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Volumn 2, Issue 1, 2014, Pages 160-178

DNA/MVA vaccines for HIV/AIDS

Author keywords

Adjuvant; CD40L; GM CSF; Rhesus macaque; SIV

Indexed keywords

DNA VACCINE; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; HUMAN GROWTH HORMONE; INTERLEUKIN 2; INTERLEUKIN 4; MODIFIED VACCINIA VIRUS ANKARA VACCINE; UNCLASSIFIED DRUG; VACCINE; VIRUS PROTEIN; VIRUS VECTOR;

EID: 85019427452     PISSN: None     EISSN: 2076393X     Source Type: Journal    
DOI: 10.3390/vaccines2010160     Document Type: Review
Times cited : (23)

References (78)
  • 3
    • 84855444592 scopus 로고    scopus 로고
    • Rare serotype adenoviral vectors for HIV vaccine development
    • Michael, N.L. Rare serotype adenoviral vectors for HIV vaccine development. J. Clin. Invest 2012, 122, 25-27.
    • (2012) J. Clin. Invest , vol.122 , pp. 25-27
    • Michael, N.L.1
  • 4
    • 84883165568 scopus 로고    scopus 로고
    • IAVI Report, November 2013, Available from:,(accessed on 31 January 2014)
    • IAVI Report. Clinical Trials Database. November 2013; Available from: http://www.iavireport. org/Trials-Database/Pages/default.aspx(accessed on 31 January 2014)
    • Clinical Trials Database
  • 6
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang, D.C.; deVit, M.; Johnston, S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 1992, 356, 152-154.
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.C.1    Devit, M.2    Johnston, S.A.3
  • 8
    • 0027213712 scopus 로고
    • Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA
    • Robinson, H.L.; Hunt, L.A.; Webster, R.G. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA. Vaccine 1993, 11, 957-960.
    • (1993) Vaccine , vol.11 , pp. 957-960
    • Robinson, H.L.1    Hunt, L.A.2    Webster, R.G.3
  • 11
    • 0030876747 scopus 로고    scopus 로고
    • Comparison of nucleic acid and protein immunization for induction of antibodies specific for HIV-1 gp120
    • Peet, N.M.; McKeating, J.A.; Ramos, B.; Klonisch, T.; de Souza, J.B.; Delves, P.J.; Lund, T. Comparison of nucleic acid and protein immunization for induction of antibodies specific for HIV-1 gp120. Clin. Exp. Immunol. 1997, 109, 226-232.
    • (1997) Clin. Exp. Immunol , vol.109 , pp. 226-232
    • Peet, N.M.1    McKeating, J.A.2    Ramos, B.3    Klonisch, T.4    de Souza, J.B.5    Delves, P.J.6    Lund, T.7
  • 13
    • 0029131261 scopus 로고
    • Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation
    • Wang, B.; Boyer, J.; Srikantan, V.; Uqen, K.; Gilbert, L.; Phan, C.; Dang, K.; Merva, M.; Aqadjanyan, M.G. Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation. Virology 1995, 211, 102-112.
    • (1995) Virology , vol.211 , pp. 102-112
    • Wang, B.1    Boyer, J.2    Srikantan, V.3    Uqen, K.4    Gilbert, L.5    Phan, C.6    Dang, K.7    Merva, M.8    Aqadjanyan, M.G.9
  • 17
    • 0030886653 scopus 로고    scopus 로고
    • Gene gun-based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV
    • Fuller, D.H.; Simpson, L.; Cole, K.S.; Clements, J.E.; Panicali, D.L.; Montelaro, R.C.; Murphey-Corb, M.; Haynes, J.R. Gene gun-based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV. Immunol. Cell Biol. 1997, 75, 389-396.
    • (1997) Immunol. Cell Biol , vol.75 , pp. 389-396
    • Fuller, D.H.1    Simpson, L.2    Cole, K.S.3    Clements, J.E.4    Panicali, D.L.5    Montelaro, R.C.6    Murphey-Corb, M.7    Haynes, J.R.8
  • 18
    • 0031924077 scopus 로고    scopus 로고
    • Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
    • Schneider, J.; Gilbert, S.C.; Blanchard, T.J.; Hanke, T.; Robson, K.J.; Hannan, C.M.; Becker, M.; Sinden, R.; Smith, G.L.; Hill, A.V. Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat. Med. 1998, 4, 397-402.
