Clozapine counteracts a ketamine-induced depression of hippocampal-prefrontal neuroplasticity and alters signaling pathway phosphorylation

PLoS ONE

Volumn 12, Issue 5, 2017, Pages

  Rame, Marion ^a,b   Caudal, Dorian ^c   Schenker, Esther ^d   Svenningsson, Per ^c   Spedding, Michael ^d,e   Jay, Therèse M ^a,b   Godsil, Bill P ^a,b  

^a CENTRE DE PSYCHIATRIE ET NEUROSCIENCES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c KAROLINSKA INSTITUTE   (Sweden)

^d INSTITUT DE RECHERCHES SERVIER   (France)

^e SPEDDING RESEARCH SOLUTIONS SARL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CLOZAPINE; GLYCOGEN SYNTHASE KINASE 3BETA; KETAMINE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE PROTEIN;

ADULT; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; EFFECT SIZE; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IMMUNOREACTIVITY; IN VIVO STUDY; LONG TERM POTENTIATION; MALE; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PREFRONTAL CORTEX; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CLOZAPINE; HIPPOCAMPUS; KETAMINE; MALE; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; PHOSPHORYLATION; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 85019068155     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0177036     Document Type: Article

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