The mir-221/222 cluster is a key player in vascular biology via the fine-tuning of endothelial cell physiology

Current Vascular Pharmacology

Volumn 15, Issue 1, 2017, Pages 40-46

  Celic, Tanja ^a   Metzinger Le Meuth, Valérie ^a,b   Six, Isabelle ^a   Massy, Ziad A ^c   Metzinger, Laurent ^a  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b UNIVERSITÉ PARIS 13   (France)

^c LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Angiogenesis; Atherosclerosis; Endothelial dysfunction; Endothelium; MicroRNA; Senescence

Indexed keywords

MICRORNA 221; MICRORNA 222; MICRORNA; MIRN221 MICRORNA, HUMAN; MIRN222 MICRORNA, HUMAN;

ATHEROGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; GENE IDENTIFICATION; HUMAN; HYPERTENSION; LIPOPROTEIN METABOLISM; OXIDATIVE STRESS; REVIEW; TUMOR GROWTH; VASCULAR BIOLOGY; VASCULITIS; ANGIOGENESIS; ANIMAL; CELL AGING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOVASCULAR DISEASES; CELL AGING; CELL PROLIFERATION; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; SIGNAL TRANSDUCTION;

EID: 85018444472     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/1570161114666160914175149     Document Type: Review

References (43)

