메뉴 건너뛰기




Volumn 19, Issue 8, 2017, Pages 974-986

Tailoring mineralocorticoid receptor antagonist therapy in heart failure patients: are we moving towards a personalized approach?

Author keywords

Heart failure; Mineralocorticoid receptor antagonists; Personalized medicine

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; EPLERENONE; NATRIURETIC FACTOR; PLACEBO; POTASSIUM; PROCOLLAGEN C PROTEINASE; PROCOLLAGEN N PROTEINASE; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; SPIRONOLACTONE; MINERALOCORTICOID ANTAGONIST;

EID: 85017459818     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.814     Document Type: Review
Times cited : (28)

References (67)
  • 2
    • 84871680200 scopus 로고    scopus 로고
    • Risk-guided therapy: a first step to personalized medicine
    • Zannad F, Koenig W. Risk-guided therapy: a first step to personalized medicine. Eur J Prev Cardiol 2012;19 (2 Suppl.):5–6.
    • (2012) Eur J Prev Cardiol , vol.19 , Issue.2 , pp. 5-6
    • Zannad, F.1    Koenig, W.2
  • 5
    • 84966533874 scopus 로고    scopus 로고
    • Efficiencies of platform clinical trials: a vision of the future
    • Saville BR, Berry SM. Efficiencies of platform clinical trials: a vision of the future. Clin Trials 2016;13:358–366.
    • (2016) Clin Trials , vol.13 , pp. 358-366
    • Saville, B.R.1    Berry, S.M.2
  • 6
    • 84939180467 scopus 로고    scopus 로고
    • Review of heart failure treatment in type 2 diabetes patients: it's at least as effective as in non-diabetic patients!
    • Girerd N, Zannad F, Rossignol P. Review of heart failure treatment in type 2 diabetes patients: it's at least as effective as in non-diabetic patients! Diabetes Metab 2015;41:446–455.
    • (2015) Diabetes Metab , vol.41 , pp. 446-455
    • Girerd, N.1    Zannad, F.2    Rossignol, P.3
  • 7
    • 84944685324 scopus 로고    scopus 로고
    • A systematic assessment of absolute treatment effect
    • Ferreira JP, Coiro S, Girerd N. A systematic assessment of absolute treatment effect. Am J Cardiol 2015;116:829–831.
    • (2015) Am J Cardiol , vol.116 , pp. 829-831
    • Ferreira, J.P.1    Coiro, S.2    Girerd, N.3
  • 8
    • 84944531479 scopus 로고    scopus 로고
    • To the Editor – Diabetes and sudden death: let's assess the absolute risk increase rather than the proportional risk from sudden cardiac death!
    • Coiro S, Pedro Ferreira J, Ambrosio G, Zannad F, Girerd N. To the Editor – Diabetes and sudden death: let's assess the absolute risk increase rather than the proportional risk from sudden cardiac death! Heart Rhythm 2015;12:e138.
    • (2015) Heart Rhythm , vol.12
    • Coiro, S.1    Pedro Ferreira, J.2    Ambrosio, G.3    Zannad, F.4    Girerd, N.5
  • 9
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341:709–717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 11
  • 12
    • 84868574835 scopus 로고    scopus 로고
    • Influence of baseline and worsening renal function on efficacy of spironolactone in patients with severe heart failure: insights from RALES (Randomized Aldactone Evaluation Study)
    • Vardeny O, Wu DH, Desai A, Rossignol P, Zannad F, Pitt B, Solomon SD. Influence of baseline and worsening renal function on efficacy of spironolactone in patients with severe heart failure: insights from RALES (Randomized Aldactone Evaluation Study). J Am Coll Cardiol 2012;60:2082–2089.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 2082-2089
    • Vardeny, O.1    Wu, D.H.2    Desai, A.3    Rossignol, P.4    Zannad, F.5    Pitt, B.6    Solomon, S.D.7
  • 13
    • 84907389177 scopus 로고    scopus 로고
    • Incidence, predictors, and outcomes related to hypo- and hyperkalemia in patients with severe heart failure treated with a mineralocorticoid receptor antagonist
    • Vardeny O, Claggett B, Anand I, Rossignol P, Desai AS, Zannad F, Pitt B, Solomon SD. Incidence, predictors, and outcomes related to hypo- and hyperkalemia in patients with severe heart failure treated with a mineralocorticoid receptor antagonist. Circ Heart Fail 2014;7:573–579.
