Physicochemical modeling of sensory irritation in humans and experimental animals

Toxicology of the Nose and Upper Airways

Volumn , Issue , 2016, Pages 376-389

  Abraham, Michael H ^a   Sánchez Moreno, Ricardo ^a   Gil Lostes, Javier ^a   Cometto Muñiz, J Enrique ^b   Cain, William S ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85019484087     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (54)

1. Parker GH. The relation of smell, taste and the common chemical sense in vertebrates. J Acad Nat Sci Phila 1912; 15: 221-234.
2. Keele CA. The common chemical sense and its receptors. Arch Int Pharmacodyn Ther 1962; 139: 547-557.
3. Bryant B, Silver WL. Chemesthesis: the common chemical senses. In Finger TE, Silver WL, Restropo D, eds The neurobiology of taste and smell, 2nd ed., New York, NY: Wiley-Liss, 2000:73-100.
4. Ressler KJ, Sullivan SL, Buck LB. A molecular dissection of special patterning in the olfactory system. Curr Opin Neurobiol 1994: 4:588-596.
5. Niimura Y, Nei M. Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates. J Hum Genet 2006; 51:505-517.
6. Firestein S. Olfaction: scents and sensibility. Curr Biol 1996; 6:666-667.
7. Mori K, Yoshihara Y. Molecular recognition and olfactory processing in the mammalian olfactory system. Prog Neurobiol 1995; 45:585-619.
8. Cometto-Muhiz JE, Cain WS. Thresholds for odor and nasal pungency. Physiol Behav 1990; 48:719-725.
9. Cometto-Muñiz JE, Cain WS. Trigeminal and olfactory sensitivity: comparison of modalities and methods of measurement. Int Arch Occup Envirion Health 1998; 71:105-110.
10. Kobal G, Van Toller S, Hummel T. Is there directional smelling? Experimentia 1989; 45:130-132.
11. Silver WL, Mason JR, Marshall DA, et al. Rat trigeminal olfactory and taste responses after capsaicin desensitization. Brain Res 1985; 333:45-54.
12. Cometto-Muñiz JE, Cain WS. Perception of odor and nasal pungency from a homologous series of volatile organic compounds. Indoor Air 1994; 4: 140-145.
13. Cometto-Muñiz JE, Cain WS, Abraham MH. Nasal pungency and odor of homologous aldehydes and carboxylic acids. Exp Brain Res 1998; 118:180-188.
14. Abraham MH, Kumarsingh R, Cometto-Muñiz JE, et al. Draize eye scores and eye irritation thresholds in man can be combined into one quantitative structure-activity relationship. Toxicol In Vitro 1998; 12: 403-408.
15. Cauna NK, Hinderer K, Wentges RT. Sensory receptor organs of the human nasal respiratory mucosa. Am J Anat 1969; 124:187-210.
16. Finger TE, St Jeor V, Kinnamon JC, et al. Ultrastructure of substance P- and CGRP-immunoreactive nerve fibres in the nasal epithelium of rodents. J Comp Neurol 1990; 294: 293-305.
17. Nielsen GD. Mechanisms of activation of the sensory irritant receptor by airborne chemicals. Crit Rev Toxicol 1991; 21:183-208.
18. Alarie Y, Schaper M, Nielsen GD, et al. Structure-activity relationships of volatile organic chemicals as sensory irritants. Arch Toxicol 1998; 72:125-140.
19. Cesare P, McNaughton P. Peripheral pain mechanisms. Curr Opin Neurobiol 1997; 7:493-499.
20. McCleskey EW, Gold MS. Ion channels of nociception. Ann Rev Physiol 1999; 61: 835-856.
21. Eccles R, Jawad MS, Morris S. The effects of oral administration of (-) menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. J Pharm Pharmacol 1990; 42: 652-654.
22. Jancso N, Jancso-Gabor A, Szolcsanyi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pre-treatment with capsaicin. Br J Pharmacol Chemother 1967; 31:138-151.
23. Alimohammadi H, Silver WL. Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the rat. Chem Senses 2000; 25:61-66.
24. Inoue T, Bryant BP. Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons. Pain 2005; 117:193-203.
25. Schmelz M, Schmidt R, Bickel A, et al. Specific C-receptors for itch in human skin. J Neurosci 1997; 17:8003-8008.
26. Jord SE, Bautista DM, Chuang HH, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004; 427:260-265.
27. Barrow C, Alarie Y, Warrick J, et al. Comparison of the sensory irritation response in mice to chlorine and hydrogen chloride. Arch Environ Health 1977; 32:68-76.