    • (1998) Nat. Med , vol.4 , pp. 397-402
    • Schneider, J.1    Gilbert, S.C.2    Blanchard, T.J.3    Hanke, T.4    Robson, K.J.5    Hannan, C.M.6    Becker, M.7    Sinden, R.8    Smith, G.L.9    Hill, A.V.10
  • 19
    • 0032920019 scopus 로고    scopus 로고
    • Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
    • Robinson, H.L.; Montefiori, D.C.; Johnson, P.; Manson, K.H.; Kalish, M.; Lifson, J.D.; Rizvi, T.A.; Lu, S.; Hu, S.L.; Mazzara, G.P.; et al. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations. Nat. Med. 1999, 5, 526-534.
    • (1999) Nat. Med , vol.5 , pp. 526-534
    • Robinson, H.L.1    Montefiori, D.C.2    Johnson, P.3    Manson, K.H.4    Kalish, M.5    Lifson, J.D.6    Rizvi, T.A.7    Lu, S.8    Hu, S.L.9    Mazzara, G.P.10
  • 20
    • 18144441678 scopus 로고    scopus 로고
    • Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen
    • Allen, T.M.; Voqel, T.U.; Fuller, D.H.; Mothé, B.R.; Steffen, S.; Boyson, J.E.; Shipley, T.; Fuller, J.; Hanke, T.; Sette, A. et al. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen. J. Immunol. 2000, 164, 4968-4978.
    • (2000) J. Immunol , vol.164 , pp. 4968-4978
    • Allen, T.M.1    Voqel, T.U.2    Fuller, D.H.3    Mothé, B.R.4    Steffen, S.5    Boyson, J.E.6    Shipley, T.7    Fuller, J.8    Hanke, T.9    Sette, A.10
  • 21
    • 0033016728 scopus 로고    scopus 로고
    • Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS
    • Hanke, T.; McMichael, A. Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS. Immunol. Lett. 1999, 66, 177-181.
    • (1999) Immunol. Lett , vol.66 , pp. 177-181
    • Hanke, T.1    McMichael, A.2
  • 23
    • 11144355460 scopus 로고    scopus 로고
    • A human immunodeficiency virus 1(HIV-1) clade A vaccine in clinical trials: Stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara(MVA) vaccines in humans
    • Mwau, M.; Cebere, I.; Sutton, J.; Chikoti, P.; Winstone, N.; Wee, E.G.; Beattie, T.; Chen, Y.H.; Dorrell, L.; McShane, H. et al. A human immunodeficiency virus 1(HIV-1) clade A vaccine in clinical trials: Stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara(MVA) vaccines in humans. J. Gen. Virol. 2004, 85, 911-919.
    • (2004) J. Gen. Virol , vol.85 , pp. 911-919
    • Mwau, M.1    Cebere, I.2    Sutton, J.3    Chikoti, P.4    Winstone, N.5    Wee, E.G.6    Beattie, T.7    Chen, Y.H.8    Dorrell, L.9    McShane, H.10
  • 25
    • 33750227671 scopus 로고    scopus 로고
    • Immunisation with recombinant modified vaccinia virus Ankara expressing HIV-1 gag in HIV-1-infected subjects stimulates broad functional CD4+ T cell responses
    • Ondondo, B.O.; Yang, H.; Dong, T.; di Gleria, K.; Suttill, A.; Conlon, C.; Brown, D.; Williams, P.; Rowland-Jones, S.L.; Hanke, T. et al. Immunisation with recombinant modified vaccinia virus Ankara expressing HIV-1 gag in HIV-1-infected subjects stimulates broad functional CD4+ T cell responses. Eur. J. Immunol. 2006, 36, 2585-2594.
    • (2006) Eur. J. Immunol , vol.36 , pp. 2585-2594
    • Ondondo, B.O.1    Yang, H.2    Dong, T.3    Di, K.4    Suttill, A.5    Conlon, C.6    Brown, D.7    Williams, P.8    Rowland-Jones, S.L.9    Hanke, T.10
  • 26
    • 33646454992 scopus 로고    scopus 로고
    • Induction of multifunctional human immunodeficiency virus type 1(HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes
    • Goonetilleke, N.; Moore, S.; Dally, L.; Winstone, N.; Cebere, I.; Mahmoud, A.; Pinheiro, S.; Gillespie, G.; Brown, D.; Loach, V. et al. Induction of multifunctional human immunodeficiency virus type 1(HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes. J. Virol. 2006, 80, 4717-4728.
