Draize eye scores and eye irritation thresholds in man combined into one quantitative structure - activity relationship

Toxicology in Vitro

Volumn 12, Issue 4, 1998, Pages 403-408

  Abraham, M H ^a   Kumarsingh, R ^a   Cometto Muniz, J E ^b   Cain, W S ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VOLATILE ORGANIC COMPOUND;

ARTICLE; CHEMICAL INJURY; EYE IRRITATION; EYE TOXICITY; HUMAN; HYDROGEN BOND; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VAPOR;

EID: 0031877290     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(98)00010-1     Document Type: Article

References (20)

1. Abraham M. H. (1994) Scales of solute hydrogen-bonding: their construction and application to physicochemical and biochemical processes. Chemical Society Reviews 22, 73-83.
2. Abraham M. H. (1996) The potency of gases and vapours: QSARs - anesthesia, sensory irritation, and odor. In Indoor Air and Human Health. 2nd Ed. Edited by R. B. Gamage and B. A. Berven, pp. 67-91. CRC Press, Boca Raton, FL.
3. Abraham M. H., Andonian-Haftvan J., Cometto-Muniz J. E. and Cain W. S. (1996) An analysis of nasal irritation thresholds using a new solvation equation. Fundamental and Applied Toxicology 31, 71-76.
4. Abraham M. H., Andonian-Haftvan J., Osei-Owusu J. P., Sakellariou P., Urieta J. S., Lopez M. C. and Fuchs R. (1993) Hydrogen bonding. Part 25. The solvation properties of methylene iodide. Journal of the Chemical Society, Perkin Transactions 2 , 299-304.
5. Abraham M. H., Andonian-Haftvan J., Whiting G. S., Leo A. and Taft R. W. (1994) Hydrogen bonding. Part 34. The factors that influence the solubility of gases and vapours in water at 298 K and a new method for its determination. Journal of the Chemical Society, Perkin Transactions 2, 1777-1791.
6. Abraham M. H., Kumarsingh R., Cometto-Muniz J. E. and Cain W. S. (1997) A quantitative structure-activity relationship (QSAR) for a Draize eye irritation database. Toxicology in Vitro 12, .
7. Abraham M. H. and Weathersby P. K. (1994) Hydrogen bonding. 30. Solubility of gases and vapours in biological liquids and tissues. Journal of the Pharmaceutical Society 83, 1450-1456.
8. Abraham M. H., Whiting G. S., Doherty R. M. and Shuely W. J. (1990) Hydrogen bonding. Part 13. A new method for the characterization of GLC stationary phases - the Laffort data set. Journal of the Chemical Society, Perkin Transactions 2, 1451-1460.
9. Balls M., Botham P. A., Bruner L. H. and Spielmann H. (1995) The EC/HO international validation study on alternatives to the Draize eye irritation test. Toxicology in Vitro 9, 871-929.
10. Cometto-Muniz J. E. and Cain W. S. (1990) Thresholds for odor and nasal pungency. Physiology and Behavior 48, 719-725.
11. Cometto-Muniz J. E. and Cain W. S. (1991) Nasal pungency, odor and eye irritation thresholds for homologous acetates. Pharmacology Biochemistry and Behavior 39, 983-989.
12. Cometto-Muniz J. E. and Cain W. S. (1992) Sensory irritation. Relation to indoor air pollution. Annals of the New York Academy of Sciences 641, 137-151.
13. Cometto-Muniz J. E. and Cain W. S. (1993) Efficacy of volatile organic compounds in evoking nasal pungency and odor. Archives of Environmental Health 48, 309-314.
14. Cometto-Muniz J. E. and Cain W. S. (1994) Sensory reactions of nasal pungency and odor to volatile organic compounds: the alkylbenzenes. American Industrial Hygiene Association Journal 55, 811-817.
15. Cometto-Muniz J. E. and Cain W. S. (1995) Relative sensitivity of the occular trigeminal, nasal trigeminal, and olfactory systems to airborne chemicals. Chemical Senses 20, 191-198.
16. Cometto-Muniz J. E., Cain W. S. and Abraham M. H. (1978) Nasal pungency and odor of homologous aldehydes and carboxylic acids. Experimental Brain Research 118, 180-188.
17. Cometto-Muniz J. E., Cain W. S. and Hudnell H. K. (1997a) Agonistic sensory effects of airborne chemicals in mixtures: odor, nasal pungency, and eye irritation. Perception and Psychophysics 59, 665-674.
18. Cronin M. T. D., Basketter D. A. and York M. (1994) A quantitative structure-activity relationship (QSAR) investigation of a Draize eye irritation database. Toxicology in Vitro 8, 21-28.
19. Kollie T. O., Poole C. F., Abraham M. H. and Whiting G. S. (1992) Comparison of two free energies of solvation models for characterizing selectivity of stationary phases used in gas-liquid chromatography. Analitica Chimica Acta 259, 1-13.
20. McGiLl R. A., Abraham M. H. and Grate J. W. (1994) Choosing polymer coatings for chemical sensors. CHEMTECH 24, 27-37.