-
1
-
-
84914677322
-
Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients
-
Abe K, Itoyama Y, Sobue G, et al. Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener. 2014;15:610–617.• This paper reports the results of double blind placebo-controlled trial of edaravone against ALS (MCI186-16) with negative results.
-
(2014)
Amyotroph Lateral Scler Frontotemporal Degener
, vol.15
, pp. 610-617
-
-
Abe, K.1
Itoyama, Y.2
Sobue, G.3
-
2
-
-
85018860386
-
A 24-week, phase III, double-blind, parallel-group study of edaravone (MCI-186) for treatment of amyotrophic lateral sclerosis (ALS)
-
Tanaka M, Sakata T, Palumbo J,MA., A 24-week, phase III, double-blind, parallel-group study of edaravone (MCI-186) for treatment of amyotrophic lateral sclerosis (ALS). Neurology. 2015;86:S189.•• This paper reports summary results of an RCT of edaravone against ALS (MCI186-19). In this summary it provides significant efficacy in ALS.
-
(2015)
Neurology
, vol.86
, pp. S189
-
-
Tanaka, M.1
Sakata, T.2
Palumbo, J.M.A.3
-
3
-
-
33847119443
-
Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study)
-
Yoshino H, Kimura A. Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study). Amyotroph Lateral Scler. 2006;7:241–245.
-
(2006)
Amyotroph Lateral Scler
, vol.7
, pp. 241-245
-
-
Yoshino, H.1
Kimura, A.2
-
4
-
-
0032731637
-
ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis
-
Kruman II, Pedersen WA, Springer JE, et al. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp Neurol. 1999;160(1):28–39.
-
(1999)
Exp Neurol
, vol.160
, Issue.1
, pp. 28-39
-
-
Kruman, I.I.1
Pedersen, W.A.2
Springer, J.E.3
-
5
-
-
0036391077
-
Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress
-
Cookson MR, Menzies FM, Manning P, et al. Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress. Amyotroph Lateral Scler Other Motor Neuron Disord. 2002;3:75–85.
-
(2002)
Amyotroph Lateral Scler Other Motor Neuron Disord
, vol.3
, pp. 75-85
-
-
Cookson, M.R.1
Menzies, F.M.2
Manning, P.3
-
6
-
-
0002770493
-
Superoxide dismutase and the death of motoneurons in ALS
-
Beckman JS, Estevez AG, Crow JP, et al. Superoxide dismutase and the death of motoneurons in ALS. Trends Neurosci. 2001;24(11 Suppl):S15–20.
-
(2001)
Trends Neurosci
, vol.24
, Issue.11
, pp. S15-S20
-
-
Beckman, J.S.1
Estevez, A.G.2
Crow, J.P.3
-
8
-
-
79955812764
-
TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology
-
Wegorzewska I, Baloh RH. TDP-43-based animal models of neurodegeneration:new insights into ALS pathology and pathophysiology. Neurodegener Dis. 2011;8:262–274.
-
(2011)
Neurodegener Dis
, vol.8
, pp. 262-274
-
-
Wegorzewska, I.1
Baloh, R.H.2
-
9
-
-
75149155060
-
Oxidative stress in ALS: key role in motor neuron injury and therapeutic target
-
Barber SC, Shaw PJ. Oxidative stress in ALS:key role in motor neuron injury and therapeutic target. Free Radic Biol Med. 2010;48:629–641.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 629-641
-
-
Barber, S.C.1
Shaw, P.J.2
-
10
-
-
0033009113
-
Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis
-
Tohgi H, Abe T, Yamazaki K, et al. Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis. Ann Neurol. 1999;46:129–131.
-
(1999)
Ann Neurol
, vol.46
, pp. 129-131
-
-
Tohgi, H.1
Abe, T.2
Yamazaki, K.3
-
11
-
-
0029923226
-
Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation
-
Shimohama S, Akaike A, Kimura J. Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation. Ann NY Acad Sci. 1996;777:356–361.
-
(1996)
Ann NY Acad Sci
, vol.777
, pp. 356-361
-
-
Shimohama, S.1
Akaike, A.2
Kimura, J.3
-
12
-
-
0030065222
-
Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon
-
Sawada H, Shimohama S, Tamura Y, et al. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. J Neurosci Res. 1996;43:55–62.
-
(1996)
J Neurosci Res
, vol.43
, pp. 55-62
-
-
Sawada, H.1
Shimohama, S.2
Tamura, Y.3
-
13
-
-
0032856942
-
MPP(+) and glutamate in the degeneration of nigral dopaminergic neurons
-
Sawada H, Shimohama S. MPP(+) and glutamate in the degeneration of nigral dopaminergic neurons. Parkinsonism Relat Disord. 1999;5:209–215.
