메뉴 건너뛰기




Volumn 57, Issue , 2017, Pages 47-55

The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine

Author keywords

CGRP; CGRP receptor; CLR; gepants; monoclonal antibodies; RAMP1

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST;

EID: 85019163118     PISSN: 00178748     EISSN: 15264610     Source Type: Journal    
DOI: 10.1111/head.13081     Document Type: Article
Times cited : (213)

References (46)
  • 1
    • 85012103641 scopus 로고    scopus 로고
    • Pathophysiology of migraine: A disorder of sensory processing
    • Goadsby PJ, Holland PR, Martins-Oliveira M, et al. Pathophysiology of migraine: A disorder of sensory processing. Physiol Rev. 2017;97:553-622.
    • (2017) Physiol Rev. , vol.97 , pp. 553-622
    • Goadsby, P.J.1    Holland, P.R.2    Martins-Oliveira, M.3
  • 2
    • 0021981893 scopus 로고
    • Functional role of perivascular peptides in the control of cerebral circulation
    • Edvinsson L. Functional role of perivascular peptides in the control of cerebral circulation. Trends Neurosci. 1985;8:126-131.
    • (1985) Trends Neurosci. , vol.8 , pp. 126-131
    • Edvinsson, L.1
  • 3
    • 0025143541 scopus 로고
    • Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
    • Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28:183-187.
    • (1990) Ann Neurol. , vol.28 , pp. 183-187
    • Goadsby, P.J.1    Edvinsson, L.2    Ekman, R.3
  • 4
    • 0027509161 scopus 로고
    • The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
    • Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol. 1993;33:48-56.
    • (1993) Ann Neurol. , vol.33 , pp. 48-56
    • Goadsby, P.J.1    Edvinsson, L.2
  • 5
    • 0028242295 scopus 로고
    • Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies
    • Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain. 1994;117:427-434.
    • (1994) Brain. , vol.117 , pp. 427-434
    • Goadsby, P.J.1    Edvinsson, L.2
  • 6
    • 77956074035 scopus 로고    scopus 로고
    • New drugs in migraine treatment and prophylaxis: Telcagepant and topiramate
    • Edvinsson L, Linde M. New drugs in migraine treatment and prophylaxis: Telcagepant and topiramate. Lancet. 2010;376:645-655.
    • (2010) Lancet. , vol.376 , pp. 645-655
    • Edvinsson, L.1    Linde, M.2
  • 7
    • 84942435654 scopus 로고    scopus 로고
    • New therapeutic approaches for the prevention and treatment of migraine
    • Diener HC, Charles A, Goadsby PJ, Holle D. New therapeutic approaches for the prevention and treatment of migraine. Lancet Neurol. 2015;14:1010-1022.
    • (2015) Lancet Neurol. , vol.14 , pp. 1010-1022
    • Diener, H.C.1    Charles, A.2    Goadsby, P.J.3    Holle, D.4
  • 8
    • 84892735076 scopus 로고    scopus 로고
    • Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks
    • Maniyar FA, Sprenger T, Monteith T, Schankin C, Goadsby PJ. Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks. Brain. 2014;137:232-241.
    • (2014) Brain. , vol.137 , pp. 232-241
    • Maniyar, F.A.1    Sprenger, T.2    Monteith, T.3    Schankin, C.4    Goadsby, P.J.5
  • 9
    • 84977528163 scopus 로고    scopus 로고
    • The migraine generator revisited: Continuous scanning of the migraine cycle over 30 days and three spontaneous attacks
    • Schulte LH, May A. The migraine generator revisited: Continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain. 2016;139:1987-1993.
    • (2016) Brain. , vol.139 , pp. 1987-1993
    • Schulte, L.H.1    May, A.2
  • 10
    • 0029012866 scopus 로고
    • Brain stem activation in spontaneous human migraine attacks
    • Weiller C, May A, Limmroth V, et al. Brain stem activation in spontaneous human migraine attacks. Nat Med. 1995;1:658-660.
    • (1995) Nat Med. , vol.1 , pp. 658-660
    • Weiller, C.1    May, A.2    Limmroth, V.3
  • 11
    • 77049204393 scopus 로고
    • Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motor neurons
    • Eccles JC, Fatt P, Koketsu K. Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motor neurons. J Physiol. 1954;126:524-562.
    • (1954) J Physiol. , vol.126 , pp. 524-562
    • Eccles, J.C.1    Fatt, P.2    Koketsu, K.3