    • (2006) J. Virol , vol.80 , pp. 4717-4728
    • Goonetilleke, N.1    Moore, S.2    Dally, L.3    Winstone, N.4    Cebere, I.5    Mahmoud, A.6    Pinheiro, S.7    Gillespie, G.8    Brown, D.9    Loach, V.10
  • 27
    • 54949106244 scopus 로고    scopus 로고
    • Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara
    • Sandstrom, E.; Nilsson, C.; Hejdeman, B.; Brave, A.; Bratt, G.; Robb, M.; Cox, J.; Vancott, T.; Marovich, M.; Stout, R. et al. Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara. J. Infect Dis. 2008, 198, 1482-1490.
    • (2008) J. Infect Dis , vol.198 , pp. 1482-1490
    • Sandstrom, E.1    Nilsson, C.2    Hejdeman, B.3    Brave, A.4    Bratt, G.5    Robb, M.6    Cox, J.7    Vancott, T.8    Marovich, M.9    Stout, R.10
  • 28
    • 29244466101 scopus 로고    scopus 로고
    • Phase I clinical trial safety of DNA- and modified virus Ankara-vectored human immunodeficiency virus type 1(HIV-1) vaccines administered alone and in a prime-boost regime to healthy HIV-1-uninfected volunteers
    • Cebere, I.; Dorrell, L.; McShane, H.; Simmons, A.; McCormack, S.; Schmidt, C.; Smith, C.; Brooks, M.; Roberts, J.E.; Darwin, S.C. et al. Phase I clinical trial safety of DNA- and modified virus Ankara-vectored human immunodeficiency virus type 1(HIV-1) vaccines administered alone and in a prime-boost regime to healthy HIV-1-uninfected volunteers. Vaccine 2006, 24, 417-425.
    • (2006) Vaccine , vol.24 , pp. 417-425
    • Cebere, I.1    Dorrell, L.2    McShane, H.3    Simmons, A.4    McCormack, S.5    Schmidt, C.6    Smith, C.7    Brooks, M.8    Roberts, J.E.9    Darwin, S.C.10
  • 29
    • 33846148643 scopus 로고    scopus 로고
    • Clinical experience with plasmid DNA-and modified vaccinia virus Ankara-vectored human immunodeficiency virus type 1 clade A vaccine focusing on T-cell induction
    • Hanke, T.; Goonetilleke, N.; McMichael, A.J.; Dorrell, L. Clinical experience with plasmid DNA-and modified vaccinia virus Ankara-vectored human immunodeficiency virus type 1 clade A vaccine focusing on T-cell induction. J. Gen. Virol. 2007, 88, 1-12.
    • (2007) J. Gen. Virol , vol.88 , pp. 1-12
    • Hanke, T.1    Goonetilleke, N.2    McMichael, A.J.3    Dorrell, L.4
  • 30
    • 58149204280 scopus 로고    scopus 로고
    • Lessons from IAVI-006, a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers
    • Guimaraes-Walker, A.; Mackie, N.; McCormack, S.; Hanke, T.; Schmidt, C.; Gilmour, J.; Barin, B.; McMichael, A.; Weber, J.; Legg, K. et al. Lessons from IAVI-006, a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers. Vaccine 2008, 26, 6671-6677.
    • (2008) Vaccine , vol.26 , pp. 6671-6677
    • Guimaraes-Walker, A.1    Mackie, N.2    McCormack, S.3    Hanke, T.4    Schmidt, C.5    Gilmour, J.6    Barin, B.7    McMichael, A.8    Weber, J.9    Legg, K.10
  • 31
    • 77954364931 scopus 로고    scopus 로고
    • Strong HIV-specific CD4+ and CD8+ T-lymphocyte proliferative responses in healthy individuals immunized with an HIV-1 DNA vaccine and boosted with recombinant modified vaccinia virus ankara expressing HIV-1 genes
    • Aboud, S.; Nilsson, C.; Karlen, K.; Marovich, M.; Wahren, B.; Sandstrom, E.; Gaines, H.; Biberfeld, G.; Godoy-Ramirez, K. Strong HIV-specific CD4+ and CD8+ T-lymphocyte proliferative responses in healthy individuals immunized with an HIV-1 DNA vaccine and boosted with recombinant modified vaccinia virus ankara expressing HIV-1 genes. Clin. Vaccine Immunol. 2010, 17, 1124-1131.
