Tissue Distribution of the MERS-Coronavirus Receptor in Bats

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Widagdo, W ^a   Begeman, Lineke ^a   Schipper, Debby ^a   Van Run, Peter R ^a   Cunningham, Andrew A ^b   Kley, Nils ^c   Reusken, Chantal B ^a   Haagmans, Bart L ^a   Van Den Brand, Judith M A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b INSTITUTE OF ZOOLOGY   (United Kingdom)

^c FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORONAVIRUS RECEPTOR; VIRUS RECEPTOR;

ANIMAL; BAT; CHEMISTRY; EPITHELIUM CELL; INTESTINE MUCOSA; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PHYSIOLOGY; RESPIRATORY MUCOSA; VIRAL TROPISM;

ANIMALS; CHIROPTERA; EPITHELIAL CELLS; INTESTINAL MUCOSA; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; RECEPTORS, VIRUS; RESPIRATORY MUCOSA; VIRAL TROPISM;

EID: 85018953628     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-01290-6     Document Type: Article

References (47)

1. Zumla, A., Hui, D.S.& Perlman, S.Middle East respiratory syndrome.Lancet 386, 995-1007, doi:10.1016/S0140-6736(15)60454-8 (2015).
2. Haagmans, B.L.et al.An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels.Science 351, 77-81, doi:10.1126/science.aad1283 (2016).
3. Raj, V.S.et al.Isolation of MERS coronavirus from a dromedary camel, Qatar, 2014.Emerg Infect Dis 20, 1339-1342, doi:10.3201/eid2008.140663 (2014).
4. Reusken, C.B.et al.Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: A comparative serological study.Lancet Infect Dis 13, 859-866, doi:10.1016/S1473-3099(13)70164-6 (2013).
5. Reusken, C.B.et al.Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013.Euro Surveill 18, 20662, doi:10.2807/1560-7917.ES2013.18.50.20662 (2013).
6. Meyer, B.et al.Antibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and 2013.Emerg Infect Dis 20, 552-559, doi:10.3201/eid2004.131746 (2014).
7. Alraddadi, B.M.et al.Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014.Emerg Infect Dis 22, 49-55, doi:10.3201/eid2201.151340 (2016).
8. Haagmans, B.L.et al.Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation.Lancet Infect Dis 14, 140-145, doi:10.1016/S1473-3099(13)70690-X (2014).
9. Vergara-Alert, J.et al.Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus.Emerg Infect Dis 23, 232-240, doi:10.3201/eid2302.161239 (2017).
10. Raj, V.S.et al.Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.J Virol 88, 1834-1838, doi:10.1128/JVI.02935-13 (2014).
11. Reusken, C.B.et al.MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic.Emerg Infect Dis 22, 1129-1131, doi:10.3201/eid2206.152113 (2016).
12. Cai, Y.et al.CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection.PLoS One 9, e112060, doi:10.1371/journal.pone.0112060 (2014).
13. Eckerle, I.et al.Replicative Capacity of MERS Coronavirus in Livestock Cell Lines.Emerg Infect Dis 20, 276-279, doi:10.3201/eid2002.131182 (2014).
14. Reusken, C.B.et al.Circulation of group 2 coronaviruses in a bat species common to urban areas in Western Europe.Vector Borne Zoonotic Dis 10, 785-791, doi:10.1089/vbz.2009.0173 (2010).
15. Memish, Z.A.et al.Middle East respiratory syndrome coronavirus in bats, Saudi Arabia.Emerg Infect Dis 19, 1819-1823, doi:10.3201/eid1911.131172 (2013).
16. Ithete, N.L.et al.Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa.Emerg Infect Dis 19, 1697-1699, doi:10.3201/eid1910.130946 (2013).
17. Annan, A.et al.Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe.Emerg Infect Dis 19, 456-459, doi:10.3201/eid1903.121503 (2013).
18. Yang, L.et al.MERS-related betacoronavirus in Vespertilio superans bats, China.Emerg Infect Dis 20, 1260-1262, doi:10.3201/eid2007.140318 (2014).
19. Wacharapluesadee, S.et al.Group C betacoronavirus in bat guano fertilizer, Thailand.Emerg Infect Dis 19, 1349-1351, doi:10.3201/eid1908.130119 (2013).
20. Kim, H.K.et al.Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats.Transbound Emerg Dis 63, 365-372, doi:10.1111/tbed.12515 (2016).
21. van Boheemen, S.et al.Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans.MBio 3, e00473-12-e00473-12, doi:10.1128/mBio.00473-12 (2012).
