Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care

Psychological Medicine

Volumn 46, Issue 16, 2016, Pages 3303-3313

  Schou, M ^a,b   Saether S G ^a,b   Borowski, K ^c   Teegen, B ^c   Kondziella, D ^a,d   Stoecker, W ^c   Vaaler, A ^a,b   Reitan, S K ^a,b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c Institute of Experimental Immunology   (Germany)

^d University of Copenhagen   (Denmark)

Author keywords

Antibodies; autoimmunity; N methyl D aspartate (NMDA) receptor; psychiatry

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; AMPA RECEPTOR; AUTOANTIBODY; CNTNAP2 PROTEIN, HUMAN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 2; LGI1 PROTEIN, HUMAN; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE PROTEIN; PROTEIN;

ADULT; BIPOLAR DISORDER; CROSS-SECTIONAL STUDY; DEPRESSION; FEMALE; HOSPITALIZATION; HUMAN; IMMUNOLOGY; MALE; MENTAL DISEASE; MIDDLE AGED; NORWAY; PSYCHOSIS; SCHIZOPHRENIA;

ADULT; AUTOANTIBODIES; BIPOLAR DISORDER; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER; FEMALE; GLUTAMATE DECARBOXYLASE; HOSPITALIZATION; HUMANS; MALE; MEMBRANE PROTEINS; MENTAL DISORDERS; MIDDLE AGED; NERVE TISSUE PROTEINS; NORWAY; PROTEINS; PSYCHOTIC DISORDERS; RECEPTORS, AMPA; RECEPTORS, GABA-B; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA;

EID: 84986628172     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291716002038     Document Type: Article

References (43)