    • (2014) Circ Heart Fail , vol.7 , pp. 573-579
    • Vardeny, O.1    Claggett, B.2    Anand, I.3    Rossignol, P.4    Desai, A.S.5    Zannad, F.6    Pitt, B.7    Solomon, S.D.8
  • 16
    • 34447275654 scopus 로고    scopus 로고
    • Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure
    • Biolo A, Chao T, Duhaney TA, Kotlyar E, Allensworth-Davies D, Loscalzo J, Sam F. Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure. Am J Cardiol 2007;100:285–290.
    • (2007) Am J Cardiol , vol.100 , pp. 285-290
    • Biolo, A.1    Chao, T.2    Duhaney, T.A.3    Kotlyar, E.4    Allensworth-Davies, D.5    Loscalzo, J.6    Sam, F.7
  • 18
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES)
    • Zannad F, Alla F, Dousset B, Perez A, Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators. Circulation 2000;102:2700–2706.
    • (2000) Rales Investigators. Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 19
    • 21244431940 scopus 로고    scopus 로고
    • Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure
    • Zannad F, Radauceanu A. Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure. Heart Fail Rev 2005;10:71–78.
    • (2005) Heart Fail Rev , vol.10 , pp. 71-78
    • Zannad, F.1    Radauceanu, A.2
  • 20
    • 84946761083 scopus 로고    scopus 로고
    • Consistency of laboratory monitoring during initiation of mineralocorticoid receptor antagonist therapy in patients with heart failure
    • Cooper LB, Hammill BG, Peterson ED, Pitt B, Maciejewski ML, Curtis LH, Hernandez AF. Consistency of laboratory monitoring during initiation of mineralocorticoid receptor antagonist therapy in patients with heart failure. JAMA 2015;314:1973–1975.
    • (2015) JAMA , vol.314 , pp. 1973-1975
    • Cooper, L.B.1    Hammill, B.G.2    Peterson, E.D.3    Pitt, B.4    Maciejewski, M.L.5    Curtis, L.H.6    Hernandez, A.F.7
  • 21
    • 84855197114 scopus 로고    scopus 로고
    • Subgroup analyses of clinical effectiveness to support health technology assessments
    • Paget MA, Chuang-Stein C, Fletcher C, Reid C. Subgroup analyses of clinical effectiveness to support health technology assessments. Pharm Stat 2011;10:532–538.
    • (2011) Pharm Stat , vol.10 , pp. 532-538
    • Paget, M.A.1    Chuang-Stein, C.2    Fletcher, C.3    Reid, C.4
  • 22
    • 84886023778 scopus 로고    scopus 로고
    • Safety and efficacy of eplerenone in patients at high risk for hyperkalemia and/or worsening renal function: analyses of the EMPHASIS-HF study subgroups (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure)
    • Eschalier R, McMurray JJ, Swedberg K, van Veldhuisen DJ, Krum H, Pocock SJ, Shi H, Vincent J, Rossignol P, Zannad F, Pitt B. Safety and efficacy of eplerenone in patients at high risk for hyperkalemia and/or worsening renal function: analyses of the EMPHASIS-HF study subgroups (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure). J Am Coll Cardiol 2013;62:1585–1593.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 1585-1593
    • Eschalier, R.1    McMurray, J.J.2    Swedberg, K.3    van Veldhuisen, D.J.4    Krum, H.5    Pocock, S.J.6    Shi, H.7    Vincent, J.8    Rossignol, P.9    Zannad, F.10    Pitt, B.11
  • 23
    • 84884890413 scopus 로고    scopus 로고
    • The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial
    • Collier TJ, Pocock SJ, McMurray JJ, Zannad F, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pitt B. The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial. Eur Heart J 2013;34:2823–2829.
    • (2013) Eur Heart J , vol.34 , pp. 2823-2829
    • Collier, T.J.1    Pocock, S.J.2    McMurray, J.J.3    Zannad, F.4    Krum, H.5    van Veldhuisen, D.J.6    Swedberg, K.7    Shi, H.8    Vincent, J.9    Pitt, B.10
  • 24
    • 84860309326 scopus 로고    scopus 로고
    • Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure) study
    • Swedberg K, Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Shi H, Vincent J, Pitt B. Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure) study. J Am Coll Cardiol 2012;59:1598–1603.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1598-1603
    • Swedberg, K.1    Zannad, F.2    McMurray, J.J.3    Krum, H.4    van Veldhuisen, D.J.5    Shi, H.6    Vincent, J.7    Pitt, B.8
  • 25
    • 84896109810 scopus 로고    scopus 로고
    • Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF)
    • Rossignol P, Dobre D, McMurray JJ, Swedberg K, Krum H, van Veldhuisen DJ, Shi H, Messig M, Vincent J, Girerd N, Bakris G, Pitt B, Zannad F. Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). Circ Heart Fail 2014;7:51–58.
