Angiotensin-(1-7) decreases the expression of collagen I via TGF-β1/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition

Clinical Science

Volumn 130, Issue 21, 2016, Pages 1983-1991

  Zhou, Jian Ping ^a   Tang, Wei ^a   Feng, Yun ^a   Li, Ning ^a   Gu, Chen Juan ^a   Li, Qing Yun ^a   Wan, Huan Ying ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Airway remodelling; Angiotensin (1 7); Collagen I; Human lung fibroblast myofibroblast transition; Smad2 3; TGF 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN[1-7]; BETA ACTIN; COLLAGEN TYPE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMAD2 PROTEIN; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1; ACTIN; ANGIOTENSIN I; ANGIOTENSIN I (1-7); PEPTIDE FRAGMENT;

ARTICLE; DOWN REGULATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CYTOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION;

ACTINS; ANGIOTENSIN I; COLLAGEN TYPE I; FIBROBLASTS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MYOFIBROBLASTS; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85018433288     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20160193     Document Type: Article

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