BDNF binds its pro-peptide with high affinity and the common val66met polymorphism attenuates the interaction

International Journal of Molecular Sciences

Volumn 18, Issue 5, 2017, Pages

  Uegaki, Koichi ^a,b   Kumanogoh, Haruko ^a,b   Mizui, Toshiyuki ^a,b   Hirokawa, Takatsugu ^a,b,c   Ishikawa, Yasuyuki ^b,d   Kojima, Masami ^a,b,e  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d MAEBASHI INSTITUTE OF TECHNOLOGY   (Japan)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

BDNF; Hippocampus; Long term depression; Polymorphism; Pro peptide

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHAPERONE; HETERODIMER; NEUROTROPHIN; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; PROTEIN BINDING;

ACIDIFICATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BRAIN FUNCTION; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; LONG TERM DEPRESSION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR INTERACTION; NERVE CELL PLASTICITY; PROTEIN BINDING; PROTEIN DOMAIN; SURFACE PLASMON RESONANCE; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; MALE; METABOLISM; MISSENSE MUTATION; MOUSE; PHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; HIPPOCAMPUS; HUMANS; LONG-TERM SYNAPTIC DEPRESSION; MALE; MICE; MICE, INBRED C57BL; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEOLYSIS;

EID: 85019212108     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18051042     Document Type: Article

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