  • 12
    • 0014187213 scopus 로고
    • Adrenergic innervation of pial arteries related to the circle of Willis in the cat
    • Nielsen KC, Owman C. Adrenergic innervation of pial arteries related to the circle of Willis in the cat. Brain Res. 1967;6:773-776.
    • (1967) Brain Res. , vol.6 , pp. 773-776
    • Nielsen, K.C.1    Owman, C.2
  • 13
    • 0015450217 scopus 로고
    • Cholinergic mechanisms in pial vessels. Histochemistry, electron microscopy and pharmacology
    • Edvinsson L, Nielsen KC, Owman C, Sporrong B. Cholinergic mechanisms in pial vessels. Histochemistry, electron microscopy and pharmacology. Z Zellforsch Mikrosk Anat. 1972;134:311-325.
    • (1972) Z Zellforsch Mikrosk Anat. , vol.134 , pp. 311-325
    • Edvinsson, L.1    Nielsen, K.C.2    Owman, C.3    Sporrong, B.4
  • 14
    • 0017211431 scopus 로고
    • Amine mechanisms in the cerebral circulation
    • Edvinsson L, MacKenzie ET. Amine mechanisms in the cerebral circulation. Pharmacol Rev. 1976;28:275-348.
    • (1976) Pharmacol Rev. , vol.28 , pp. 275-348
    • Edvinsson, L.1    MacKenzie, E.T.2
  • 15
    • 0015393308 scopus 로고
    • Purinergic nerves
    • Burnstock G. Purinergic nerves. Pharmacol Rev. 1972;24:509-558.
    • (1972) Pharmacol Rev. , vol.24 , pp. 509-558
    • Burnstock, G.1
  • 16
    • 0017077664 scopus 로고
    • Immunohistochemical localization of a vasodilatory polypeptide (VIP) in cerebrovascular nerves
    • Larsson LI, Edvinsson L, Fahrenkrug J, et al. Immunohistochemical localization of a vasodilatory polypeptide (VIP) in cerebrovascular nerves. Brain Res. 1976;11:400-404.
    • (1976) Brain Res. , vol.11 , pp. 400-404
    • Larsson, L.I.1    Edvinsson, L.2    Fahrenkrug, J.3
  • 17
    • 0019185987 scopus 로고
    • VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals
    • Edvinsson L, Fahrenkrug J, Hanko J, et al. VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals. Cell Tissue Res. 1980;208:135-142.
    • (1980) Cell Tissue Res. , vol.208 , pp. 135-142
    • Edvinsson, L.1    Fahrenkrug, J.2    Hanko, J.3
  • 18
    • 0022852245 scopus 로고
    • Multiple co-existence of peptides and classical transmitters in peripheral autonomic and sensory neurons—Functional and pharmacological implications
    • Lundberg JM, Hökfelt T. Multiple co-existence of peptides and classical transmitters in peripheral autonomic and sensory neurons—Functional and pharmacological implications. Prog Brain Res. 1986;68:241-262.
    • (1986) Prog Brain Res. , vol.68 , pp. 241-262
    • Lundberg, J.M.1    Hökfelt, T.2
  • 20
    • 0019948176 scopus 로고
    • Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
    • Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature. 1982;298:240-244.
    • (1982) Nature. , vol.298 , pp. 240-244
    • Amara, S.G.1    Jonas, V.2    Rosenfeld, M.G.3    Ong, E.S.4    Evans, R.M.5
  • 21
    • 0020607936 scopus 로고
    • Production of a novel neuropeptide encoded by the calcitonin gene expression generates mRNAs encoding different polypeptide products
    • Rosenfeld MG, Mermod JJ, Amara SG, et al. Production of a novel neuropeptide encoded by the calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature. 1983;304:129-135.
    • (1983) Nature. , vol.304 , pp. 129-135
    • Rosenfeld, M.G.1    Mermod, J.J.2    Amara, S.G.3
  • 22
    • 0022356240 scopus 로고
    • Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and coexistence with substance P
    • Uddman R, Edvinsson L, Ekman R, Kingman T, McCulloch J. Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and coexistence with substance P. Neurosci Lett. 1985;62:131-136.
    • (1985) Neurosci Lett. , vol.62 , pp. 131-136
    • Uddman, R.1    Edvinsson, L.2    Ekman, R.3    Kingman, T.4    McCulloch, J.5
  • 23
    • 84887643807 scopus 로고    scopus 로고
    • CGRP in the trigeminovascular system: A role for CGRP, adrenomedullin and amylin receptors?
    • Walker CS, Hay DL. CGRP in the trigeminovascular system: A role for CGRP, adrenomedullin and amylin receptors? Br J Pharmacol. 2013;170:1293-1307.
