Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: A modeling analysis

American Journal of Physiology - Renal Physiology

Volumn 312, Issue 5, 2017, Pages F819-F835

  Hallow, K Melissa ^a   Gebremichael, Yeshitila ^a   Helmlinger, Gabriel ^b   Vallon, Volker ^c,d  

^a University of Georgia   (United States)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Diabetic hyperfiltration; Diabetic kidney disease; Glomerular hypertension; Mathematical model

Indexed keywords

SODIUM;

ARTICLE; DIABETES MELLITUS; DOWN REGULATION; GLOMERULUS FILTRATION; HUMAN; HYPERTENSION; KIDNEY PERFUSION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE DISORDER; MATHEMATICAL MODEL; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; SODIUM BALANCE; SODIUM TRANSPORT; ULTRAFILTRATION; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DIABETIC NEPHROPATHIES; ELECTROLYTE BALANCE; GLOMERULUS; GLOMERULUS FILTRATION RATE; HEMODYNAMICS; HYPERTENSION, RENAL; KIDNEY CIRCULATION; METABOLISM; NATRIURESIS; PATHOPHYSIOLOGY; PHYSIOLOGICAL FEEDBACK; SPECIES DIFFERENCE; TIME FACTOR; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; COMPUTER SIMULATION; DIABETIC NEPHROPATHIES; FEEDBACK, PHYSIOLOGICAL; GLOMERULAR FILTRATION RATE; HEMODYNAMICS; HUMANS; HYPERTENSION, RENAL; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; MODELS, BIOLOGICAL; NATRIURESIS; RENAL CIRCULATION; RENAL REABSORPTION; SODIUM; SPECIES SPECIFICITY; TIME FACTORS; WATER-ELECTROLYTE BALANCE;

EID: 85018278015     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00497.2016     Document Type: Article

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