    • (2010) Clin. Vaccine Immunol , vol.17 , pp. 1124-1131
    • Aboud, S.1    Nilsson, C.2    Karlen, K.3    Marovich, M.4    Wahren, B.5    Sandstrom, E.6    Gaines, H.7    Biberfeld, G.8    Godoy-Ramirez, K.9
  • 32
    • 79751487021 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles
    • Goepfert, P.A.; Elizaga, M.L.; Sato, A.; Qin, L.; Cardinali, M.; Hay, C.M.; Hural, J.; DeRosa, S.C.; DeFawe, O.D.; Tomaras, G.D. et al. Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles. J. Infect Dis. 2011, 203, 610-619.
    • (2011) J. Infect Dis , vol.203 , pp. 610-619
    • Goepfert, P.A.1    Elizaga, M.L.2    Sato, A.3    Qin, L.4    Cardinali, M.5    Hay, C.M.6    Hural, J.7    Derosa, S.C.8    Defawe, O.D.9    Tomaras, G.D.10
  • 33
    • 84895540725 scopus 로고    scopus 로고
    • Broad and potent cellular and humoral immune responses after a second late HIV-modified vaccinia virus Ankara vaccination in HIV-DNA-primed and HIV-modified vaccinia virus Ankara-Boosted Swedish vaccinees
    • Nilsson, C.; Godoy-Ramirez, K.; Hejdeman, B.; Brave, A.; Gudmundsdotter, L.; Hallengard, D.; Currier, J.R.; Wieczorek, L.; Hasselrot, K.; Earl, P.L. et al. Broad and potent cellular and humoral immune responses after a second late HIV-modified vaccinia virus Ankara vaccination in HIV-DNA-primed and HIV-modified vaccinia virus Ankara-Boosted Swedish vaccinees. AIDS Res. Hum. Retrovir. 2013, doi:10.1089/aid.2013.0149.
    • (2013) AIDS Res. Hum. Retrovir
    • Nilsson, C.1    Godoy-Ramirez, K.2    Hejdeman, B.3    Brave, A.4    Gudmundsdotter, L.5    Hallengard, D.6    Currier, J.R.7    Wieczorek, L.8    Hasselrot, K.9    Earl, P.L.10
  • 34
    • 52449104809 scopus 로고    scopus 로고
    • Vaccines: Ready for prime time? Nat
    • Kutzler, M.A.; Weiner, D.B. DNA vaccines: Ready for prime time? Nat. Rev. Genet. 2008, 9, 776-788.
    • (2008) Rev. Genet , vol.9 , pp. 776-788
    • Kutzler, M.A.1    Weiner, D.B.2
  • 36
    • 0029956512 scopus 로고    scopus 로고
    • Gene vaccination with naked plasmid DNA: Mechanism of CTL priming
    • Corr, M.; Lee, D.J.; Carson, D.A.; Tighe, H. Gene vaccination with naked plasmid DNA: Mechanism of CTL priming. J. Exp. Med. 1996, 184, 1555-1560.
    • (1996) J. Exp. Med , vol.184 , pp. 1555-1560
    • Corr, M.1    Lee, D.J.2    Carson, D.A.3    Tighe, H.4
  • 37
    • 0033979001 scopus 로고    scopus 로고
    • Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production
    • Asakura, Y.; Liu, L.J.; Shono, N.; Hinkula, J.; Kjerrstrom, A.; Aoki, I.; Okuda, K.; Wahren, B.; Fukushima, J. Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production. Clin. Exp. Immunol. 2000, 119, 130-139.
    • (2000) Clin. Exp. Immunol , vol.119 , pp. 130-139
    • Asakura, Y.1    Liu, L.J.2    Shono, N.3    Hinkula, J.4    Kjerrstrom, A.5    Aoki, I.6    Okuda, K.7    Wahren, B.8    Fukushima, J.9
  • 38
    • 0031093543 scopus 로고    scopus 로고
    • Helper cell types and antibody isotypes generated by saline and gene gun DNA immunization
    • Feltquate, D.M.; Heaney, S.; Webster, R.G.; Robinson, H.L. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 1997, 158, 2278-2784.
    • (1997) J. Immunol , vol.158 , pp. 2278-2784
    • Feltquate, D.M.1    Heaney, S.2    Webster, R.G.3    Robinson, H.L.4    Different, T.5
  • 39
    • 39149102819 scopus 로고    scopus 로고
    • Comparative studies on in vitro expression and in vivo immunogenicity of supercoiled and open circular forms of plasmid DNA vaccines
    • Pillai, V.B.; Hellerstein, M.; Yu, T.; Amara, R.R.; Robinson, H.L. Comparative studies on in vitro expression and in vivo immunogenicity of supercoiled and open circular forms of plasmid DNA vaccines. Vaccine 2008, 26, 1136-1141.
