marker of age
-
Garagnani P, Bacalini MG, Pirazzini C et al. Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell 2012;11:1132–4.
-
(2012)
Aging Cell
, vol.11
, pp. 1132-1134
-
-
Garagnani, P.1
Bacalini, M.G.2
Pirazzini, C.3
-
39
-
-
84879537717
-
Continuous aging of the human DNA methylome throughout the human lifespan
-
Johansson A, Enroth S, Gyllensten U. Continuous aging of the human DNA methylome throughout the human lifespan. PLoS One 2013;8:e67378.
-
(2013)
PLoS One
, vol.8
-
-
Johansson, A.1
Enroth, S.2
Gyllensten, U.3
-
40
-
-
84908317108
-
Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science
-
_ et al. Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science. Forensic Sci Int Genet 2015;14:161–7.
-
(2015)
Forensic Sci Int Genet
, vol.14
, pp. 161-167
-
-
Zbiec-Piekarska, R.1
Spolnicka, M.2
Kupiec, T.3
Makowska, Z.4
-
41
-
-
33745080013
-
Regulatory mechanisms and functions of MAP kinase signaling pathways
-
Imajo M, Tsuchiya Y, Nishida E. Regulatory mechanisms and functions of MAP kinase signaling pathways. IUBMB Life 2006;58:312–17.
-
(2006)
IUBMB Life
, vol.58
, pp. 312-317
-
-
Imajo, M.1
Tsuchiya, Y.2
Nishida, E.3
-
42
-
-
40549101870
-
Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats
-
Abidi P, Leers-Sucheta S, Cortez Y, Han J, Azhar S. Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats. Aging Cell 2008;7:168–78.
-
(2008)
Aging Cell
, vol.7
, pp. 168-178
-
-
Abidi, P.1
Leers-Sucheta, S.2
Cortez, Y.3
Han, J.4
Azhar, S.5
-
43
-
-
0037444470
-
Mitogen-activated protein kinase (MAPK) pathway activation: Effects of age and acute exercise on human skeletal muscle
-
Williamson D, Gallagher P, Harber M, Hollon C, Trappe S. Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J Physiol 2003;547:977–87.
-
(2003)
J Physiol
, vol.547
, pp. 977-987
-
-
Williamson, D.1
Gallagher, P.2
Harber, M.3
Hollon, C.4
Trappe, S.5
-
44
-
-
84896130272
-
P38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
-
Bernet JD, Doles JD, Hall JK, Kelly Tanaka K, Carter TA, Olwin BB. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat Med 2014;20:265–71.
-
(2014)
Nat Med
, vol.20
, pp. 265-271
-
-
Bernet, J.D.1
Doles, J.D.2
Hall, J.K.3
Kelly Tanaka, K.4
Carter, T.A.5
Olwin, B.B.6
-
45
-
-
31044435260
-
The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging
-
Larbi A, Douziech N, Fortin C, Linteau A, Dupuis G, Fulop T Jr. The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun Ageing 2005;2(1):6.
-
(2005)
Immun Ageing
, vol.2
, Issue.1
, pp. 6
-
-
Larbi, A.1
Douziech, N.2
Fortin, C.3
Linteau, A.4
Dupuis, G.5
Fulop, T.6
-
46
-
-
76749088358
-
Pathological roles of MAPK signaling pathways in human diseases
-
Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010;1802:396–405.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 396-405
-
-
Kim, E.K.1
Choi, E.J.2
-
47
-
-
16844381070
-
Another dimension to calcium signaling: A look at extracellular calcium
-
Hofer AM. Another dimension to calcium signaling: a look at extracellular calcium. J Cell Sci 2005;118:855–62.
-
(2005)
J Cell Sci
, vol.118
, pp. 855-862
-
-
Hofer, A.M.1
-
48
-
-
70349479191
-
Calcium and cell death signaling in neurodegeneration and aging
-
Smaili S, Hirata H, Ureshino R et al. Calcium and cell death signaling in neurodegeneration and aging. An Acad Bras Cienc 2009;81:467–75.
-
(2009)
An Acad Bras Cienc
, vol.81
, pp. 467-475
-
-
Smaili, S.1
Hirata, H.2
Ureshino, R.3
-
49
-
-
84884274458
-
Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain
-
Garwood C, Faizullabhoy A, Wharton SB et al. MRC Cognitive Function and Ageing Neuropathology Study Group. Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol 2013;39:788–99.
-
(2013)
Neuropathol Appl Neurobiol
, vol.39
, pp. 788-799
-
-
Garwood, C.1
Faizullabhoy, A.2
Wharton, S.B.3
-
50
-
-
84901790304
-
Calcium signaling alterations, oxidative stress, and autophagy in aging
-
Ureshino RP, Rocha KK, Lopes GS, Bincoletto C, Smaili SS. Calcium signaling alterations, oxidative stress, and autophagy in aging. Antioxid Redox Signal 2014;21:123–37.
-
(2014)
Antioxid Redox Signal
, vol.21
, pp. 123-137
-
-
Ureshino, R.P.1
Rocha, K.K.2
Lopes, G.S.3
Bincoletto, C.4
Smaili, S.S.5
-
51
-
-
33947164895
-
Focal adhesions regulate Ab signaling and cell death in Alzheimer’s disease
-
Caltagaronea J, Jing Z, Bowser R. Focal adhesions regulate Ab signaling and cell death in Alzheimer’s disease. Biochim Biophys Acta 2007;1772:438–45.
-
(2007)
Biochim Biophys Acta
, vol.1772
, pp. 438-445
-
-
Caltagaronea, J.1
Jing, Z.2
Bowser, R.3
-
52
-
-
84897972050
-
Dynamic regulation of genetic pathways and targets during aging in Caenorhabditis elegans
-
He K, Zhou T, Shao J, Ren X, Zhao Z, Liu D. Dynamic regulation of genetic pathways and targets during aging in Caenorhabditis elegans. Aging (Albany NY) 2014;6:215–30.
-
(2014)
Aging (Albany NY)
, vol.6
, pp. 215-230
-
-
He, K.1
Zhou, T.2
Shao, J.3
Ren, X.4
Zhao, Z.5
Liu, D.6
-
53
-
-
33947620698
-
Synapse specificity of long-term potentiation breaks down with aging
-
Ris L, Godaux E. Synapse specificity of long-term potentiation breaks down with aging. Learn Mem 2007;14:185–9.
-
(2007)
Learn Mem
, vol.14
, pp. 185-189
-
-
Ris, L.1
Godaux, E.2
-
54
-
-
84867362632
-
Twins for epigenetic studies of human aging and development
-
Tan Q, Christiansen L, Thomassen M, Kruse TA, Christensen K. Twins for epigenetic studies of human aging and development. Ageing Res Rev 2013;12:182–7.
-
(2013)
Ageing Res Rev
, vol.12
, pp. 182-187
-
-
Tan, Q.1
Christiansen, L.2
Thomassen, M.3
Kruse, T.A.4
Christensen, K.5
|