1. Bagoien G, Bjorngaard JH, Ostensen C, Reitan SK, Romundstad P, Morken G (2013). The effects of motivational interviewing on patients with comorbid substance use admitted to a psychiatric emergency unit-A randomised controlled trial with two year follow-up. BMC Psychiatry 13, 93.
2. Barry H, Hardiman O, Healy DG, Keogan M, Moroney J, Molnar PP, Cotter DR, Murphy KC (2011). Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis. British Journal of Psychiatry 199, 508-509.
3. Bergink V, Armangue T, Titulaer MJ, Markx S, Dalmau J, Kushner SA (2015). Autoimmune encephalitis in postpartum psychosis. American Journal of Psychiatry 172, 901-908.
4. Busse S, Busse M, Brix B, Probst C, Genz A, Bogerts B, Stoecker W, Steiner J (2014). Seroprevalence of N-methyl-D-Aspartate glutamate receptor (NMDA-R) autoantibodies in aging subjects without neuropsychiatric disorders and in dementia patients. European Archives of Psychiatry and Clinical Neuroscience 264, 545-550.
5. Chapman MR, Vause HE (2011). Anti-NMDA receptor encephalitis: diagnosis, psychiatric presentation, and treatment. American Journal of Psychiatry 168, 245-251.
6. Cohen BJ, McGarvey EL, Pinkerton RC, Kryzhanivska L (2004). Willingness and competence of depressed and schizophrenic inpatients to consent to research. Journal of the American Academy of Psychiatry and the Law 32, 134-143.
7. Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stocker W, Ehrenreich H (2014). Seroprevalence of autoantibodies against brain antigens in health and disease. Annals of Neurology 76, 82-94.
8. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R, Lynch DR (2008). Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurology 7, 1091-1098.
9. De Witte LD, Hoffmann C, Van Mierlo HC, Titulaer MJ, Kahn RS, Martinez-Martinez P; European Consortium of Autoimmune Mental Disorders (CAIMED) (2015). Absence of N-methyl-D-Aspartate receptor IgG autoantibodies in schizophrenia: the importance of cross-validation studies. JAMA Psychiatry 72, 731-733.
10. Dogan Onugoren M, Deuretzbacher D, Haensch CA, Hagedorn HJ, Halve S, Isenmann S, Kramme C, Lohner H, Melzer N, Monotti R, Presslauer S, Schabitz WR, Steffanoni S, Stoeck K, Strittmatter M, Stogbauer F, Trinka E, Von Oertzen TJ, Wiendl H, Woermann FG, Bien CG (2015). Limbic encephalitis due to GABAB and AMPA receptor antibodies: a case series. Journal of Neurology, Neurosurgery, and Psychiatry 86, 965-972.
11. Doss S, Wandinger KP, Hyman BT, Panzer JA, Synofzik M, Dickerson B, Mollenhauer B, Scherzer CR, Ivinson AJ, Finke C, Schöls L, Müller Vom Hagen J, Trenkwalder C, Jahn H, Höltje M, Biswal BB, Harms L, Ruprecht K, Buchert R, Höglinger GU, Oertel WH, Unger MM, Körtvélyessy P, Bittner D, Priller J, Spruth EJ, Paul F, Meisel A, Lynch DR, Dirnagl U, Endres M, Teegen B, Probst C, Komorowski L, Stöcker W, Dalmau J, Prüss H (2014). High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types. Annals of Clinical and Translational Neurology 1, 822-832.
12. Endres D, Perlov E, Baumgartner A, Hottenrott T, Dersch R, Stich O, Tebartz Van Elst L (2015). Immunological findings in psychotic syndromes: a tertiary care hospital's CSF sample of 180 patients. Frontiers in Human Neuroscience 9, 476.
13. Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H (2014). Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Molecular Psychiatry 19, 1143-1149.
14. Höftberger R, Van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J (2015). Encephalitis and AMPA receptor antibodies: novel findings in a case series of 22 patients. Neurology 84, 2403-2412.
15. Huda S, Wong SH, Pettingill P, O?Connell D, Vincent A, Steiger M (2015). An 11-year retrospective experience of antibodies against the voltage-gated potassium channel (VGKC) complex from a tertiary neurological centre. Journal of Neurology 262, 418-424.
16. Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A (2010). Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-Associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 133, 2734-2748.
17. Jørgensen A, Hansen BS, Stanislaus S, Düring S, Jørgensen MB, Pinborg LH, Kondziella D (2015). Anti-N-methyl-D-Aspartate receptor encephalitis is an important differential diagnosis in acute psychiatric disease. Acta Psychiatrica Scandinavica 131, 69-70.
18. Kawasaki E (2014). Type 1 diabetes and autoimmunity. Clinical Pediatric Endocrinology 23, 99-105.
19. Kayser MS, Kohler CG, Dalmau J (2010). Psychiatric manifestations of paraneoplastic disorders. American Journal of Psychiatry 167, 1039-1050.
20. Kayser MS, Titulaer MJ, Gresa-Arribas N, Dalmau J (2013). Frequency and characteristics of isolated psychiatric episodes in anti-N-methyl-D-Aspartate receptor encephalitis. JAMA Neurology 70, 1133-1139.
21. Klein CJ, Lennon VA, Aston PA, McKeon A, O?Toole O, Quek A, Pittock SJ (2013). Insights from LGI1 and CASPR2 potassium channel complex autoantibody subtyping. JAMA Neurology 70, 229-234.
22. Kohigashi M, Kitabayashi Y, Okamura A, Nakamura M, Hoshiyama A, Kunizawa M, Futori K, Kitabayashi M, Narumoto J, Fukui K (2013). Relationship between patient's quality of life and coercion in psychiatric acute wards. Psychiatry Research 208, 88-90.