    • (2008) Vaccine , vol.26 , pp. 1136-1141
    • Pillai, V.B.1    Hellerstein, M.2    Yu, T.3    Amara, R.R.4    Robinson, H.L.5
  • 41
    • 0037045012 scopus 로고    scopus 로고
    • T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev
    • MacGregor, R.R.; Ginsberg, R.; Ugen, K.E.; Baine, Y.; Kang, C.U.; Tu, X.M.; Higgins, T.; Weiner, D.B.; Boyer, J.D. T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev. AIDS 2002, 16, 2137-2143.
    • (2002) AIDS , vol.16 , pp. 2137-2143
    • Macgregor, R.R.1    Ginsberg, R.2    Ugen, K.E.3    Baine, Y.4    Kang, C.U.5    Tu, X.M.6    Higgins, T.7    Weiner, D.B.8    Boyer, J.D.9
  • 42
    • 79957781340 scopus 로고    scopus 로고
    • Electroporation delivery of DNA vaccines: Prospects for success
    • Sardesai, N.Y.; Weiner, D.B. Electroporation delivery of DNA vaccines: Prospects for success. Curr. Opin. Immunol. 2011, 23, 421-429.
    • (2011) Curr. Opin. Immunol , vol.23 , pp. 421-429
    • Sardesai, N.Y.1    Weiner, D.B.2
  • 43
  • 44
    • 0026442276 scopus 로고
    • Nonreplicating vaccinia vector efficiently expresses recombinant genes
    • Sutter, G.; Moss, B. Nonreplicating vaccinia vector efficiently expresses recombinant genes. Proc. Natl. Acad. Sci. USA 1992, 89, 10847-10851.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10847-10851
    • Sutter, G.1    Moss, B.2
  • 45
    • 0031585552 scopus 로고    scopus 로고
    • Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: Propagation and generation of recombinant viruses in a nonhuman mammalian cell line
    • Carroll, M.W.; Moss, B. Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line. Virology 1997, 238, 198-211.
    • (1997) Virology , vol.238 , pp. 198-211
    • Carroll, M.W.1    Moss, B.2
  • 47
    • 0032544063 scopus 로고    scopus 로고
    • Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer
    • USA
    • Seth, A.; Ourmanov, I.; Kuroda, M.J.; Schmitz, J.E.; Carroll, M.W.; Wyatt, L.S.; Moss, B.; Forman, M.A.; Hirsch, V.M.; Letvin, N.L. Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer. Proc. Natl. Acad. Sci. USA 1998, 95, 10112-10116.
    • (1998) Proc. Natl. Acad. Sci , vol.95 , pp. 10112-10116
    • Seth, A.1    Ourmanov, I.2    Kuroda, M.J.3    Schmitz, J.E.4    Carroll, M.W.5    Wyatt, L.S.6    Moss, B.7    Forman, M.A.8    Hirsch, V.M.9    Letvin, N.L.10
  • 48
    • 14744278299 scopus 로고    scopus 로고
    • Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: Stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2
    • Sadagopal, S.; Amara, R.R.; Montefiori, D.C.; Wyatt, L.S.; Staprans, S.I.; Kozyr, N.L.; McClure, H.M.; Moss, B.; Robinson, H.L. Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: Stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2. J. Virol. 2005, 79, 3243-3253.
    • (2005) J. Virol , vol.79 , pp. 3243-3253
    • Sadagopal, S.1    Amara, R.R.2    Montefiori, D.C.3    Wyatt, L.S.4    Staprans, S.I.5    Kozyr, N.L.6    McClure, H.M.7    Moss, B.8    Robinson, H.L.9
  • 49
    • 0036113771 scopus 로고    scopus 로고
    • Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine
    • Amara, R.R.; Smith, J.M.; Staprans, S.I.; Montefiori, D.C.; Villinger, F.; Altman, J.D.; O'Neil, S.P.; Kozyr, N.L.; Xu, Y.; Wyatt, L.S. et al. Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine. J. Virol. 2002, 76, 6138-6146.