    • (2014) Circ Heart Fail , vol.7 , pp. 51-58
    • Rossignol, P.1    Dobre, D.2    McMurray, J.J.3    Swedberg, K.4    Krum, H.5    van Veldhuisen, D.J.6    Shi, H.7    Messig, M.8    Vincent, J.9    Girerd, N.10    Bakris, G.11    Pitt, B.12    Zannad, F.13
  • 27
    • 84985940539 scopus 로고    scopus 로고
    • Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: an analysis of the EMPHASIS-HF study
    • Chin KL, Collier TJ, Pitt B, McMurray JJ, Swedberg K, van Veldhuisen DJ, Pocock SJ, Vincent J, Turgonyi E, Zannad F, Krum H. Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: an analysis of the EMPHASIS-HF study. Eur J Heart Fail 2016;18:1175–1181.
    • (2016) Eur J Heart Fail , vol.18 , pp. 1175-1181
    • Chin, K.L.1    Collier, T.J.2    Pitt, B.3    McMurray, J.J.4    Swedberg, K.5    van Veldhuisen, D.J.6    Pocock, S.J.7    Vincent, J.8    Turgonyi, E.9    Zannad, F.10    Krum, H.11
  • 30
    • 84924989431 scopus 로고    scopus 로고
    • Obesity and the obesity paradox in heart failure
    • Gupta PP, Fonarow GC, Horwich TB. Obesity and the obesity paradox in heart failure. Can J Cardiol 2015;31:195–202.
    • (2015) Can J Cardiol , vol.31 , pp. 195-202
    • Gupta, P.P.1    Fonarow, G.C.2    Horwich, T.B.3
  • 34
    • 84978064544 scopus 로고    scopus 로고
    • Adaptive designs for clinical trials
    • Bhatt DL, Mehta C. Adaptive designs for clinical trials. N Engl J Med 2016;375:65–74.
    • (2016) N Engl J Med , vol.375 , pp. 65-74
    • Bhatt, D.L.1    Mehta, C.2
  • 37
    • 84925582236 scopus 로고    scopus 로고
    • Regional differences in heart failure with preserved ejection fraction trials: when nephrology meets cardiology but east does not meet west
    • Rossignol P, Zannad F. Regional differences in heart failure with preserved ejection fraction trials: when nephrology meets cardiology but east does not meet west. Circulation 2015;131:7–10.
    • (2015) Circulation , vol.131 , pp. 7-10
    • Rossignol, P.1    Zannad, F.2
  • 40
    • 84961629211 scopus 로고    scopus 로고
    • Statistical controversies in reporting of clinical trials: Part 2 of a 4-part series on statistics for clinical trials
    • Pocock SJ, McMurray JJ, Collier TJ. Statistical controversies in reporting of clinical trials: Part 2 of a 4-part series on statistics for clinical trials. J Am Coll Cardiol 2015;66:2648–2662.
    • (2015) J Am Coll Cardiol , vol.66 , pp. 2648-2662
    • Pocock, S.J.1    McMurray, J.J.2    Collier, T.J.3
  • 42
    • 84999711630 scopus 로고    scopus 로고
    • A tentative interpretation of the TOPCAT trial based on randomized evidence from the brain natriuretic peptide stratum analysis
    • Girerd N, Ferreira JP, Rossignol P, Zannad F. A tentative interpretation of the TOPCAT trial based on randomized evidence from the brain natriuretic peptide stratum analysis. Eur J Heart Fail 2016;18:1411–1414.
    • (2016) Eur J Heart Fail , vol.18 , pp. 1411-1414
    • Girerd, N.1    Ferreira, J.P.2    Rossignol, P.3    Zannad, F.4
  • 44
    • 84939547364 scopus 로고    scopus 로고
    • Prognostic importance of impaired systolic function in heart failure with preserved ejection fraction and the impact of spironolactone
    • Shah AM, Claggett B, Sweitzer NK, Shah SJ, Anand IS, Liu L, Pitt B, Pfeffer MA, Solomon SD. Prognostic importance of impaired systolic function in heart failure with preserved ejection fraction and the impact of spironolactone. Circulation 2015;132:402–414.
