Homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17

Current Protein and Peptide Science

Volumn 18, Issue 5, 2017, Pages 515-521

  Holien, Jessica K ^a   Parker, Michael W ^a,b   Conley, Alan J ^c   Corbin, Cynthia Jo ^c   Rodgers, Raymond J ^d   Martin, Lisandra L ^e  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Cytochrome b5; Cytochrome P450 oxidoreductase; Cytochrome P450c17 (P450 17A1, CYP17A1); FRET; Homo dimerisation; Protein protein interaction

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450 REDUCTASE; GLUCOCORTICOID; HOMODIMER; HYDROCORTISONE; STEROID 17ALPHA MONOOXYGENASE; PROTEIN BINDING; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANDROGEN SYNTHESIS; BINDING COMPETITION; BINDING SITE; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HORMONE SYNTHESIS; HUMAN; HYDROGEN BOND; HYDROXYLATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; X RAY CRYSTALLOGRAPHY; ADRENAL GLAND; ALPHA HELIX; BETA SHEET; CHEMISTRY; ENZYMOLOGY; FEMALE; GENE EXPRESSION; GENETICS; MALE; METABOLISM; MOLECULAR MODEL; OVARY; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN MULTIMERIZATION; TESTIS;

ADRENAL GLANDS; AMINO ACID MOTIFS; BINDING SITES; BINDING, COMPETITIVE; CYTOCHROMES B5; FEMALE; GENE EXPRESSION; HUMANS; MALE; MODELS, MOLECULAR; NADPH-FERRIHEMOPROTEIN REDUCTASE; OVARY; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; STEROID 17-ALPHA-HYDROXYLASE; TESTIS;

EID: 85018463074     PISSN: 13892037     EISSN: 18755550     Source Type: Journal    
DOI: 10.2174/1389203717666161220142957     Document Type: Review

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