    • (2002) J. Virol , vol.76 , pp. 6138-6146
    • Amara, R.R.1    Smith, J.M.2    Staprans, S.I.3    Montefiori, D.C.4    Villinger, F.5    Altman, J.D.6    O'Neil, S.P.7    Kozyr, N.L.8    Xu, Y.9    Wyatt, L.S.10
  • 50
    • 41949088384 scopus 로고    scopus 로고
    • Expansion and exhaustion of T-cell responses during mutational escape from long-term viral control in two DNA/modified vaccinia virus Ankara-vaccinated and simian-human immunodeficiency virus SHIV-89.6P-challenged macaques
    • Sadagopal, S.; Amara, R.R.; Kannanganat, S.; Sharma, S.; Chennareddi, L.; Robinson, H.L. Expansion and exhaustion of T-cell responses during mutational escape from long-term viral control in two DNA/modified vaccinia virus Ankara-vaccinated and simian-human immunodeficiency virus SHIV-89.6P-challenged macaques. J. Virol. 2008, 82,4149-4153.
    • (2008) J. Virol , vol.82 , pp. 4149-4153
    • Sadagopal, S.1    Amara, R.R.2    Kannanganat, S.3    Sharma, S.4    Chennareddi, L.5    Robinson, H.L.6
  • 51
    • 27744609130 scopus 로고    scopus 로고
    • Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA- vaccinated macaques
    • Amara, R.R.; Ibegbu, C.; Villinger, F.; Montefiori, D.C.; Sharma, S.; Nigam, P.; Xu, Y.; McClure, H.M.; Robinson, H.L. Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA- vaccinated macaques. Virology 2005, 343, 246-255.
    • (2005) Virology , vol.343 , pp. 246-255
    • Amara, R.R.1    Ibegbu, C.2    Villinger, F.3    Montefiori, D.C.4    Sharma, S.5    Nigam, P.6    Xu, Y.7    McClure, H.M.8    Robinson, H.L.9
  • 52
    • 0036310296 scopus 로고    scopus 로고
    • Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara(MVA) and DNA/MVA vaccines
    • Amara, R.R.; Villinger, F.; Staprans, S.I.; Altman, J.D.; Montefiori, D.C.; Kozyr, N.L.; Xu, Y.; Wyatt, L.S.; Earl, P.L.; Herndon, J.G.; et al. Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara(MVA) and DNA/MVA vaccines. J. Virol. 2002, 76, 7625-7631.
    • (2002) J. Virol , vol.76 , pp. 7625-7631
    • Amara, R.R.1    Villinger, F.2    Staprans, S.I.3    Altman, J.D.4    Montefiori, D.C.5    Kozyr, N.L.6    Xu, Y.7    Wyatt, L.S.8    Earl, P.L.9    Herndon, J.G.10
  • 53
    • 84856810276 scopus 로고    scopus 로고
    • SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses
    • Lai, L.; Kwa, S.F.; Kozlowski, P.A.; Montefiori, D.C.; Nolen, T.L.; Hudgens, M.G.; Johnson, W.E.; Ferrari, G.; Hirsch, V.M.; Felber, B.K. et al. SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses. Vaccine 2012, 30, 1737-1745.
    • (2012) Vaccine , vol.30 , pp. 1737-1745
    • Lai, L.1    Kwa, S.F.2    Kozlowski, P.A.3    Montefiori, D.C.4    Nolen, T.L.5    Hudgens, M.G.6    Johnson, W.E.7    Ferrari, G.8    Hirsch, V.M.9    Felber, B.K.10
  • 54
    • 0031066827 scopus 로고    scopus 로고
    • Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids
    • Geissler, M.; Gesien, A.; Tokushige, K.; Wands, J.R. Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J. Immunol. 1997, 158, 1231-1237.
    • (1997) J. Immunol , vol.158 , pp. 1231-1237
    • Geissler, M.1    Gesien, A.2    Tokushige, K.3    Wands, J.R.4
  • 57
    • 0023244861 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigenpresenting cells
    • Morrissey, P.J.; Bressler, L.; Park, L.S.; Alpert, A.; Gillis, S. Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigenpresenting cells. J. Immunol. 1987, 139, 1113-1119.
    • (1987) J. Immunol , vol.139 , pp. 1113-1119
    • Morrissey, P.J.1    Bressler, L.2    Park, L.S.3    Alpert, A.4    Gillis, S.5
  • 58
    • 0025947916 scopus 로고
    • Selective up-regulation of macrophage function in granulocyte-macrophage colony-stimulating factor transgenic mice
    • Elliott, M.J.; Strasser, A.; Metcalf, D. Selective up-regulation of macrophage function in granulocyte-macrophage colony-stimulating factor transgenic mice. J. Immunol. 1991, 147, 2957-2963.