    • (2015) Circulation , vol.132 , pp. 402-414
    • Shah, A.M.1    Claggett, B.2    Sweitzer, N.K.3    Shah, S.J.4    Anand, I.S.5    Liu, L.6    Pitt, B.7    Pfeffer, M.A.8    Solomon, S.D.9
  • 46
    • 85006189685 scopus 로고    scopus 로고
    • Effect of mineralocorticoid receptor antagonists on cardiac structure and function in patients with diastolic dysfunction and heart failure with preserved ejection fraction: a meta-analysis and systematic review
    • Pandey A, Garg S, Matulevicius SA, Shah AM, Garg J, Drazner MH, Amin A, Berry JD, Marwick TH, Marso SP, de Lemos JA, Kumbhani DJ. Effect of mineralocorticoid receptor antagonists on cardiac structure and function in patients with diastolic dysfunction and heart failure with preserved ejection fraction: a meta-analysis and systematic review. J Am Heart Assoc 2015;4:e002137.
    • (2015) J Am Heart Assoc , vol.4
    • Pandey, A.1    Garg, S.2    Matulevicius, S.A.3    Shah, A.M.4    Garg, J.5    Drazner, M.H.6    Amin, A.7    Berry, J.D.8    Marwick, T.H.9    Marso, S.P.10    de Lemos, J.A.11    Kumbhani, D.J.12
  • 47
    • 84924043305 scopus 로고    scopus 로고
    • Effects of mineralocorticoid receptor antagonists in patients with preserved ejection fraction: a meta-analysis of randomized clinical trials
    • Chen Y, Wang H, Lu Y, Huang X, Liao Y, Bin J. Effects of mineralocorticoid receptor antagonists in patients with preserved ejection fraction: a meta-analysis of randomized clinical trials. BMC Med 2015;13:10.
    • (2015) BMC Med , vol.13 , pp. 10
    • Chen, Y.1    Wang, H.2    Lu, Y.3    Huang, X.4    Liao, Y.5    Bin, J.6
  • 49
    • 84899426616 scopus 로고    scopus 로고
    • Heart failure with systolic dysfunction complicating acute myocardial infarction – differential outcomes but similar eplerenone efficacy by ST-segment or non-ST-segment elevation: a post hoc substudy of the EPHESUS trial
    • Carillo S, Zhang Y, Fay R, Angioi M, Vincent J, Sutradhor SC, Ahmed A, Pitt B, Zannad F. Heart failure with systolic dysfunction complicating acute myocardial infarction – differential outcomes but similar eplerenone efficacy by ST-segment or non-ST-segment elevation: a post hoc substudy of the EPHESUS trial. Arch Cardiovasc Dis 2014;107:149–157.
    • (2014) Arch Cardiovasc Dis , vol.107 , pp. 149-157
    • Carillo, S.1    Zhang, Y.2    Fay, R.3    Angioi, M.4    Vincent, J.5    Sutradhor, S.C.6    Ahmed, A.7    Pitt, B.8    Zannad, F.9
  • 50
    • 70350694017 scopus 로고    scopus 로고
    • Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial
    • Adamopoulos C, Ahmed A, Fay R, Angioi M, Filippatos G, Vincent J, Pitt B, Zannad F. Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial. Eur J Heart Fail 2009;11:1099–1105.
    • (2009) Eur J Heart Fail , vol.11 , pp. 1099-1105
    • Adamopoulos, C.1    Ahmed, A.2    Fay, R.3    Angioi, M.4    Filippatos, G.5    Vincent, J.6    Pitt, B.7    Zannad, F.8
  • 51
    • 84941197910 scopus 로고    scopus 로고
    • Clinical benefits of eplerenone in patients with systolic heart failure and mild symptoms when initiated shortly after hospital discharge: analysis from the EMPHASIS-HF trial
    • Girerd N, Collier T, Pocock S, Krum H, McMurray JJ, Swedberg K, van Veldhuisen DJ, Vincent J, Pitt B, Zannad F. Clinical benefits of eplerenone in patients with systolic heart failure and mild symptoms when initiated shortly after hospital discharge: analysis from the EMPHASIS-HF trial. Eur Heart J 2015;36:2310–2317.
