Clinical clues for autoimmunity and neuroinflammation in patients with autistic regression

Developmental Medicine and Child Neurology

Volumn 59, Issue 9, 2017, Pages 947-951

  Scott, Ori ^a   Shi, Diya ^b   Andriashek, Diana ^c   Clark, Brenda ^c   Goez, Helly R ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c GLENROSE REHABILITATION HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTISM; AUTISM DIAGNOSTIC INTERVIEW REVISED; AUTOIMMUNE THYROIDITIS; AUTOIMMUNITY; CELIAC DISEASE; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DSM-5; FACIAL EXPRESSION; FEMALE; FIRST-DEGREE RELATIVE; HUMAN; IMMUNE RESPONSE; INCIDENCE; INFLAMMATORY BOWEL DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; LANGUAGE DEVELOPMENT; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; MEDICAL RECORD REVIEW; MOTOR PERFORMANCE; NERVOUS SYSTEM INFLAMMATION; PERINATAL PERIOD; PREGNANCY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK FACTOR; SECOND-DEGREE RELATIVE; SOCIAL INTERACTION; SPEECH DEVELOPMENT; AUTISM SPECTRUM DISORDER; DIABETES MELLITUS, TYPE 1; DISEASE COURSE; FAMILY; FEVER; GENETIC PREDISPOSITION; IMMUNOLOGY; IMMUNOMODULATION; PRESCHOOL CHILD; PREVALENCE; THYROID DISEASES;

AUTISM SPECTRUM DISORDER; AUTOIMMUNITY; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; FAMILY; FEMALE; FEVER; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; NEUROIMMUNOMODULATION; PREVALENCE; THYROID DISEASES;

EID: 85017439245     PISSN: 00121622     EISSN: 14698749     Source Type: Journal    
DOI: 10.1111/dmcn.13432     Document Type: Article

References (25)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th edn. Arlington, VA: American Psychiatric Publishing, 2013.
2. Thomas MS, Knowland VC, Karmiloff-Smith A. Mechanisms of developmental regression in autism and the broader phenotype: a neural network modeling approach. Psychol Rev 2011; 118: 637–54.
3. Kobayashi R, Murata T. Setback phenomenon in autism and long-term prognosis. Acta Psychiatr Scand 1998; 98: 296–303.
4. D'Onofrio BM, Class QA, Rickert ME, Larsson H, Långström N, Lichtenstein P. Preterm birth and mortality and morbidity: a population-based quasi-experimental study. JAMA Psychiatry 2013; 70: 1231–40.
5. Luyster R, Richler J, Risi S, et al. Early regression in social communication in autism spectrum disorders: a CPEA Study. Dev Neuropsychol 2005; 27: 311–36.
6. Tuchman RF, Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates. Pediatrics 1997; 99: 560–6.
7. Wasilewska J, Kaczmarski M, Stasiak-Barmuta A, Tobolczyk J, Kowalewska E. Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3–6 years old. Arch Med Sci 2012; 8: 324–31.
8. Duffy FH, Shankardass A, McAnulty GB, et al. Corticosteroid therapy in regressive autism: a retrospective study of effects on the Frequency Modulated Auditory Evoked Response (FMAER), language, and behavior. BMC Neurol 2014; 14: 70.
9. Schou M, Sæther SG, Borowski K, et al. Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care. Psychol Med 2016; 46: 3303.
10. Scott O, Richer L, Forbes K, et al. Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis: an unusual cause of autistic regression in a toddler. J Child Neurol 2014; 29: 691–4.
11. Hacohen Y, Wright S, Gadian J, et al. N-methyl-d-aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression. Dev Med Child Neurol 2016; 58: 1092–4.
12. Shenoy S, Arnold S, Chatila T. Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome. J Pediatr 2000; 136: 682–7.
13. Ercolini AM, Miller SD. The role of infections in autoimmune disease. Clin Exp Immunol 2009; 155: 1–15.
14. Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994; 24: 659–85.
15. Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 1986; 51: 1173–82.
16. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plas-ma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2011; 25: 40–5.
17. Heuer L, Ashwood P, Schauer J, et al. Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res 2008; 1: 275–83.
18. Atladóttir HO, Pedersen MG, Thorsen P, et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 2009; 124: 687–94.
19. Molloy CA, Morrow AL, Meinzen-Derr J, et al. Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study. J Autism Dev Disord 2006; 36: 317–24.
20. Dalton P, Deacon R, Blamire A, et al. Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol 2003; 53: 533–7.
21. Brimberg L, Sadiq A, Gregersen PK, Diamond B. Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder. Mol Psychiatry 2013; 18: 1171–7.
22. Vinet É, Pineau CA, Clarke AE, et al. Increased risk of autism spectrum disorders in children born to women with systemic lupus erythematosus: results from a large population-based cohort. Arthritis Rheumatol 2015; 67: 3201–8.
23. Stefanatos GA, Grover W, Geller E. Case study: corticosteroid treatment of language regression in pervasive developmental disorder. J Am Acad Child Adolesc Psychiatry 1995; 34: 1107–11.
24. Gupta S, Aggarwal S, Heads C. Dysregulated immune system in children with autism: beneficial effects of intravenous immune globulin on autistic characteristics. J Autism Dev Disord 1996; 26: 439–52.
25. Boris M. Improvement in children with autism treated with intravenous gamma globulin. J Nutr Environ Med 2005; 15: 169–76.