28. Alarie Y, Kane L, Barrow C. Sensory irritation: the use of an animal model to establish acceptable exposure to airborne chemical irritants. In: Reeves AL, ed. Toxicology: principles and practice, Vol 1. New York, NY: John Wiley and Sons, 1980: 48-92.
29. American Society for testing and materials (ASTM). Standard test method for estimating sensory irritancy of airborne chemicals. Designation E 981-84. Philadelphia, PA: ASTM, 1984.
30. Alarie Y. Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable levels of exposure in man. Food Cosmet Toxicol 1981; 19: 623-626.
31. Alarie Y. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 1981; 42:9-13.
32. Nielsen GD, Alarie Y. Sensory irritation, pulmonary irritation, and respiratory stimulation by airborne benzene and alkyl benzenes: prediction of safe industrial exposure levels and correlation with their thermodynamic properties. Toxicol Appl Pharmacol 1982; 65:459-477.
33. Nielsen GD, Wolkoff P, Alarie Y. Sensory irritation: risk assessment approaches. Regul Toxicol Pharmacol 2007; 48:6-18.
34. 50 for determining acceptable exposure levels of airborne sensory irritants for the general public. Environ Health Perspect 2007; 115:1609-1616.
35. Ferguson J. Use of chemical potentials as indexes of toxicity. Proc R Soc (London) 1939; B127:387-404.
36. Brink F, Pasternak JM. Thermodynamic analysis of the effectiveness of narcotics. J Cell Comp Physiol 1948; 32: 211-233.
37. Abraham MH, Nielsen GD, Alarie Y. The Ferguson principle and an analysis of biological activity of gases and vapors. J Pharm Sci 1994; 83:680-688.
38. Muller J, Gref G. Recherche de relations entre toxicite de molecules d'interet industriel et proprietes physico-chimiques: test d'irritation des voies aeriennes superieures applique a quatre familles chimiques. Food Chem Toxicol 1984; 22: 661-664.
39. Roberts DW. QSAR for upper-respiratory tract irritation. Chem Biol Interact 1986; 57:325-345.
40. Schaper M. Development of a data base for sensory irritants and its use in establishing occupational exposure limits. Am Ind Hyg Assoc J 1993; 54:488-544.
41. Alarie Y, Schaper M, Nielsen GD, Abraham MH. Estimating the sensory irritating potency of airborne nonreactive volatile organic chemicals and their mixtures. SAR QSAR Environ Res 1996; 5:151-165.
42. Abraham MH, Acree WE Jr., Mintz C, Payne S. Effect of anesthetic structure on inhalation anesthesia: implications for the mechanism. J Pharm Sci 2008; 97:2373-2384.
43. 50: alternatives to animal studies. Toxicol Appl Pharmacol 1995; 134:92-99.
44. Nielsen GD, Thomsen ES, Alarie Y. Sensory irritation receptor compartment properties. Acta Pharm Nord 1990; 1:31-44.
45. Gagnaire F, Azim S, Simon P, et al. Sensory and pulmomary irritation of aliphatic amines in mice: a structure-activity relationship. J Appl Toxicol 1993; 13:129-135.
46. Abraham MH, Whiting GS, Alarie Y, et al. Hydrogen bonding.12. A new QSAR for upper respiratory tract irritation by airborne chemicals in mice. Quant Struct Act Relat 1990; 9:6-10.
47. Abraham MH, Ibrahim A, Zissimos AM. The determination of sets of solute descriptors from chromatographic measurements. J Chromatogr A 2004; 1037:29-47.
48. Luan F, Ma W, Zhang X, et al. Quantitative structure-activity relationship models for prediction of sensory irritants (log RD50) of volatile organic compounds. Chemo-sphere 2006; 63:1142-1153.
49. Abraham MH, Andonian-Haftvan J, Cometto-Muhiz JE, Cain WS. An analysis of nasal irritation thresholds using a new solvation equation. Fundam App Toxicol 1996; 31:71-76.
50. Hawkins DM. The problem of overfitting. J Chem Inf Comput Sci 2004; 44:1-12.
51. Abraham MH, Acree WE Jr., Leo AJ, et al. Partition from water and from air into wet and dry ketones. New J Chem. 2009; 33:568-573.
52. Famini GR, Aguiar D, Payne MA, et al. Using the theoretical linear solvation energy relationship to correlate and predict nasal pungency thresholds. J Mol Graphics Model 2002; 20:277-280.
53. Hau KM, Connell DW, Richardson BJ. Quantitative structure-activity relationship for nasal pungency thresholds of volatile organic compounds. Toxicol Sci 1999; 47:91-98.
54. Hau KM, Connell DW, Richardson BJ. Use of partition models in setting health guidelines for volatile organic compounds. Regul Toxicol Pharmacol 2000; 31: 22-29.