    • (2015) Eur Heart J , vol.36 , pp. 2310-2317
    • Girerd, N.1    Collier, T.2    Pocock, S.3    Krum, H.4    McMurray, J.J.5    Swedberg, K.6    van Veldhuisen, D.J.7    Vincent, J.8    Pitt, B.9    Zannad, F.10
  • 53
    • 84884812809 scopus 로고    scopus 로고
    • Tailoring diuretic therapy in acute heart failure: insight into early diuretic response predictors
    • Ferreira JP, Santos M, Almeida S, Marques I, Bettencourt P, Carvalho H. Tailoring diuretic therapy in acute heart failure: insight into early diuretic response predictors. Clin Res Cardiol 2013;102:745–753.
    • (2013) Clin Res Cardiol , vol.102 , pp. 745-753
    • Ferreira, J.P.1    Santos, M.2    Almeida, S.3    Marques, I.4    Bettencourt, P.5    Carvalho, H.6
  • 56
    • 0034126414 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology
    • Delyani JA. Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int 2000;57:1408–1411.
    • (2000) Kidney Int , vol.57 , pp. 1408-1411
    • Delyani, J.A.1
  • 57
    • 0020558966 scopus 로고
    • Single-dose i.v. aldactone for congestive heart failure: a preliminary observation
    • Ceremuzynski L, Budaj A, Michorowski B. Single-dose i.v. aldactone for congestive heart failure: a preliminary observation. Int J Clin Pharmacol Ther Toxicol 1983;21:417–421.
    • (1983) Int J Clin Pharmacol Ther Toxicol , vol.21 , pp. 417-421
    • Ceremuzynski, L.1    Budaj, A.2    Michorowski, B.3
  • 58
    • 77649106201 scopus 로고    scopus 로고
    • Aldosterone receptor antagonists: effective but often forgotten
    • Maron BA, Leopold JA. Aldosterone receptor antagonists: effective but often forgotten. Circulation 2010;121:934–939.
    • (2010) Circulation , vol.121 , pp. 934-939
    • Maron, B.A.1    Leopold, J.A.2
  • 59
    • 84945979032 scopus 로고    scopus 로고
    • Effect of patiromer on reducing serum potassium and preventing recurrent hyperkalaemia in patients with heart failure and chronic kidney disease on RAAS inhibitors
    • Pitt B, Bakris GL, Bushinsky DA, Garza D, Mayo MR, Stasiv Y, Christ-Schmidt H, Berman L, Weir MR. Effect of patiromer on reducing serum potassium and preventing recurrent hyperkalaemia in patients with heart failure and chronic kidney disease on RAAS inhibitors. Eur J Heart Fail 2015;17:1057–1065.
    • (2015) Eur J Heart Fail , vol.17 , pp. 1057-1065
    • Pitt, B.1    Bakris, G.L.2    Bushinsky, D.A.3    Garza, D.4    Mayo, M.R.5    Stasiv, Y.6    Christ-Schmidt, H.7    Berman, L.8    Weir, M.R.9
  • 62
    • 84914703676 scopus 로고    scopus 로고
    • Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial
    • Kosiborod M, Rasmussen HS, Lavin P, Qunibi WY, Spinowitz B, Packham D, Roger SD, Yang A, Lerma E, Singh B. Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial. JAMA 2014;312:2223–2233.
    • (2014) JAMA , vol.312 , pp. 2223-2233
    • Kosiborod, M.1    Rasmussen, H.S.2    Lavin, P.3    Qunibi, W.Y.4    Spinowitz, B.5    Packham, D.6    Roger, S.D.7    Yang, A.8    Lerma, E.9    Singh, B.10
  • 64
    • 84891629671 scopus 로고    scopus 로고
    • Number needed to treat from absolute risk and incidence rate: how to make apples and oranges comparable?
    • Girerd N, Rabilloud M, Duarte K, Roy P. Number needed to treat from absolute risk and incidence rate: how to make apples and oranges comparable? J Clin Epidemiol 2014;67:236–238.
    • (2014) J Clin Epidemiol , vol.67 , pp. 236-238
    • Girerd, N.1    Rabilloud, M.2    Duarte, K.3    Roy, P.4
  • 65
    • 84928739516 scopus 로고    scopus 로고
    • The platform trial: an efficient strategy for evaluating multiple treatments
    • Berry SM, Connor JT, Lewis RJ. The platform trial: an efficient strategy for evaluating multiple treatments. JAMA 2015;313:1619–1620.
    • (2015) JAMA , vol.313 , pp. 1619-1620
    • Berry, S.M.1    Connor, J.T.2    Lewis, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.