Quantitative 3D Telomeric Imaging of Buccal Cells Reveals Alzheimer's Disease-Specific Signatures

Journal of Alzheimer's Disease

Volumn 58, Issue 1, 2017, Pages 139-145

  Garcia, Angeles ^b   Mathur, Shubha ^a   Kalaw, Maria Carmela ^a   McAvoy, Elizabeth ^b   Anderson, James ^b   Luedke, Angela ^b   Itorralba, Justine ^b   Mai, Sabine ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; buccal cells; telomeres

Indexed keywords

AGE; AGED; ALZHEIMER DISEASE; ARTICLE; CAREGIVER; CHEEK CELL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENDER; HUMAN; HUMAN CELL; MALE; MILD COGNITIVE IMPAIRMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLE SIZE; TELOMERE LENGTH; THREE DIMENSIONAL IMAGING; VERY ELDERLY; ANALYSIS OF VARIANCE; CASE CONTROL STUDY; FLUORESCENCE IMAGING; MOUTH MUCOSA; PATHOLOGY; PROCEDURES; PSYCHOLOGICAL RATING SCALE; TELOMERE; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MOUTH MUCOSA; OPTICAL IMAGING; PSYCHIATRIC STATUS RATING SCALES; TELOMERE;

EID: 85019104126     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-161169     Document Type: Article

References (40)