1. Spieker LE, Flammer AJ, Luscher TF. The vascular endothelium in hypertension. Handb Exp Pharmacol 2006; (176 Pt 2): 249-83.
2. Vita JA. Endothelial function. Circulation 2011; 124(25): e906-12.
3. Fliser D, Wiecek A, Suleymanlar G, et al. The dysfunctional endothelium in CKD and in cardiovascular disease: mapping the origin(s) of cardiovascular problems in CKD and of kidney disease in cardiovascular conditions for a research agenda. Kidney Int Suppl (2011); 1(1): 6-9.
4. Cinamon G, Grabovsky V, Winter E, et al. Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow. J Leukoc Biol 2001; 69(6): 860-6.
5. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993; 362(6423): 801-9.
6. Santulli G. microRNAs and Endothelial (Dys) Function. J Cell Physiol 2015, Dec 2. doi: 10.1002/jcp.25276. [Epub ahead of print]
7. Chang SH, Hla T. Gene regulation by RNA binding proteins and microRNAs in angiogenesis. Trends Mol Med 2011; 17(11): 650-8.
8. Suarez Y, Sessa WC. MicroRNAs as novel regulators of angiogenesis. Circ Res 2009; 104(4): 442-54.
9. Taibi F, Metzinger-Le Meuth V, M'Baya-Moutoula E, et al. Possible involvement of microRNAs in vascular damage in experimental chronic kidney disease. Biochim Biophys Acta 2014; 1842(1): 88-98.
10. Kuehbacher A, Urbich C, Dimmeler S. Targeting microRNA expression to regulate angiogenesis. Trends Pharmacol Sci 2008; 29(1): 12-5.
11. Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C. A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 2009; 104(4): 476-87.
12. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136(2): 215-33.
13. Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ. miRBase: tools for microRNA genomics. Nucleic Acids Res 2008; 36(Database issue): D154-8.
14. Taibi F, Metzinger-Le Meuth V, Massy ZA, Metzinger L. miR-223: An inflammatory oncomiR enters the cardiovascular field. Biochim Biophys Acta 2014; 1842(7): 1001-9.
15. Poliseno L, Tuccoli A, Mariani L, et al. MicroRNAs modulate the angiogenic properties of HUVECs. Blood 2006; 108(9): 3068-71.
16. Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res 2007; 101(1): 59-68.
17. Suarez Y, Fernandez-Hernando C, Yu J, et al. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci USA 2008; 105(37): 14082-7.
18. Ungvari Z, Tucsek Z, Sosnowska DT, et al. Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J Gerontol A Biol Sci Med Sci 2013; 68(8): 877-91.
19. Pineau P, Volinia S, McJunkin K, et al. miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci USA 2010; 107(1): 264-9.
20. Dentelli P, Rosso A, Orso F, Olgasi C, Taverna D, Brizzi MF. microRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5A expression. Arterioscler Thromb Vasc Biol 2009; 30(8): 1562-8.
21. Eelen G, de Zeeuw P, Simons M, Carmeliet P. Endothelial cell metabolism in normal and diseased vasculature. Circ Res 2015; 116(7): 1231-44.
22. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 2008; 79(4): 581-8.
23. Chen Y, Banda M, Speyer CL, Smith JS, Rabson AB, Gorski DH. Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol Cell Biol 2010; 30(15): 3902-13.
24. Di J, Jiang L, Zhou Y, et al. Ets-1 targeted by microrna-221 regulates angiotensin II-induced renal fibroblast activation and fibrosis. Cell Physiol Biochem 2014; 34(4): 1063-74.
25. van Rooij E. The art of microRNA research. Circ Res 2012; 108(2): 219-34.
26. Higashi Y, Sukhanov S, Anwar A, Shai SY, Delafontaine P. Aging, atherosclerosis, and IGF-1. J Gerontol A Biol Sci Med Sci 2013; 67(6): 626-39.
27. Lei J, Vodovotz Y, Tzeng E, Billiar TR. Nitric oxide, a protective molecule in the cardiovascular system. Nitric Oxide 2013; 35: 175-85.
28. Bhayadia R, Schmidt BM, Melk A, et al. Senescence-Induced oxidative stress causes endothelial dysfunction. J Gerontol A Biol Sci Med Sci 2016; 71(2): 161-9.
29. Rippe C, Blimline M, Magerko KA, et al. MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Exp Gerontol 2012; 47(1): 45-51.
30. Chen YH, Lin SJ, Lin FY, et al. High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 2007; 56(6): 1559-68.
31. Li Y, Song YH, Li F, Yang T, Lu YW, Geng YJ. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. Biochem Biophys Res Commun 2009; 381(1): 81-3.
32. Xue Y, Wei Z, Ding H, et al. MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1alpha in the progression of atherosclerosis. Atherosclerosis 2015; 241(2): 671-81.
33. Noren Hooten N, Abdelmohsen K, Gorospe M, Ejiogu N, Zonderman AB, Evans MK. microRNA expression patterns reveal differential expression of target genes with age. PLoS One 2010; 5(5): e10724.
34. Hamrick MW, Herberg S, Arounleut P, et al. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. Biochem Biophys Res Commun 2010; 400(3): 379-83.
35. Ding XM. MicroRNAs: regulators of cancer metastasis and epithelial-mesenchymal transition (EMT). Chin J Cancer 2014; 33(3): 140-7.
36. Howe EN, Cochrane DR, Richer JK. The miR-200 and miR-221/222 microRNA families: opposing effects on epithelial identity. J Mammary Gland Biol Neoplasia 2012; 17(1): 65-77.
37. Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroR-NAs--the micro steering wheel of tumour metastases. Nat Rev Cancer 2009; 9(4): 293-302.
38. Zhang X, Shao S, Geng H, et al. Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study. J Clin Endocrinol Metab 2014; 99(5): E766-74.
39. Li T, Cao H, Zhuang J, et al. Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans. Clin Chim Acta 2011; 412(1-2): 66-70.
40. Bye A, Rosjo H, Aspenes ST, Condorelli G, Omland T, Wisloff U. Circulating microRNAs and aerobic fitness-the HUNT-Study. PLoS One 2013; 8(2): e57496.
41. Borel F, Kay MA, Mueller C. Recombinant AAV as a platform for translating the therapeutic potential of RNA interference. Mol Ther 2014; 22(4): 692-701.
42. Takahashi M, Yamada N, Hatakeyama H, et al. In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle. Nucleic Acids Res 2013; 41(22): 10659-67.
43. Janssen HL, Reesink HW, Lawitz EJ, et al. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013; 368(18): 1685-94.