Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity

Science

Volumn 356, Issue 6335, 2017, Pages 311-315

  Bergmiller, Tobias ^a   Andersson, Anna M C ^a   Tomasek, Kathrin ^a   Balleza, Enrique ^b   Kiviet, Daniel J ^c   Hauschild, Robert ^d   Tkačik, Gašper ^a   Guet, Cǎlin C ^a  

^a INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA   (Austria)

^b HARVARD UNIVERSITY   (United States)

^c ETH ZURICH   (Switzerland)

^d SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GREEN FLUORESCENT PROTEIN; KANAMYCIN; MEMBRANE PROTEIN; PROTEIN ACRA; PROTEIN ACRB; TETRACYCLINE; TOLC PROTEIN; UNCLASSIFIED DRUG; ACRAB-TOLC PROTEIN, E COLI; ANTIINFECTIVE AGENT; DOXYCYCLINE; ESCHERICHIA COLI PROTEIN;

BACTERIUM; CELLS AND CELL COMPONENTS; COLIFORM BACTERIUM; CONCENTRATION (COMPOSITION); DRUG RESISTANCE; EMERGENCE; GROWTH RATE; HETEROGENEITY; MICROBIAL ACTIVITY; PHENOTYPE; POPULATION STRUCTURE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MEMBRANE; CELL HETEROGENEITY; COMPLEX FORMATION; DAUGHTER CELL; ESCHERICHIA COLI; GROWTH RATE; MULTIDRUG RESISTANCE; PHENOTYPE; POLAR BODY; PRIORITY JOURNAL; SEGREGATION ANALYSIS; CELL DIVISION; CYTOLOGY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; METABOLISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ANTI-BACTERIAL AGENTS; CARRIER PROTEINS; CELL DIVISION; DOXYCYCLINE; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GREEN FLUORESCENT PROTEINS; PHENOTYPE; TETRACYCLINE;

EID: 85018563532     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf4762     Document Type: Article

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