1. Alzheimer's Association (2014) 2014 Alzheimer's Disease Facts and Figures. Alzheimers Dement 10, e47-e92.
2. Hebert L, Weuve J, Scherr P, Evans D (2013) Alzheimer disease in the United States (2010-2050) estimated using the 2010 Census. Neurology 80, 1778-1783.
3. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
4. Jack CR, Albert MS, Knopman DS, McKhannGM,Sperling RA, Carrillo MC, Thies B, Phelps CH (2011) Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's Disease. Alzheimers Dement 7, 257-262.
5. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, PhelpsCH(2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 270-279.
6. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 263-269.
7. Hanninen T, Hallikainen M, Tuomainen S, Vanhanen M, SoininenH(2002) Prevalence of mild cognitive impairment: A population-based study in elderly subjects. Acta Neurol Scand 106, 148-154.
8. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol 56, 303-308.
9. Tan L, Yu J, Liu Q, TanM, ZhangW, Hu N,Wang Y, Sun L, Jiang T, Tan L (2014) Circulating miR-125b as a biomarker of Alzheimer's disease. J Neurol Sci 336, 52-56.
10. Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (1995) The Montreal Cognitive Assessment, MoCA:Abrief screening tool for mild cognitive impairment. J Am Geriatr Soc 53, 695-699.
11. FolsteinMF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
12. McDowell I, Kristjansson B, Hill GB, Hebert R (1997) Community screening for dementia: The Mini Mental State Exam (MMSE) and Modified Mini-Mental State Exam (3MS) compared. J Clin Epidemiol 50, 377-383.
13. Boustani M, Peterson B, Hanson L, Harris R, LohrK(2003) Screening for dementia in primary care: A summary of the evidence for the U.S. Preventative Services task force. Ann Intern Med 138, 927-937.
14. Cai Z, Yan L, Ratka A (2013) Telomere shortening and Alzheimer's disease. Neuromol Med 15, 25-48.
15. Geller LN, Potter H (1999) Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's diseas. Neurobiol Dis 6, 167-179.
16. Migliore L, Testa A, Scarpato R, Pavese N, Petrozzi L, Bonuccelli U (1997) Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's Disease. Hum Genet 101, 299-305.
17. Thomas P, Fenech M (2008) Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. Mutagenesis 23, 57-65.
18. Panossian LA, Porter VR,Valenzuela HF, Zhu X, Reback E, Masterman D, Cummings JL, Effros RB (2003) Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging 24, 77-84.
19. ForeroDA, Gonz'alez-GiraldoY, L'opez-Quintero C, Castro-Vega LJ, Barreto GE, Perry G (2016) Meta-analysis of telomere length in Alzheimer's disease. J Gerontol A Biol Sci Med Sci 71, 1069-1073.
20. Watson JD (1972) Origin of concatemic T7 DNA. Nat New Biol 239, 197-201.
21. Olovnikov AM (1972) The immune response and the process of marginotomy in lymphoid cells. Vestn Akad Nauk SSSR 27, 85-87.
22. Kruk PA, Rampino NJ, Bohr VA (1995) DNA damage and repair in telomeres: Relation to aging. Proc Natl Acad Sci U S A 92, 258-262.
23. de Lange T (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev 19, 2100-2110.
24. Thomas P, O'Callaghan NJ, Fenech M (2008) Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech Ageing Dev 129, 183-190.
25. Gadji M, Adebayo Awe J, Rodrigues P, Kumar R, Houston DS, Klewes L, Di'eye TN, Rego EM, PassettoRF, de Oliveira FM, Mai S (2012) Profiling three-dimensional nuclear telomeric architecture of myelodysplastic syndromes and acute myeloid leukemia defines patient subgroups. Clin Cancer Res 18, 3293-3304.
26. Knecht H, Kongruttanachok N, Sawan B, Brossard J, Pr'evost S, Turcotte E, Lichtensztejn Z, Lichtensztejn D, Mai S (2012) Three-dimensional telomere signatures of Hodgkin-and Reed-Sternberg cells at diagnosis identify patients with poor response to conventional chemotherapy. Transl Oncol 5, 269-277.
27. Vermolen B, Garini Y, Mai S, Mougey V, Fest T, Chuang T, Chuang A, Wark L, Young I (2005) Characterizing the three-dimensional organization of telomeres. Cytometry A 67, 144-150.
28. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37, 614-636.
29. Campisi J (2001) Cellular senescence as tumor-suppressor mechanism. Trends Cell Biol 11, 27-31.
30. Raz V, Vermolen BJ, Garini Y, Onderwater JJ, Mommaas-Kienhuis MA, Koster AJ, Young IT, Tanke H, Dirks RW (2008) The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells. J Cell Sci 121(Pt 24), 4018-4028.
31. Kim MJ, Kim MH, Kim SA, Chang JS (2008) Age-related deterioration of hematopoietic stem cells. Int J Stem Cells 1, 55-63.
32. Patel PL, Suram A, Mirani N, Bischof O, Herbig U (2016) Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Proc Natl Acad Sci U S A 113, E5024-E5033.
33. Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Matsuda Y, Arai T, Takubo K (2016) Changes of telomere status with aging: An update. Geriatr Gerontol Int Suppl 1, 30-42.
34. Seimiya H (2015) Predicting risk at the end of the end: Telomere G-tail as a biomarker. EBioMedicine 2, 804-805.
35. Mai S (2010) Initiation of telomere-mediated chromosomal rearrangements in cancer. J Cell Biochem 109, 1095-1102.
36. Mathur S, Glogowska A, McAvoy E, Righolt C, Rutherford J, Willing C, Banik U, Ruthirakuhan M, Mai S, Garcia A (2014) Three-dimensional quantitative imaging of telomeres in buccal cells identifies mild, moderate, and severe Alzheimer's disease patients. J Alzheimers Dis 39, 35-48.
37. Poon SS, Martens UM, Ward RK, Lansdorp PM (1999) Telomere length measurements using digital fluorescence microscopy. Cytometry 36, 267-278.
38. Schaefer LH, Schuster D, Herz H (2001) Generalized approach for accelerated maximum likelihood based image restoration applied to three-dimensional fluorescence microscopy. J Microsc 204, 99-107.
39. Damjanovic AK, Yang Y, Glaser R, Kiecolt-Glaser JK, Nguyen H, Laskowski B, Zou Y, Beversdorf DQ, Weng NP (2007) Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients. J Immunol 179, 4249-4254.
40. O'Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES (2012) Stress appraisals and cellular aging: A key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain Behav Immun 26, 573-579.