    • (2013) Br J Pharmacol. , vol.170 , pp. 1293-1307
    • Walker, C.S.1    Hay, D.L.2
  • 25
    • 0037395801 scopus 로고    scopus 로고
    • RPR100893, a substance-P antagonist, is not effective in the treatment of migraine attacks
    • Diener HC. RPR100893 Study Group. RPR100893, a substance-P antagonist, is not effective in the treatment of migraine attacks. Cephalalgia. 2003;23:183-185.
    • (2003) Cephalalgia. , vol.23 , pp. 183-185
    • Diener, H.C.1
  • 26
    • 40949083906 scopus 로고    scopus 로고
    • Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
    • Lennerz JK, Ruhle V, Ceppa EP, et al. Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution. J Comp Neurol. 2008;507:1277-1299.
    • (2008) J Comp Neurol. , vol.507 , pp. 1277-1299
    • Lennerz, J.K.1    Ruhle, V.2    Ceppa, E.P.3
  • 27
    • 77954620156 scopus 로고    scopus 로고
    • Differential distribution of calcitonin gene-related peptide (CGRP) and its receptor components in the human trigeminal ganglion
    • Eftekhari S, Salvatore CA, Calamari A, et al. Differential distribution of calcitonin gene-related peptide (CGRP) and its receptor components in the human trigeminal ganglion. Neuroscience. 2010;169:683-696.
    • (2010) Neuroscience. , vol.169 , pp. 683-696
    • Eftekhari, S.1    Salvatore, C.A.2    Calamari, A.3
  • 28
    • 81055126935 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and the spinal cord at C1-level
    • Eftekhari S, Edvinsson L. Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and the spinal cord at C1-level. BMC Neuroscience. 2011;12:112.
    • (2011) BMC Neuroscience. , vol.12 , pp. 112
    • Eftekhari, S.1    Edvinsson, L.2
  • 29
    • 84940026739 scopus 로고    scopus 로고
    • A second trigeminal CGRP receptor: Function and expression of the AMY1 receptor
    • Walker CS, Eftekhari S, Bower RL, et al. A second trigeminal CGRP receptor: Function and expression of the AMY1 receptor. Ann Clin Transl Neurol. 2015;2:595-608.
    • (2015) Ann Clin Transl Neurol. , vol.2 , pp. 595-608
    • Walker, C.S.1    Eftekhari, S.2    Bower, R.L.3
  • 30
    • 0022255204 scopus 로고
    • Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat
    • Edvinsson L, Fredholm BB, Hamel E, Jansen I, Verrecchia C. Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neurosci Lett. 1985;58:213-217.
    • (1985) Neurosci Lett. , vol.58 , pp. 213-217
    • Edvinsson, L.1    Fredholm, B.B.2    Hamel, E.3    Jansen, I.4    Verrecchia, C.5
  • 31
    • 0023025088 scopus 로고
    • On the functional role of the trigeminocerebrovascular system in the regulation of cerebral circulation
    • In, Owman C, Hardebo JE, eds., Amsterdam, Elsevier Science
    • Edvinsson L, McCulloch J, Kingman T, Uddman R, On the functional role of the trigeminocerebrovascular system in the regulation of cerebral circulation. In: Owman C, Hardebo JE, eds. Neural Regulation of the Cerebral Circulation. Amsterdam: Elsevier Science; 1986:407-418.
    • (1986) Neural Regulation of the Cerebral Circulation , pp. 407-418
    • Edvinsson, L.1    McCulloch, J.2    Kingman, T.3    Uddman, R.4
  • 32
    • 0001704648 scopus 로고
    • Calcitonin gene-related peptide: Functional role in cerebrovascular regulation
    • McCulloch J, Uddman R, Kingman TA, Edvinsson L. Calcitonin gene-related peptide: Functional role in cerebrovascular regulation. Proc Natl Acad Sci USA. 1986; 83:5731-5735.
    • (1986) Proc Natl Acad Sci USA. , vol.83 , pp. 5731-5735
    • McCulloch, J.1    Uddman, R.2    Kingman, T.A.3    Edvinsson, L.4
  • 33
    • 0023874663 scopus 로고
    • Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
    • Goadsby PJ, Edvinsson L, Ekman R. Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol. 1988;23:193-196.
    • (1988) Ann Neurol. , vol.23 , pp. 193-196
    • Goadsby, P.J.1    Edvinsson, L.2    Ekman, R.3
  • 34
    • 77957922955 scopus 로고    scopus 로고
    • CGRP and its receptors provide new insights into migraine pathophysiology
    • Ho TW, Edvinsson L, Goadsby PJ. CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol. 2010; 6:573-582.
