A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-Resistant Gram-Negative Bacteria

Journal of Medicinal Chemistry

Volumn 60, Issue 9, 2017, Pages 3913-3932

  Yang, Xuan ^a   Goswami, Sudeep ^a   Gorityala, Bala Kishan ^a   Domalaon, Ronald ^a   Lyu, Yinfeng ^a,b   Kumar, Ayush ^a   Zhanel, George G ^a   Schweizer, Frank ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b NORTHEAST AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 NAPHTHYLMETHYL)PIPERAZINE; 5 O (DODECYLPAROXETINE)TOBRAMYCIN; CHLORAMPHENICOL; COLISTIN; ERYTHROMYCIN; MINOCYCLINE; NOVOBIOCIN; PAROXETINE; PEPTIDE DERIVATIVE; PIPERAZINE DERIVATIVE; RIFAMPICIN; TOBRAMYCIN; TRIMETHOPRIM; UNCLASSIFIED DRUG; VANCOMYCIN; CARRIER PROTEIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL OUTER MEMBRANE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SYNTHESIS; ENTEROBACTER CLOACAE; FRACTIONAL INHIBITORY CONCENTRATION INDEX; GALLERIA MELLONELLA; GRAM NEGATIVE BACTERIUM; KLEBSIELLA PNEUMONIAE; NONHUMAN; PSEUDOMONAS AERUGINOSA; DRUG EFFECTS; GRAM POSITIVE BACTERIUM; METABOLISM; MULTIDRUG RESISTANCE;

DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MEMBRANE TRANSPORT PROTEINS; TOBRAMYCIN;

EID: 85019215287     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.7b00156     Document Type: Article

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