    • (1991) J. Immunol , vol.147 , pp. 2957-2963
    • Elliott, M.J.1    Strasser, A.2    Metcalf, D.3
  • 59
    • 0034292354 scopus 로고    scopus 로고
    • Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including immature dendritic cells into injected muscles
    • Haddad, D.; Ramprakash, J.; Sedegah, M.; Charoenvit, Y.; Baumgartner, R.; Kumar, S.; Hoffman, S.L.; Weiss, W.R. Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including immature dendritic cells into injected muscles. J. Immunol. 2000, 165, 3772-3781.
    • (2000) J. Immunol , vol.165 , pp. 3772-3781
    • Haddad, D.1    Ramprakash, J.2    Sedegah, M.3    Charoenvit, Y.4    Baumgartner, R.5    Kumar, S.6    Hoffman, S.L.7    Weiss, W.R.8
  • 61
    • 35649027418 scopus 로고    scopus 로고
    • GM-CSF DNA: An adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine
    • Lai, L.; Vodros, D.; Kozlowski, P.A.; Montefiori, D.C.; Wilson, R.L.; Akerstrom, V.L.; Chennareddi, L.; Yu, T.; Kannanganat, S.; Ofielu, L. et al. GM-CSF DNA: An adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. Virology 2007, 369, 153-167.
    • (2007) Virology , vol.369 , pp. 153-167
    • Lai, L.1    Vodros, D.2    Kozlowski, P.A.3    Montefiori, D.C.4    Wilson, R.L.5    Akerstrom, V.L.6    Chennareddi, L.7    Yu, T.8    Kannanganat, S.9    Ofielu, L.10
  • 62
    • 79957947384 scopus 로고    scopus 로고
    • Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine
    • Lai, L.; Kwa, S.; Kozlowski, P.A.; Montefiori, D.C.; Ferrari, G.; Johnson, W.E.; Hirsch, V.; Villinger, F.; Chennareddi, L.; Earl, P.L. et al. Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine. J. Infect Dis. 2011, 204, 164-173.
    • (2011) J. Infect Dis , vol.204 , pp. 164-173
    • Lai, L.1    Kwa, S.2    Kozlowski, P.A.3    Montefiori, D.C.4    Ferrari, G.5    Johnson, W.E.6    Hirsch, V.7    Villinger, F.8    Chennareddi, L.9    Earl, P.L.10
  • 63
    • 84869848516 scopus 로고    scopus 로고
    • Co-expression of HIV-1 virus-like particles and granulocyte-macrophage colony stimulating factor by GEO-D03 DNA vaccine
    • Hellerstein, M.; Xu, Y.; Marino, T.; Lu, S.; Yi, H.; Wright, E.R.; Robinson, H.L. Co-expression of HIV-1 virus-like particles and granulocyte-macrophage colony stimulating factor by GEO-D03 DNA vaccine. Hum. Vaccin. Immunother. 2012, 8, 1654-1658.
    • (2012) Hum. Vaccin. Immunother , vol.8 , pp. 1654-1658
    • Hellerstein, M.1    Xu, Y.2    Marino, T.3    Lu, S.4    Yi, H.5    Wright, E.R.6    Robinson, H.L.7
  • 65
    • 0037117542 scopus 로고    scopus 로고
    • CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity
    • USA
    • Van Mierlo, G.J.; den Boer, A.T.; Medema, J.P.; van der Voort, E.I.; Fransen, M.F.; Offringa, R.; Melief, C.J.; Toes, R.E. CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity. Proc. Natl. Acad. Sci. USA 2002, 99, 5561-5566.
    • (2002) Proc. Natl. Acad. Sci , vol.99 , pp. 5561-5566
    • van Mierlo, G.J.1    den, B.A.T.2    Medema, J.P.3    van der, V.E.I.4    Fransen, M.F.5    Offringa, R.6    Melief, C.J.7    Toes, R.E.8
  • 66
    • 0032896709 scopus 로고    scopus 로고
    • CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
    • French, R.R.; Chan, H.T.; Tutt, A.L.; Glennie, M.J. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat. Med. 1999, 5, 548-553.