    • (2010) Nat Rev Neurol. , vol.6 , pp. 573-582
    • Ho, T.W.1    Edvinsson, L.2    Goadsby, P.J.3
  • 35
    • 77956259028 scopus 로고    scopus 로고
    • Measurement of vasoactive neuropeptides in biological materials: Problems and pitfalls from 30 years of experience and novel future approaches
    • Edvinsson L, Ekman R, Goadsby PJ. Measurement of vasoactive neuropeptides in biological materials: Problems and pitfalls from 30 years of experience and novel future approaches. Cephalalgia. 2010;30:761-766.
    • (2010) Cephalalgia. , vol.30 , pp. 761-766
    • Edvinsson, L.1    Ekman, R.2    Goadsby, P.J.3
  • 36
    • 84888324384 scopus 로고    scopus 로고
    • Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine
    • Cernuda-Morollón E, Larrosa D, Ramón C, et al. Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine. Neurology. 2013;81:1191-1196.
    • (2013) Neurology. , vol.81 , pp. 1191-1196
    • Cernuda-Morollón, E.1    Larrosa, D.2    Ramón, C.3
  • 37
    • 78650413846 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura
    • Hansen JM, Hauge AW, Olesen J, Ashina M. Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia. 2010;30:1179-1186.
    • (2010) Cephalalgia. , vol.30 , pp. 1179-1186
    • Hansen, J.M.1    Hauge, A.W.2    Olesen, J.3    Ashina, M.4
  • 39
    • 84948104998 scopus 로고    scopus 로고
    • Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography
    • Eftekhari S, Gaspar RC, Roberts R, et al. Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography. J Comp Neurol. 2016;524:90-118.
    • (2016) J Comp Neurol. , vol.524 , pp. 90-118
    • Eftekhari, S.1    Gaspar, R.C.2    Roberts, R.3
  • 40
    • 85019057908 scopus 로고    scopus 로고
    • Distribution of CGRP and CGRP receptor components in the rat brain
    • Warfvinge K, Edvinsson L. Distribution of CGRP and CGRP receptor components in the rat brain. Cephalalgia. 2017;37.
    • (2017) Cephalalgia. , vol.37
    • Warfvinge, K.1    Edvinsson, L.2
  • 42
    • 35648995321 scopus 로고    scopus 로고
    • CGRP antagonists: Unraveling the role of CGRP in migraine
    • Doods H, Arndt K, Rudolf K, Just S. CGRP antagonists: Unraveling the role of CGRP in migraine. Trends Pharmacol Sci. 2007;28:580-587.
    • (2007) Trends Pharmacol Sci. , vol.28 , pp. 580-587
    • Doods, H.1    Arndt, K.2    Rudolf, K.3    Just, S.4
  • 43
    • 84937517146 scopus 로고    scopus 로고
    • CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment
    • Edvinsson L. CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment. Br J Clin Pharmacol. 2015;80:193-199.
    • (2015) Br J Clin Pharmacol. , vol.80 , pp. 193-199
    • Edvinsson, L.1
  • 44
    • 84923335592 scopus 로고    scopus 로고
    • Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier
    • Eftekhari S, Salvatore CA, Johansson S, et al. Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier. Brain Res. 2015;1600:93-109.
    • (2015) Brain Res. , vol.1600 , pp. 93-109
    • Eftekhari, S.1    Salvatore, C.A.2    Johansson, S.3
  • 45
    • 84886024087 scopus 로고    scopus 로고
    • In vivo quantification of calcitonin gene-related peptide (CGRP) receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography (PET) tracer [11C]MK-4232
    • Hostetler ED, Joshi AD, Sanabria-Bohorquez S, et al. In vivo quantification of calcitonin gene-related peptide (CGRP) receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography (PET) tracer [11C]MK-4232. J Pharmacol Exp Ther. 2013;347:478-486.
    • (2013) J Pharmacol Exp Ther. , vol.347 , pp. 478-486
    • Hostetler, E.D.1    Joshi, A.D.2    Sanabria-Bohorquez, S.3
  • 46
    • 84958164333 scopus 로고    scopus 로고
    • Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain or trigeminal mircrovascular passage
    • Lundblad C, Haanes KA, Grände G, Edvinsson L. Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain or trigeminal mircrovascular passage. J Headache Pain. 2015;16:91.
    • (2015) J Headache Pain. , vol.16 , pp. 91
    • Lundblad, C.1    Haanes, K.A.2    Grände, G.3    Edvinsson, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.