-
(1999)
Parkinsonism Relat Disord
, vol.5
, pp. 209-215
-
-
Sawada, H.1
Shimohama, S.2
-
14
-
-
0031795392
-
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection
-
Urushitani M, Shimohama S, Kihara T, et al. Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate:involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection. Ann Neurol. 1998;44:796–807.
-
(1998)
Ann Neurol
, vol.44
, pp. 796-807
-
-
Urushitani, M.1
Shimohama, S.2
Kihara, T.3
-
15
-
-
0035283075
-
N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx
-
Urushitani M, Nakamizo T, Inoue R, et al. N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death:a mechanism distinct from chronic neurotoxicity after Ca(2+) influx. J Neurosci Res. 2001;63:377–387.
-
(2001)
J Neurosci Res
, vol.63
, pp. 377-387
-
-
Urushitani, M.1
Nakamizo, T.2
Inoue, R.3
-
16
-
-
0031473081
-
Abnormal dephosphorylation effect on NMDA receptor regulation in ALS spinal cord
-
Wagey R, Krieger C, Shaw CA. Abnormal dephosphorylation effect on NMDA receptor regulation in ALS spinal cord. Neurobiol Dis. 1997;4:350–355.
-
(1997)
Neurobiol Dis
, vol.4
, pp. 350-355
-
-
Wagey, R.1
Krieger, C.2
Shaw, C.A.3
-
17
-
-
0030888919
-
Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis
-
Abe K, Pan LH, Watanabe M, et al. Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis. Neurol Res. 1997;19:124–128.
-
(1997)
Neurol Res
, vol.19
, pp. 124-128
-
-
Abe, K.1
Pan, L.H.2
Watanabe, M.3
-
19
-
-
84978726307
-
Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone
-
Fujisawa A, Yamamoto Y. Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone. Redox Rep. 2016;21:98–103.
-
(2016)
Redox Rep
, vol.21
, pp. 98-103
-
-
Fujisawa, A.1
Yamamoto, Y.2
-
20
-
-
84978698157
-
Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration
-
Nagase M, Yamamoto Y, Miyazaki Y, et al. Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration. Redox Rep. 2016;21:104–112.
-
(2016)
Redox Rep
, vol.21
, pp. 104-112
-
-
Nagase, M.1
Yamamoto, Y.2
Miyazaki, Y.3
-
21
-
-
84878937019
-
Edaravone ameliorates oxidative damage associated with Abeta25-35 treatment in PC12 cells
-
Zhang GL, Zhang WG, Du Y, et al. Edaravone ameliorates oxidative damage associated with Abeta25-35 treatment in PC12 cells. J Mol Neurosci. 2013;50:494–503.
-
(2013)
J Mol Neurosci
, vol.50
, pp. 494-503
-
-
Zhang, G.L.1
Zhang, W.G.2
Du, Y.3
-
22
-
-
34250730257
-
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum
-
Kawasaki T, Ishihara K, Ago Y, et al. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J Pharmacol Exp Ther. 2007;322:274–281.
-
(2007)
J Pharmacol Exp Ther
, vol.322
, pp. 274-281
-
-
Kawasaki, T.1
Ishihara, K.2
Ago, Y.3
-
23
-
-
51549119688
-
Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
-
Ito H, Wate R, Zhang J, et al. Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice. Exp Neurol. 2008;213:448–455.
-
(2008)
Exp Neurol
, vol.213
, pp. 448-455
-
-
Ito, H.1
Wate, R.2
Zhang, J.3
-
24
-
-
84949035818
-
Edaravone, a free radical scavenger, delayed symptomatic and pathological progression of motor neuron disease in the wobbler mouse
-
Ikeda K, Iwasaki Y. Edaravone, a free radical scavenger, delayed symptomatic and pathological progression of motor neuron disease in the wobbler mouse. PLoS One. 2015;10:e0140316.
-
(2015)
PLoS One
, vol.10
, pp. e0140316
-
-
Ikeda, K.1
Iwasaki, Y.2
-
25
-
-
79952537198
-
Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger
-
Aoki M, Warita H, Mizuno H, et al. Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger. Brain Res. 2011;1382:321–325.
-
(2011)
Brain Res
, vol.1382
, pp. 321-325
-
-
Aoki, M.1
Warita, H.2
Mizuno, H.3
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