Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation

Biomedicine and Pharmacotherapy

Volumn 91, Issue , 2017, Pages 147-154

  Zhang, Gong ^a   Wang, Wenjun ^b   Yao, Chunxiao ^a   Ren, Jinjin ^a   Zhang, Shuping ^a   Han, Muyuan ^a  

^a SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Nasopharyngeal carcinoma; Nrf2; Radioresistance; ROS; Salinomycin

Indexed keywords

REACTIVE OXYGEN METABOLITE; SALINOMYCIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR NRF2; PYRAN DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CANCER RESISTANCE; CLONOGENESIS; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; HUMAN; HUMAN CELL; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; WESTERN BLOTTING; CARCINOMA; CHEMISTRY; DRUG EFFECTS; IONIZING RADIATION; METABOLISM; NASOPHARYNX TUMOR; PATHOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; TUMOR CELL LINE;

APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; DNA DAMAGE; HUMANS; NASOPHARYNGEAL NEOPLASMS; NF-E2-RELATED FACTOR 2; PYRANS; RADIATION TOLERANCE; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES;

EID: 85018645534     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.04.095     Document Type: Article

References (25)

1. [1] Lee, A.W., Ma, B.B., Ng, W.T., Chan, A.T., Management of nasopharyngeal carcinoma: current practice and future perspective. J. Clin. Oncol. 33 (2015), 3356–3364.
2. [2] Perri, F., Pacelli, R., Della Vittoria Scarpati, G., Cella, L., Giuliano, M., Caponigro, F., Pepe, S., Radioresistance in head and neck squamous cell carcinoma: biological bases and therapeutic implications. Head Neck 37 (2015), 763–770.
3. [3] Zhou, S., Wang, F., Wong, E.T., Fonkem, E., Hsieh, T.C., Wu, J.M., Wu, E., Salinomycin: a novel anti-cancer agent with known anti-coccidial activities. Curr. Med. Chem. 20 (2013), 4095–4101.
4. [4] Mitani, M., Yamanishi, T., Miyazaki, Y., Otake, N., Salinomycin effects on mitochondrial ion translocation and respiration. Antimicrob. Agents Chemother. 9 (1976), 655–660.
5. [5] Gupta, P.B., Onder, T.T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R.A., Lander, E.S., Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 (2009), 645–659.
6. [6] Kim, W.K., Kim, J.H., Yoon, K., Kim, S., Ro, J., Kang, H.S., Yoon, S., Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest. Invest. New Drugs 30 (2012), 1311–1318.
7. [7] Zhou, S., Ye, W., Shao, Q., Zhang, M., Liang, J., Nrf2 is a potential therapeutic target in radioresistance in human cancer. Crit. Rev. Oncol. Hematol. 88 (2013), 706–715.
8. [8] Ohta, T., Iijima, K., Miyamoto, M., Nakahara, I., Tanaka, H., Ohtsuji, M., Suzuki, T., Kobayashi, A., Yokota, J., Sakiyama, T., Shibata, T., Yamamoto, M., Hirohashi, S., Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res. 68 (2008), 1303–1309.
9. [9] Shibata, T., Kokubu, A., Saito, S., Narisawa-Saito, M., Sasaki, H., Aoyagi, K., Yoshimatsu, Y., Tachimori, Y., Kushima, R., Kiyono, T., Yamamoto, M., NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer. Neoplasia 13 (2011), 864–873.
10. [10] McDonald, J.T., Kim, K., Norris, A.J., Vlashi, E., Phillips, T.M., Lagadec, C., Della Donna, L., Ratikan, J., Szelag, H., Hlatky, L., McBride, W.H., Ionizing radiation activates the Nrf2 antioxidant response. Cancer Res. 70 (2010), 8886–8895.
11. [11] Kang, K.A., Lee, H.C., Lee, J.J., Hong, M.N., Park, M.J., Lee, Y.S., Choi, H.D., Kim, N., Ko, Y.G., Lee, J.S., Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cells. J. Radiat. Res. 55 (2014), 265–276.
12. [12] Alan Mitteer, R., Wang, Y., Shah, J., Gordon, S., Fager, M., Butter, P.P., Jun Kim, H., Guardiola-Salmeron, C., Carabe-Fernandez, A., Fan, Y., Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species. Sci. Rep., 10, 2015, 13961.
13. [13] Kim TH1, Hur, E.G., Kang, S.J., Kim, J.A., Thapa, D., Lee, Y.M., Ku, S.K., Jung, Y., Kwak, M.K., NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Cancer Res. 71 (2011), 2260–2275.
14. [14] Wiznerowicz, M., Trono, D., Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J. Virol. 77 (2003), 8957–8961.
15. [15] Dorie, M.J., Kovacs, M.S., Gabalski, E.C., Adam, M., Le, Q.T., Bloch, D.A., Pinto, H.A., Terris, D.J., Brown, J.M., DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine. Neoplasia 1 (1999), 461–467.
16. [16] Rhodes, A., Hillen, T., Mathematical modeling of the role of survivin on dedifferentiation and radioresistance in cancer. Bull. Math. Biol. 78 (2016), 1162–1188.
17. [17] Jonathan, E.C., Bernhard, E.J., McKenna, W.G., How does radiation kill cells?. Curr. Opin. Chem. Biol. 3 (1999), 77–83.
18. [18] Kim, J.H., Yoo, H.I., Kang, H.S., Ro, J., Yoon, S., Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest. Biochem. Biophys. Res. Commun. 418 (2012), 98–103.
19. [19] Fuchs D1, Daniel, V., Sadeghi, M., Opelz, G., Naujokat, C., Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells. Biochem. Biophys. Res. Commun. 394 (2010), 1098–1104.
20. [20] Knatko, E.V., Higgins, M., Fahey, J.W., Dinkova-Kostova, A.T., Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma. Sci. Rep., 6, 2016, 25804.
21. [21] Prasad, K.N., Simultaneous activation of Nrf2 and elevation of dietary and endogenous antioxidant chemicals for cancer prevention in humans. J. Am. Coll. Nutr. 35 (2016), 175–184.
22. [22] Dayal, R., Singh, A., Pandey, A., Mishra, K.P., Reactive oxygen species as mediator of tumor radiosensitivity. J. Cancer Res. Ther. 10 (2014), 811–818.
23. [23] Bertram, C., Hass, R., Cellular responses to reactive oxygen species-induced DNA damage and aging. Biol. Chem. 389 (2008), 211–220.
24. [24] Verdoodt, B., Vogt, M., Schmitz, I., Liffers, S.T., Tannapfel, A., Mirmohammadsadegh, A., Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species. PLoS ONE, 7, 2012, e44132.
25. [25] Petrosillo, G., Ruggiero, F.M., Pistolese, M., Paradies, G., Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis. FEBS Lett. 509 (2001), 435–438.