23. Krishnamoorthy ES, Trimble MR, Blumer D (2007). The classification of neuropsychiatric disorders in epilepsy: a proposal by the ILAE Commission on Psychobiology of Epilepsy. Epilepsy and Behavior 10, 349-353.
24. Malter MP, Helmstaedter C, Urbach H, Vincent A, Bien CG (2010). Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Annals of Neurology 67, 470-478.
25. Manto M, Honnorat J, Hampe CS, Guerra-Narbona R, López-Ramos JC, Delgado-García JM, Saitow F, Suzuki H, Yanagawa Y, Mizusawa H, Mitoma H (2015). Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions. Frontiers in Behavioral Neuroscience 9, 78.
26. Mordal J, Medhus S, Holm B, Morland J, Bramness JG (2013). Influence of drugs of abuse and alcohol upon patients admitted to acute psychiatric wards: physician's assessment compared to blood drug concentrations. Journal of Clinical Psychopharmacology 33, 415-419.
27. Padmos RC, Bekris L, Knijff EM, Tiemeier H, Kupka RW, Cohen D, Nolen WA, Lernmark A, Drexhage HA (2004). A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Biological Psychiatry 56, 476-482.
28. Paterson RW, Zandi MS, Armstrong R, Vincent A, Schott JM (2014). Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre. Journal of Neurology, Neurosurgery, and Psychiatry 85, 625-630.
29. Pathmanandavel K, Starling J, Merheb V, Ramanathan S, Sinmaz N, Dale RC, Brilot F (2015). Antibodies to surface dopamine-2 receptor and N-methyl-D-Aspartate receptor in the first episode of acute psychosis in children. Biological Psychiatry 77, 537-547.
30. Pollak TA, McCormack R, Peakman M, Nicholson TR, David AS (2014). Prevalence of anti-N-methyl-D-Aspartate (NMDA) receptor [corrected] antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-Analysis. Psychological Medicine 44, 2475-2487.
31. Probst C, Saschenbrecker S, Stoecker W, Komorowski L (2014). Anti-neuronal autoantibodies: current diagnostic challenges. Multiple Sclerosis and Related Disorders 3, 303-320.
32. Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, Borowski K, Ahnert-Hilger G, Harms L, Schwab JM, Ploner CJ, Komorowski L, Stoecker W, Dalmau J, Wandinger KP (2012). N-methyl-D-Aspartate receptor antibodies in herpes simplex encephalitis. Annals of Neurology 72, 902-911.
33. Prüss H, Höltje M, Maier N, Gomez A, Buchert R, Harms L, Ahnert-Hilger G, Schmitz D, Terborg C, Kopp U, Klingbeil C, Probst C, Kohler S, Schwab JM, Stoecker W, Dalmau J, Wandinger KP (2012). IgA NMDA receptor antibodies are markers of synaptic immunity in slow cognitive impairment. Neurology 78, 1743-1753.
34. Somers KJ, Lennon VA, Rundell JR, Pittock SJ, Drubach DA, Trenerry MR, Lachance DH, Klein CJ, Aston PA, McKeon A (2011). Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity. Journal of Neuropsychiatry and Clinical Neurosciences 23, 425-433.
35. Steiner J, Teegen B, Schiltz K, Bernstein HG, Stoecker W, Bogerts B (2014). Prevalence of N-methyl-D-Aspartate receptor autoantibodies in the peripheral blood: healthy control samples revisited. JAMA Psychiatry 71, 838-839.
36. Steiner J, Walter M, Glanz W, Sarnyai Z, Bernstein HG, Vielhaber S, Kastner A, Skalej M, Jordan W, Schiltz K, Klingbeil C, Wandinger KP, Bogerts B, Stoecker W (2013). Increased prevalence of diverse N-methyl-D-Aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-Aspartate glutamate receptor encephalitis. JAMA Psychiatry 70, 271-278.
37. Tidswell J, Kleinig T, Ash D, Thompson P, Galletly C (2013). Early recognition of anti-N-methyl D-Aspartate (NMDA) receptor encephalitis presenting as acute psychosis. Australasian Psychiatry 21, 596-599.
38. Vaaler AE, Morken G, Iversen VC, Kondziella D, Linaker OM (2010). Acute unstable depressive syndrome (AUDS) is associated more frequently with epilepsy than major depression. BMC Neurology 10, 67.
39. Van Mierlo HC, Titulaer MJ, Kromkamp M, Van De Kraats R, Van Veelen NM, Palmen SJ, Kahn RS, De Witte LD (2015). Early recognition of anti-N-methyl-D-Aspartate receptor encephalitis in psychiatric patients. Acta Psychiatrica Scandinavica 132, 312-313.
40. Waters P, Reindl M, Saiz A, Schanda K, Tuller F, Kral V, Nytrova P, Sobek O, Nielsen HH, Barington T, Lillevang ST, Illes Z, Rentzsch K, Berthele A, Berki T, Granieri L, Bertolotto A, Giometto B, Zuliani L, Hamann D, Van Pelt ED, Hintzen R, Höftberger R, Costa C, Comabella M, Montalban X, Tintoré M, Siva A, Altintas A, Deniz G, Woodhall M, Palace J, Paul F, Hartung HP, Aktas O, Jarius S, Wildemann B, Vedeler C, Ruiz A, Leite MI, Trillenberg P, Probst M, Saschenbrecker S, Vincent A, Marignier R (2016). Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica. Journal of Neurology, Neurosurgery, and Psychiatry 87, 1005-1015.
41. World Health Organization (1993). The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. World Health Organization: Geneva, Switzerland.
42. Zandi MS, Deakin JB, Morris K, Buckley C, Jacobson L, Scoriels L, Cox AL, Coles AJ, Jones PB, Vincent A, Lennox BR (2014). Immunotherapy for patients with acute psychosis and serum N-methyl D-Aspartate receptor (NMDAR) antibodies: a description of a treated case series. Schizophrenia Research 160, 193-195.
43. Zandi MS, Irani SR, Lang B, Waters P, Jones PB, McKenna P, Coles AJ, Vincent A, Lennox BR (2011). Disease-relevant autoantibodies in first episode schizophrenia. Journal of Neurology 258, 686-688.