    • (1999) Nat. Med , vol.5 , pp. 548-553
    • French, R.R.1    Chan, H.T.2    Tutt, A.L.3    Glennie, M.J.4
  • 67
    • 2542476167 scopus 로고    scopus 로고
    • CD40/CD154 interactions at the interface of tolerance and immunity
    • Quezada, S.A.; Jarvinen, L.Z.; Lind, E.F.; Noelle, R.J. CD40/CD154 interactions at the interface of tolerance and immunity. Annu. Rev. Immunol. 2004, 22, 307-328.
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 307-328
    • Quezada, S.A.1    Jarvinen, L.Z.2    Lind, E.F.3    Noelle, R.J.4
  • 69
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells(TFH)
    • Crotty, S. Follicular helper CD4 T cells(TFH). Annu. Rev. Immunol. 2011, 29, 621-663.
    • (2011) Annu. Rev. Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 71
    • 32444446901 scopus 로고    scopus 로고
    • Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines
    • Stone, G.W.; Barzee, S.; Snarsky, V.; Kee, K.; Spina, C.A.; Yu, X.F.; Kornbluth, R.S. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines. J. Virol. 2006, 80, 1762-1772.
    • (2006) J. Virol , vol.80 , pp. 1762-1772
    • Stone, G.W.1    Barzee, S.2    Snarsky, V.3    Kee, K.4    Spina, C.A.5    Yu, X.F.6    Kornbluth, R.S.7
  • 72
    • 67349168133 scopus 로고    scopus 로고
    • Multimeric soluble CD40 ligand(sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens
    • Gomez, C.E.; Najera, J.L.; Sanchez, R.; Jimenez, V.; Esteban, M. Multimeric soluble CD40 ligand(sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens. Vaccine 2009, 27, 3165-3174.
    • (2009) Vaccine , vol.27 , pp. 3165-3174
    • Gomez, C.E.1    Najera, J.L.2    Sanchez, R.3    Jimenez, V.4    Esteban, M.5
  • 73
    • 47149112188 scopus 로고    scopus 로고
    • CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals
    • Liu, J.; Yu, Q.; Stone, G.W.; Yue, F.Y.; Ngai, N.; Jones, R.B.; Kornbluth, R.S.; Ostrowski, M.A. CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals. Vaccine 2008, 26, 4062-4072.
    • (2008) Vaccine , vol.26 , pp. 4062-4072
    • Liu, J.1    Yu, Q.2    Stone, G.W.3    Yue, F.Y.4    Ngai, N.5    Jones, R.B.6    Kornbluth, R.S.7    Ostrowski, M.A.8
  • 74
    • 68149156979 scopus 로고    scopus 로고
    • Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand
    • Wyzgol, A.; Yu, Q.; Stone, G.W.; Yue, F.Y.; Ngai, N.; Jones, R.B.; Kornbluth, R.S.; Ostrowski, M.A. Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand. J. Immunol. 2009, 183, 1851-1861.
    • (2009) J. Immunol , vol.183 , pp. 1851-1861
    • Wyzgol, A.1    Yu, Q.2    Stone, G.W.3    Yue, F.Y.4    Ngai, N.5    Jones, R.B.6    Kornbluth, R.S.7    Ostrowski, M.A.8
  • 75
    • 0033566813 scopus 로고    scopus 로고
    • Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment
    • Calarota, S.A.; Leandersson, A.C.; Bratt, G.; Hinkula, J.; Klinman, D.M.; Weinhold, K.J.; Sandstrom, E.; Wahren, B. Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. J. Immunol. 1999, 163, 2330-2338.
    • (1999) J. Immunol , vol.163 , pp. 2330-2338
    • Calarota, S.A.1    Leandersson, A.C.2    Bratt, G.3    Hinkula, J.4    Klinman, D.M.5    Weinhold, K.J.6    Sandstrom, E.7    Wahren, B.8
  • 77
    • 84873920547 scopus 로고    scopus 로고
    • Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: A phase I randomised Trial in HIV-uninfected Indian volunteers
    • Mehendale, S.; Thakar, M.; Sahay, S.; Kumar, M.; Shete, A.; Sathyamurthi, P.; Verma, A.; Kurle, S.; Shrotri, A.; Gilmour, J. et al. Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers. PLoS One 2013, 8, e55831.
    • (2013) PLoS One , vol.e55831 , pp. 8
    • Mehendale, S.1    Thakar, M.2    Sahay, S.3    Kumar, M.4    Shete, A.5    Sathyamurthi, P.6    Verma, A.7    Kurle, S.8    Shrotri, A.9    Gilmour, J.10


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