22. Raj, V.S.et al.Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.Nature 495, 251-254, doi:10.1038/nature12005 (2013).
23. Cui, J., Eden, J.S., Holmes, E.C.& Wang, L.F.Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): implications for the origin and emergence of Middle East respiratory syndrome coronavirus.Virol J 10, 304, doi:10.1186/1743-422X-10-304 (2013).
24. Wang, Q.et al.Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26.Cell Host Microbe 16, 328-337, doi:10.1016/j.chom.2014.08.009 (2014).
25. Yang, Y.et al.Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-To-human transmission of MERS coronavirus.Proc Natl Acad Sci USA 111, 12516-12521, doi:10.1073/pnas.1405889111 (2014).
26. Widagdo, W.et al.Differential expression of the MERS-coronavirus receptor in the upper respiratory tract of humans and dromedary camels.J Virol.90, 4838-4842, doi:10.1128/JVI.02994-15 (2016).
27. Who Mers-Cov Research, G.State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans.PLoS Curr 5, doi: 10.1371/currents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8 (2013).
28. Hutson, A.et al.Eptesicus serotinus, http://dx.doi.org/10.2305/IUCN.UK.2008.RLTS.T7911A12867244.en (2008).
29. Hutson, A.et al.Pipistrellus pipistrellus, http://dx.doi.org/10.2305/IUCN.UK.2008.RLTS.T17317A6968203.en (2008).
30. Korine, C.Rousettus aegyptiacus, http://dx.doi.org/10.2305/IUCN.UK.2016-2.RLTS.T29730A22043105.en (2016).
31. Tanshi, I.& Fahr, J.Epomophorus gambianus, e.T7903A22122670 (2016).
32. Uhlen, M.et al.Proteomics.Tissue-based map of the human proteome.Science 347, 1260419-1260419, doi:10.1126/science.1260419 (2015).
33. Gorvel, J.P.et al.Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon.Gastroenterology 101, 618-625, doi:S0016508591003001 [pii], 101, 618-25 (1991).
34. Quaroni, A.et al.Expression and different polarity of aminopeptidase N in normal human colonic mucosa and colonic tumors.Int J Cancer 51, 404-411, doi:10.1002/(ISSN)1097-0215 (1992).
35. Darmoul, D.et al.Regional expression of epithelial dipeptidyl peptidase IV in the human intestines.Biochem Biophys Res Commun 203, 1224-1229, doi:S0006291X84723138 [pii], 203, 1224-9 (1994).
36. Corman, V.M.et al.Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat.J Virol 88, 11297-11303, doi:10.1128/JVI.01498-14 (2014).
37. Munster, V.J.et al.Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis).Sci Rep 6, 21878, doi:10.1038/srep21878 (2016).
38. Ng, D.L.et al.Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014.Am J Pathol 186, 652-658, doi:10.1016/j.ajpath.2015.10.024 (2016).
39. Hocke, A.C.et al.Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs.Am J Respir Crit Care Med 188, 882-886, doi:10.1164/rccm.201305-0954LE (2013).
40. Hemida, M.G.et al.MERS coronavirus in dromedary camel herd, Saudi Arabia.Emerg Infect Dis 20, 1231-1234, doi:10.3201/eid2007.140571 (2014).
41. Drosten, C.et al.Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection.Lancet Infect Dis 13, 745-751, doi:10.1016/S1473-3099(13)70154-3 (2013).
42. Tsiodras, S.et al.A case of imported Middle East Respiratory Syndrome coronavirus infection and public health response, Greece, April 2014.Euro Surveill 19, 20782, doi:10.2807/1560-7917.ES2014.19.16.20782 (2014).
43. Assiri, A.et al.Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study.Lancet Infect Dis 13, 752-761, doi:10.1016/S1473-3099(13)70204-4 (2013).
44. Guery, B.et al.Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: A report of nosocomial transmission.Lancet 381, 2265-2272, doi:10.1016/S0140-6736(13)60982-4 (2013).
45. Peterson, L.W.& Artis, D.Intestinal epithelial cells: regulators of barrier function and immune homeostasis.Nat Rev Immunol 14, 141-153, doi:10.1038/nri3608 (2014).
46. Edwards, Y.H., Hopkinson, D.A.& Harris, H.Adenosine deaminase isozymes in human tissues.Ann Hum Genet 35, 207-219, doi:10.1111/ahg.1971.35.issue-2 (1971).
47. Chan, C.M.et al.Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus.J Virol 90, 9114-9127, doi:10.1128/JVI.01133-16 (2016).